NZ732278B2 - Oral rehydration composition and methods thereof - Google Patents
Oral rehydration composition and methods thereof Download PDFInfo
- Publication number
- NZ732278B2 NZ732278B2 NZ732278A NZ73227815A NZ732278B2 NZ 732278 B2 NZ732278 B2 NZ 732278B2 NZ 732278 A NZ732278 A NZ 732278A NZ 73227815 A NZ73227815 A NZ 73227815A NZ 732278 B2 NZ732278 B2 NZ 732278B2
- Authority
- NZ
- New Zealand
- Prior art keywords
- oral rehydration
- composition according
- composition
- glycine
- rehydration composition
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract 22
- 238000000034 method Methods 0.000 title claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract 14
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract 13
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract 10
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract 7
- 229960001031 glucose Drugs 0.000 claims abstract 7
- 239000011780 sodium chloride Substances 0.000 claims abstract 7
- 239000000230 xanthan gum Substances 0.000 claims abstract 6
- 229920001285 xanthan gum Polymers 0.000 claims abstract 6
- 229940082509 xanthan gum Drugs 0.000 claims abstract 6
- 235000010493 xanthan gum Nutrition 0.000 claims abstract 6
- 108010046377 Whey Proteins Proteins 0.000 claims abstract 5
- 102000007544 Whey Proteins Human genes 0.000 claims abstract 5
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims abstract 5
- 239000004223 monosodium glutamate Substances 0.000 claims abstract 5
- 235000013923 monosodium glutamate Nutrition 0.000 claims abstract 5
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims abstract 5
- 235000019799 monosodium phosphate Nutrition 0.000 claims abstract 5
- 239000001103 potassium chloride Substances 0.000 claims abstract 5
- 235000011164 potassium chloride Nutrition 0.000 claims abstract 5
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims abstract 5
- 241000209140 Triticum Species 0.000 claims abstract 4
- 235000021307 Triticum Nutrition 0.000 claims abstract 4
- 108090000623 proteins and genes Proteins 0.000 claims abstract 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract 4
- 239000001509 sodium citrate Substances 0.000 claims abstract 4
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims abstract 4
- 229940038773 trisodium citrate Drugs 0.000 claims abstract 4
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 claims abstract 3
- 206010012735 Diarrhoea Diseases 0.000 claims abstract 3
- 102000004190 Enzymes Human genes 0.000 claims abstract 3
- 108090000790 Enzymes Proteins 0.000 claims abstract 3
- 239000004383 Steviol glycoside Substances 0.000 claims abstract 3
- 229960002303 citric acid monohydrate Drugs 0.000 claims abstract 3
- 150000002772 monosaccharides Chemical class 0.000 claims abstract 3
- 229930182488 steviol glycoside Natural products 0.000 claims abstract 3
- 235000019411 steviol glycoside Nutrition 0.000 claims abstract 3
- 150000008144 steviol glycosides Chemical class 0.000 claims abstract 3
- 235000019202 steviosides Nutrition 0.000 claims abstract 3
- 239000005862 Whey Substances 0.000 claims abstract 2
- 235000013339 cereals Nutrition 0.000 claims abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 8
- 239000004471 Glycine Substances 0.000 claims 6
- 229960002989 glutamic acid Drugs 0.000 claims 6
- 239000007864 aqueous solution Substances 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 4
- 235000008504 concentrate Nutrition 0.000 claims 3
- 239000012141 concentrate Substances 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 235000021119 whey protein Nutrition 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 2
- 230000018044 dehydration Effects 0.000 claims 2
- 238000006297 dehydration reaction Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000000819 hypertonic solution Substances 0.000 claims 1
- 229940021223 hypertonic solution Drugs 0.000 claims 1
- 239000000815 hypotonic solution Substances 0.000 claims 1
- 235000014483 powder concentrate Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 235000019263 trisodium citrate Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/032—Citric acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0618—Glutamic acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/02—Acid
- A23V2250/06—Amino acid
- A23V2250/0622—Glycine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/15—Inorganic Compounds
- A23V2250/156—Mineral combination
- A23V2250/16—Potassium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/15—Inorganic Compounds
- A23V2250/156—Mineral combination
- A23V2250/1614—Sodium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/24—Non-sugar sweeteners
- A23V2250/262—Stevioside
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/50—Polysaccharides, gums
- A23V2250/502—Gums
- A23V2250/5086—Xanthan
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/54—Proteins
- A23V2250/548—Vegetable protein
- A23V2250/5482—Cereal protein
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/54—Proteins
- A23V2250/55—Peptide, protein hydrolysate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Abstract
oral rehydration composition comprising the following: 1-glutamic acid in a range of about 0.01% to about 0.40% w/w and monosodium glutamate in a range of about 0.05% to about 0.80% w/w; about 1.50% w/w glucose monohydrate; about 0.20% w/w sodium chloride; about 0.15% w/w potassium chloride; about 0.35% w/w glycine; about 0.30% w/w trisodiumcitrate; about 0.15% w/w sodium dihydrogen phosphate; about 0.10% w/w xanthan gum; 85% Steviol Glycoside extract in a range of about 0.01% to about 0.03% w/w; about 0.20% w/w citric acid monohydrate; hydrolyzed whey in a range of about 0.15% to about 1.00% w/w; about 1.00% w/w hydrolyzed wheat; comprises cereals as a protein source; comprises enzyme co- factors; comprises a monosaccharide. The oral rehydration composition can be used on humans or animals that suffer from diarrhea.
Claims (14)
1.00% w/W, and the balance water; aqueous solutions sing 1.45% w/w glucose monohydrate, 0.26% W/w sodium chloride, 0.15% w/w potassium chloride, 0.30% w/w glycine, 0.10% w/w sodium dihydrogen phosphate, 0.10% w/w xanthan gum, 0.20% w/w citric acid monohydrate, 0.15% w/w hydrolysed whey protein, 0.04% w/w L- glutamic acid, 0.25% w/W monosodium glutamate, 0.001% w/w 85% Steviol Glycoside extract, and the balance water; aqueous solutions comprising 1.50% w/w glucose monohydrate, 0.26% w/W sodium de, 0.15% w/w ium chloride, 0.40% w/w glycine, 0.29% w/w trisodium citrate, 0.05% w/w xanthan gum, 1.00% w/w hydrolysed wheat protein, 0.04% w/w L—glutamic acid, 0.04% w/w monosodium glutamate, and the balance water; aqueous solutions comprising 1.50% w/w glucose monohydrate, 0.26% w/w sodium chloride, 0.15% W/W potassium chloride, 0.40% w/w glycine, 0.10% w/w sodium dihydrogen phosphate, 0.05% w/w xanthan gum, 1.00% w/W hydrolysed Wheat protein, 0.04% w/w L—glutamic acid, 0.04% w/W monosodium glutamate, and the balance water; aqueous ons sing 1.50% W/W glucose monohydrate, 0.26% W/w sodium chloride, 0.15% w/w potassium chloride, 0.40% w/w glycine, 0.29% w/w trisodium citrate, 0.05% w/w xanthan gum, 1.00% w/w hydrolyzed Whey protein, 0.04% w/w L-glutamic acid, 0.04% w/w monosodium glutamate, and the balance water; and, s solutions comprising 1.50% w/w glucose monohydrate, 0.26% w/w sodium chloride, 0.15% w/w ium chloride, 0.40% w/w glycine, 0.10% w/w sodium dihydrogen phosphate, 0.05% w/w xanthan gum, 1.00% w/w hydrolysed whey protein, 0.04% W/w L—glutamic acid, 0.04% w/w monosodium ate, and the balance water.
2.The oral rehydration ition ing to claim 1, wherein said composition is in the form of a powder concentrate.
3.The oral rehydration composition according to claim 1, wherein said composition is in a form selected from the group consisting of gels, sprays, and quick ve tablets.
4.The oral rehydration composition according to claim 1, wherein said composition is an ic solution.
5.The oral rehydration composition according to claim 4, wherein said the tonicity of said solution is comparable to the tonicity of a 0.9% solution of sodium chloride.
6.The oral rehydration composition according to claim 1, wherein said composition is a hypotonic solution.
7.The oral rehydration composition according to claim 1, wherein said composition is a hypertonic solution.
8.The oral rehydration composition according to claim 1, wherein said composition is tailored to suit the ?avoring preferences of different species or individuals.
9.The oral rehydration composition according to claim 2, wherein said concentrate comprises enzyme tors.
10. The oral rehydration composition according to claim 2, n said concentrate ses a monosaccharide.
11. The use of the oral rehydration composition according to claim 1 in the preparation of a medicament for preventing ation, excluding for use in non—human animals.
12. The use according to claim 11, wherein said medicament is for use in prevention of dehydration in an individual suffering from diarrhea.
13. A method for preventing dehydration in a non—human animal, wherein said method comprises: preparing an oral ation composition according to claim 1; and, stering said oral rehydration composition to an individual in need thereof.
14. The method according to claim 13, wherein said non—human animal is suffering from diarrhea.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462081588P | 2014-11-19 | 2014-11-19 | |
| PCT/IB2015/058699 WO2016079640A1 (en) | 2014-11-19 | 2015-11-11 | Oral rehydration composition and methods thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NZ732278A NZ732278A (en) | 2024-02-23 |
| NZ732278B2 true NZ732278B2 (en) | 2024-05-24 |
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