EA041454B1 - FUNGICIDE COMBINATIONS - Google Patents

Description

Technical field

The present invention relates to a combination of fungicides. More specifically, the present invention relates to combinations of fungicides containing mancozeb, a succinate dehydrogenase inhibitor and at least one other fungicide for controlling a wide range of fungal diseases.

Prerequisites for the creation of the invention

Fungicides are an essential and important tool used by farmers to control diseases and improve crop yields and quality. Over the years, various fungicides have been developed with many desirable properties such as specificity, systemicity, curative and eradicant properties, and high activity at low application concentrations.

Succinate dehydrogenase inhibitor (SDHI) fungicides are known in the art to have a broad spectrum of activity and high efficacy. Pyrazolecarboxamides are a group of active compounds in the SDHI family of fungicides known to be more effective than most other SDHI fungicides. These molecules specifically bind to the ubiquinone binding site (Q site) of the mitochondrial complex II, thereby inhibiting fungal respiration. These fungicides are known to control a wide range of fungal diseases.

Various other classes of fungicides are also known in the art, such as inhibitors of the external quinone binding site of the cytochrome bcl complex (external quinone inhibitors, QoI), inhibitors of ergosterol biosynthesis, fungicides that act at multiple sites, fungicides that affect mitosis, and the like. . These fungicides have been blended with SDHI fungicides to control a wide range of diseases.

WO 2006037632 gives ideas for combinations of SDHI fungicides with a second active compound. WO 2013127818 gives ideas for combinations of SDHI fungicides with various herbicides. WO 2006037634 describes methods for controlling fungi using a combination of SDHI fungicide with various fungicides. However, the prior art does not involve the use of triple or multiple combinations of SDHI fungicides.

Dithiocarbamate is known in the art as a multisite fungicide. These fungicides are used to control a wide range of diseases in more than 70 crops. Mancozeb is especially important in the fight against devastating and rapidly spreading diseases such as late blight caused by Phytophthora infestans, Venturia inaequalis, etc. Dithiocarbamate fungicides, especially mancozeb, are particularly useful in disease control due to their broad spectrum of action, high crop tolerance, and general usefulness in controlling fungal plant diseases that are not inhibited by active compounds acting only on a single target site in the fungus.

Mancozeb has been combined with various SDHI fungicides to control disease. There is a need in the art to expand the range of diseases that can be controlled by such combinations.

Thus, there is a need in the art for combinations of SDCI with a specific fungicide that helps broaden the spectrum. With decreasing resistance in crops, using lower application concentrations and increasingly noticeable resistance, there is a need for a combination of active substances that provide control over a wider range of diseases, a combination that combines curative and preventive active substances and has a lower dosage.

Thus, embodiments of the present invention may alleviate one or more of the problems mentioned above.

Thus, embodiments of the present invention may provide combinations of fungicides that are more effective than individual fungicides used alone.

Another object of the present invention is to provide a combination of fungicides that results in an enhanced landscaping effect on the crops to which it is applied.

Another object of the present invention is to provide a combination of fungicides that results in delaying the senescence of the crop to which it is applied, thus resulting in increased yield.

Yet another object of the present invention is to provide a combination of fungicides that results in a reduction in the incidence of fungal diseases in the crops to which it is applied.

Another object of the present invention is to provide a combination of fungicides that provides increased yield of the crops to which it is applied.

Some or all of these and other objects of the invention can be achieved using the invention described later in this document.

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Statement of the Invention

Thus, in one aspect of the present invention, a fungicide combination consisting of mancozeb, one succinate dehydrogenase inhibitor selected from benzovindiflupyr and isopyrazam, and at least one other fungicide selected from prothioconazole and azoxystrobin, and combinations thereof, can be provided.

In another aspect of the present invention, a combination of fungicides can be provided that is formulated as wettable powders, granules, powders, soluble (liquid) concentrates, suspension concentrates, oil-in-water emulsions, water-in-oil emulsions, emulsifiable concentrates, capsule suspensions, ZC formulations or oil dispersions.

In yet another aspect of the present invention, a combination of fungicides may be provided wherein the total amount of succinate dehydrogenase inhibitor in the composition is in the range of 0.1-99% by weight; the total amount of mancozeb in the composition is in the range of 0.1-99 wt.%; the total amount of azoxystrobin in the composition is in the range of 0.1-99 wt.%; and the total amount of prothioconazole in the composition is in the range of 0.1-99% by weight.

In yet another aspect of the present invention, a combination of fungicides can be provided for foliar application or incorporation into plant propagation materials.

In yet another aspect of the present invention, a method for controlling fungal diseases can be provided, comprising applying said combination of fungicides to a plant locus.

Detailed description

As used herein, the term disease control means disease control and disease prevention. Control effects include all deviations from natural development, such as the elimination, slowing down, suppression of a fungal disease. The term plant refers to all the physical parts of a plant, including seeds, seedlings, seedlings, roots, tubers, stems, shoots, foliage, and fruits. As used herein, the term locus is intended to indicate the location where plants grow, where plant propagation materials are sown, or where plant propagation materials will be applied to the soil. The term plant propagation material means propagating plant parts such as seeds, plant material such as sprouts or tubers, roots, fruits, tubers, bulbs, rhizomes and parts of plants, germinating plants and young plants that need to be replanted after germination or after germination. Such young plants can be protected before transplanting by full or partial dip treatment. The term agriculturally acceptable amount of active substance refers to the amount of active substance that eliminates or inhibits the plant disease to be controlled, and this amount does not have a significant toxic effect on the treated plant.

Succinate dehydrogenase inhibitor (SDHI) fungicides play an important role in plant protection against many phytopathogenic fungi. These molecules specifically bind to the ubiquinone binding site (Q site) of the mitochondrial complex II, thereby inhibiting fungal respiration. Dithiocarbamate is a multi-site contact fungicide. These molecules attack many sites in fungal cells.

Surprisingly, it has been found that the addition of a dithiocarbamate fungicide in combination of succinate dehydrogenase inhibitors with at least another fungicide selected from ergosterol biosynthesis inhibitors or external quinone inhibitors, or a combination thereof, results in unusual and unexpected benefits. Surprisingly, it was found that the addition of a dithiocarbamate fungicide in combination of a succinate dehydrogenase inhibitor with at least another fungicide selected from ergosterol biosynthesis inhibitors and/or external quinone inhibitors, or a combination thereof, resulted in an increase in efficacy and an unexpected decrease in the incidence of fungal diseases, which was observed only with the combination succinate dehydrogenase inhibitors with at least another fungicide selected from ergosterol biosynthesis inhibitors or external quinone inhibitors, or combinations thereof. In addition, it was found that the addition of a dithiocarbamate fungicide to such combinations and the application of these combinations at the flowering stage of the crop slowed down the aging of the crop to which they were applied, resulting in a better greening effect for crops, thus increasing the level of photosynthesis in the plant, the more thereby increasing the yield of the crop to which they were applied.

In the absence of a dithiocarbamate fungicide in the combination, these unexpected benefits of the combinations of the present invention were not observed. Therefore, these unexpected combination advantages of the present invention may be due to the inclusion of a dithiocarbamate fungicide in the combination of a succinate dehydrogenase inhibitor with at least another fungicide selected from ergosterol biosynthesis inhibitors and/or external quinone inhibitors, or combinations thereof.

Thus, in one aspect, the present invention provides a combination of fungicides containing (a) at least one dithiocarbamate fungicide;

(b) at least one succinate dehydrogenase inhibitor fungicide; And

- 2 041454 (c) at least another fungicide selected from ergosterol biosynthesis inhibitors and/or external quinone inhibitors.

In one embodiment, the dithiocarbamate fungicide is selected from the group consisting of amobam, asomat, azithiram, carbamorph, kufraneb, cuprobam, disulfiram, ferbam, metam, nabam, tekoram, thiram, urbacid, ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb.

In one embodiment, the preferred dithiocarbamate fungicide is mancozeb.

In one embodiment, the succinate dehydrogenase inhibitor is selected from the pyrazolecarboxamide class of succinate dehydrogenase inhibitor fungicides. However, it should be understood that the choice of succinate dehydrogenase inhibitors is not limited to these pyrazolecarboxamide fungicides.

In one embodiment, the succinate dehydrogenase inhibitor fungicide of the pyrazolecarboxamide class can be selected from benzovindiflupyr, bixafen, fluxapiroxad, furametpyr, isopyrazam, penflufen, pentiopyrad, and sedaxan.

Benzovindiflupyr has the chemical name N-[(1RS,4SR)-9-(dichloromethylene)-1,2,3,4tetrahydro-1,4-methannaphthalen-5-yl]-3-(difluoromethyl)-1-methylpyrazol-4- carboxamide and has the structure

Bixafen has the chemical name N-(3',4'-dichloro-5-fluorobiphenyl-2-yl)-3-(difluoromethyl)-1methylpyrazole-4-carboxamide and has the structure

Fluxapiroxade has the chemical name 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl2-yl)pyrazole-4-carboxamide and has the structure

Furametpyr has the chemical name (RS)-5-chloro-N-(1,3-dihydro-1,1,3-trimethylisobenzofuran4-yl)-1,3-dimethylpyrazole-4-carboxamide and has the structure

Isopyrazam is a mixture of 2 isomers -4-carboxamide and 2 isomers of 3-(difluoromethyl)-1methyl-N-[(1RS,4SR,9SR)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methannaphthalene-5-yl] pyrazole-4-3 041454 carboxamide, and its tautomers have the structure

Penflufen has the chemical name N-[2-(1,3-dimethylbutyl)phenyl]-5-fluoro-1,3-dimethyl-1Hpyrazole-4-carboxamide and has the following structure:

Penthiopyrad has the chemical name (RS)-N-[2-(1,3-dimethylbutyl)-3-thienyl]-1-methyl-3(trifluoromethyl)pyrazole-4-carboxamide and has the following structure:

Sedaxan is a mixture of 2 cis isomers

2'-[( 1 RS,2RS)-1,1'-bicycloprop-2-yl]-3(difluoromethyl)-1-methylpyrazole-4-carboxanilide and 2 trans-isomers 2'-[(1RS,2SR)- 1,1'-bicycloprop-2yl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxanilide and its tautomers have the structure

In one embodiment, the succinate dehydrogenase inhibitor fungicide can be selected from the group consisting of benodanil, flutolanil, mepronil, isofetamide, fluopyram, fenfuram, carboxin, oxycarboxin, thifluzamide, boscalid, and IR9792.

In one embodiment, the third and/or fourth fungicide in the combinations of the present invention may be selected from ergosterol biosynthesis inhibitors and/or external quinone (Qo) inhibitors, or mixtures thereof.

Thus, in an embodiment, the ergosterol biosynthesis inhibitors may be selected from the group consisting of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, methaconazole, imibenconazole, ipibuconazole , penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, imazalil, oxpoconazole, pefurazoate, prochlorase, triflumizole, fenarimol, nuarimol, pirifenox, pyrisoxazole, triforin and mixtures thereof.

In another embodiment, the ergosterol biosynthesis inhibitors may be selected from prothioconazole, tebuconazole, hexaconazole, ciroconazole, or epoxiconazole.

In one embodiment, the third fungicide may be an external quinone (Qo) inhibitor fungicide selected from azoxystrobin, cumoxystrobin, enoxastrobin,

- 4 041454 fluphenoxystrobin, picoxystrobin, pyroxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopiricarb, kresoxim-methyl, dimoxystrobin, phenaminostrobin, methominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, piribencarb and mixtures thereof.

In one embodiment, an external quinone (Qo) inhibitor fungicide can be selected from azoxystrobin, picoxystrobin, kresoximmethyl, pyraclostrobin, and trifloxystrobin.

In one embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is isopyrazam.

In one embodiment, the combinations of the present invention include the following preferred combinations:

No. p / p I II III IV 1 Mancozeb Isopyr azam Cyproconazole - 2 Mancozeb Isopyr azam Difenoconazole - 3 Mancozeb Isopyr azam Epoxiconazole - 4 Mancozeb Isopyr azam Hexaconazole - 5 Mancozeb Izo pir azam Tebuconazole - 6 Mancozeb Isopyr azam Tetraconazole - 7 Mancozeb Izo pir azam Prothioconazole - 8 Mancozeb Isopyr azam - Azoxystrobin 9 Mancozeb Isopyr azam - Picoxystrobin 10 Mancozeb Isopyr azam - pyraclostrobin eleven Mancozeb Isopyr azam - Cresoximmethyl 12 Mancozeb Isopyr azam - Trifloxystrobin 13 Mancozeb Isopyr azam Cyproconazole Azoxystrobin 14 Mancozeb Isopyr azam Cyproconazole Picoxystrobin 15 Mancozeb Isopyr azam Cyproconazole pyraclostrobin 16 Mancozeb Isopyr azam Cyproconazole Cresoximmethyl 17 Mancozeb Isopyr azam Cyproconazole Trifloxystrobin 18 Mancozeb Isopyr azam Difenoconazole Azoxystrobin 19 Mancozeb Isopyr azam Difenoconazole Picoxystrobin 20 Mancozeb Isopyr azam Difenoconazole pyraclostrobin 21 Mancozeb Isopyr azam Difenoconazole Cresoximmethyl 22 Mancozeb Isopyr azam Difenoconazole Trifloxystrobin 23 Mancozeb Isopyr azam Epoxiconazole Azoxystrobin 24 Mancozeb Isopyr azam Epoxiconazole Picoxystrobin 25 Mancozeb Isopyr azam Epoxiconazole pyraclostrobin 26 Mancozeb Isopyr azam Epoxiconazole Cresoximmethyl 27 Mancozeb Isopyr azam Epoxiconazole Trifloxystrobin 28 Mancozeb Isopyr azam Hexaconazole Azoxystrobin 29 Mancozeb Isopyr azam Hexaconazole Picoxystrobin thirty Mancozeb Isopyr azam Hexaconazole pyraclostrobin 31 Mancozeb Isopyr azam Hexaconazole Cresoximmethyl 32 Mancozeb Isopyr azam Hexaconazole Trifloxystrobin 33 Mancozeb Isopyr azam Tebuconazole Azoxystrobin

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34 Mancozeb Isopyr azam Tebuconazole Picoxystrobin 35 Mancozeb Isopyr azam Tebuconazole pyraclostrobin 36 Mancozeb Isopyr azam Tebuconazole Cresoximmethyl 37 Mancozeb Isopyr azam Tebuconazole Trifloxystrobin 38 Mancozeb Isopyr azam Tetraconazole Azoxystrobin 39 Mancozeb Isopyr azam Tetraconazole Picoxystrobin 40 Mancozeb Isopyr azam Tetraconazole pyraclostrobin 41 Mancozeb Isopyr azam Tetraconazole Cresoximmethyl 42 Mancozeb Isopyr azam Tetraconazole Trifloxystrobin 43 Mancozeb Isopyr azam Prothioconazole Azoxystrobin 44 Mancozeb Isopyr azam Prothioconazole Picoxystrobin 45 Mancozeb Isopyr azam Prothioconazole pyraclostrobin 46 Mancozeb Isopyr azam Prothioconazole Cresoximmethyl 47 Mancozeb Isopyr azam Prothioconazole Trifloxystrobin

In one embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is benzovindiflupyr.

In one embodiment, the combinations of the present invention include the following preferred combinations:

No. p / p I II III IV 48 Mancozeb Benzovindiflupyr Cyproconazole - 49 Mancozeb Benzovindiflupyr Difenoconazole - 50 Mancozeb Benzovindiflupyr Epoxiconazole - 51 Mancozeb Benzovindiflupyr Hexaconazole - 52 Mancozeb Benzovindiflupyr Tebuconazole - 53 Mancozeb Benzovindiflupyr Tetraconazole - 54 Mancozeb Benzovindiflupyr Prothioconazole - 55 Mancozeb Benzovindiflupyr - Azoxystrobin 56 Mancozeb Benzovindiflupyr - Picoxystrobin 57 Mancozeb Benzovindiflupyr - pyraclostrobin 58 Mancozeb Benzovindiflupyr - Cresoximmethyl 59 Mancozeb Benzovindiflupyr - Trifloxystrobin 60 Mancozeb Benzovindiflupyr Cyproconazole Azoxystrobin 61 Mancozeb Benzovindiflupyr Cyproconazole Picoxystrobin 62 Mancozeb Benzovindiflupyr Cyproconazole pyraclostrobin 63 Mancozeb Benzovindiflupyr Cyproconazole Cresoximmethyl 64 Mancozeb Benzovindiflupyr Cyproconazole Trifloxystrobin 65 Mancozeb Benzovindiflupyr Difenoconazole Azoxystrobin

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66 Mancozeb Benzovindiflupyr Difenoconazole Picoxyssrobin 67 Mancozeb Benzovindiflupyr Difenoconazole pyraclosrobin 68 Mancozeb Benzovindiflupyr Difenoconazole Kresoximmesil 69 Mancozeb Benzovindiflupyr Difenoconazole Trifloxissrobin 70 Mancozeb Benzovindiflupyr Epoxiconazole Azoxyssrobin 71 Mancozeb Benzovindiflupyr Epoxiconazole Picoxyssrobin 72 Mancozeb Benzovindiflupyr Epoxiconazole pyraclosrobin 73 Mancozeb Benzovindiflupyr Epoxiconazole Kresoximmesil 74 Mancozeb Benzovindiflupyr Epoxiconazole Trifloxissrobin 75 Mancozeb Benzovindiflupyr Hexaconazole Azoxyssrobin 76 Mancozeb Benzovindiflupyr Hexaconazole Picoxyssrobin 77 Mancozeb Benzovindiflupyr Hexaconazole pyraclosrobin 78 Mancozeb Benzovindiflupyr Hexaconazole Kresoximmesil 79 Mancozeb Benzovindiflupyr Hexaconazole Trifloxissrobin 80 Mancozeb Benzovindiflupyr Tebuconazole Azoxyssrobin 81 Mancozeb Benzovindiflupyr Tebuconazole Picoxyssrobin 82 Mancozeb Benzovindiflupyr Tebuconazole pyraclosrobin 83 Mancozeb Benzovindiflupyr Tebuconazole Kresoximmesil 84 Mancozeb Benzovindiflupyr Tebuconazole Trifloxissrobin 85 Mancozeb Benzovindiflupyr Tezraconazole Azoxyssrobin 86 Mancozeb Benzovindiflupyr Tezraconazole Picoxyssrobin 87 Mancozeb Benzovindiflupyr Tezraconazole pyraclosrobin 88 Mancozeb Benzovindiflupyr Tezraconazole Kresoximmesil 89 Mancozeb Benzovindiflupyr Tezraconazole Trifloxissrobin 90 Mancozeb Benzovindiflupyr Prosioconazole Azoxyssrobin 91 Mancozeb Benzovindiflupyr Prosioconazole Picoxyssrobin 92 Mancozeb Benzovindiflupyr Prosioconazole pyraclosrobin 93 Mancozeb Benzovindiflupyr Prosioconazole Kresoximmesil 94 Mancozeb Benzovindiflupyr Prosioconazole Trifloxissrobin

In one embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is penthiopyrad.

In one embodiment, the combinations of the present invention include the following preferred combinations:

No. p / p I II III IV 95 Mancozeb Penziopyrad Cyproconazole - 96 Mancozeb Penziopyrad Difenoconazole - 97 Mancozeb Penziopyrad Epoxiconazole - 98 Mancozeb Penziopyrad Hexaconazole - 99 Mancozeb Penthiopyrad Tebuconazole - 100 Mancozeb Penthiopyrad Tezraconazole -

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101 Mancozeb Penthiopyrad Prothioconazole - 102 Mancozeb Penthiopyrad - Azoxystrobin 103 Mancozeb Penthiopyrad - Picoxystrobin 104 Mancozeb Penthiopyrad - pyraclostrobin 105 Mancozeb Penthiopyrad - Cresoximmethyl 106 Mancozeb Penthiopyrad - Trifloxystrobin 107 Mancozeb Penthiopyrad Cyproconazole Azoxystrobin 108 Mancozeb Penthiopyrad Cyproconazole Picoxystrobin 109 Mancozeb Penthiopyrad Cyproconazole pyraclostrobin BY Mancozeb Penthiopyrad Cyproconazole Cresoximmethyl 111 Mancozeb Penthiopyrad Cyproconazole Trifloxystrobin 112 Mancozeb Penthiopyrad Difenoconazole Azoxystrobin 113 Mancozeb Penthiopyrad Difenoconazole Picoxystrobin 114 Mancozeb Penthiopyrad Difenoconazole pyraclostrobin 115 Mancozeb Penthiopyrad Difenoconazole Cresoximmethyl 116 Mancozeb Penthiopyrad Difenoconazole Trifloxystrobin 117 Mancozeb Penthiopyrad Epoxiconazole Azoxystrobin 118 Mancozeb Penthiopyrad Epoxiconazole Picoxystrobin 119 Mancozeb Penthiopyrad Epoxiconazole pyraclostrobin 120 Mancozeb Penthiopyrad Epoxiconazole Cresoximmethyl 121 Mancozeb Penthiopyrad Epoxiconazole Trifloxystrobin 122 Mancozeb Penthiopyrad Hexaconazole Azoxystrobin 123 Mancozeb Penthiopyrad Hexaconazole Picoxystrobin 124 Mancozeb Penthiopyrad Hexaconazole pyraclostrobin 125 Mancozeb Penthiopyrad Hexaconazole Cresoximmethyl 126 Mancozeb Penthiopyrad Hexaconazole Trifloxystrobin 127 Mancozeb Penthiopyrad Tebuconazole Azoxystrobin 128 Mancozeb Penthiopyrad Tebuconazole Picoxystrobin 129 Mancozeb Penthiopyrad Tebuconazole pyraclostrobin 130 Mancozeb Penthiopyrad Tebuconazole Cresoximmethyl 131 Mancozeb Penthiopyrad Tebuconazole Trifloxystrobin 132 Mancozeb Penthiopyrad Tetraconazole Azoxystrobin 133 Mancozeb Penthiopyrad Tetraconazole Picoxystrobin 134 Mancozeb Penthiopyrad Tetraconazole pyraclostrobin 135 Mancozeb Penthiopyrad Tetraconazole Cresoximmethyl 136 Mancozeb Penthiopyrad Tetraconazole Trifloxystrobin 137 Mancozeb Penthiopyrad Prothioconazole Azoxystrobin 138 Mancozeb Penthiopyrad Prothioconazole Picoxystrobin 139 Mancozeb Penthiopyrad Prothioconazole pyraclostrobin 140 Mancozeb Penthiopyrad Prothioconazole Cresoximmethyl 141 Mancozeb Penthiopyrad Prothioconazole Trifloxystrobin

In one embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is boscalid.

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In one embodiment, the combinations of the present invention include the following preferred combinations:

No. p / p I II III IV 142 Mancozeb Boscalid Cyproconazole - 143 Mancozeb Boscalid Difenoconazole - 144 Mancozeb Boscalid Epoxiconazole - 145 Mancozeb Boscalid Hexaconazole - 146 Mancozeb Boscalid Tebuconazole - 147 Mancozeb Boscalid Tetraconazole - 148 Mancozeb Boscalid Prothioconazole - 149 Mancozeb Boscalid - Azoxystrobin 150 Mancozeb Boscalid - Picoxyirobin 151 Mancozeb Boscalid - pyraclostrobin 152 Mancozeb Boscalid - Cresoximmethyl 153 Mancozeb Boscalid - Trifloxystrobin 154 Mancozeb Boscalid Cyproconazole Azoxystrobin 155 Mancozeb Boscalid Cyproconazole Picoxyirobin 156 Mancozeb Boscalid Cyproconazole pyracloirobin 157 Mancozeb Boscalid Cyproconazole Cresoximmethyl 158 Mancozeb Boscalid Cyproconazole Trifloxystrobin 159 Mancozeb Boscalid Difenoconazole Azoxystrobin 160 Mancozeb Boscalid Difenoconazole Picoxystrobin 161 Mancozeb Boscalid Difenoconazole pyraclostrobin 162 Mancozeb Boscalid Difenoconazole Cresoximmethyl 163 Mancozeb Boscalid Difenoconazole Trifloxystrobin 164 Mancozeb Boscalid Epoxiconazole Azoxystrobin 165 Mancozeb Boscalid Epoxiconazole Picoxystrobin 166 Mancozeb Boscalid Epoxiconazole pyraclostrobin 167 Mancozeb Boscalid Epoxiconazole Cresoximmethyl 168 Mancozeb Boscalid Epoxiconazole Trifloxystrobin 169 Mancozeb Boscalid Hexaconazole Azoxystrobin 170 Mancozeb Boscalid Hexaconazole Picoxystrobin 171 Mancozeb Boscalid Hexaconazole pyraclostrobin 172 Mancozeb Boscalid Hexaconazole Cresoximmethyl 173 Mancozeb Boscalid Hexaconazole Trifloxystrobin 174 Mancozeb Boscalid Tebuconazole Azoxystrobin 175 Mancozeb Boscalid Tebuconazole Picoxystrobin 176 Mancozeb Boscalid Tebuconazole pyraclostrobin 177 Mancozeb Boscalid Tebuconazole Cresoximmethyl

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178 Mancozeb Boscalid Tebuconazole Trifloxystrobin 179 Mancozeb Boscalid Tetraconazole Azoxystrobin 180 Mancozeb Boscalid Tetraconazole Picoxystrobin 181 Mancozeb Boscalid Tetraconazole pyraclostrobin 182 Mancozeb Boscalid Tetraconazole Cresoximmethyl 183 Mancozeb Boscalid Tetraconazole Trifloxystrobin 184 Mancozeb Boscalid Prothioconazole Azoxystrobin 185 Mancozeb Boscalid Prothioconazole Picoxystrobin 186 Mancozeb Boscalid Prothioconazole pyraclostrobin 187 Mancozeb Boscalid Prothioconazole Cresoximmethyl 188 Mancozeb Boscalid Prothioconazole Trifloxystrobin

In one embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is IR9792. IR9792 is an SDHI fungicide developed by Isagro with the proposed generic name fluindapir.

In one embodiment, the combinations of the present invention include the following preferred combinations:

No. p / p I II III IV 189 Mancozeb IR9792 Cyproconazole - 190 Mancozeb IR9792 Difenoconazole - 191 Mancozeb IR9792 Epoxiconazole - 192 Mancozeb IR9792 Hexaconazole - 193 Mancozeb IR9792 Tebuconazole - 194 Mancozeb IR9792 Tetraconazole - 195 Mancozeb IR9792 Prothioconazole - 196 Mancozeb IR9792 - Azoxystrobin 197 Mancozeb IR9792 - Picoxystrobin 198 Mancozeb IR9792 - pyraclostrobin 199 Mancozeb IR9792 - Cresoximmethyl 200 Mancozeb IR9792 - Trifloxystrobin 201 Mancozeb IR9792 Cyproconazole Azoxystrobin 202 Mancozeb IR9792 Cyproconazole Picoxystrobin 203 Mancozeb IR9792 Cyproconazole pyraclostrobin 204 Mancozeb IR9792 Cyproconazole Cresoximmethyl 205 Mancozeb IR9792 Cyproconazole Trifloxystrobin 206 Mancozeb IR9792 Difenoconazole Azoxystrobin 207 Mancozeb IR9792 Difenoconazole Picoxystrobin 208 Mancozeb IR9792 Difenoconazole pyraclostrobin 209 Mancozeb IR9792 Difenoconazole Cresoximmethyl 210 Mancozeb IR9792 Difenoconazole Trifloxystrobin 211 Mancozeb IR9792 Epoxiconazole Azoxystrobin 212 Mancozeb IR9792 Epoxiconazole Picoxystrobin

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213 Mancozeb IR9792 Epoxiconazole pyraclostrobin 214 Mancozeb IR9792 Epoxiconazole Cresoximmethyl 215 Mancozeb IR9792 Epoxiconazole Trifloxystrobin 216 Mancozeb IR9792 Hexaconazole Azoxystrobin 217 Mancozeb IR9792 Hexaconazole Picoxystrobin 218 Mancozeb IR9792 Hexaconazole pyraclostrobin 219 Mancozeb IR9792 Hexaconazole Cresoximmethyl 220 Mancozeb IR9792 Hexaconazole Trifloxystrobin 221 Mancozeb IR9792 Tebuconazole Azoxystrobin 222 Mancozeb IR9792 Tebuconazole Picoxystrobin 223 Mancozeb IR9792 Tebuconazole pyraclostrobin 224 Mancozeb IR9792 Tebuconazole Cresoximmethyl 225 Mancozeb IR9792 Tebuconazole Trifloxystrobin 226 Mancozeb IR9792 Tetraconazole Azoxystrobin 227 Mancozeb IR9792 Tetraconazole Picoxystrobin 228 Mancozeb IR9792 Tetraconazole pyraclostrobin 229 Mancozeb IR9792 Tetraconazole Cresoximmethyl 230 Mancozeb IR9792 Tetraconazole Trifloxystrobin 231 Mancozeb IR9792 Prothioconazole Azoxystrobin 232 Mancozeb IR9792 Prothioconazole Picoxystrobin 233 Mancozeb IR9792 Prothioconazole pyraclostrobin 234 Mancozeb IR9792 Prothioconazole Cresoximmethyl 235 Mancozeb IR9792 Prothioconazole Trifloxystrobin

In one embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is bixafen.

In one embodiment, the combinations of the present invention include the following preferred combinations:

No. p / p I II III IV 236 Mancozeb Bixafen Cyproconazole - 237 Mancozeb Bixafen Difenoconazole - 238 Mancozeb Bixafen Epoxiconazole - 239 Mancozeb Bixafen Hexaconazole - 240 Mancozeb Bixafen Tebuconazole - 241 Mancozeb Bixafen Tetraconazole - 242 Mancozeb Bixafen Prothioconazole - 243 Mancozeb Bixafen - Azoxystrobin 244 Mancozeb Bixafen - Picoxystrobin 245 Mancozeb Bixafen - pyraclostrobin 246 Mancozeb Bixafen - Cresoximmethyl 247 Mancozeb Bixafen - Trifloxystrobin 248 Mancozeb Bixafen Cyproconazole Azoxystrobin

- 11 041454

249 Mancozeb Bixafen Cyproconazole Picoxystrobin 250 Mancozeb Bixafen Cyproconazole pyraclostrobin 251 Mancozeb Bixafen Cyproconazole Cresoximmethyl 252 Mancozeb Bixafen Cyproconazole Trifloxystrobin 253 Mancozeb Bixafen Difenoconazole Azoxystrobin 254 Mancozeb Bixafen Difenoconazole Picoxystrobin 255 Mancozeb Bixafen Difenoconazole pyraclostrobin 256 Mancozeb Bixafen Difenoconazole Cresoximmethyl 257 Mancozeb Bixafen Difenoconazole Trifloxystrobin 258 Mancozeb Bixafen Epoxiconazole Azoxystrobin 259 Mancozeb Bixafen Epoxiconazole Picoxystrobin 260 Mancozeb Bixafen Epoxiconazole pyraclostrobin 261 Mancozeb Bixafen Epoxiconazole Cresoximmethyl 262 Mancozeb Bixafen Epoxiconazole Trifloxystrobin 263 Mancozeb Bixafen Hexaconazole Azoxystrobin 264 Mancozeb Bixafen Hexaconazole Picoxystrobin 265 Mancozeb Bixafen Hexaconazole pyraclostrobin 266 Mancozeb Bixafen Hexaconazole Cresoximmethyl 267 Mancozeb Bixafen Hexaconazole Trifloxystrobin 268 Mancozeb Bixafen Tebuconazole Azoxystrobin 269 Mancozeb Bixafen Tebuconazole Picoxystrobin 270 Mancozeb Bixafen Tebuconazole pyraclostrobin 271 Mancozeb Bixafen Tebuconazole Cresoximmethyl 272 Mancozeb Bixafen Tebuconazole Trifloxystrobin 273 Mancozeb Bixafen Tetraconazole Azoxystrobin 274 Mancozeb Bixafen Tetraconazole Picoxystrobin 275 Mancozeb Bixafen Tetraconazole pyraclostrobin 276 Mancozeb Bixafen Tetraconazole Cresoximmethyl 277 Mancozeb Bixafen Tetraconazole Trifloxystrobin 278 Mancozeb Bixafen Prothioconazole Azoxystrobin 279 Mancozeb Bixafen Prothioconazole Picoxystrobin 280 Mancozeb Bixafen Prothioconazole Pyraclostrobin 281 Mancozeb Bixafen Prothioconazole Cresoximmethyl 282 Mancozeb Bixafen Prothioconazole Trifloxystrobin

In one embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is fluxapiroxad.

In one embodiment, the combinations of the present invention include the following preferred combinations:

No. p / p I II III IV 283 Mancozeb Fluxapiroxade Cyproconazole - 284 Mancozeb Fluxapiroxade Difenoconazole - 285 Mancozeb Fluxapiroxade Epoxiconazole - 286 Mancozeb Fluxapiroxade Hexaconazole - 287 Mancozeb Fluxapiroxade Tebuconazole -

- 12 041454

288 Mancozeb Fluxapiroxade Tetraconazole - 289 Mancozeb Fluxapiroxade Prothioconazole - 290 Mancozeb Fluxapiroxade - Azoxystrobin 291 Mancozeb Fluxapiroxade - Picoxystrobin 292 Mancozeb Fluxapiroxade - pyraclostrobin 293 Mancozeb Fluxapiroxade - Cresoximmethyl 294 Mancozeb Fluxapiroxade - Trifloxystrobin 295 Mancozeb Fluxapiroxade Cyproconazole Azoxystrobin 296 Mancozeb Fluxapiroxade Cyproconazole Picoxystrobin 297 Mancozeb Fluxapiroxade Cyproconazole pyraclostrobin 298 Mancozeb Fluxapiroxade Cyproconazole Cresoximmethyl 299 Mancozeb Fluxapiroxade Cyproconazole Trifloxystrobin 300 Mancozeb Fluxapiroxade Difenoconazole Azoxystrobin 301 Mancozeb Fluxapiroxade Difenoconazole Picoxystrobin 302 Mancozeb Fluxapiroxade Difenoconazole pyraclostrobin 303 Mancozeb Fluxapiroxade Difenoconazole Cresoximmethyl 304 Mancozeb Fluxapiroxade Difenoconazole Trifloxystrobin 305 Mancozeb Fluxapiroxade Epoxiconazole Azoxystrobin 306 Mancozeb Fluxapiroxade Epoxiconazole Picoxystrobin 307 Mancozeb Fluxapiroxade Epoxiconazole pyraclostrobin 308 Mancozeb Fluxapiroxade Epoxiconazole Cresoximmethyl 309 Mancozeb Fluxapiroxade Epoxiconazole Trifloxystrobin 310 Mancozeb Fluxapiroxade Hexaconazole Azoxystrobin 311 Mancozeb Fluxapiroxade Hexaconazole Picoxystrobin 312 Mancozeb Fluxapiroxade Hexaconazole pyraclostrobin 313 Mancozeb Fluxapiroxade Hexaconazole Cresoximmethyl 314 Mancozeb Fluxapiroxade Hexaconazole Trifloxystrobin 315 Mancozeb Fluxapiroxade Tebuconazole Azoxystrobin 316 Mancozeb Fluxapiroxade Tebuconazole Picoxystrobin 317 Mancozeb Fluxapiroxade Tebuconazole pyraclostrobin 318 Mancozeb Fluxapiroxade Tebuconazole Cresoximmethyl 319 Mancozeb Fluxapiroxade Tebuconazole Trifloxystrobin 320 Mancozeb Fluxapiroxade Tetraconazole Azoxystrobin 321 Mancozeb Fluxapiroxade Tetraconazole Picoxystrobin 322 Mancozeb Fluxapiroxade Tetraconazole pyraclostrobin 323 Mancozeb Fluxapiroxade Tetraconazole Cresoximmethyl 324 Mancozeb Fluxapiroxade Tetraconazole Trifloxystrobin 325 Mancozeb Fluxapiroxade Prothioconazole Azoxystrobin 326 Mancozeb Fluxapiroxade Prothioconazole Picoxystrobin 327 Mancozeb Fluxapiroxade Prothioconazole pyraclostrobin 328 Mancozeb Fluxapiroxade Prothioconazole Cresoximmethyl 329 Mancozeb Fluxapiroxade Prothioconazole Trifloxystrobin

In one embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is furametpyr.

- 13 041454

In one embodiment, the combinations of the present invention include the following preferred combinations:

No. p / p I II III IV 330 Mancozeb Furametpir Cyproconazole - 331 Mancozeb Furametpir Difenoconazole - 332 Mancozeb Furametpir Epoxiconazole - 333 Mancozeb Furametpir Hexaconazole - 334 Mancozeb Furametpir Tebuconazole - 335 Mancozeb Furametpir Tetraconazole - 336 Mancozeb Furametpir Prothioconazole - 337 Mancozeb Furametpir - Azoxystrobin 338 Mancozeb Furametpir - Picoxystrobin 339 Mancozeb Furametpir - pyraclostrobin 340 Mancozeb Furametpir - Cresoximmethyl 341 Mancozeb Furametpir - Trifloxystrobin 342 Mancozeb Furametpir Cyproconazole Azoxystrobin 343 Mancozeb Furametpir Cyproconazole Picoxystrobin 344 Mancozeb Furametpir Cyproconazole pyraclostrobin 345 Mancozeb Furametpir Cyproconazole Cresoximmethyl 346 Mancozeb Furametpir Cyproconazole Trifloxystrobin 347 Mancozeb Furametpir Difenoconazole Azoxystrobin 348 Mancozeb Furametpir Difenoconazole Picoxystrobin 349 Mancozeb Furametpir Difenoconazole pyraclostrobin 350 Mancozeb Furametpir Difenoconazole Cresoximmethyl 351 Mancozeb Furametpir Difenoconazole Trifloxystrobin 352 Mancozeb Furametpir Epoxiconazole Azoxystrobin 353 Mancozeb Furametpir Epoxiconazole Picoxystrobin 354 Mancozeb Furametpir Epoxiconazole pyraclostrobin 355 Mancozeb Furametpir Epoxiconazole Cresoximmethyl 356 Mancozeb Furametpir Epoxiconazole Trifloxystrobin 357 Mancozeb Furametpir Hexaconazole Azoxystrobin 358 Mancozeb Furametpir Hexaconazole Picoxystrobin 359 Mancozeb Furametpir Hexaconazole pyraclostrobin 360 Mancozeb Furametpir Hexaconazole Cresoximmethyl 361 Mancozeb Furametpir Hexaconazole T rif loxystrobin 362 Mancozeb Furametpir Tebuconazole Azoxystrobin 363 Mancozeb Furametpir Tebuconazole Picoxystrobin 364 Mancozeb Furametpir Tebuconazole pyraclostrobin 365 Mancozeb Furametpir Tebuconazole Cresoximmethyl 366 Mancozeb Furametpir Tebuconazole Trifloxystrobin 367 Mancozeb Furametpir Tetraconazole Azoxystrobin 368 Mancozeb Furametpir Tetraconazole Picoxystrobin 369 Mancozeb Furametpir Tetraconazole pyraclostrobin 370 Mancozeb Furametpir Tetraconazole Cresoximmethyl

- 14 041454

In one embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is penflufen.

In one embodiment, the combinations of the present invention include the following preferred combinations:

371 Mancozeb Furametpir Tetraconazole Trifloxystrobin 372 Mancozeb Furametpir Prothioconazole Azoxystrobin 273 Mancozeb Furametpir Prothioconazole Picoxystrobin 374 Mancozeb Furametpir Prothioconazole pyraclostrobin 375 Mancozeb Furametpir Prothioconazole Cresoximmethyl 376 Mancozeb Furametpir Prothioconazole Trifloxystrobin

No. p / p I II III IV 377 Mancozeb Penflufen Cyproconazole - 378 Mancozeb Penflufen Difenoconazole - 379 Mancozeb Penflufen Epoxiconazole - 380 Mancozeb Penflufen Hexaconazole - 381 Mancozeb Penflufen Tebuconazole - 382 Mancozeb Penflufen Tetraconazole - 383 Mancozeb Penflufen Prothioconazole - 384 Mancozeb Penflufen - Azoxystrobin 385 Mancozeb Penflufen - Picoxystrobin 386 Mancozeb Penflufen - pyraclostrobin 387 Mancozeb Penflufen - Cresoximmethyl 388 Mancozeb Penflufen - Trifloxystrobin 389 Mancozeb Penflufen Cyproconazole Azoxystrobin 390 Mancozeb Penflufen Cyproconazole Picoxystrobin 391 Mancozeb Penflufen Cyproconazole pyraclostrobin 392 Mancozeb Penflufen Cyproconazole Cresoximmethyl 393 Mancozeb Penflufen Cyproconazole Trifloxystrobin 394 Mancozeb Penflufen Difenoconazole Azoxystrobin 395 Mancozeb Penflufen Difenoconazole Picoxystrobin 396 Mancozeb Penflufen Difenoconazole pyraclostrobin 397 Mancozeb Penflufen Difenoconazole Cresoximmethyl 398 Mancozeb Penflufen Difenoconazole Trifloxystrobin 399 Mancozeb Penflufen Epoxiconazole Azoxystrobin 400 Mancozeb Penflufen Epoxiconazole Picoxystrobin 401 Mancozeb Penflufen Epoxiconazole pyraclostrobin 402 Mancozeb Penflufen Epoxiconazole Cresoximmethyl 403 Mancozeb Penflufen Epoxiconazole Trifloxystrobin 404 Mancozeb Penflufen Hexaconazole Azoxystrobin 405 Mancozeb Penflufen Hexaconazole Picoxystrobin 406 Mancozeb Penflufen Hexaconazole pyraclostrobin 407 Mancozeb Penflufen Hexaconazole Cresoximmethyl 408 Mancozeb Penflufen Hexaconazole Trifloxystrobin

- 15 041454

409 Mancozeb Penflufen Tebuconazole Azoxystrobin 410 Mancozeb Penflufen Tebuconazole Picoxystrobin 411 Mancozeb Penflufen Tebuconazole pyraclostrobin 412 Mancozeb Penflufen Tebuconazole Cresoximmethyl 413 Mancozeb Penflufen Tebuconazole Trifloxystrobin 414 Mancozeb Penflufen Tetraconazole Azoxystrobin 415 Mancozeb Penflufen Tetraconazole Picoxystrobin 416 Mancozeb Penflufen Tetraconazole pyraclostrobin 417 Mancozeb Penflufen Tetraconazole Cresoximmethyl 418 Mancozeb Penflufen Tetraconazole Trifloxystrobin 419 Mancozeb Penflufen Prothioconazole Azoxystrobin 420 Mancozeb Penflufen Prothioconazole Picoxystrobin 421 Mancozeb Penflufen Prothioconazole pyraclostrobin 422 Mancozeb Penflufen Prothioconazole Cresoximmethyl 423 Mancozeb Penflufen Prothioconazole Trifloxystrobin

In one embodiment of the combinations of the present invention, the preferred succinate dehydrogenase inhibitor fungicide is sedaxane.

In one embodiment, the combinations of the present invention include the following preferred combinations:

No. p / p I II III IV 424 Mancozeb Sedaksan Cyproconazole - 425 Mancozeb Sedaksan Difenoconazole - 426 Mancozeb Sedaksan Epoxiconazole - 427 Mancozeb Sedaksan Hexaconazole - 428 Mancozeb Sedaksan Tebuconazole - 429 Mancozeb Sedaksan Tetraconazole - 430 Mancozeb Sedaksan Prothioconazole - 431 Mancozeb Sedaksan - Azoxystrobin 432 Mancozeb Sedaksan - Picoxystrobin 433 Mancozeb Sedaksan - pyraclostrobin 434 Mancozeb Sedaksan - Cresoximmethyl 435 Mancozeb Sedaksan - Trifloxystrobin 436 Mancozeb Sedaksan Cyproconazole Azoxystrobin 437 Mancozeb Sedaksan Cyproconazole Picoxystrobin 438 Mancozeb Sedaksan Cyproconazole pyraclostrobin 439 Mancozeb Sedaksan Cyproconazole Cresoximmethyl 440 Mancozeb Sedaksan Cyproconazole Trifloxystrobin 441 Mancozeb Sedaksan Difenoconazole Azoxystrobin 442 Mancozeb Sedaksan Difenoconazole Picoxystrobin 443 Mancozeb Sedaksan Difenoconazole pyraclostrobin 444 Mancozeb Sedaksan Difenoconazole Cresoximmethyl

- 16 041454

445 Mancozeb Sedaksan Difenoconazole Trifloxystrobin 446 Mancozeb Sedaksan Epoxiconazole Azoxystrobin 447 Mancozeb Sedaksan Epoxiconazole Picoxystrobin 448 Mancozeb Sedaksan Epoxiconazole pyraclostrobin 449 Mancozeb Sedaksan Epoxiconazole Cresoximmethyl 450 Mancozeb Sedaksan Epoxiconazole Trifloxystrobin 451 Mancozeb Sedaksan Hexaconazole Azoxystrobin 452 Mancozeb Sedaksan Hexaconazole Picoxystrobin 453 Mancozeb Sedaksan Hexaconazole pyraclostrobin 454 Mancozeb Sedaksan Hexaconazole Cresoximmethyl 455 Mancozeb Sedaksan Hexaconazole Trifloxystrobin 456 Mancozeb Sedaksan Tebuconazole Azoxystrobin 457 Mancozeb Sedaksan Tebuconazole Picoxystrobin 458 Mancozeb Sedaksan Tebuconazole pyraclostrobin 459 Mancozeb Sedaksan Tebuconazole Cresoximmethyl 460 Mancozeb Sedaksan Tebuconazole Trifloxystrobin 461 Mancozeb Sedaksan Tetraconazole Azoxystrobin 462 Mancozeb Sedaksan Tetraconazole Picoxystrobin 463 Mancozeb Sedaksan Tetraconazole pyraclostrobin 464 Mancozeb Sedaksan Tetraconazole Cresoximmethyl 465 Mancozeb Sedaksan Tetraconazole Trifloxystrobin 466 Mancozeb Sedaksan Prothioconazole Azoxystrobin 467 Mancozeb Sedaksan Prothioconazole Picoxystrobin 468 Mancozeb Sedaksan Prothioconazole pyraclostrobin 469 Mancozeb Sedaksan Prothioconazole Cresoximmethyl 470 Mancozeb Sedaksan Prothioconazole Trifloxystrobin

The combinations of the present invention may be formulated in the form of a composition.

In one embodiment, the present invention may provide a composition comprising (a) at least one succinate dehydrogenase inhibitor fungicide;

(b) at least one dithiocarbamate fungicide;

(c) at least one external quinone inhibitor; and (d) at least one agrochemically acceptable excipient.

In one embodiment, the present invention may provide a composition comprising (a) at least one succinate dehydrogenase inhibitor fungicide;

(b) at least one dithiocarbamate fungicide;

(c) at least one ergosterol biosynthesis inhibitor; and (d) at least one agrochemically acceptable excipient.

In one embodiment, the present invention may provide a composition comprising (a) at least one succinate dehydrogenase inhibitor fungicide;

(b) at least one dithiocarbamate fungicide;

(c) at least one external quinone inhibitor;

(d) at least one ergosterol biosynthesis inhibitor; and (e) at least one agrochemically acceptable excipient.

The amount of the composition of the present invention will depend on various factors such as, for example, the object of treatment, such as, for example, plants, soil or seeds; type of treatment, such as, for example, spraying, pollination or seed dressing; the purpose of the treatment, such as, for example, disease prevention or disease control; in case of fighting a disease, the type of fungus being fought or the time of application. This is the number of combinations of the present invention that

- 17 041454 should be applied, can be easily identified by a qualified agronomist.

Thus, in one embodiment, the present invention may provide compositions comprising (a) at least one pyrazolecarboxamide selected from benzvindiflupyr, bixafen, fluxapiroxad, furametpyr, isopyrazam, penflufen, pentiopyrad, and sedaxane;

(b) at least one external quinone inhibitor and/or at least one ergosterol biosynthesis inhibitor; and (c) at least one dithiocarbamate fungicide;

wherein said fungicides are combined in agrochemically acceptable amounts.

In one embodiment, the total amount of succinate dehydrogenase inhibitor in the composition can typically be in the range of 0.1-99% by weight, preferably 0.2-90% by weight. The total amount of dithiocarbamate fungicide in the composition may be in the range of 0.1-99% by weight. The total amount of the ergosterol biosynthesis inhibitor in the composition may be in the range of 0.1-99% by weight. The total amount of external quinone inhibitor in the composition may be in the range of 0.1-99% by weight.

In one embodiment, the fungicides that are components of the combination of the present invention can be mixed in a ratio of (1-80):(1-80):(1-80) dithiocarbamate fungicide, succinate dehydrogenase inhibitor fungicide and third fungicide, respectively.

In one embodiment, the components of the composition of the present invention may be mixed in a reservoir and sprayed at the site of infection, or alternatively may be mixed with surfactants and then sprayed.

In one embodiment, the components of the composition of the present invention can be used for foliar application, soil application, or application to plant propagation materials.

In one embodiment, the compositions of the present invention can generally be prepared by mixing the active substances in the composition with an inert carrier and adding surfactants and other excipients and carriers as needed to solid or liquid compositions, including without limitation wettable powders, granules, pulverized powders, soluble (liquid) concentrates, suspension concentrates, oil-in-water emulsions, water-in-oil emulsions, emulsifiable concentrates, capsule suspensions, ZC formulations, oil dispersions, or other known types of formulations. The composition can also be used to treat plant propagation material such as seeds and the like.

Examples of solid carriers used in the formulation include fine powders or granules of minerals such as kaolin clay, attapulgite clay, bentonite, montmorillonite, acid white clay, pyrophyllite, talc, diatomaceous earth and calcite; natural organic materials such as corn stalk powder and walnut shell powder; synthetic organic materials such as urea; salts such as calcium carbonate and ammonium sulfate; synthetic inorganic materials such as synthetic silicon hydroxide; and as a liquid carrier, aromatic hydrocarbons such as xylene, alkylbenzene and methylnaphthalene; alcohols such as 2-propanol, ethylene glycol, propylene glycol and ethylene glycol monoethyl ether; ketones such as acetone, cyclohexanone and isophorone; vegetable oil such as soybean oil and cottonseed oil; aliphatic petroleum hydrocarbons, esters, dimethyl sulfoxide, acetonitrile and water.

Examples of surfactants include anionic surfactants such as alkyl sulfate ester salts, alkyl aryl sulfonate salts, dialkyl sulfosuccinate salts, polyoxyethylene alkyl aryl ether phosphate ester salts, lignosulfonate salts, and formaldehyde naphthalenesulfonate polycondensates; and nonionic surfactants such as polyoxyethylene alkyl aryl ethers, polyoxyethylene alkyl polyoxypropylene block copolymers and sorbitan fatty acid esters and cationic surfactants such as alkyl trimethyl ammonium salts.

Examples of other formulation auxiliaries include water soluble polymers such as polyvinyl alcohol and polyvinylpyrrolidone, polysaccharides such as gum arabic, alginic acid and its salts, CMC (carboxymethyl cellulose), xanthan gum, inorganic materials such as aluminum magnesium silicate and sol alumina, preservatives, colorants and stabilizers such as PAP (isopropyl acid phosphate) and butylhydroxytoluene (BHT).

The compositions of the present invention are effective in controlling the following plant diseases.

Rice diseases: blast (Magnaporthe grisea), leaf spotted helminthosporiasis (Cochliobolus miyabeanus), root rot (Rhizoctonia solani) and rice gibberellosis (Gibberella fujikuroi).

Wheat diseases: powdery mildew (Erysiphe graminis), head blight (Fusarium graminearam, F. avenaceram, F. culmoram, Microdochium nivale), rust (Puccinia striiformis, P. graminis, P. recondita), pink snow mold (Micronectriella nivale), gray snow mold (Typhula sp.), loose smut (Ustilago tritici), hard smut (Tilletia caries), eye spot (Pseudocercosporella her- 18 041454 potrichoides), leaf spot (Mycosphaerella graminicola), wheat septoria glume blotch (Stagonospora nodorum), septoria and yellow spotting (pyrenophorosis).

Barley diseases: powdery mildew (Erysiphe graminis), head blight (Fusarium graminearam, F. avenaceram, F. culmoram, Microdochium nivale), rust (Puccinia striiformis, P. graminis, P. hordei), loose smut (Ustilago nuda), bordering leaf spot (Rhynchosporium secalis), net spot (Pyrenophora teres), helminthosporium root blight of cereals (Cochliobolus sativus), striped leaf spot (Pyrenophora graminea) and rhizoctoniosis (Rhizoctonia solani).

Maize diseases: blister smut (Ustilago maydis), brown leaf or fruit spot (Cochliobolus heterostrophus), copper spot (Gloeocercospora sorghi), southern rust (Puccinia polysora), gray leaf spot (Cercospora zeae-maydis), white leaf spot (Phaeosphaeria mydis) and/or Pantoe ananatis) and rhizoctonia (Rhizoctonia solani).

Citrus diseases: melanosis (Diaporthe citri), cladosporiosis (Elsinoe fawcetti), mold rot (Penicillium digitatum, P. italicum) and brown rot (Phytophthora parasitica, Phytophthora citrophthora).

Apple tree diseases: moldy gray mold (Monilinia mali), tree cancer (Valsa ceratosperma), powdery mildew (Podosphaera leucotricha), Alternaria (apple pathotype Altemaria altemata), cladosporiosis (Venturia inaequalis), powdery mildew, bitter rot (Colletotrichut), root rot collar rot (Phytophtora cactorum), spotting (Diplocarpon mali) and ring rot (Botryosphaeria berengeriana).

Pear diseases: cladosporiosis (Venturia nashicola, V. pirina), powdery mildew, black spot (Japanese pear pathotype Alternaria alternata), rust (Phytophtora cactorum) and late blight fruit rot (Phytophtora cactorum).

Diseases of peach: brown rot (Monilinia fracticola), powdery mildew, cladosporiosis (Cladosporium carpophilum) and phomopsis rot (Phomopsis sp.).

Vine diseases: anthracnose (Elsinoe ampelina), glomerella rot (Glomerella cingulata), powdery mildew (Uncinula necator), rust (Phakopsora ampelopsidis), black rot (Guignardia bidwellii), botrites and downy mildew (Plasmopara viticola).

Japanese persimmon diseases: anthracnose (Gloeosporium kaki) and leaf spot (Cercospora kaki, Mycosphaerella nawae).

Pumpkin diseases: anthracnose (Colletotrichum lagenarium), powdery mildew (Sphaerotheca fuliginea), mycospherella black rot (Mycosphaerella melonis), fusarium wilt (Fusarium oxysporam), downy mildew (Pseudoperonospora cubensis), late blight (Phytophthora sp.) and rhizoctonia sp. sp.).

Tomato diseases: Alternaria (Alternaria solani), cladosporiosis (Cladosporium fulvum) and late blight (Phytophthora infestans).

Eggplant diseases: brown leaf or fruit spot (Phomopsis vexans) and powdery mildew (Erysiphe cichoracearum). Diseases of cruciferous vegetables: alternariosis (Altemaria japonica), white spot (Cercosporella brassicae), cruciferous clubroot (Plasmodiophora brassicae) and downy mildew (Peronospora parasitica).

Onion diseases: rust (Puccinia allii) and downy mildew (Peronospora destructor).

Soybean diseases: purple seed spot (Cercospora kikuchii), spotted anthracnose (Elsinoe glycines), bean and stem rot (Diaporthe phaseoloram var. Sojae), septoria brown leaf or fruit spot (Septoria glycines), selenophomose spot of cereal grasses (Cercospora sojina), rust (Phakopsora pachyrhizi), yellow rust, soybean stalk brown rot (Phytophthora sojae) and rhizoctoniosis (Rhizoctonia solani).

Bean diseases: Anthracnose (Colletotrichum lindemthianum).

Peanut diseases: leaf spot (Cercospora personata), physodermosis (Cercospora arachidicola) and southern sclerotial rot (Sclerotium rolfsii).

Garden pea diseases: powdery mildew (Erysiphe pisi) and root rot (Fusarium solani f. sp. pisi).

Potato diseases: Alternaria (Alternaria solani), late blight (Phytophthora infestans), rose rot (Phytophthora erythroseptica) and powdery potato scab (Spongospora subterranean f. sp. subterranea).

Strawberry diseases: powdery mildew (Sphaerotheca humuli) and anthracnose (Glomerella cingulata).

Tea diseases: exobasidiosis (Exobasidium reticulatum), white scab (Elsinoe leucospila), gray tea leaf spot (Pestalotiopsis sp.) and anthracnose (Colletotrichum theae - sinensis).

Tobacco diseases: brown leaf or fruit spot (Alternaria longipes), powdery mildew (Erysiphe cichoracearam), anthracnose (Colletotrichum tabacum), downy mildew (Peronospora tabacina) and late blight of tobacco (Phytophthora nicotianae).

Canola diseases: white rot (Sclerotinia sclerotiorum) and rhizoctoniosis (Rhizoctonia solani).

Cotton diseases: rhizoctoniosis (Rhizoctonia solani).

Sugar beet diseases: Cercospora leaf spot (Cercospora beticola), leaf spot (Thanatephorus cucumeris), root rot (Thanatephoras cucumeris) and Aphanomyces root rot (Aphanomyces cochlioides).

Rose diseases: black spot (Diplocarpon rosae), powdery mildew (Sphaerotheca pannosa) and

- 19 041454 downy mildew (Peronospora sparsa).

Diseases of chrysanthemums and composite plants: downy mildew (Bremia lactucae), leaf spot (Septoria chrysanthemi-indici) and white rust (Puccinia horiana).

Diseases of various groups: diseases caused by Pythium spp. (Pythium aphanidermatum, Pythium debarianum, Pythium graminicola, Pythium irregulare, Pythium ultimum), gray mold (Botrytis cinerea) and white mold (Sclerotinia sclerotiorum).

Japanese radish disease: Alternaria blight (Alternaria brassicicola).

Lawn grass diseases: dollar spot (Sclerotinia homeocarpa), brown spot and large spot (Rhizoctonia solani).

Banana diseases: black sigatoka (Mycosphaerella fijiensis), yellow sigatoka (Mycosphaerella musicola).

Sunflower disease: downy mildew (Plasmopara halstedii).

Seed diseases or diseases of various plants in the early stages of growth caused by Aspergillus spp., Penicillium spp., Fusarium spp., Gibberella spp., Tricoderma spp., Thielaviopsis spp., Rhizopus spp., Mucor spp., Corticium spp., Phoma spp., Rhizoctonia spp. and Diplodia spp.

Viral diseases of various plants caused by Polymixa spp. or Olpidium spp.; and so on.

The compositions of the present invention can be used on agricultural land, such as fields, rice fields, lawns and gardens, or on non-agricultural land. The present invention can be used to control diseases in agricultural land for growing plants without any phytotoxicity to the plant.

Examples of crops on which the present compositions can be used include, without limitation, corn, rice, wheat, barley, rye, oats, sorghum, cotton, soybeans, peanuts, buckwheat, beets, rapeseed, sunflowers, sugarcane, tobacco, etc. P.; vegetables: nightshade vegetables such as eggplant, tomato, red pepper, pepper, potato, etc., cucurbits such as cucumber, pumpkin, zucchini, watermelon, melon, marrow, etc., cruciferous vegetables, such as radish, white turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, Sarepta mustard, broccoli, cauliflower, etc., composite vegetable and ornamental plants, such as burdock, chrysanthemum, artichoke, lettuce, etc., lily plants such as green onions, onions, garlic and asparagus, root vegetables of the Umbelliferae family such as carrots, parsley, celery, parsnips, etc. Lamiaceae, such as perilla vulgaris, mint, basil, etc., strawberries, sweet potatoes, Japanese Dioscorea, taro, etc., flowers, ornamental foliage plants, lawn grasses, fruits: pome fruit, such as apple, pear, quince, etc., fleshy stone fruits such as peach, plum, nectarine, Japanese abr icos, cherry, apricot, prunes, etc., citrus fruits such as orange, lemon, grapefruit, etc., nuts, such as chestnuts, walnuts, hazelnuts, almonds, pistachios, cashew nuts, macadamia nuts and the like, berries such as blueberries, cranberries, blackberries, raspberries, etc., grapes, oriental persimmons, olives, plums, bananas, coffee, date palms, coconuts, etc., other non-fruit trees ; tea, mulberry, flowering plants, trees such as ash, birch, dogwood, eucalyptus, ginkgo biloba, lilac, maple, oak, poplar, purpurea, Formosan liquidambar, sycamore, zelkova, Japanese thuja, fir, hemlock, juniper, pine , spruce, yew, etc.

In one embodiment, the fungicides that are components of the combination of the present invention can be mixed in a ratio of (1-80):(1-80):(1-80):(1:80).

In one aspect, the present invention may provide methods for controlling fungal diseases comprising the use of a combination comprising (a) at least one succinate dehydrogenase inhibitor fungicide;

(b) at least one external quinone inhibitor and/or at least one ergosterol biosynthesis inhibitor; and (c) at least one dithiocarbamate fungicide.

In one embodiment, the succinate dehydrogenase inhibitor fungicide, the extrinsic quinone inhibitor fungicide, the ergosterol biosynthesis inhibitor fungicide, and the dithiocarbamate fungicide can be selected according to any of the preferred combination embodiments described above.

The combinations of the present invention may be sold as a pre-mix composition or kit so that the individual active ingredients can be mixed prior to spraying. In an alternative embodiment, the component kit may comprise a succinate dehydrogenase inhibitor fungicide and a premixed dithiocarbamate fungicide, and the third active component may be mixed with an adjuvant so that the two components can be mixed in a tank prior to spraying.

The composition of the present invention may be applied simultaneously as a mixture from a reservoir or formulation, or it may be applied sequentially. The composition can be applied to the soil before the appearance of plants, before or after planting. Application can be done by foliar spraying at different times during crop development with one or two applications at an early or

- 20 041454 late stage after germination.

The compositions of the invention can be applied before or after infection of useful plants or plant propagation material.

As will be shown in the examples, the addition of a dithiocarbamate fungicide to a combination of succinate dehydrogenase inhibitors that are combined with external quinone inhibitors and/or ergosterol biosynthesis inhibitors significantly improved disease control as well as improved yield and demonstrated a synergistic effect. The lower the effectiveness of the mixture in controlling diseases, the greater the additional benefit of mancozeb when added to the compositions of the present invention.

Examples

Studies have been conducted to investigate the addition of dithiocarbamate fungicides to succinate dehydrogenase inhibitor fungicides and at least one other fungicide, and the contribution of dithiocarbamate to the effectiveness of these mixtures. Experiments were conducted over a period of two years to study the effect of the addition of dithiocarbamates on the efficacy of succinate dehydrogenase inhibitors alone and in combination with a shared fungicide such as external quinone inhibitors and/or an ergosterol biosynthesis inhibitor fungicide. The tested doses were 1500 g/ha for mancozeb, 150 ml/ha for an ergosterol biosynthesis inhibitor, 200 g/ha for an external quinone inhibitor, 1000 and 200 g/ha for succinate dehydrogenase inhibitor fungicides. The combinations have been tested for disease control efficacy in soybean to control Asian soybean rust. Trials were carried out at various locations in India.

The test was carried out on soybean variety Monsoy 9144 RR. Commercially available individual active ingredients were used at the indicated dosages.

In table. 1 shows the efficacy of mancozeb when added to combinations containing fungicides based on a succinate dehydrogenase inhibitor and an ergosterol biosynthesis inhibitor.

Table 1

Type of processing Dose levels (ml/g/ha) Average percentage of successful disease control 2015/16 2016/17 Prothioconazole + benzovindiflupyr 150+200 88.04 71.04 Prothioconazole + benzovindiflupyr + mancozeb 150 + 200+ 1500 95.07 95.07 Prothioconazole + isopyrazam 150+1000 87.14 70.23 Prothioconazole + isopyrazam + mancozeb 150 + 1000 + 1500 93.4 93.07 Prothioconazole + penthiopyrad 150+ 1000 83.33 68.15 Prothioconazole + penthiopyrad + mancozeb 150 + 1000 + 1500 93.07 92.18

From the data given in table. 1, the increase in disease cure is clearly seen when mancozeb is added to the combination of ergosterol biosynthesis inhibitors and succinate dehydrogenase inhibitor fungicides.

Tab. 2 demonstrates the effectiveness of adding mancozeb in a combination of fungicides based on succinate dehydrogenase inhibitors and fungicides based on an external quinone inhibitor and ergosterol biosynthesis inhibitors.

table 2

Type of processing Dose levels (ml/g/ha) Average percentage successful disease control 2015/16 2016/17 Prothioconazole + benzovindiflupyr + azoxystrobin 150+200+500 93.07 91.07 Prothioconazole + benzovindiflupyr + azoxystrobin + mancozeb 150 + 200 + 500+ 1500 96.36 95.03

From the data given in table. 2 clearly shows the importance of adding mancozeb to the combination. The addition of mancozeb improved disease control.

Thus, it has been found that the administration of mancozeb significantly improves the efficacy and disease control when treated with a succinate dehydrogenase inhibitor fungicide when mixed with ergosterol biosynthesis inhibitors or extrinsic quinone inhibitors. Thus, it was concluded that the addition of mancozeb increased the effectiveness of the combination and unexpectedly provided a synergistic effect. The addition of dithiocarbamate improved disease control and increased plant yields. The present invention is more specifically explained by the above examples. However, it should be understood that the scope of the present invention is in no way limited by the examples. The person skilled in the art will understand that the present invention includes the above examples and may be further modified and changed within the technical scope of the present invention.

While the above written description of the invention allows one of ordinary skill in the art to make and use what is currently considered to be the best, those of ordinary skill in the art will understand and appreciate the existence of variations, combinations, and equivalents to the particular embodiment, method, and examples provided herein. Thus, the invention is not to be limited to the embodiment, method and examples described above, but to all embodiments and methods falling within the scope and spirit of the present invention.

Claims (5)

CLAIM 1. Combination of fungicides, consisting of a) mancozeb; b) one succinate dehydrogenase inhibitor selected from benzovindiflupyr and isopyrazam; c) at least another fungicide selected from prothioconazole and azoxystrobin, and combinations thereof. 2. The combination according to claim 1, which is formulated as wettable powders, granules, pulverized powders, soluble (liquid) concentrates, suspension concentrates, oil-in-water emulsions, water-in-oil emulsions, emulsifiable concentrates, capsule suspensions, formulations ZC or oil dispersions. 3. Combination according to claim 1 or 2, in which the total amount of inhibitor of succinate dehydrogenase in the composition is in the range of 0.1-99 wt.%; the total amount of mancozeb in the composition is in the range of 0.1-99 wt.%; the total amount of azoxystrobin in the composition is in the range of 0.1-99 wt.%; and the total amount of prothioconazole in the composition is in the range of 0.1-99% by weight. 4. Combination according to claim 3, intended for foliar application or for incorporation into plant propagation materials. 5. A method for combating fungal diseases, including the introduction of a combination according to claim 1 into the plant locus.