NZ752945B2 - High purity lactose - Google Patents
High purity lactose Download PDFInfo
- Publication number
- NZ752945B2 NZ752945B2 NZ752945A NZ75294517A NZ752945B2 NZ 752945 B2 NZ752945 B2 NZ 752945B2 NZ 752945 A NZ752945 A NZ 752945A NZ 75294517 A NZ75294517 A NZ 75294517A NZ 752945 B2 NZ752945 B2 NZ 752945B2
- Authority
- NZ
- New Zealand
- Prior art keywords
- stream
- lactose
- adsorbent resin
- clarified
- insoluble impurities
- Prior art date
Links
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 title claims abstract description 40
- 239000008101 lactose Substances 0.000 title claims abstract description 40
- 238000000034 method Methods 0.000 claims abstract description 24
- 239000003463 adsorbent Substances 0.000 claims abstract description 19
- 229920005989 resin Polymers 0.000 claims abstract description 19
- 239000011347 resin Substances 0.000 claims abstract description 19
- 239000012535 impurity Substances 0.000 claims abstract description 13
- 238000001179 sorption measurement Methods 0.000 claims abstract description 10
- 238000005352 clarification Methods 0.000 claims abstract description 9
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 14
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 8
- 239000000178 monomer Substances 0.000 claims description 8
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 7
- 229960002477 riboflavin Drugs 0.000 claims description 7
- 235000019192 riboflavin Nutrition 0.000 claims description 7
- 239000002151 riboflavin Substances 0.000 claims description 7
- SLBOQBILGNEPEB-UHFFFAOYSA-N 1-chloroprop-2-enylbenzene Chemical compound C=CC(Cl)C1=CC=CC=C1 SLBOQBILGNEPEB-UHFFFAOYSA-N 0.000 claims description 4
- MHHJQVRGRPHIMR-UHFFFAOYSA-N 1-phenylprop-2-en-1-ol Chemical compound C=CC(O)C1=CC=CC=C1 MHHJQVRGRPHIMR-UHFFFAOYSA-N 0.000 claims description 4
- IGGDKDTUCAWDAN-UHFFFAOYSA-N 1-vinylnaphthalene Chemical compound C1=CC=C2C(C=C)=CC=CC2=C1 IGGDKDTUCAWDAN-UHFFFAOYSA-N 0.000 claims description 4
- 238000005727 Friedel-Crafts reaction Methods 0.000 claims description 4
- XYLMUPLGERFSHI-UHFFFAOYSA-N alpha-Methylstyrene Chemical compound CC(=C)C1=CC=CC=C1 XYLMUPLGERFSHI-UHFFFAOYSA-N 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 239000003054 catalyst Substances 0.000 claims description 4
- 229920006026 co-polymeric resin Polymers 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 238000004132 cross linking Methods 0.000 claims description 4
- HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 claims description 4
- 150000003440 styrenes Chemical class 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 3
- 239000013078 crystal Substances 0.000 claims 8
- 239000000047 product Substances 0.000 claims 7
- 238000002425 crystallisation Methods 0.000 claims 2
- 230000008025 crystallization Effects 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000002002 slurry Substances 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 1
- 238000005516 engineering process Methods 0.000 claims 1
- 230000003134 recirculating effect Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 239000012465 retentate Substances 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920001429 chelating resin Polymers 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- -1 for example Substances 0.000 description 1
- 235000013350 formula milk Nutrition 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K13/00—Sugars not otherwise provided for in this class
- C13K13/007—Separation of sugars provided for in subclass C13K
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K5/00—Lactose
Abstract
example system for purifying a supply stream including lactose includes a clarification system configured to separate insoluble impurities from the stream to produce a clarified stream. The system includes an adsorption system fluidically coupled to the clarification system. The adsorption system includes an adsorbent resin configured to purify the clarified stream. An example technique for purifying a supply stream including lactose includes separating insoluble impurities from the supply stream to produce a clarified stream and passing the clarified stream over an adsorbent resin to produce a decolorized stream. includes an adsorbent resin configured to purify the clarified stream. An example technique for purifying a supply stream including lactose includes separating insoluble impurities from the supply stream to produce a clarified stream and passing the clarified stream over an adsorbent resin to produce a decolorized stream.
Description
products which require disposal. Any voids in the filter aid or a malfunction of the vacuum filter can allow contamination of the previously clarified batch of lactose.
Food-grade adsorbent resins such as Amberlite FPX66 are not currently FDA- approved for production of high purity lactose intended to be consumed, for example, in infant formula, pharmaceutical formulations, and other such products.
The present disclosure describes efficient and commercially useful systems and techniques for purifying lactose, for example, edible grade lactose, to obtain high purity lactose suitable for edible and pharmaceutical applications. [0007a] In a first aspect of the invention, there is provided a system for purifying a supply stream containing lactose, the system comprising: a clarification system configured to remove insoluble impurities from the supply stream to produce a clarified stream; and an adsorption system fluidically coupled to the clarification system, wherein the adsorption system comprises an adsorbent resin selected to bind riboflavin to decolorize the clarified stream, wherein the adsorbent resin comprises a riboflavin binding macroporous copolymer resin comprising: a monovinyl aromatic monomer selected from styrene and styrene derivatives chosen from α-methylstyrene, vinyl toluene, vinyl naphthalene, vinylbenzyl chloride, and vinylbenzyl alcohol, and a crosslinking monomer, where the macroporous copolymer has been post-crosslinked in a swollen state in the presence of a Friedel-Crafts catalyst and functionalized with hydrophilic groups. [0007b] In a second aspect of the invention, there is provided a method for purifying a supply stream comprising lactose, the method comprising: clarifying the supply stream by removing insoluble impurities to produce a clarified stream; and mixing the clarified stream with an adsorbent resin selected to bind riboflavin to produce a decolorized stream, wherein the adsorbent resin comprises a macroporous copolymer resin comprising: a monovinyl aromatic monomer selected from styrene and styrene derivatives chosen from α-methylstyrene, vinyl toluene, vinyl naphthalene, vinylbenzyl chloride, and vinylbenzyl alcohol, and a crosslinking monomer, where the macroporous copolymer has been post-crosslinked in a swollen state in the presence of a Friedel-Crafts catalyst and functionalized with hydrophilic groups. [0007c] In a third aspect of the invention, there is provided a lactose product produced using the method of the second aspect of the invention.
In one embodiment, the disclosure describes a system for purifying a supply stream including lactose. The system includes a clarification system configured to remove insoluble impurities from the supply stream to produce a clarified stream. The system also includes an adsorption system that includes an adsorbent resin. The adsorbent resin in the adsorption system removes colorants or contaminants, for example, riboflavin, from the clarified stream, to decolorize the clarified stream.
In another embodiment, the disclosure describes an example technique for purifying a supply stream including lactose. The example technique includes clarifying the supply stream by removing insoluble impurities to produce a clarified stream. The example technique also includes mixing the clarified stream with an adsorbent resin to produce a decolorized stream.
The details of one or more aspects of the invention are set forth in the accompanying drawings and the description below. Other features, objects, and advantages of the invention will be apparent from the description and drawings, and from the claims.
BRIEF DESCRIPTION OF DRAWINGS The foregoing and other aspects of this invention are made more evident in the following Detailed Description, when read in conjunction with the attached Figures. is a schematic flow diagram illustrating an example system for processing lactose to obtain high purity lactose. is a flowchart illustrating an example process for preparing high purity lactose.
It should be understood the Figures present non-exclusive examples of the techniques disclosed herein.
Claims (23)
1. A system for purifying a supply stream containing lactose, the system comprising: a clarification system configured to remove insoluble impurities from the supply stream to produce a clarified stream; and an adsorption system fluidically coupled to the clarification system, wherein the adsorption system comprises an adsorbent resin selected to bind riboflavin to decolorize the clarified stream, wherein the adsorbent resin comprises a riboflavin binding macroporous copolymer resin comprising: a monovinyl aromatic monomer selected from styrene and styrene derivatives chosen from α-methylstyrene, vinyl toluene, vinyl naphthalene, vinylbenzyl chloride, and vinylbenzyl alcohol, and a crosslinking monomer, where the macroporous copolymer has been post-crosslinked in a swollen state in the presence of a Friedel-Crafts catalyst and functionalized with hydrophilic groups.
2. The system of claim 1, wherein the adsorption system comprises a packed bed comprising the adsorbent resin.
3. The system of claim 1, wherein the adsorption system comprises a stirred tank comprising the adsorbent resin.
4. The system of any one of claims 1 to 3, wherein the clarification system comprises a membrane filter having a predetermined molecular weight cutoff configured to remove the insoluble impurities.
5. The system of any one of claims 1 to 4, wherein the clarification system comprises a centrifugal clarifier configured to remove the insoluble impurities.
6. The system of any one of claims 1 to 5, further comprising one or more of a crystallization system configured to crystallize lactose crystals, a crystal separation system configured to separate lactose crystals from a solution, and a drying system configured to dry lactose crystals.
7. The system of any one of claims 1 to 6, further comprising a lactose recovery system configured to wash lactose from a stream received from the crystallization system.
8. A method for purifying a supply stream comprising lactose, the method comprising: clarifying the supply stream by removing insoluble impurities to produce a clarified stream; and mixing the clarified stream with an adsorbent resin selected to bind riboflavin to produce a decolorized stream, wherein the adsorbent resin comprises a macroporous copolymer resin comprising: a monovinyl aromatic monomer selected from styrene and styrene derivatives chosen from α-methylstyrene, vinyl toluene, vinyl naphthalene, vinylbenzyl chloride, and vinylbenzyl alcohol, and a crosslinking monomer, where the macroporous copolymer has been post-crosslinked in a swollen state in the presence of a Friedel-Crafts catalyst and functionalized with hydrophilic groups.
9. The method of claim 8, wherein the adsorbent resin is arranged in a packed bed.
10. The method of any one of claims 8 or 9, wherein the clarifying comprises passing the stream through a membrane filter having a predetermined molecular weight cutoff configured to remove the insoluble impurities.
11. The method of any one of claims 8 to 10, wherein the clarifying comprises centrifuging the stream in a centrifugal clarifier to remove the insoluble impurities.
12. The method of any one of claims 8 to 11, further comprising maintaining the supply stream at a predetermined temperature sufficient to solubilize lactose in the supply stream.
13. The method of claim 12, wherein the predetermined temperature is between about 60 and about 100 °C.
14. The method of any one of claims 8 to 13, further comprising adjusting pH of the supply stream to a pH between about 7 and about 11.
15. The method of any one of claims 8 to 14, further comprising recirculating lactose from a retentate stream into the supply stream.
16. The method of any one of claims 8 to 15, further comprising cooling the decolorized stream to a predetermined second temperature to crystallize lactose crystals from the decolorized stream to produce a slurry stream.
17. The method of claim 16, wherein the predetermined temperature is about 16 °C.
18. The method of claim 16 or 17, further comprising separating lactose crystals from the slurry stream.
19. The method of claim 18, further comprising one or both of washing the lactose crystals or drying the lactose crystals.
20. A lactose product produced using the method of any one of claims 8 to 19.
21. The lactose product of claim 20, wherein the lactose product comprises pharmaceutical-grade lactose.
22. The lactose product of claim 21, wherein the lactose product comprises at least 99% lactose by weight on a moisture-free basis.
23. The lactose product of claim 21, wherein the lactose product comprises at least 99.9% lactose by weight on a moisture-free basis. Keller Technologies, Inc Patent Attorneys for the Applicant/Nominated Person SPRUSON & FERGUSON
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662408580P | 2016-10-14 | 2016-10-14 | |
| US62/408,580 | 2016-10-14 | ||
| PCT/US2017/056334 WO2018071665A1 (en) | 2016-10-14 | 2017-10-12 | High purity lactose |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NZ752945A NZ752945A (en) | 2021-03-26 |
| NZ752945B2 true NZ752945B2 (en) | 2021-06-29 |
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