NZ733226A - Crystalline forms of grapiprant - Google Patents
Crystalline forms of grapiprantInfo
- Publication number
- NZ733226A NZ733226A NZ733226A NZ73322615A NZ733226A NZ 733226 A NZ733226 A NZ 733226A NZ 733226 A NZ733226 A NZ 733226A NZ 73322615 A NZ73322615 A NZ 73322615A NZ 733226 A NZ733226 A NZ 733226A
- Authority
- NZ
- New Zealand
- Prior art keywords
- grapiprant
- crystalline
- crystalline forms
- substantially pure
- group
- Prior art date
Links
- HZVLFTCYCLXTGV-UHFFFAOYSA-N 1-[2-[4-(2-ethyl-4,6-dimethylimidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea Chemical compound CCC1=NC2=C(C)N=C(C)C=C2N1C(C=C1)=CC=C1CCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 HZVLFTCYCLXTGV-UHFFFAOYSA-N 0.000 title abstract 7
- 229950004517 grapiprant Drugs 0.000 title abstract 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012047 saturated solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present disclosure provides a crystalline form of grapiprant selected from the group consisting of Form X, Form X2, Form X3, Form F, Form K, Form L, Form M, and Form N. Also provided is a pharmaceutical composition, the composition comprising at least one crystalline form of grapiprant, and at least one pharmaceutically acceptable excipient, wherein the crystalline form of grapiprant is selected from the group consisting of Form X, Form X2, Form X3, Form F, Form K, Form L, Form M, and Form N. Other aspects of the disclosure provide a process for preparing a substantially pure crystalline Form A of grapiprant. The process comprises contacting grapiprant at ambient temperature with a solvent comprising dichloromethane and acetone to form a saturated or a near saturated solution. Crystals of the substantially pure crystalline Form A of grapiprant are formed.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461949006P | 2014-03-06 | 2014-03-06 | |
| US201461996961P | 2014-07-30 | 2014-07-30 | |
| NZ724923A NZ724923A (en) | 2014-03-06 | 2015-03-05 | Crystalline forms of grapiprant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ733226A true NZ733226A (en) | 2018-03-23 |
Family
ID=61626674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ733226A NZ733226A (en) | 2014-03-06 | 2015-03-05 | Crystalline forms of grapiprant |
Country Status (1)
| Country | Link |
|---|---|
| NZ (1) | NZ733226A (en) |
-
2015
- 2015-03-05 NZ NZ733226A patent/NZ733226A/en unknown
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Legal Events
| Date | Code | Title | Description |
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Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 05 MAR 2020 BY AJ PARK Effective date: 20190228 |
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Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 05 MAR 2024 BY THOMSON REUTERS Effective date: 20230201 |
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