DK469381A - PIPERIDE INGREDIENTS AND PROCEDURES FOR THEIR PREPARATION - Google Patents
PIPERIDE INGREDIENTS AND PROCEDURES FOR THEIR PREPARATIONInfo
- Publication number
- DK469381A DK469381A DK469381A DK469381A DK469381A DK 469381 A DK469381 A DK 469381A DK 469381 A DK469381 A DK 469381A DK 469381 A DK469381 A DK 469381A DK 469381 A DK469381 A DK 469381A
- Authority
- DK
- Denmark
- Prior art keywords
- group
- formula
- compound
- optionally substituted
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Piperidine derivatives of the general formula I <IMAGE> where R denotes hydrogen, C1-4-alkyl, hydroxy-C1-4-alkyl, C1-4-alkoxycarbonyl, benzyl (optionally substituted with halogen and/or C1-4-alkoxy), phenethyl or 3-phenylpropyl, X denotes one or more hydrogen or halogen atoms or one or more C1-4-alkyl, C1-4-alkoxy, trifluoromethyl or methylenedioxy groups, or X forms, together with the phenyl ring, a naphthyl group, with it not, however, being possible for R and X to be hydrogen simultaneously, and acid addition salts thereof. The compounds are prepared by reacting a compound of the formula II <IMAGE> where R' is a protecting group for the nitrogen atom, such as a 4-nitrobenzoyl group, an optionally substituted benzoyl group, an optionally substituted benzyl group or an alkyl group, with a compound of the formula III <IMAGE> where Y is a reactive group, such as a chlorine or bromine atom, after which the protecting group R' is removed provided that it does not correspond to the group R, or an optionally substituted benzoyl group which has been used as the protecting group is reduced, or by reacting a compound of the formula I' <IMAGE> with a compound of the formula RZ, where Z is a reactive group. The compounds of the formula I and their acid addition salts can be used in medicine as antidepressants.
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000388595A CA1173039A (en) | 1981-10-23 | 1981-10-23 | 4-benzyloxypiperidine compounds |
| AU76769/81A AU545739B2 (en) | 1981-10-23 | 1981-10-23 | Piperidine derivatives |
| JP56170536A JPS5872565A (en) | 1981-10-23 | 1981-10-23 | Piperidine derivative and application to medicine |
| GR66337A GR75364B (en) | 1981-10-23 | 1981-10-23 | |
| NO813577A NO153890C (en) | 1981-10-23 | 1981-10-23 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERIDE INGREDIENTS. |
| DK469381A DK157853C (en) | 1981-10-23 | 1981-10-23 | ANALOGY PROCEDURE FOR THE PREPARATION OF 4-BENZYLOXYPIPERIDE INGREDIATES |
| FI813330A FI77850C (en) | 1981-10-23 | 1981-10-23 | Process for the preparation of 4-benzyloxy or 4-naphthylmethoxypipe ridin derivatives which have antidepressant effect. |
| PT73875A PT73875B (en) | 1981-10-23 | 1981-10-23 | PROCESS FOR THE PREPARATION OF THERAPEUTICALLY APPLICABLE PIPERIDINE DERIVATIVES |
| IE2500/81A IE51707B1 (en) | 1981-10-23 | 1981-10-23 | Piperidine derivatives,their preparation and pharmaceutical compositions containing them |
| ZA817373A ZA817373B (en) | 1981-10-23 | 1981-10-23 | Piperidine derivatives,their preparation and pharmaceutical compositions containing them |
| NZ198748A NZ198748A (en) | 1981-10-23 | 1981-10-23 | Piperidine derivatives and pharmaceutical compositions |
| ES506500A ES8206476A1 (en) | 1981-10-23 | 1981-10-23 | Piperidine derivative and application to medicine |
Applications Claiming Priority (24)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE250081 | 1981-10-23 | ||
| FI813330 | 1981-10-23 | ||
| CA000388595A CA1173039A (en) | 1981-10-23 | 1981-10-23 | 4-benzyloxypiperidine compounds |
| GR810166337 | 1981-10-23 | ||
| AU76769/81A AU545739B2 (en) | 1981-10-23 | 1981-10-23 | Piperidine derivatives |
| AU7676981 | 1981-10-23 | ||
| PT7387581 | 1981-10-23 | ||
| JP56170536A JPS5872565A (en) | 1981-10-23 | 1981-10-23 | Piperidine derivative and application to medicine |
| JP17053681 | 1981-10-23 | ||
| GR66337A GR75364B (en) | 1981-10-23 | 1981-10-23 | |
| ES506500 | 1981-10-23 | ||
| CA388595 | 1981-10-23 | ||
| NO813577A NO153890C (en) | 1981-10-23 | 1981-10-23 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERIDE INGREDIENTS. |
| DK469381A DK157853C (en) | 1981-10-23 | 1981-10-23 | ANALOGY PROCEDURE FOR THE PREPARATION OF 4-BENZYLOXYPIPERIDE INGREDIATES |
| FI813330A FI77850C (en) | 1981-10-23 | 1981-10-23 | Process for the preparation of 4-benzyloxy or 4-naphthylmethoxypipe ridin derivatives which have antidepressant effect. |
| DK469381 | 1981-10-23 | ||
| PT73875A PT73875B (en) | 1981-10-23 | 1981-10-23 | PROCESS FOR THE PREPARATION OF THERAPEUTICALLY APPLICABLE PIPERIDINE DERIVATIVES |
| IE2500/81A IE51707B1 (en) | 1981-10-23 | 1981-10-23 | Piperidine derivatives,their preparation and pharmaceutical compositions containing them |
| NO813577 | 1981-10-23 | ||
| NZ19874881 | 1981-10-23 | ||
| ZA8107373 | 1981-10-23 | ||
| ZA817373A ZA817373B (en) | 1981-10-23 | 1981-10-23 | Piperidine derivatives,their preparation and pharmaceutical compositions containing them |
| NZ198748A NZ198748A (en) | 1981-10-23 | 1981-10-23 | Piperidine derivatives and pharmaceutical compositions |
| ES506500A ES8206476A1 (en) | 1981-10-23 | 1981-10-23 | Piperidine derivative and application to medicine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK469381A true DK469381A (en) | 1983-04-24 |
| DK157853B DK157853B (en) | 1990-02-26 |
| DK157853C DK157853C (en) | 1990-08-06 |
Family
ID=27582840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK469381A DK157853C (en) | 1981-10-23 | 1981-10-23 | ANALOGY PROCEDURE FOR THE PREPARATION OF 4-BENZYLOXYPIPERIDE INGREDIATES |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5872565A (en) |
| AU (1) | AU545739B2 (en) |
| CA (1) | CA1173039A (en) |
| DK (1) | DK157853C (en) |
| ES (1) | ES8206476A1 (en) |
| FI (1) | FI77850C (en) |
| GR (1) | GR75364B (en) |
| IE (1) | IE51707B1 (en) |
| NO (1) | NO153890C (en) |
| NZ (1) | NZ198748A (en) |
| PT (1) | PT73875B (en) |
| ZA (1) | ZA817373B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02148948U (en) * | 1989-05-17 | 1990-12-18 | ||
| US5169855A (en) * | 1990-03-28 | 1992-12-08 | Du Pont Merck Pharmaceutical Company | Piperidine ether derivatives as psychotropic drugs or plant fungicides |
| JPH0535676U (en) * | 1991-06-06 | 1993-05-14 | 株式会社カネマス | Pack for reconstitution of dried seaweed |
-
1981
- 1981-10-23 NO NO813577A patent/NO153890C/en unknown
- 1981-10-23 JP JP56170536A patent/JPS5872565A/en active Granted
- 1981-10-23 DK DK469381A patent/DK157853C/en not_active IP Right Cessation
- 1981-10-23 GR GR66337A patent/GR75364B/el unknown
- 1981-10-23 IE IE2500/81A patent/IE51707B1/en not_active IP Right Cessation
- 1981-10-23 ZA ZA817373A patent/ZA817373B/en unknown
- 1981-10-23 PT PT73875A patent/PT73875B/en unknown
- 1981-10-23 FI FI813330A patent/FI77850C/en not_active IP Right Cessation
- 1981-10-23 ES ES506500A patent/ES8206476A1/en not_active Expired
- 1981-10-23 CA CA000388595A patent/CA1173039A/en not_active Expired
- 1981-10-23 NZ NZ198748A patent/NZ198748A/en unknown
- 1981-10-23 AU AU76769/81A patent/AU545739B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5872565A (en) | 1983-04-30 |
| IE51707B1 (en) | 1987-02-18 |
| JPS6135177B2 (en) | 1986-08-12 |
| CA1173039A (en) | 1984-08-21 |
| NO813577L (en) | 1983-04-25 |
| DK157853C (en) | 1990-08-06 |
| FI77850C (en) | 1989-05-10 |
| FI77850B (en) | 1989-01-31 |
| NZ198748A (en) | 1984-08-24 |
| GR75364B (en) | 1984-07-13 |
| DK157853B (en) | 1990-02-26 |
| AU545739B2 (en) | 1985-08-01 |
| ES506500A0 (en) | 1982-08-16 |
| NO153890B (en) | 1986-03-03 |
| NO153890C (en) | 1986-06-11 |
| PT73875B (en) | 1983-01-25 |
| IE812500L (en) | 1983-04-21 |
| ES8206476A1 (en) | 1982-08-16 |
| PT73875A (en) | 1981-11-01 |
| ZA817373B (en) | 1983-03-30 |
| FI813330L (en) | 1983-04-24 |
| AU7676981A (en) | 1983-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |