OA09374A - "New 1, 2, 3, 4, 5, 6-hexahydroazepino [4,5-b] indoles and 1, 2, 3, 4-tetrahydro B carbolines, their preparation processes and pharmaceutical compositions which contain them". - Google Patents

"New 1, 2, 3, 4, 5, 6-hexahydroazepino [4,5-b] indoles and 1, 2, 3, 4-tetrahydro B carbolines, their preparation processes and pharmaceutical compositions which contain them".

Info

Publication number
OA09374A
OA09374A OA60030A OA60030A OA09374A OA 09374 A OA09374 A OA 09374A OA 60030 A OA60030 A OA 60030A OA 60030 A OA60030 A OA 60030A OA 09374 A OA09374 A OA 09374A
Authority
OA
OAPI
Prior art keywords
hexahydroazepino
carbolines
indoles
tetrahydro
contain
Prior art date
Application number
OA60030A
Other languages
French (fr)
Inventor
Levy Jean
Laronze Jean Yves
Devissaguet Michelle
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of OA09374A publication Critical patent/OA09374A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
OA60030A 1990-06-27 1991-06-27 "New 1, 2, 3, 4, 5, 6-hexahydroazepino [4,5-b] indoles and 1, 2, 3, 4-tetrahydro B carbolines, their preparation processes and pharmaceutical compositions which contain them". OA09374A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9008094A FR2663935A1 (en) 1990-06-27 1990-06-27 NOVEL 1,2,3,4,5,6-HEXAHYDROAZEPINO [4,5-B] INDOLES AND 1,2,3,4-TETRAHYDROBETHACARBOLINES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
OA09374A true OA09374A (en) 1992-09-15

Family

ID=9398070

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60030A OA09374A (en) 1990-06-27 1991-06-27 "New 1, 2, 3, 4, 5, 6-hexahydroazepino [4,5-b] indoles and 1, 2, 3, 4-tetrahydro B carbolines, their preparation processes and pharmaceutical compositions which contain them".

Country Status (10)

Country Link
EP (1) EP0466548A1 (en)
JP (1) JPH04243879A (en)
AU (1) AU636232B2 (en)
CA (1) CA2045450A1 (en)
FR (1) FR2663935A1 (en)
IE (1) IE912225A1 (en)
NZ (1) NZ238709A (en)
OA (1) OA09374A (en)
PT (1) PT98101A (en)
ZA (1) ZA914970B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0620222A3 (en) * 1993-04-14 1995-04-12 Lilly Co Eli Tetrahydro-beta-carbolines.
US5300645A (en) * 1993-04-14 1994-04-05 Eli Lilly And Company Tetrahydro-pyrido-indole
US5663178A (en) * 1995-02-06 1997-09-02 Eli Lilly And Company Tetrahydro-beta carbolines
FR2724384B1 (en) * 1994-09-14 1999-04-16 Cemaf NOVEL 3,4-DIHYDRO BETA-CARBOLINE DERIVATIVES OF MELATONIN AGONISTS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
WO2002024700A2 (en) 2000-09-20 2002-03-28 Pharmacia & Upjohn Company SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES
US20020160999A1 (en) * 2001-01-08 2002-10-31 Jacobsen Susan Fox Substituted indolines
DE60216745T2 (en) * 2001-04-25 2007-05-16 Lilly Icos Llc, Wilmington Chemical compounds
US7250514B1 (en) * 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
DE10252667A1 (en) 2002-11-11 2004-05-27 Grünenthal GmbH New spiro-((cyclohexane)-tetrahydropyrano-(3,4-b)-indole) derivatives, are ORL1 receptor ligands useful e.g. for treating anxiety, depression, epilepsy, senile dementia, withdrawal symptoms or especially pain
US20040248880A1 (en) * 2003-04-25 2004-12-09 Jacobsen Eric Jon 1,2,3,4,5,6-Hexahydroazepino[4,5-B]indoles containing arylsulfones at the 9-position
DE10360792A1 (en) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclic cyclohexane derivatives
DE10360793A1 (en) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclic cyclohexane derivatives
DE102004039382A1 (en) * 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclic cyclohexane derivatives
WO2006122931A1 (en) * 2005-05-20 2006-11-23 Biovitrum Ab (Publ) Beta-carboline derivatives and theri use as ghsr modulators
US20070149557A1 (en) * 2005-11-21 2007-06-28 Amgen Inc. CXCR3 antagonists
CA2633243C (en) * 2005-12-15 2014-05-27 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
DE102006019597A1 (en) * 2006-04-27 2007-10-31 Grünenthal GmbH New spirocyclic cyclohexane derivatives useful for treating pain, depression, urinary incontinence, diarrhea, pruritis, alcohol and drug abuse, medicament dependence, lack of drive and/or anxiety
EP2285808B1 (en) * 2008-04-29 2013-11-20 Novartis AG Spiro-indole derivatives for the treatment of parasitic diseases
JP5588991B2 (en) 2008-10-31 2014-09-10 メディベイション テクノロジーズ， インコーポレイテッド Pyrido [4,3-b] indole with rigid part
JP5551708B2 (en) * 2008-10-31 2014-07-16 メディベイション テクノロジーズ， インコーポレイテッド Azepino [4,5-b] indole compounds and methods of use thereof
AU2012254158B2 (en) 2011-02-18 2016-02-04 Medivation Technologies, Inc. Compounds and methods of treating diabetes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3293254A (en) * 1964-01-31 1966-12-20 Upjohn Co 2', 3', 4', 9'-tetrahydro-6'-alkoxy spiro
GR35044B (en) * 1966-05-10 1968-07-31 The Upjohn Company METHOD OF PREPARATION OF ORGANIC COMPOUNDS.
FR1524830A (en) * 1966-05-31 1968-05-10 Geigy Ag J R New indole derivatives and their preparation
US3525750A (en) * 1966-05-31 1970-08-25 Geigy Chem Corp 1,2,3,4,5,6-hexahydro-azepino(4,5-b) indole derivatives
FR2455044A1 (en) * 1979-04-26 1980-11-21 Synthelabo PYRIDO-INDOLES AND THEIR APPLICATION IN THERAPEUTICS
DE3070467D1 (en) * 1979-11-02 1985-05-15 Sandoz Ag Azepinoindoles, process for their production and pharmaceutical compositions containing them
JPS5995286A (en) * 1982-11-19 1984-06-01 Otsuka Pharmaceut Factory Inc Imidazo(4,5-c)pyridine-6-carboxylic acid derivative
LU85894A1 (en) * 1985-05-10 1986-12-05 Omnichem Sa DERIVATIVES OF 1,2,3,4,5,6-HEXAHYDRO-AZEPINO (4,5-B) INDOLE THEIR PREPARATION, INTERMEDIATE COMPOUNDS, AND THEIR THERAPEUTIC APPLICATION
ATE136032T1 (en) * 1987-07-20 1996-04-15 Duphar Int Res 8,9-ANNELLATED 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE DERIVATIVES
US5006531A (en) * 1989-07-10 1991-04-09 Hoechst-Roussel Pharmaceuticals Inc. 5,6-dihydro(1H-indolo(3,2-C)quinoline-6,4'-piperidines) and related compounds which are useful for treating pain, psychosis or convulsions

Also Published As

Publication number Publication date
PT98101A (en) 1992-03-31
ZA914970B (en) 1992-04-29
IE912225A1 (en) 1992-01-01
EP0466548A1 (en) 1992-01-15
AU7929391A (en) 1992-01-02
CA2045450A1 (en) 1991-12-28
FR2663935A1 (en) 1992-01-03
NZ238709A (en) 1992-05-26
AU636232B2 (en) 1993-04-22
JPH04243879A (en) 1992-08-31

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