OA08508A - Unsymmetrical derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acid, methods of preparation and use in therapy. - Google Patents

Unsymmetrical derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acid, methods of preparation and use in therapy.

Info

Publication number
OA08508A
OA08508A OA59099A OA59099A OA08508A OA 08508 A OA08508 A OA 08508A OA 59099 A OA59099 A OA 59099A OA 59099 A OA59099 A OA 59099A OA 08508 A OA08508 A OA 08508A
Authority
OA
OAPI
Prior art keywords
group
therapy
dicarboxylic acid
dihydropyridine
preparation
Prior art date
Application number
OA59099A
Other languages
French (fr)
Inventor
Jacques Robin
Didier Pruneau
Francois Bellamy
Original Assignee
Soc D Rech Ind S O R I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Soc D Rech Ind S O R I filed Critical Soc D Rech Ind S O R I
Publication of OA08508A publication Critical patent/OA08508A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Abstract

The present invention relates to novel asymmetrical esters derived from 1,4-dihydrophyridine-3,5-dicarboxylic acid, of the formula: <IMAGE> (I) in which: R1 represents a C1-C4 alkyl group, R2 represents a C1-C4 alkyl group, a benzyl group, a benzoyl group or a phenyl group optionally substituted by one or more C1-C4 alkoxy, C1-C4 alkyl, cyano, nitro, hydroxyl or trifluoromethyl groups or by one or more halogen atoms, and R3 and R4, which are identical or different, each represent the hydrogen atom, a nitro group or a chlorine atom, their optical isomers and diastereoisomers and also the corresponding addition salts. These novel esters are useful in therapy, especially as antihypertensives.
OA59099A 1986-04-02 1987-03-31 Unsymmetrical derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acid, methods of preparation and use in therapy. OA08508A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8604685A FR2596760B1 (en) 1986-04-02 1986-04-02 DISSYMMETRIC DERIVATIVES OF 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID, METHODS OF PREPARATION AND THERAPEUTIC USE

Publications (1)

Publication Number Publication Date
OA08508A true OA08508A (en) 1988-07-29

Family

ID=9333794

Family Applications (1)

Application Number Title Priority Date Filing Date
OA59099A OA08508A (en) 1986-04-02 1987-03-31 Unsymmetrical derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acid, methods of preparation and use in therapy.

Country Status (25)

Country Link
US (2) US4806544A (en)
EP (1) EP0240398B1 (en)
JP (1) JPS6317883A (en)
KR (1) KR900005956B1 (en)
CN (1) CN1015460B (en)
AT (1) ATE63555T1 (en)
AU (2) AU590690B2 (en)
CS (1) CS268828B2 (en)
DD (2) DD263291A5 (en)
DE (1) DE3770037D1 (en)
DK (1) DK161787A (en)
ES (1) ES2028886T3 (en)
FI (1) FI86302C (en)
FR (1) FR2596760B1 (en)
GR (1) GR3002267T3 (en)
HU (2) HU199479B (en)
IL (1) IL81933A (en)
NO (1) NO167029C (en)
NZ (1) NZ219758A (en)
OA (1) OA08508A (en)
PT (1) PT84560B (en)
SU (1) SU1586515A3 (en)
TN (1) TNSN87043A1 (en)
YU (2) YU57287A (en)
ZA (1) ZA872258B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7058991A (en) * 1989-12-22 1991-07-24 Byk Gulden Lomberg Chemische Fabrik Gmbh New dihydropyridines
DE4125271A1 (en) * 1991-07-31 1993-02-11 Bayer Ag NEW N-ALKYLATED 1,4-DIHYDROPYRIDINDICARBONIC ACID ESTERS
WO1993006082A1 (en) * 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
EP2410854B1 (en) * 2009-03-27 2016-06-29 Council of Scientific & Industrial Research Substituted 1, 4-dioxa-8-azaspiro ý4,5¨decanes useful as fungicides and a process for the preparation thereof
WO2012123966A1 (en) 2011-03-04 2012-09-20 Arch Pharmalabs Limited Process for the preparation of 4 -substituted -1, 4-dihydropyridines
CN102796111B (en) * 2012-09-10 2014-09-24 贵州大学 Carboxylate (sulfonate) compounds with oxoaza-spiro-amido group, and preparation method and application thereof
CN104860873A (en) * 2015-05-28 2015-08-26 石家庄学院 Preparation method for (S)-1,4-dihydropyridine calcium ion antagonist
CN108430989B (en) * 2015-10-13 2021-10-08 轩竹生物科技有限公司 Process for preparing 1, 4-dihydropyridine-3, 5-dicarboxylate derivatives and intermediates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (en) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridine-33-dicarboxylic acid alkyl ester
GB1245087A (en) * 1967-10-26 1971-09-02 Wyeth John & Brother Ltd Heterocyclic compounds
JPS4932542B1 (en) * 1970-08-17 1974-08-31
GB1591089A (en) * 1976-12-17 1981-06-10 Fujisawa Pharmaceutical Co 1,4-dihydropyridine derivatives and process for preparation thereof
US4250312A (en) * 1979-12-28 1981-02-10 Argus Chemical Corp. Process for preparing 4-piperidone spiroketal compounds
US4250313A (en) * 1980-02-01 1981-02-10 Argus Chemical Corp. Process for preparing 4-piperidone spiroketal compounds
DE3208628A1 (en) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen NEW COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
JPS58159462A (en) * 1982-03-17 1983-09-21 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivative
WO1983003249A1 (en) * 1982-03-17 1983-09-29 Yoshitomi Pharmaceutical 1,4-dihydropyridine-3,5-dicarboxylate derivatives
FR2577552B1 (en) * 1985-02-20 1987-09-04 Sori Soc Rech Ind DISSYMMETRIC HETEROCYCLIC ESTERS OF 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACIDS, METHOD OF PREPARATION AND THERAPEUTIC USE

Also Published As

Publication number Publication date
NZ219758A (en) 1989-04-26
FI86302C (en) 1992-08-10
JPS6317883A (en) 1988-01-25
CN1015460B (en) 1992-02-12
NO871339L (en) 1987-10-05
HUT53080A (en) 1990-09-28
KR870010055A (en) 1987-11-30
DK161787D0 (en) 1987-03-30
ATE63555T1 (en) 1991-06-15
PT84560B (en) 1989-11-30
HU199479B (en) 1990-02-28
FR2596760A1 (en) 1987-10-09
FI871316A0 (en) 1987-03-25
DD278793A5 (en) 1990-05-16
DD263291A5 (en) 1988-12-28
IL81933A0 (en) 1987-10-20
EP0240398B1 (en) 1991-05-15
EP0240398A1 (en) 1987-10-07
ES2028886T3 (en) 1992-07-16
FI871316A (en) 1987-10-03
NO871339D0 (en) 1987-03-31
SU1586515A3 (en) 1990-08-15
FI86302B (en) 1992-04-30
HUT49613A (en) 1989-10-30
NO167029B (en) 1991-06-17
DE3770037D1 (en) 1991-06-20
AU610753B2 (en) 1991-05-23
AU7041087A (en) 1987-10-08
DK161787A (en) 1987-10-03
ZA872258B (en) 1987-11-25
FR2596760B1 (en) 1988-12-09
YU44714B (en) 1990-12-31
CN87102452A (en) 1987-10-14
TNSN87043A1 (en) 1990-01-01
IL81933A (en) 1991-06-30
AU590690B2 (en) 1989-11-09
GR3002267T3 (en) 1992-12-30
US4806544A (en) 1989-02-21
AU4126389A (en) 1989-12-21
CS268828B2 (en) 1990-04-11
PT84560A (en) 1987-04-01
NO167029C (en) 1991-09-25
US4900833A (en) 1990-02-13
CS229287A2 (en) 1989-08-14
YU48088A (en) 1988-12-31
KR900005956B1 (en) 1990-08-18
YU57287A (en) 1988-10-31

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