NZ791083A - Fungicidal combinations - Google Patents

Abstract

combination comprising a dithiocarbamate fungicide, a succinate dehydrogenase fungicide and at least one of ergosterol biosynthesis inhibitor fungicide or a quinone outside inhibitor fungicide.

Description

PCT00717 FUNGICIDAL COMBINATIONS Technical field: The t invention relates to a combination of fungicides. More specifically, the t invention relates to fungicidal combinations comprising succinate dehydrogenase inhibitor fungicides for controlling a broad spectrum of fungal diseases.

Background of the invention: Fungicides are an al and important tool d by farmers to control diseases, as well as to e yields and quality of the crops. There are various fungicides that have been developed over the years with many desirable attributes such as specificity, systemicity, curative and eradicant action and high ty at low use rates.

Succinate dehydrogenase inhibitor (SDHI) fungicides are known in the art to be broad spectrum and have a high potency. Pyrazolecarboxamides are a group of active compounds within the SDHI family of fungicides that are known to be more potent than most other SDHI fungicides. These molecules specifically bind to the ubiquinone-binding site (Q-site) of the mitochondrial complex II, thereby inhibiting fungal respiration. These fungicides are known to control a broad um of fungal diseases.

Various other classes of fungicides are also known in the art, such as Quinone outside inhibitors (QoIs), ergosterol-biosynthesis inhibitors, fungicides that act on le sites, fungicides that affect mitosis etc. These fungicides have been mixed with SDHI fungicides to achieve a broad spectrum of disease control.

PCT00717 WO2006037632 teaches combinations of SDHI fungicides with a second active compound. WO2013127818 teaches ations of SDHI fungicides with various herbicides. 037634 teaches methods of controlling fungi using a combination of SDHI fungicide with various fungicides. However, the prior art does not teach the use of ternary or higher combinations of SDHI fungicides.

Dithiocarbamate are known in the art as multi-site fungicides. These fungicides are used for broad-spectrum disease control in more than 70 crops. eb is especially important for controlling devastating and fast ing diseases such as Phytophthora infestans, Venturia inaequalis etc.

Dithiocarbamate fungicides, especially mancozeb, are particularly useful for disease control because of their broad spectrum of activity, high tolerance by crop plants, and l usefulness for controlling fungal plant diseases not controlled by active nds that act on only a single target site in the fungus.

Mancozeb has been combined with various SDHI fungicides for e control. There is a need in the art to improve on the disease spectrum provided by these combinations.

There is therefore a need in the art for combinations of SDHIs with a specific fungicide that helps improve spectrum. With crop tolerances sing, lower use rates being imposed and resistance being increasingly observed, there is a need for a combination of actives that allows for broader disease l spectrum that combines curative and preventive actives and has a lower dosage.

PCT00717 Therefore, embodiments of the present invention may ameliorate one or more of the above mentioned problems: Therefore, embodiments of the present invention may provide combinations of fungicides that possess an enhanced efficacy over the individual fungicides used in isolation.

Another object of the present invention is to provide a fungicidal ation that causes an enhanced ng of the crops to which it is administered.

Another object of the present invention is to provide a idal combination that causes late ence to the crop to which it is d thereby resulting into an increasing yield of the crop.

Yet another object of the present invention is to provide a fungicidal combination that results into d fungal disease nce in the crops to which it is applied.

Another object of the present invention is to provide a fungicidal combination that achieves increased yield in the crops to which it is applied.

Some or all these and other objects of the invention are can be achieved by way of the invention described hereinafter.

Summary of the invention: Thus, an aspect of the present invention can provide a fungicidal combination comprising at least one succinate dehydrogenase inhibitor PCT00717 fungicide, at least one dithiocarbamate fungicide, and at least another fungicide.

Another aspect of the present invention can provide a fungicidal combination comprising at least one succinate ogenase inhibitor fungicide, at least one dithiocarbamate fungicide and at least two other fungicides.

Another aspect of the present invention can provide synergistic compositions comprising at least one succinate dehydrogenase inhibitor fungicide, at least one dithiocarbamate ide, and at least one other fungicide.

Another aspect of the present invention can provide synergistic compositions comprising at least one succinate dehydrogenase inhibitor fungicide, at least one dithiocarbamate fungicide and at least two other fungicides.

Detailed Description: The term ‘disease control’ as used herein denotes control and prevention of a disease. Controlling effects include all deviation from natural development, for example: killing, ation, decrease of the fugal disease.

The term ‘plants’ refers to all al parts of a plant, ing seeds, seedlings, saplings, roots, tubers, stems, stalks, foliage and fruits. The term "locus" of a plant as used herein is ed to embrace the place on which the plants are growing, where the plant propagation materials of the plants are sown or where the plant propagation materials of the plants will be placed into the soil. The term "plant propagation material" is understood to denote generative parts of a plant, such as seeds, vegetative material such as cuttings or tubers, roots, , tubers, bulbs, rhizomes and parts of plants, ated plants and young plants which are to be transplanted after germination or after emergence from the soil. These young plants may be protected before transplantation by a total or partial treatment by immersion. The term "agriculturally acceptable amount of active" refers to an amount of an active that kills or inhibits the plant disease for which control is desired, in an amount not significantly toxic to the plant being treated.

Succinate dehydrogenase inhibitor (SDHI) fungicides play an important role in plant tion against many phytopathogenic fungi. These molecules specifically bind to the ubiquinone-binding site (Q-site) of the mitochondrial complex II, thereby inhibiting fungal respiration. Dithiocarbamate are multisite contact fungicides. These molecules attack multiple sites within the fugal cells.

It has singly been found that the on of a dithiocarbamate ide to the combinations of succinate dehydrogenase inhibitors with at least another fungicide selected from an ergosterol biosynthesis tors or Quinone outside inhibitors or a ation thereof, resulted in surprising and unexpected advantages. It was surprising that the addition of a dithiocarbamate fungicide to the combination of a succinate dehydrogenase inhibitor with at least another fungicide selected from an ergosterol biosynthesis inhibitors and/or Quinone outside inhibitors or a combination thereof resulted in an enhancement of the efficacy, and a sing reduction in fungal disease incidence, seen only with the combination of succinate dehydrogenase inhibitors with at least another fungicide selected from an ergosterol biosynthesis inhibitors or Quinone outside inhibitors or a combination thereof. It has further been found that the addition of a PCT00717 dithiocarbamate fungicide to these combinations and ation of these combinations during the flowering stage of the crop delayed the senescence in the crop to which they were applied, which led to better greening in the crop thereby increasing the level of photosynthesis occurring within the plant, thereby leading to a greater yield from the crop to which they were applied.

These surprising advantages of the combinations of the invention were not observed when the dithiocarbamate fungicide was not present in the combination. Therefore, these unexpected ages of the combination of the present invention could be attributed to the inclusion of a carbamate fungicide to the combination of a succinate dehydrogenase inhibitor with at least another fungicide ed from an ergosterol biosynthesis inhibitors and/or Quinone outside inhibitors or a combination thereof.

Thus, in an aspect, the present invention provides a fungicidal combination comprising: (a) at least one dithiocarbamate fungicide; (b) at least one succinate dehydrogenase inhibitor fungicide; and (c) at least another fungicide selected from an ergosterol biosynthesis inhibitors and/or Quinone outside inhibitors.

In an embodiment, the carbamate fungicide is selected from the group consisting of amobam, asomate, ram, carbamorph, cufraneb, cuprobam, iram, ferbam, metam, nabam, tecoram, thiram, urbacide, ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, m, polycarbamate, propineb and zineb.

In an embodiment, the preferred dithiocarbamate ide is eb.

In an embodiment, the succinate dehydrogenase inhibitor is selected from pyrazole carboxamide class of succinate dehydrogenase inhibitor fungicides.

However, it should be tood that the choice of succinate dehydrogenase inhibitors is not understood to be limited to these pyrazole carboxamide fungicides alone.

In an embodiment, the pyrazole carboxamide class of succinate dehydrogenase inhibitor fungicide may be selected from benzovindiflupyr, bixafen, yroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, and sedaxane.

Benzovindiflupyr has the chemical name N-[(1RS,4SR)(dichloromethylene)- 1,2,3,4-tetrahydro-1,4-methanonaphthalenyl](difluoromethyl) methylpyrazolecarboxamide and has the structure: Bixafen has the chemical name N-(3',4'-dichlorofluorobiphenylyl) (difluoromethyl)methylpyrazolecarboxamide and the structure: PCT00717 Fluxapyroxad has the chemical name 3-(difluoromethyl)methyl-N-(3',4',5'- trifluorobiphenylyl)pyrazolecarboxamide and has the structure: Furametpyr has the chemical name (RS)chloro-N-(1,3-dihydro-1,1,3- hylisobenzofuranyl)-1,3-dimethylpyrazolecarboxamide and has the structure: Isopyrazam is a mixture of 2 isomers 3-(difluoromethyl)methyl-N- [(1RS,4SR,9RS)-1,2,3,4-tetrahydroisopropyl-1,4-methanonaphthalen yl]pyrazolecarboxamide and 2 aisomers 3-(difluoromethyl)methyl-N- PCT00717 [(1RS,4SR,9SR)-1,2,3,4-tetrahydroisopropyl-1,4-methanonaphthalen yl]pyrazolecarboxamide and its tautomer’s have the structure: Penflufen has the chemical name N-[2-(1,3-dimethylbutyl)phenyl]fluoro- 1,3-dimethyl-1H-pyrazolecarboxamide, and has the following structure: opyrad has the chemical name (RS)-N-[2-(1,3-dimethylbutyl)thienyl]- 1-methyl(trifluoromethyl)pyrazolecarboxamide, and has the following structure: PCT00717 Sedaxane is a mixture of 2 cis-isomers 2'-[(1RS,2RS)-1,1'-bicyclopropyl]- 3-(difluoromethyl)methylpyrazolecarboxanilide and 2 isomers 2'- [(1RS,2SR)-1,1'-bicyclopropyl](difluoromethyl)methylpyrazole carboxanilide , and its tautomer’s have the structure: In an embodiment, the succinate dehydrogenase inhibitor fungicide may be ed from the group consisting of benodanil, flutolanil, mepronil, amid, fluopyram, fenfuram, carboxin, oxycarboxin, zamide, boscalid and IR9792.

In an embodiment, the third and/or fourth fungicides in the combinations of the present invention may be selected from ergosterol biosynthesis inhibitors, and/or Quinone outside (Qo) inhibitors or mixtures thereof.

Thus in an embodiment, the ergosterol biosynthesis inhibitors may be selected from the group consisting of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, Ipconazole, metconazole, myclobutanil, penconazole, onazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, imazalil, PCT00717 oxpoconazole, pefurazoate, prochloraz, triflumizole, fenarimol, nuarimol, pyrifenox , pyrisoxazole, triforine and mixtures thereof.

In another embodiment, the ergosterol thesis inhibitors may be selected from oconazole, tebuconazole, nazole, cyroconazole or epoxiconazole.

In an embodiment, the third fungicide may be a Quinone e (Qo) inhibitor fungicide selected from azoxystrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, strobin, fenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, ncarb and mixtures thereof.

In an embodiment, the Quinone outside (Qo) inhibitor fungicide may be selected from azoxystrobin, picoxystrobin, kresoxim-methyl, pyraclostrobin and trifloxystrobin.

In an embodiment of the combinations of the present invention, the preferred succinate ogenase inhibitor fungicide is isopyrazam.

In an embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 1 Mancozeb Isopyrazam onazole - 2 Mancozeb Isopyrazam Difenoconazole - PCT00717 3 Mancozeb azam Epoxiconazole - 4 Mancozeb Isopyrazam Hexaconazole - Mancozeb Isopyrazam Tebuconazole - 6 Mancozeb Isopyrazam Tetraconazole - 7 Mancozeb Isopyrazam Prothioconazole - 8 Mancozeb Isopyrazam - Azoxystrobin 9 Mancozeb Isopyrazam - Picoxystrobin eb Isopyrazam - Pyraclostrobin 11 Mancozeb Isopyrazam - Kresoximmethyl 12 Mancozeb azam - Trifloxystrobin 13 Mancozeb Isopyrazam Cyproconazole Azoxystrobin 14 Mancozeb Isopyrazam onazole Picoxystrobin Mancozeb Isopyrazam Cyproconazole Pyraclostrobin 16 Mancozeb Isopyrazam Cyproconazole Kresoximmethyl 17 Mancozeb azam Cyproconazole Trifloxystrobin 18 Mancozeb Isopyrazam conazole Azoxystrobin 19 Mancozeb Isopyrazam Difenoconazole Picoxystrobin Mancozeb Isopyrazam Difenoconazole ostrobin 21 Mancozeb Isopyrazam Difenoconazole Kresoximmethyl 22 Mancozeb Isopyrazam Difenoconazole Trifloxystrobin 23 Mancozeb Isopyrazam Epoxiconazole Azoxystrobin 24 Mancozeb Isopyrazam Epoxiconazole strobin Mancozeb Isopyrazam Epoxiconazole Pyraclostrobin PCT00717 26 Mancozeb Isopyrazam Epoxiconazole Kresoximmethyl 27 Mancozeb Isopyrazam Epoxiconazole xystrobin 28 Mancozeb azam Hexaconazole Azoxystrobin 29 Mancozeb Isopyrazam Hexaconazole Picoxystrobin Mancozeb Isopyrazam Hexaconazole Pyraclostrobin 31 Mancozeb Isopyrazam Hexaconazole Kresoximmethyl 32 Mancozeb Isopyrazam Hexaconazole Trifloxystrobin 33 Mancozeb azam Tebuconazole Azoxystrobin 34 Mancozeb Isopyrazam Tebuconazole Picoxystrobin Mancozeb Isopyrazam Tebuconazole Pyraclostrobin 36 Mancozeb azam Tebuconazole Kresoximmethyl 37 Mancozeb Isopyrazam Tebuconazole Trifloxystrobin 38 Mancozeb Isopyrazam Tetraconazole trobin 39 Mancozeb Isopyrazam Tetraconazole Picoxystrobin 40 Mancozeb Isopyrazam Tetraconazole Pyraclostrobin 41 eb Isopyrazam Tetraconazole Kresoximmethyl 42 Mancozeb Isopyrazam Tetraconazole Trifloxystrobin 43 Mancozeb Isopyrazam Prothioconazole Azoxystrobin 44 Mancozeb Isopyrazam Prothioconazole Picoxystrobin 45 Mancozeb Isopyrazam Prothioconazole Pyraclostrobin 46 Mancozeb Isopyrazam Prothioconazole Kresoximmethyl 47 eb Isopyrazam Prothioconazole Trifloxystrobin PCT00717 In an embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is Benzovindiflupyr.

In an embodiment, the combinations of the present invention include the ing preferred combinations: S No. I II III IV 48 Mancozeb Benzovindiflupyr Cyproconazole - 49 eb Benzovindiflupyr Difenoconazole - 50 Mancozeb Benzovindiflupyr Epoxiconazole - 51 Mancozeb Benzovindiflupyr Hexaconazole - 52 eb Benzovindiflupyr nazole - 53 Mancozeb Benzovindiflupyr onazole - 54 Mancozeb Benzovindiflupyr Prothioconazole - 55 Mancozeb Benzovindiflupyr - Azoxystrobin 56 Mancozeb Benzovindiflupyr - Picoxystrobin 57 Mancozeb Benzovindiflupyr - Pyraclostrobin 58 Mancozeb Benzovindiflupyr - Kresoximmethyl 59 Mancozeb Benzovindiflupyr - xystrobin 60 Mancozeb indiflupyr Cyproconazole Azoxystrobin 61 Mancozeb Benzovindiflupyr Cyproconazole Picoxystrobin 62 Mancozeb Benzovindiflupyr Cyproconazole Pyraclostrobin 63 Mancozeb Benzovindiflupyr Cyproconazole Kresoximmethyl 64 Mancozeb Benzovindiflupyr Cyproconazole Trifloxystrobin PCT00717 65 Mancozeb Benzovindiflupyr Difenoconazole trobin 66 Mancozeb Benzovindiflupyr Difenoconazole Picoxystrobin 67 Mancozeb Benzovindiflupyr Difenoconazole Pyraclostrobin 68 Mancozeb Benzovindiflupyr Difenoconazole Kresoximmethyl 69 Mancozeb indiflupyr Difenoconazole Trifloxystrobin 70 Mancozeb Benzovindiflupyr Epoxiconazole Azoxystrobin 71 Mancozeb Benzovindiflupyr Epoxiconazole Picoxystrobin 72 Mancozeb Benzovindiflupyr Epoxiconazole Pyraclostrobin 73 Mancozeb Benzovindiflupyr Epoxiconazole Kresoximmethyl 74 eb Benzovindiflupyr Epoxiconazole Trifloxystrobin 75 Mancozeb Benzovindiflupyr Hexaconazole Azoxystrobin 76 Mancozeb Benzovindiflupyr Hexaconazole Picoxystrobin 77 Mancozeb indiflupyr nazole Pyraclostrobin 78 Mancozeb Benzovindiflupyr Hexaconazole Kresoximmethyl 79 Mancozeb Benzovindiflupyr Hexaconazole Trifloxystrobin 80 Mancozeb Benzovindiflupyr Tebuconazole Azoxystrobin 81 Mancozeb Benzovindiflupyr Tebuconazole strobin 82 Mancozeb Benzovindiflupyr Tebuconazole Pyraclostrobin 83 Mancozeb indiflupyr Tebuconazole Kresoximmethyl 84 Mancozeb Benzovindiflupyr Tebuconazole Trifloxystrobin 85 Mancozeb Benzovindiflupyr onazole Azoxystrobin 86 Mancozeb Benzovindiflupyr Tetraconazole Picoxystrobin 87 Mancozeb Benzovindiflupyr Tetraconazole Pyraclostrobin PCT00717 88 Mancozeb Benzovindiflupyr Tetraconazole Kresoximmethyl 89 eb Benzovindiflupyr Tetraconazole Trifloxystrobin 90 Mancozeb Benzovindiflupyr Prothioconazole Azoxystrobin 91 Mancozeb Benzovindiflupyr Prothioconazole Picoxystrobin 92 Mancozeb Benzovindiflupyr Prothioconazole Pyraclostrobin 93 Mancozeb Benzovindiflupyr oconazole Kresoximmethyl 94 Mancozeb Benzovindiflupyr Prothioconazole Trifloxystrobin In an embodiment of the combinations of the present invention, the preferred ate dehydrogenase inhibitor ide is Penthiopyrad.

In an embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 95 Mancozeb Penthiopyrad Cyproconazole - 96 Mancozeb Penthiopyrad Difenoconazole - 97 eb opyrad Epoxiconazole - 98 Mancozeb Penthiopyrad Hexaconazole - 99 Mancozeb Penthiopyrad Tebuconazole - 100 Mancozeb Penthiopyrad Tetraconazole - 101 Mancozeb Penthiopyrad Prothioconazole - 102 Mancozeb Penthiopyrad - Azoxystrobin 103 Mancozeb Penthiopyrad - strobin 104 Mancozeb Penthiopyrad - Pyraclostrobin PCT00717 105 Mancozeb Penthiopyrad - Kresoximmethyl 106 Mancozeb Penthiopyrad - Trifloxystrobin 107 Mancozeb Penthiopyrad Cyproconazole Azoxystrobin 108 Mancozeb Penthiopyrad Cyproconazole Picoxystrobin 109 Mancozeb Penthiopyrad Cyproconazole Pyraclostrobin 110 eb Penthiopyrad Cyproconazole Kresoximmethyl 111 eb Penthiopyrad Cyproconazole Trifloxystrobin 112 Mancozeb Penthiopyrad Difenoconazole Azoxystrobin 113 Mancozeb Penthiopyrad Difenoconazole strobin 114 eb opyrad Difenoconazole Pyraclostrobin 115 Mancozeb Penthiopyrad Difenoconazole Kresoximmethyl 116 Mancozeb opyrad Difenoconazole Trifloxystrobin 117 Mancozeb Penthiopyrad Epoxiconazole Azoxystrobin 118 Mancozeb opyrad Epoxiconazole Picoxystrobin 119 Mancozeb Penthiopyrad Epoxiconazole Pyraclostrobin 120 Mancozeb opyrad Epoxiconazole Kresoximmethyl 121 Mancozeb Penthiopyrad Epoxiconazole Trifloxystrobin 122 Mancozeb Penthiopyrad Hexaconazole Azoxystrobin 123 Mancozeb Penthiopyrad Hexaconazole Picoxystrobin 124 Mancozeb Penthiopyrad Hexaconazole Pyraclostrobin 125 Mancozeb Penthiopyrad Hexaconazole Kresoximmethyl 126 Mancozeb Penthiopyrad Hexaconazole Trifloxystrobin PCT00717 127 Mancozeb Penthiopyrad Tebuconazole Azoxystrobin 128 Mancozeb Penthiopyrad Tebuconazole Picoxystrobin 129 Mancozeb Penthiopyrad Tebuconazole Pyraclostrobin 130 eb Penthiopyrad Tebuconazole Kresoximmethyl 131 Mancozeb Penthiopyrad Tebuconazole Trifloxystrobin 132 Mancozeb Penthiopyrad Tetraconazole Azoxystrobin 133 Mancozeb Penthiopyrad Tetraconazole Picoxystrobin 134 Mancozeb Penthiopyrad onazole Pyraclostrobin 135 Mancozeb Penthiopyrad Tetraconazole Kresoximmethyl 136 Mancozeb Penthiopyrad Tetraconazole Trifloxystrobin 137 Mancozeb Penthiopyrad Prothioconazole Azoxystrobin 138 eb Penthiopyrad Prothioconazole Picoxystrobin 139 Mancozeb opyrad Prothioconazole Pyraclostrobin 140 Mancozeb Penthiopyrad Prothioconazole Kresoximmethyl 141 Mancozeb Penthiopyrad Prothioconazole Trifloxystrobin In an embodiment of the combinations of the present invention, the preferred succinate ogenase inhibitor fungicide is boscalid.

In an embodiment, the combinations of the present invention include the ing preferred combinations: S No. I II III IV 142 Mancozeb Boscalid Cyproconazole - PCT00717 143 eb Boscalid Difenoconazole - 144 Mancozeb Boscalid Epoxiconazole - 145 Mancozeb Boscalid Hexaconazole - 146 Mancozeb Boscalid Tebuconazole - 147 Mancozeb Boscalid Tetraconazole - 148 Mancozeb Boscalid Prothioconazole - 149 eb Boscalid - Azoxystrobin 150 Mancozeb Boscalid - Picoxystrobin 151 Mancozeb Boscalid - Pyraclostrobin 152 Mancozeb Boscalid - Kresoximmethyl 153 Mancozeb Boscalid - Trifloxystrobin 154 Mancozeb Boscalid Cyproconazole Azoxystrobin 155 eb Boscalid Cyproconazole strobin 156 Mancozeb Boscalid Cyproconazole Pyraclostrobin 157 Mancozeb Boscalid Cyproconazole Kresoximmethyl 158 Mancozeb id Cyproconazole Trifloxystrobin 159 Mancozeb Boscalid conazole Azoxystrobin 160 Mancozeb Boscalid Difenoconazole Picoxystrobin 161 Mancozeb id Difenoconazole Pyraclostrobin 162 Mancozeb Boscalid Difenoconazole Kresoximmethyl 163 Mancozeb Boscalid Difenoconazole Trifloxystrobin 164 Mancozeb Boscalid Epoxiconazole Azoxystrobin 165 Mancozeb Boscalid Epoxiconazole strobin 166 Mancozeb Boscalid Epoxiconazole Pyraclostrobin PCT00717 167 Mancozeb Boscalid onazole immethyl 168 Mancozeb id Epoxiconazole Trifloxystrobin 169 Mancozeb Boscalid Hexaconazole Azoxystrobin 170 Mancozeb Boscalid Hexaconazole Picoxystrobin 171 Mancozeb Boscalid Hexaconazole Pyraclostrobin 172 Mancozeb Boscalid Hexaconazole Kresoximmethyl 173 Mancozeb Boscalid Hexaconazole Trifloxystrobin 174 Mancozeb id Tebuconazole Azoxystrobin 175 Mancozeb Boscalid Tebuconazole Picoxystrobin 176 Mancozeb Boscalid Tebuconazole Pyraclostrobin 177 Mancozeb Boscalid Tebuconazole Kresoximmethyl 178 Mancozeb Boscalid Tebuconazole Trifloxystrobin 179 Mancozeb Boscalid Tetraconazole Azoxystrobin 180 Mancozeb Boscalid Tetraconazole strobin 181 eb Boscalid Tetraconazole Pyraclostrobin 182 Mancozeb Boscalid Tetraconazole Kresoximmethyl 183 Mancozeb Boscalid Tetraconazole Trifloxystrobin 184 Mancozeb id Prothioconazole Azoxystrobin 185 Mancozeb Boscalid oconazole Picoxystrobin 186 Mancozeb Boscalid Prothioconazole Pyraclostrobin 187 Mancozeb Boscalid Prothioconazole Kresoximmethyl 188 Mancozeb Boscalid Prothioconazole Trifloxystrobin PCT00717 In an embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is . IR9792 is a SDHI fungicide, developed by Isagro, with the ed common name fluindapyr.

In an embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 189 Mancozeb IR9792 Cyproconazole - 190 Mancozeb IR9792 Difenoconazole - 191 Mancozeb IR9792 Epoxiconazole - 192 Mancozeb IR9792 Hexaconazole - 193 Mancozeb IR9792 Tebuconazole - 194 eb IR9792 Tetraconazole - 195 Mancozeb IR9792 Prothioconazole - 196 Mancozeb IR9792 - Azoxystrobin 197 eb IR9792 - Picoxystrobin 198 Mancozeb IR9792 - Pyraclostrobin 199 Mancozeb IR9792 - Kresoximmethyl 200 Mancozeb IR9792 - Trifloxystrobin 201 Mancozeb IR9792 Cyproconazole Azoxystrobin 202 eb IR9792 Cyproconazole Picoxystrobin 203 Mancozeb IR9792 Cyproconazole Pyraclostrobin PCT00717 204 Mancozeb IR9792 Cyproconazole Kresoximmethyl 205 Mancozeb IR9792 Cyproconazole Trifloxystrobin 206 Mancozeb IR9792 conazole Azoxystrobin 207 Mancozeb IR9792 Difenoconazole Picoxystrobin 208 Mancozeb IR9792 Difenoconazole Pyraclostrobin 209 Mancozeb IR9792 Difenoconazole Kresoximmethyl 210 Mancozeb IR9792 Difenoconazole Trifloxystrobin 211 Mancozeb IR9792 onazole trobin 212 Mancozeb IR9792 Epoxiconazole Picoxystrobin 213 Mancozeb IR9792 Epoxiconazole Pyraclostrobin 214 eb IR9792 Epoxiconazole Kresoximmethyl 215 Mancozeb IR9792 Epoxiconazole Trifloxystrobin 216 Mancozeb IR9792 Hexaconazole Azoxystrobin 217 Mancozeb IR9792 Hexaconazole Picoxystrobin 218 Mancozeb IR9792 Hexaconazole Pyraclostrobin 219 eb IR9792 Hexaconazole Kresoximmethyl 220 Mancozeb IR9792 Hexaconazole Trifloxystrobin 221 Mancozeb IR9792 nazole Azoxystrobin 222 Mancozeb IR9792 Tebuconazole Picoxystrobin 223 Mancozeb IR9792 Tebuconazole Pyraclostrobin 224 Mancozeb IR9792 Tebuconazole Kresoximmethyl 225 Mancozeb IR9792 Tebuconazole Trifloxystrobin PCT00717 226 Mancozeb IR9792 Tetraconazole Azoxystrobin 227 Mancozeb IR9792 Tetraconazole Picoxystrobin 228 Mancozeb IR9792 Tetraconazole Pyraclostrobin 229 eb IR9792 onazole Kresoximmethyl 230 Mancozeb IR9792 Tetraconazole Trifloxystrobin 231 eb IR9792 Prothioconazole Azoxystrobin 232 Mancozeb IR9792 Prothioconazole Picoxystrobin 233 Mancozeb IR9792 Prothioconazole Pyraclostrobin 234 Mancozeb IR9792 Prothioconazole Kresoximmethyl 235 Mancozeb IR9792 Prothioconazole Trifloxystrobin In an embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is Bixafen.

In an embodiment, the combinations of the t ion include the following preferred combinations: S No. I II III IV 236 Mancozeb Bixafen Cyproconazole - 237 Mancozeb Bixafen Difenoconazole - 238 Mancozeb Bixafen Epoxiconazole - 239 Mancozeb Bixafen Hexaconazole - 240 Mancozeb Bixafen nazole - 241 Mancozeb Bixafen Tetraconazole - 242 Mancozeb n Prothioconazole - PCT00717 243 Mancozeb Bixafen - Azoxystrobin 244 Mancozeb Bixafen - Picoxystrobin 245 eb Bixafen - Pyraclostrobin 246 Mancozeb n - Kresoximmethyl 247 Mancozeb Bixafen - Trifloxystrobin 248 Mancozeb n onazole Azoxystrobin 249 Mancozeb Bixafen Cyproconazole Picoxystrobin 250 eb Bixafen onazole Pyraclostrobin 251 Mancozeb Bixafen Cyproconazole Kresoximmethyl 252 Mancozeb Bixafen Cyproconazole Trifloxystrobin 253 Mancozeb Bixafen conazole Azoxystrobin 254 Mancozeb Bixafen Difenoconazole Picoxystrobin 255 Mancozeb Bixafen Difenoconazole Pyraclostrobin 256 Mancozeb Bixafen Difenoconazole Kresoximmethyl 257 Mancozeb Bixafen Difenoconazole Trifloxystrobin 258 Mancozeb Bixafen Epoxiconazole Azoxystrobin 259 Mancozeb Bixafen Epoxiconazole Picoxystrobin 260 Mancozeb Bixafen Epoxiconazole Pyraclostrobin 261 Mancozeb Bixafen Epoxiconazole Kresoximmethyl 262 Mancozeb Bixafen Epoxiconazole Trifloxystrobin 263 Mancozeb Bixafen Hexaconazole Azoxystrobin 264 eb Bixafen Hexaconazole Picoxystrobin 265 Mancozeb Bixafen Hexaconazole Pyraclostrobin PCT00717 266 Mancozeb Bixafen Hexaconazole Kresoximmethyl 267 Mancozeb Bixafen Hexaconazole Trifloxystrobin 268 Mancozeb Bixafen Tebuconazole Azoxystrobin 269 Mancozeb n Tebuconazole Picoxystrobin 270 Mancozeb Bixafen Tebuconazole Pyraclostrobin 271 Mancozeb n Tebuconazole Kresoximmethyl 272 Mancozeb Bixafen Tebuconazole xystrobin 273 Mancozeb n Tetraconazole Azoxystrobin 274 Mancozeb Bixafen Tetraconazole Picoxystrobin 275 Mancozeb n Tetraconazole Pyraclostrobin 276 Mancozeb Bixafen Tetraconazole Kresoximmethyl 277 Mancozeb Bixafen Tetraconazole Trifloxystrobin 278 Mancozeb Bixafen Prothioconazole trobin 279 Mancozeb Bixafen Prothioconazole Picoxystrobin 280 Mancozeb Bixafen Prothioconazole Pyraclostrobin 281 Mancozeb Bixafen oconazole Kresoximmethyl 282 Mancozeb Bixafen Prothioconazole Trifloxystrobin In an embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is Fluxapyroxad.

In an embodiment, the combinations of the present ion include the following preferred combinations: PCT00717 S No. I II III IV 283 eb Fluxapyroxad Cyproconazole - 284 Mancozeb Fluxapyroxad Difenoconazole - 285 Mancozeb Fluxapyroxad Epoxiconazole - 286 Mancozeb Fluxapyroxad Hexaconazole - 287 Mancozeb Fluxapyroxad Tebuconazole - 288 Mancozeb yroxad Tetraconazole - 289 Mancozeb Fluxapyroxad Prothioconazole - 290 Mancozeb Fluxapyroxad - Azoxystrobin 291 Mancozeb yroxad - Picoxystrobin 292 Mancozeb Fluxapyroxad - Pyraclostrobin 293 Mancozeb Fluxapyroxad - Kresoximmethyl 294 Mancozeb Fluxapyroxad - Trifloxystrobin 295 Mancozeb Fluxapyroxad Cyproconazole Azoxystrobin 296 Mancozeb Fluxapyroxad Cyproconazole Picoxystrobin 297 eb Fluxapyroxad Cyproconazole Pyraclostrobin 298 eb yroxad Cyproconazole Kresoximmethyl 299 Mancozeb Fluxapyroxad Cyproconazole Trifloxystrobin 300 Mancozeb Fluxapyroxad Difenoconazole Azoxystrobin 301 Mancozeb Fluxapyroxad Difenoconazole Picoxystrobin 302 Mancozeb Fluxapyroxad Difenoconazole Pyraclostrobin 303 Mancozeb Fluxapyroxad Difenoconazole Kresoximmethyl 304 Mancozeb Fluxapyroxad Difenoconazole Trifloxystrobin PCT00717 305 Mancozeb Fluxapyroxad Epoxiconazole Azoxystrobin 306 Mancozeb Fluxapyroxad Epoxiconazole Picoxystrobin 307 Mancozeb Fluxapyroxad Epoxiconazole Pyraclostrobin 308 Mancozeb Fluxapyroxad Epoxiconazole immethyl 309 Mancozeb Fluxapyroxad Epoxiconazole Trifloxystrobin 310 eb Fluxapyroxad Hexaconazole Azoxystrobin 311 Mancozeb Fluxapyroxad Hexaconazole Picoxystrobin 312 eb Fluxapyroxad Hexaconazole Pyraclostrobin 313 Mancozeb Fluxapyroxad Hexaconazole Kresoximmethyl 314 Mancozeb Fluxapyroxad Hexaconazole Trifloxystrobin 315 Mancozeb Fluxapyroxad Tebuconazole Azoxystrobin 316 eb Fluxapyroxad Tebuconazole Picoxystrobin 317 Mancozeb Fluxapyroxad Tebuconazole Pyraclostrobin 318 Mancozeb Fluxapyroxad nazole Kresoximmethyl 319 Mancozeb Fluxapyroxad nazole Trifloxystrobin 320 Mancozeb Fluxapyroxad Tetraconazole Azoxystrobin 321 Mancozeb Fluxapyroxad Tetraconazole Picoxystrobin 322 Mancozeb Fluxapyroxad Tetraconazole Pyraclostrobin 323 Mancozeb Fluxapyroxad Tetraconazole Kresoximmethyl 324 Mancozeb yroxad onazole Trifloxystrobin 325 Mancozeb yroxad Prothioconazole Azoxystrobin 326 Mancozeb Fluxapyroxad Prothioconazole Picoxystrobin 327 Mancozeb Fluxapyroxad Prothioconazole Pyraclostrobin PCT00717 328 Mancozeb Fluxapyroxad Prothioconazole immethyl 329 Mancozeb Fluxapyroxad Prothioconazole Trifloxystrobin In an embodiment of the combinations of the present invention, the preferred succinate ogenase inhibitor fungicide is Furametpyr.

In an embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 330 eb Furametpyr Cyproconazole - 331 Mancozeb Furametpyr conazole - 332 Mancozeb Furametpyr Epoxiconazole - 333 Mancozeb tpyr Hexaconazole - 334 Mancozeb Furametpyr Tebuconazole - 335 Mancozeb Furametpyr Tetraconazole - 336 Mancozeb Furametpyr Prothioconazole - 337 Mancozeb Furametpyr - Azoxystrobin 338 Mancozeb Furametpyr - Picoxystrobin 339 Mancozeb Furametpyr - Pyraclostrobin 340 Mancozeb Furametpyr - Kresoximmethyl 341 Mancozeb Furametpyr - Trifloxystrobin 342 Mancozeb Furametpyr Cyproconazole Azoxystrobin 343 Mancozeb tpyr Cyproconazole Picoxystrobin 344 Mancozeb Furametpyr Cyproconazole Pyraclostrobin PCT00717 345 Mancozeb Furametpyr Cyproconazole Kresoximmethyl 346 Mancozeb Furametpyr Cyproconazole xystrobin 347 Mancozeb Furametpyr Difenoconazole Azoxystrobin 348 Mancozeb tpyr Difenoconazole Picoxystrobin 349 Mancozeb Furametpyr Difenoconazole ostrobin 350 Mancozeb Furametpyr Difenoconazole Kresoximmethyl 351 Mancozeb Furametpyr Difenoconazole Trifloxystrobin 352 Mancozeb Furametpyr Epoxiconazole Azoxystrobin 353 Mancozeb tpyr Epoxiconazole Picoxystrobin 354 Mancozeb Furametpyr Epoxiconazole Pyraclostrobin 355 Mancozeb Furametpyr Epoxiconazole Kresoximmethyl 356 Mancozeb Furametpyr Epoxiconazole Trifloxystrobin 357 Mancozeb Furametpyr Hexaconazole Azoxystrobin 358 Mancozeb Furametpyr Hexaconazole Picoxystrobin 359 Mancozeb tpyr nazole Pyraclostrobin 360 Mancozeb Furametpyr Hexaconazole Kresoximmethyl 361 Mancozeb Furametpyr Hexaconazole Trifloxystrobin 362 Mancozeb Furametpyr Tebuconazole Azoxystrobin 363 Mancozeb Furametpyr Tebuconazole Picoxystrobin 364 Mancozeb Furametpyr nazole Pyraclostrobin 365 Mancozeb Furametpyr Tebuconazole Kresoximmethyl 366 Mancozeb Furametpyr Tebuconazole Trifloxystrobin PCT00717 367 Mancozeb Furametpyr onazole Azoxystrobin 368 Mancozeb Furametpyr Tetraconazole Picoxystrobin 369 Mancozeb Furametpyr Tetraconazole Pyraclostrobin 370 Mancozeb Furametpyr Tetraconazole Kresoximmethyl 371 Mancozeb Furametpyr Tetraconazole Trifloxystrobin 372 Mancozeb Furametpyr Prothioconazole Azoxystrobin 273 Mancozeb tpyr Prothioconazole Picoxystrobin 374 Mancozeb Furametpyr oconazole Pyraclostrobin 375 eb Furametpyr Prothioconazole Kresoximmethyl 376 Mancozeb Furametpyr Prothioconazole Trifloxystrobin In an embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is Penflufen.

In an embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 377 Mancozeb Penflufen Cyproconazole - 378 Mancozeb fen Difenoconazole - 379 Mancozeb Penflufen Epoxiconazole - 380 Mancozeb fen Hexaconazole - 381 Mancozeb Penflufen Tebuconazole - 382 Mancozeb Penflufen Tetraconazole - 383 eb Penflufen Prothioconazole - PCT00717 384 Mancozeb Penflufen - Azoxystrobin 385 Mancozeb Penflufen - Picoxystrobin 386 Mancozeb Penflufen - Pyraclostrobin 387 eb Penflufen - Kresoximmethyl 388 Mancozeb Penflufen - Trifloxystrobin 389 Mancozeb fen Cyproconazole Azoxystrobin 390 Mancozeb Penflufen Cyproconazole Picoxystrobin 391 Mancozeb Penflufen Cyproconazole ostrobin 392 Mancozeb Penflufen Cyproconazole Kresoximmethyl 393 Mancozeb Penflufen Cyproconazole Trifloxystrobin 394 Mancozeb Penflufen Difenoconazole trobin 395 Mancozeb Penflufen Difenoconazole Picoxystrobin 396 Mancozeb Penflufen conazole Pyraclostrobin 397 Mancozeb fen Difenoconazole Kresoximmethyl 398 Mancozeb Penflufen Difenoconazole Trifloxystrobin 399 Mancozeb Penflufen Epoxiconazole Azoxystrobin 400 Mancozeb Penflufen Epoxiconazole Picoxystrobin 401 Mancozeb Penflufen Epoxiconazole Pyraclostrobin 402 Mancozeb Penflufen Epoxiconazole Kresoximmethyl 403 Mancozeb Penflufen Epoxiconazole xystrobin 404 Mancozeb Penflufen Hexaconazole Azoxystrobin 405 Mancozeb Penflufen Hexaconazole Picoxystrobin 406 Mancozeb Penflufen Hexaconazole Pyraclostrobin PCT00717 407 Mancozeb Penflufen Hexaconazole Kresoximmethyl 408 Mancozeb Penflufen Hexaconazole Trifloxystrobin 409 Mancozeb Penflufen Tebuconazole Azoxystrobin 410 Mancozeb Penflufen Tebuconazole Picoxystrobin 411 Mancozeb Penflufen Tebuconazole Pyraclostrobin 412 Mancozeb Penflufen Tebuconazole immethyl 413 Mancozeb Penflufen Tebuconazole xystrobin 414 Mancozeb Penflufen Tetraconazole Azoxystrobin 415 Mancozeb fen Tetraconazole Picoxystrobin 416 Mancozeb Penflufen onazole Pyraclostrobin 417 Mancozeb Penflufen Tetraconazole immethyl 418 eb Penflufen Tetraconazole Trifloxystrobin 419 Mancozeb Penflufen Prothioconazole Azoxystrobin 420 Mancozeb Penflufen oconazole Picoxystrobin 421 Mancozeb Penflufen Prothioconazole ostrobin 422 Mancozeb Penflufen Prothioconazole Kresoximmethyl 423 Mancozeb Penflufen Prothioconazole Trifloxystrobin In an embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is Sedaxane.

In an embodiment, the combinations of the present invention include the following preferred combinations: PCT00717 S No. I II III IV 424 Mancozeb ne Cyproconazole - 425 Mancozeb Sedaxane Difenoconazole - 426 Mancozeb Sedaxane Epoxiconazole - 427 Mancozeb Sedaxane Hexaconazole - 428 Mancozeb Sedaxane Tebuconazole - 429 Mancozeb Sedaxane Tetraconazole - 430 Mancozeb Sedaxane Prothioconazole - 431 Mancozeb Sedaxane - Azoxystrobin 432 Mancozeb ne - Picoxystrobin 433 Mancozeb ne - Pyraclostrobin 434 Mancozeb Sedaxane - Kresoximmethyl 435 Mancozeb Sedaxane - Trifloxystrobin 436 Mancozeb Sedaxane onazole Azoxystrobin 437 Mancozeb Sedaxane Cyproconazole strobin 438 Mancozeb Sedaxane Cyproconazole Pyraclostrobin 439 Mancozeb Sedaxane Cyproconazole Kresoximmethyl 440 Mancozeb Sedaxane Cyproconazole Trifloxystrobin 441 Mancozeb Sedaxane Difenoconazole Azoxystrobin 442 Mancozeb Sedaxane Difenoconazole strobin 443 Mancozeb Sedaxane Difenoconazole Pyraclostrobin 444 Mancozeb Sedaxane Difenoconazole Kresoximmethyl 445 eb Sedaxane Difenoconazole Trifloxystrobin PCT00717 446 eb Sedaxane Epoxiconazole Azoxystrobin 447 Mancozeb Sedaxane Epoxiconazole Picoxystrobin 448 eb Sedaxane Epoxiconazole Pyraclostrobin 449 eb Sedaxane Epoxiconazole Kresoximmethyl 450 eb Sedaxane Epoxiconazole Trifloxystrobin 451 eb Sedaxane Hexaconazole Azoxystrobin 452 Mancozeb Sedaxane Hexaconazole Picoxystrobin 453 Mancozeb Sedaxane Hexaconazole Pyraclostrobin 454 Mancozeb Sedaxane Hexaconazole Kresoximmethyl 455 Mancozeb Sedaxane Hexaconazole Trifloxystrobin 456 Mancozeb Sedaxane nazole Azoxystrobin 457 Mancozeb Sedaxane Tebuconazole Picoxystrobin 458 Mancozeb Sedaxane Tebuconazole Pyraclostrobin 459 Mancozeb Sedaxane Tebuconazole immethyl 460 Mancozeb Sedaxane Tebuconazole Trifloxystrobin 461 Mancozeb Sedaxane Tetraconazole Azoxystrobin 462 Mancozeb Sedaxane Tetraconazole Picoxystrobin 463 Mancozeb Sedaxane Tetraconazole Pyraclostrobin 464 Mancozeb Sedaxane Tetraconazole Kresoximmethyl 465 Mancozeb Sedaxane Tetraconazole xystrobin 466 Mancozeb Sedaxane Prothioconazole trobin 467 Mancozeb Sedaxane Prothioconazole Picoxystrobin 468 Mancozeb Sedaxane Prothioconazole Pyraclostrobin PCT00717 469 Mancozeb Sedaxane Prothioconazole Kresoximmethyl 470 Mancozeb ne Prothioconazole Trifloxystrobin The combinations of the present invention may be formulated in the form of a composition.

In an embodiment, the present invention may provide a ition comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one dithiocarbamate fungicide; (c) at least one quinone outside tor; and (d) at least one agrochemically acceptable excipient.

In an embodiment, the present invention may provide a ition comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one dithiocarbamate fungicide; (c) at least one ergostrol biosynthesis inhibitor; and (d) at least one agrochemically able ent.

In an ment, the present invention may provide a composition comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one dithiocarbamate fungicide; (c) at least one a quinone outside inhibitor; (d) at least one ergostrol biosynthesis inhibitor; and (e) at least one agrochemically acceptable excipient.

PCT00717 The amount of a composition according to the invention to be applied, will depend on various factors, such as the subject of the treatment, such as, for example plants, soil or seeds; the type of treatment, such as, for example ng, dusting or seed dressing; the purpose of the treatment, such as, for example prophylactic or therapeutic e control; in case of disease control the type of fungi to be lled or the application time. This amount of the combinations of the present invention to be applied can be readily deduced by a skilled agronomist.

Thus in an embodiment, the present invention may provide compositions comprising: (a) at least one pyrazaole carboxamide ed from benzovindiflupyr, bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, opyrad, and sedaxane; (b) at least one quinone outside tor, and/or at least one ergostrol biosynthesis inhibitor; and (c) at last one dithiocarbamate fungicide; said fungicides being combined in agrochemically acceptable amounts.

In an embodiment, the total amount of succinate ogenase inhibitor in the composition may typically be in the range of 0.1 to 99% by weight, preferably 0.2 to 90% by weight. The total amount of dithiocarbamate fungicide in the composition may be in the range of 0.1 to 99% by weight.

The total amount of ergostrol biosynthesis inhibitor in the composition may be in the range of 0.1 to 99% by weight. The total amount of Quinone outside inhibitor in the composition may be in the range of 0.1 to 99% by weight.

PCT00717 In an embodiment, the constituent fungicides of the combination of the present invention may be admixed in ratio of (1-80): (1-80): (1-80) of the dithiocarbamate fungicide, succinate dehydrogenase inhibitor fungicide and the third fungicide respectively.

In an embodiment, the constituents of the ition of the present invention may be tank mixed and sprayed at the locus of the infection, or may be alternatively be mixed with tants and then sprayed.

In an embodiment, the tuents of the composition of the t invention may be used for foliar application, ground or applications to plant propagation materials.

In an embodiment, the itions of the present invention may typically be produce by mixing the actives in the composition with an inert carrier, and adding surfactants and other adjuvants and rs as needed and formulated into solid, or liquid formulations, including but not limited to wettable powders, granules, dusts, Soluble d) concentrates, suspension concentrates, oil in water emulsion, water in oil emulsion, emulsifiable concentrates, capsule suspensions, ZC formulations, oil dispersions or other known formulation types. The composition may also be used for ent of a plant propagation material such as seeds etc.

Examples of the solid r used in formulation include fine powders or granules such as minerals such as kaolin clay, attapulgite clay, bentonite, montmorillonite, acid white clay, pyrophyllite, talc, diatomaceous earth and calcite; natural organic materials such as corn rachis powder and walnut PCT00717 husk powder; synthetic organic materials such as urea; salts such as calcium ate and ammonium e; synthetic inorganic als such as synthetic hydrated silicon oxide; and as a liquid carrier, aromatic hydrocarbons such as xylene, alkylbenzene and methylnaphthalene; alcohols such as 2-propanol, ethyleneglycol, propylene glycol, and ethylene glycol monoethyl ether; s such as acetone, exanone and isophorone; vegetable oil such as soybean oil and cotton seed oil; petroleum tic arbons, esters, dimethylsulfoxide, acetonitrile and water.

Examples of the surfactant include anionic surfactants such as alkyl sulfate ester salts, alkylaryl sulfonate salts, dialkyl sulfosuccinate salts, polyoxyethylene alkylaryl ether phosphate ester salts, lignosulfonate salts and naphthalene sulfonate formaldehyde polycondensates; and nonionic surfactants such as polyoxyethylene alkyl aryl ethers, polyoxyethylene alkylpolyoxypropylene block copolymers and sorbitan fatty acid esters and cationic surfactants such as alkyltrimethylammonium salts.

Examples of the other ation auxiliary agents include water-soluble polymers such as polyvinyl alcohol and polyvinylpyrrolidone, polysaccharides such as Arabic gum, alginic acid and the salt thereof, CMC (carboxymethylcellulose ) , Xanthan gum, inorganic materials such as aluminum magnesium silicate and alumina sol, preservatives, coloring agents and stabilization agents such as PAP (acid phosphate pyl) and BHT.

The compositions according to the present invention is effective for the following plant diseases: PCT00717 e in rice: Blast (Magnaporthe grisea), Helminthosporium leaf spot iobolus miyabeanus), sheath blight (Rhizoctonia solani) , and bakanae disease (Gibberella fujikuroi).

Diseases in wheat: powdery mildew (Erysiphe is) , Fusariuin head blight (Fusarium graminearum, F. avenacerum, F. culmorum, Microdochium nivale) , rust (Puccinia striiformis, P. graminis, P. recondita) , pink snow mold (Micronectriella ), Typhula snow blight (Typhula sp . ) , loose smut (Ustilago tritici) , bunt (Tilletia caries) , t (Pseudocercosporella herpotrichoides) , leaf blotch (Mycosphaerella icola) , glume blotch (Stagonospora nodorum) , septoria, and yellow spot (Pyrenophora triticirepentis Diseases of : powdery mildew (Erysiphe graminis), Fusarium head blight (Fusarium graminearum, F. erum, F. culmorum, Microdochium nivale), rust (Puccinia striiformis, P. graminis, P. hordei) , loose smut (Ustilago nuda) , scald (Rhynchosporium secalis) , net blotch (Pyrenophora teres), spot blotch (Cochliobolus sativus), leaf stripe (Pyrenophora graminea) , and Rhizoctonia damping-off (Rhizoctonia solani) .

Diseases in corn: smut (Ustilago ), brown spot (Cochliobolus heterostrophus), copper spot (Gloeocercospora sorghi), southern rust (Puccinia polysora), gray leaf spot (Cercospora zeae-maydis), white spot (Phaeosphaeria mydis and/or Pantoea ananatis) and Rhizoctonia damping- off (Rhizoctonia solani).

Diseases of citrus: melanose (Diaporthe , scab (Elsinoe fawcetti), penicillium rot illium digitatum, P.italicum), and brown rot (Phytophthora parasitica, Phytophthora citrophthora) .

Diseases of apple: blossom blight (Monilinia mali), canker (Valsa ceratosperma), powdery mildew (Podosphaera leucotricha), aria leaf spot (Alternaria alternata apple pathotype) , scab (Venturia inaequalis) , powdery mildew, bitter rot (Colletotrichum acutatum), crown rot (Phytophtora cactorum) , blotch (Diplocarpon mali) , and ring rot (Botryosphaeria berengeriana) .

Diseases of pear: scab ria nashicola, V. pirina) , powdery mildew, black spot (Alternaria alternata Japanese pear pathotype) , rust (Gymnosporangium haraeanum) , and phytophthora fruit rot (Phytophtora cactorum).

Diseases of peach: brown rot inia fructicola), powdery mildew, scab (Cladosporium carpophilum), and phomopsis rot (Phomopsis sp.).

Diseases of grape: anthracnose (Elsinoe ampelina) , ripe rot (Glomerella ata), powdery mildew (Uncinula necator) , rust (Phakopsora ampelopsidis) , black rot (Guignardia bidwellii) , botrytis, and downy mildew (Plasmopara viticola) .

Diseases of Japanese persimmon: cnose (Gloeosporium kaki) , and leaf spot (Cercospora kaki, Mycosphaerella nawae) .

PCT00717 Diseases of gourd: anthracnose (Colletotrichum lagenarium) , y mildew (Sphaerotheca fuliginea) , gummy stem blight (Mycosphaerella melonis) , Fusarium wilt (Fusarium oxysporum) , downy mildew (Pseudoperonospora cubensis) , Phytophthora rot (Phytophthora sp.) , and damping-off (Pythium sp . ).

Diseases of tomato: early blight (Alternaria solani) , leaf mold sporium fulvum) , and late blight (Phytophthora ans) .

Diseases of eggplant: brown spot (Phomopsis vexans) , and powdery mildew (Erysiphe cichoracearum) Diseases of cruciferous vegetables: Alternaria leaf spot (Alternaria japonica) , white spot sporella brassicae) , clubroot (Plasmodiophora brassicae) , and downy mildew (Peronospora tica) .

Diseases of onion: rust nia allii) , and downy mildew (Peronospora destructor).

Diseases of soybean: purple seed stain spora kikuchii) , sphaceloma scad (Elsinoe glycines) , pod and stem blight (Diaporthe phaseolorum var. sojae) , septoria brown spot (Septoria glycines), frogeye leaf spot (Cercospora sojina), rust (Phakopsora pachyrhizi) , Yellow rust, brown stem rot (Phytophthora sojae), and Rhizoctonia damping-off (Rhizoctonia solani) .

Diseases of kidney bean: anthracnose (Colletotrichum lindemthianum) .

Diseases of peanut: leaf spot (Cercospora personata), brown leaf spot (Cercospora arachidicola) and southern blight (Sclerotium rolfsii).

PCT00717 Diseases of garden pea: powdery mildew (Erysiphe pisi) , and root rot (Fusarium solani f. sp. pisi) .

Diseases of potato: early blight (Alternaria solani), late blight (Phytophthora infestans), pink rot (Phytophthora erythroseptica), and powdery scab (Spongospora subterranean f. sp. ranea).

Diseases of strawberry: powdery mildew (Sphaerotheca humuli), and anthracnose (Glomerella cingulata).

Diseases of tea: net r blight (Exobasidium reticulatum), white scab (Elsinoe leucospila) , gray blight (Pestalotiopsis sp.), and anthracnose (Colletotrichum theae- sinensis) .

Diseases of tobacco: brown spot (Alternaria longipes) , powdery mildew phe cichoracearum), anthracnose (Colletotrichum tabacum), downy mildew (Peronospora tabacina) , and black shank (Phytophthora anae).

Diseases of rapeseed: tinia rot (Sclerotinia tiorum) , and Rhizoctonia damping-off (Rhizoctonia solani) . Diseases of cotton: Rhizoctonia damping-off (Rhizoctonia solani) .

Diseases of sugar beat: Cercospora leaf spot (Cercospora beticola) , leaf blight (Thanatephorus ris), Root rot (Thanatephorus cucumeris), and Aphanomyces root rot (Aphanomyces cochlioides) .

Diseases of rose: black spot (Diplocarpon rosae) , powdery mildew (Sphaerotheca pannosa) , and downy mildew (Peronospora sparsa) .

PCT00717 Diseases of chrysanthemum and ceous plants: downy mildew (Bremia lactucae), leaf blight (Septoria chrysanthemi-indici) , and white rust (Puccinia horiana).

Diseases of various groups: diseases caused by Pythium spp. (Pythium aphanidermatum, Pythium anum, Pythium graminicola, Pythium irregulare, Pythium ultimum), gray mold. (Botrytis cinerea), and Sclerotinia rot (Sclerotinia sclerotiorum).

Disease of Japanese radish: Alternaria leaf spot naria brassicicola).

Diseases of turfgrass: dollar spot (Sclerotinia homeocarpa), and brown patch and large patch (Rhizoctonia solani).

Disease of banana: Black sigatoka (Mycosphaerella fijiensis), Yellow sigatoka (Mycosphaerella musicola).

Disease of wer: downy mildew (Plasmopara halstedii) .

Seed diseases or diseases in the early stages of the growth of various plants caused by Aspergillus spp., Penicillium spp., Fusarium spp., Gibberella spp., Tricoderma spp., Thielaviopsis spp., Rhizopus spp., Mucor spp., Corticium spp., Phoma spp., Rhizoctonia spp. and Diplodia spp.

Viral es of various plants mediated by xa spp. or Olpidium spp. and so on.

PCT00717 The compositions of the present invention can be used in agricultural lands such as fields, paddy fields, lawns and orchards or in non-agricultural lands.

The present invention may be used to control diseases in agricultural lands for cultivating the plants without any phytotoxicity to the plant.

Examples of the crops on which the present compositions may be used include but are not limited to corn, rice, wheat, barley, rye, oat, sorghum, cotton, soybean, peanut, buckwheat, beet, rapeseed, sunflower, sugar cane, tobacco, etc.; vegetables: solanaceous vegetables such as eggplant, , o, , potato, etc., cucurbit vegetables such as er, pumpkin, zucchini, water melon, melon, squash, etc., cruciferous bles such as radish, white turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, cauliflower, etc., asteraceous vegetables such as burdock, crown daisy, artichoke, lettuce, etc, liliaceous bles such as green onion, onion, garlic, and asparagus, ammiaceous vegetables such as carrot, y, celery, parsnip, etc., chenopodiaceous vegetables such as spinach, Swiss chard, etc., lamiaceous vegetables such as Perilla frutescens, mint, basil, etc, strawberry, sweet potato, Dioscorea ca, colocasia, etc., flowers, e plants, turf grasses, fruits: pome fruits such apple, pear, quince, etc, stone fleshy fruits such as peach, plum, nectarine, Prunus mume, cherry fruit, t, prune, etc., citrus fruits such as orange, lemon, rime, grapefruit, etc., nuts such as chestnuts, walnuts, hazelnuts, , pistachio, cashew nuts, macadamia nuts, etc. berries such as blueberry, cranberry, blackberry, raspberry, etc., grape, kaki fruit, olive, plum, banana, coffee, date palm, coconuts, etc. , trees other than fruit trees; tea, mulberry, flowering plant, trees such as ash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple, Quercus, poplar, Judas tree, Liquidambar PCT00717 formosana, plane tree, zelkova, Japanese arborvitae, fir wood, hemlock, juniper, Pinus, Picea, and Taxus cuspidate, etc.

In an embodiment, the constituent fungicides of the ation of the present invention may be d in ratio of (1-80): (1-80): (1-80): (1:80) In an aspect, the present invention may provide methods of controlling fungal diseases comprising applying a combination comprising: (a) at least one succinate dehydrogenase tor fungicide; (b) at least one quinone outside inhibitor and/or at least one ergostrol biosynthesis inhibitor; and (c) at least one dithiocarbamate fungicide.

In an embodiment, the succinate dehydrogenase inhibitor fungicide, the quinone outside inhibitor ide, the ergosterol biosynthesis inhibitor fungicide, and the dithiocarbamate ide may be selected according to any of the preferred embodiments of the combinations described hereinabove.

The combinations of the t invention may be sold as a pre-mix composition or a kit of parts such that individual actives may be mixed before spraying. Alternatively, the kit of parts may contain succinate dehydrogenase inhibitor fungicide and the dithiocarbamate fungicide premixed and the third active may be d with an adjuvant such that the two components may be tank mixed before ng.

The composition of the t invention maybe applied simultaneously as a tank mix or a formulation or may be applied sequentially. The application PCT00717 may be made to the soil before emergence of the plants, either pre-planting or post-planting. The application may be made as a foliar spray at different timings during crop development, with either one or two applications early or late post-emergence.

The compositions according to the invention can be d before or after infection of the useful plants or the propagation material thereof by the fungi.

As will be demonstrated in the examples, the addition of a dithiocarbamate fungicide to a combination of succinate dehydrogenase inhibitors which are combined with Quinone outside tors and/or ergosterol biosynthesis inhibitors, y improved the disease control as well as improved yield and demonstrated a synergistic effect. The lower the mixture performance in the disease control, the r the additional benefit of the mancozeb when added to the compositions of the present ion.

Examples: Studies were conducted to study the addition of dithiocarbamate fungicides to succinate dehydrogenase inhibitor fungicides and at least one other ide and the contribution of the dithiocarbamate to the efficacy of these mixtures. ments were conducted over a period of two years to study the effect of the addition of dithiocarbamates on the efficacy of succinate dehydrogenase inhibitors alone and when combined with a cofungicide such as a Quinone outside inhibitors and/or ergosterol biosynthesis inhibitor fungicide. Doses tested were at rates of 1500 g/ha for Mancozeb, 150 ml/ha for the ergosterol biosynthesis inhibitor, 200 g/ha for the Quinone e inhibitor, 1000 g/ha and 200 g/ha for succinate dehydrogenase inhibitor fungicides. The combinatios were tested for PCT00717 cy of disease control in soybean for the control of Asian soybean rust. The trials were carried out at s locations in India.

The test were conducted on soybean cultivar Monsoy 9144 RR. The commercially available individual active ingredients were used at the indicated s.

Table 1: Table 1 shows the efficacy of mancozeb when added to combinations containing succinate dehydrogenase inhibitor ides and ergosterol thesis inhibitor.

Treatment Dose rates Mean percent disease (ml/g/ha) control 2015/16 2016/17 Prothioconazole + Benzovindiflupyr 150+200 88.04 71.04 Prothioconazole + 95.07 95.07 150+200+1500 Benzovindiflupyr+ Mancozeb Prothioconazole + Isopyrazam 150+1000 87.14 70.23 Prothioconazole + Isopyrazam+ 150+1000+150 93.4 93.07 eb 0 Prothioconazole + Penthoipyrad 150+1000 83.33 68.15 Prothioconazole + Penthiopyrad + 150+1000+150 93.07 92.18 Mancozeb 0 Table 1 clearly demonstrates the increase in control when mancozeb is added to the combination of ergosterol biosynthesis inhibitors and succinate dehydrogenase inhibitor fungicides.

PCT00717 Table 2: Table 2 demonstrates effiacacy when mancozeb is added to combinations of succinate dehydrogenase inhibitor fungicides and quinone outside inhibitor fungicides and ergosterol thesis inhibitors.

Treatment Dose rates Mean percent disease (ml/g/ha) control 6 7 Prothioconazole + Benzovindiflupyr 150+200+500 + Azoxystrobin 93.07 91.07 Prothioconazole + Benzovindiflupyr 0+500+1500 + Azoxystrobin + Mancozeb 96.36 95.03 Table 2 clearly trates the importance of adding mancozeb to the ation. The addition of mancozeb improved disease control.

It was thus found that the incorporation of mancozeb y increased efficacy and disease control of the succinate dehydrogenase inhibitor fungicide treatments when mixed with ergosterol thesis inhibitors or quinone outside inhibitors. It was thus concluded that the on of mancozeb enhanced the efficacy of the combination and surpsingly gave a synergistic effect. The addition of a dithiocarbamate increased disease control and improved yield of plants. The instant invention is more specifically explained by above examples. However, it should be understood that the scope of the present invention is not limited by the examples in any manner. It will be appreciated by any person skilled in this art that the present invention includes aforesaid examples and further can be modified and altered within the technical scope of the present invention.

While the ing written description of the ion enables one of ordinary skill to make and use what is considered presently to be the best mode thereof, those of ordinary skill will understand and appreciate the existence of ions, combinations, and lents of the specific embodiment, method, and examples herein. The invention should therefore not be limited by the above described embodiment, method, and examples, but by all embodiments and methods within the scope and spirit of the invention.

EMBODIMENTS OF THE DISCLOSURE The following numbered paragraphs define some particular embodiments of the present disclosure: 1. A fungicidal combination comprising at least one succinate dehydrogenase inhibitor ide, at least one dithiocarbamate fungicide, and at least another fungicide. 2. The combination of paragraph 1, n the dithiocarbamate fungicide is selected from amobam, asomate, azithiram, carbamorph, cufraneb, cuprobam, disulfiram, ferbam, metam, nabam, tecoram, thiram, urbacide, ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, metiram, rbamate, propineb and zineb. 3. The combination of paragraph 2, wherein the dithiocarbamate fungicide is mancozeb.

PCT00717 4. The combination of aph 1, wherein the succinate dehydrogenase inhibitor is selected from le carboxamide class of succinate dehydrogenase inhibitor fungicides. 5. The combination of paragraph 4, wherein the pyrazole carboxamide class of succinate dehydrogenase tor fungicide is selected from benzovindiflupyr, bixafen, fluxapyroxad, furametpyr, azam, penflufen, penthiopyrad, and ne. 6. The combination of aph 1, wherein atleast another fungicide is selected from an atleast one of erol biosynthesis tor fungicide, and quinone e inhibitor fungicide. 7. The combination of paragraph 6, n the ergosterol biosynthesis inhibitors is selected azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, nconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, Ipconazole, metconazole, myclobutanil, penconazole, Propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole, fenarimol, nuarimol, pyrifenox , pyrisoxazole, triforine and mixtures thereof. 8. The combination of paragraph 6, wherein the Quinone outside (Qo) inhibitor fungicide is selected from azoxystrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, PCT00717 dimoxystrobin, fenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, pyribencarb and mixtures thereof. 9. A fungicidal combination comprising at least one succinate dehydrogenase inhibitor fungicide, at least one dithiocarbamate fungicide and at least two other fungicides.

. The ation of paragraph 1 comprising: (a) Mancozeb; and (b) azam, benzovindiflupyr, penthiopyrad, boscalid, fluindapyr, bixafen, fluxapyroxad, furametpyr, penflufen, or ne; and (c) Cyproconazole, difenoconazole, epoxiconazole, hexaconazole, hexaconazole, tebuconazole, tetraconazole, prothioconazole, trobin, picoxystrobin, ostrobin, kresoxim-methyl, trifloxystrobin, or combinations thereof. 11. The combination of paragraph 1 comprising: (a) Mancozeb; and (b) Benzovindiflupyr, isopyrazam, or penthipyrad; and (c) Prothioconazole and/or azoxystrobin. 12. A composition comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one dithiocarbamate fungicide; (c) at least one rol biosynthesis tor and/or at least one a quinone outside inhibitor; and (d) at least one agrochemically acceptable excipient.

PCT00717 13. The composition of paragraph 12, wherein the composition is formulated into le powders, granules, dusts, Soluble (liquid) concentrates, sion concentrates, oil in water emulsion, water in oil emulsion, emulsifiable concentrates, capsule suspensions, ZC formulations, oil dispersions. 14. The combination of any one of the preceding paragraphs, wherein the constituent fungicides of the combination are admixed in ratio of (1- 80): (1-80): (1-80): .

. The combination of any one of the preceding aphs, wherein the total amount of succinate dehydrogenase inhibitor in the composition is in the range of 0.1 to 99% by weight, the total amount of dithiocarbamate ide in the composition is in the range of 0.1 to 99% by weight; the total amount of ergostrol biosynthesis inhibitor in the composition is in the range of 0.1 to 99% by weight; and the total amount of Quinone outside inhibitor in the composition is in the range of 0.1 to 99% by weight. 16. The composition of any one of the preceding paragraphs, wherein the composition is used for foliar application, or applications to plant propagation als. 17. A method of lling fungal diseases comprising applying to the locus of the plant a combination comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one quinone e inhibitor and/or at least one ergostrol biosynthesis inhibitor; and (c) at least one dithiocarbamate fungicide.

PCT00717

Claims (17)

1. A fungicidal combination comprising at least one succinate dehydrogenase inhibitor fungicide, at least one dithiocarbamate 5 fungicide, and at least another fungicide

2. The ation of claim 1, wherein the dithiocarbamate fungicide is selected from amobam, asomate, azithiram, orph, cufraneb, cuprobam, disulfiram, ferbam, metam, nabam, tecoram, thiram, 10 urbacide, ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb.

3. The combination of claim 2, wherein the dithiocarbamate ide is mancozeb.

4. The ation of claim 1, wherein the succinate dehydrogenase inhibitor is from a pyrazole carboxamide class of succinate dehydrogenase inhibitor fungicides.. 20

5. The combination as claimed in claim 4, wherein the pyrazole carboxamide class of succinate dehydrogenase inhibitor fungicide is ed from bixafen, apyr, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, and sedaxane. 25 6. The combination as claimed in claim 1, n at least another fungicide is selected from an ergosterol biosynthesis inhibitor fungicide, and quinone outside inhibitor fungicide

6. PCT00717

7. The ation as claimed in claim 6, wherein the erol biosynthesis tor is selected from azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, 5 flusilazole, flutriafol, hexaconazole, imibenconazole, Ipconazole, metconazole, utanil, penconazole, Propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, imazalil, oxpoconazole, pefurazoate, oraz, triflumizole, fenarimol, nuarimol, pyrifenox , pyrisoxazole, triforine and 10 mixtures thereof.

8. The combination as claimed in claim 6, wherein the Quinone outside (Qo) inhibitor ide is selected from azoxystrobin, coumoxystrobin, trobin, flufenoxystrobin, strobin, pyraoxystrobin, 15 mandestrobin, pyraclostrobin, tostrobin, triclopyricarb, kresoxim-methyl, dimoxystrobin, fenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, pyribencarb, and mixtures thereof. 20

9. A fungicidal combination comprising at least one succinate dehydrogenase inhibitor ide, at least one dithiocarbamate fungicide and at least two other fungicides.

10. The combination as claimed in claim 1 comprising: 25 (a) mancozeb; and (b) Isopyrazam, penthiopyrad, boscalid, fluindapyr, bixafen, fluxapyroxad, furametpyr, penflufen, or sedaxane as the succinate dehydrogenase inhibitor; and PCT00717 (c) cyproconazole, difenoconazole, epoxiconazole, hexaconazole, tebuconazole, tetraconazole, prothioconazole, azoxystrobin, picoxystrobin, pyraclostrobin, kresoxim-methyl, trifloxystrobin, or combinations thereof as the atleast another fungicide.

11. The combination as claimed in claim 1 comprising: (a) Mancozeb and (b) isopyrazam, or penthiopyrad as the succinate dehydrogenase inhibitor; and 10 (c) prothioconazole and/or azoxystrobin as the t another fungicide.

12. A composition sing: (a) at least one succinate dehydrogenase inhibitor ide; 15 (b) at least one dithiocarbamate fungicide; (c) at least one ergosterol biosynthesis inhibitor and/or at least one a quinone outside inhibitor; and (d) at least one agrochemically acceptable excipient. 20

13. The composition as d in claim 12, n the composition is ated into le powders, es, dusts, soluble (liquid) concentrates, suspension concentrates, oil in water emulsion, water in oil emulsion, emulsifiable concentrates, capsule suspensions, ZC formulations or oil dispersions.

14. The combination as claimed in any one of the preceding claims, wherein the constituent fungicides of the combination are admixed in ratio of (1-80): (1-80): (1-80): (1-80). PCT00717

15. The composition as claimed in claim 12, wherein the total amount of succinate dehydrogenase inhibitor in the ition is in the range of 0.1 to 99% by , the total amount of dithiocarbamate 5 fungicide in the composition is in the range of 0.1 to 99% by weight; the total amount of ergosterol biosynthesis inhibitor in the composition is in the range of 0.1 to 99% by weight; and the total amount of Quinone outside inhibitor in the ition is in the range of 0.1 to 99% by weight.

16. The composition as claimed in claim 12, n the composition is used for foliar application, or applications to plant propagation materials. 15

17. A method of controlling fungal diseases comprising applying to the locus of the plant a combination comprising: (a) at least one succinate dehydrogenase inhibitor fungicide; (b) at least one quinone outside inhibitor and/or at least one ergosterol biosynthesis inhibitor; and 20 (c) at least one dithiocarbamate fungicide.