NZ720006B2 - Dispenser Cap Arrangement - Google Patents

Abstract

dispenser cap (71) for enclosing a portion of a dispenser of a medicament, the dispenser cap comprising: a hollow body having a lower open end for engaging with a body portion of a dispenser, and an upper open end for receiving a dispenser cap closure device for closing the upper open end. The upper open end comprises an engageable portion for engaging with a dispenser cap closure device for closing the upper open end of the hollow body and an upper surface of the dispenser cap comprises a limiting means (teeth 81) for preventing rotation in either direction of the cap closure device when engaged with the dispenser cap. er open end comprises an engageable portion for engaging with a dispenser cap closure device for closing the upper open end of the hollow body and an upper surface of the dispenser cap comprises a limiting means (teeth 81) for preventing rotation in either direction of the cap closure device when engaged with the dispenser cap.

Description

Dispenser Cap Arrangem ent FIELD OF THE INVENTION The present invention relates to a dispenser cap arrangement for enclosing a portion of a ser of a medicament. in ular. the present invention relates to a dispenser cap arrangement, a dispenser cap, a dispenser cap closure device, a method of g a dispenser, and a closure ement. The present application is a divisional application from New Zealand patent ation number 624907, ed Dispenser Cap Arrangement, the disclosure in which is incorporated herein by reference.

BACKGROUND OF THE INVENTION in general, metered-doseinhalers (MDis) are devices for dispensing medicaments, in aerosol form, to the lungs. Broadly speaking dispensers such as MDls are comprised oftwo components: a container and a delivery device. The container holds the medication, e.g_ dissolved or suspended in a propellant under high pressure to maintain a liquid phase. Additionally the container often comprises an internal metering valve, which is designed to release a precisely measured, reproducible dose of medicament when the valve is actuated. The delivery device typically includes an actuator and a mouthpiece. The actuator, which can be triggered by the user, for example by inhalation or manual operation, typically interacts with the ng valve of the container to induce release of a dose. The mouthpiece serves to direct the medication towards the user.

We have previously described a number of dispensers, see for example US 7,721,731.

However, it has been found that manufacturing tolerances mean that the length of a container or substance source can vary from container to ner. Furthermore, the length of the spout of the container may vary, too.

This can cause problems in ser devices wherein the l can is stationary and another part is moved relative to the can to displace its valve and dispense medicament. Typically the other moving part can only move a certain distance (is. a predetermined amount of travel) which means that if, forexample a can or its valve is relatively short, the valve may not be fully displaced. As a result, a full dose of medicament may not be dispensed.

There have been different approaches taken to overcoming this problem. See, for e, W02003/080161 or W02007/029019.

In the above—mentioned previous approaches, the dispenser body and cap are a constant size and the er is placed in the body at the same position in all dispensers. The variation in the resulting space between the end of the er and the cap is taken by deformable materials placed atop the container. However, the above solutions do not always e satisfactory results, so we have appreciated the need for an improved dispenser cap arrangement.

STATEMENT OF THE INVENTION The present invention therefore provides a dispenser cap arrangement for enclosing a portion of a dispenser of a medicament, the dispenser cap arrangement sing: a dispenser cap comprising a hollow body having a lower open end for engaging with a body n of a dispenser, and an upper open end for receiving a cap e device for closing the upper open end, the upper open end comprising an engageable portion; and a cap closure device, comprising: an upper cap closure portion for engaging with the upper open end of the dispenser cap to close the upper open end of the dispenser 2O cap; a lower cap closure portion for engaging with the engageable portion to secure the cap closure device to the dispenser cap; and a bistable portion connecting the upper cap closure portion and the lower cap closure portion, the bistable portion being switchable between a first stable form in which the bistable portion is extended, and a second stable form in which the bistable portion is collapsed, n, when the bistable portion is in the second stable form, the upper cap closure portion engages with the upper open end of the dispenser cap to close the dispenser cap.

The cap, in ation with the closure device, provide a means of enclosing a portion of a dispenser. Advantageously, the bistable portion of the closure device that is switchable between two stable forms (extended and collapsed) enables the e device to be inserted and the cap closed when the closure device is in the desired position ve to the cap. Furthermore, the cap closure device, once in a stable form, requires a force to be d to the upper closure portion to switch between the stable forms. As such, once in the collapsed form, the closure device is difficult to remove from the cap, thereby ng the closure device to the cap so that it cannot easily be removed. Furthermore, by using the above—mentioned cap closure device, a dispenser is able to be assembled where the medicament container of a ser can be fixed in the body in such a position that le and reproducible dosing can be achieved regardless of differences in the length of the spout and/or length of the container due to manufacturing nces. in embodiments of the dispenser cap arrangement, the bistable portion of the cap closure device comprises: a substantially rigid separator connected to the upper cap closure portion; and a resiliently deformable separator having first and second ends, the first end being connected to the substantially rigid separator via a resiliently deformable joint, and the second end being connected to the lower cap e portion via a resiliently deformable joint, wherein the resiliently deformable tor is configured to resiliently deform upon application of a force to the upper cap closure portion and lower cap closure portion so as to permit a change of form of the dispenser cap closure device n the first stable form and second stable form Such a configuration advantageously provides the cap e device with the ability to be switched between the two stable forms, Preferably, an angle defined between an outer surface of the substantially rigid 2O separator and the resiliently deformable separator is acute when in the second stable form, and obtuse when in the first stable form. in further embodiments of the dispenser cap arrangement, the lower cap e portion comprises a plurality of protrusions extending radially outwards having an upper surface for engaging with the engageable portion of the dispensercap, and wherein a lower surface of the lower cap closure portion is engageable with a surface of a medicament container in a dispenser. The plurality of protrusions extending from the lower cap closure portion thus provide a means to secure the cap e portion to the cap.

Preferably, the engageable portion of the ser cap comprises a ramped portion, and wherein the ramped portion and the protrusions on the lower cap closure portion are configured such that rotation of the cap closure device causes the upper e of the plurality of protrusions to ride along the ramped portion so as to draw the cap closure device further into the dispenser cap. Preferably, when the cap closure device is d, the riding of the upper surface of the protrusions along the ramped portion causes the lower surface of the lower cap closure portion to drive down onto a medicament container in a ser, By providing the ramped portions, the protrusions on the lower cap closure portion of the cap e device may ride along the ramped portion and thus be drawn into the cap during rotation of the cap closure device. The position of the cap closure device relative to the cap may thus be adjusted prior to the bistable portion being switched from the extended to the collapsed forms. As such, tolerances in the length of the container or the container spout in the dispenser may be accounted for prior to final ly of the dispenser.

In embodiments with the ramped portion, the ramped portion comprises a plurality of ramped portions around the circumference of a lip of the dispenser cap, the plurality of ramped ns equalling the number of plurality of protrusions on the lower cap portion of the cap e device. Preferably, the ramped portions are separated from one and other by a gap having a width that is greater than or equal to the width of a protrusion on the lower cap closure portion, 2O in further ments, of the ser cap ement, an upper surface of the dispenser cap comprises a limiting means for preventing rotation of the cap closure device when in the second stable form. Preferably, the limiting means comprises a plurality of teeth located on an upper surface of the dispensercap, and wherein the dispenser cap closure device comprises a ity of protrusions on a lower surface of the upper cap closure portion, the teeth and protrusions being ured to engage with one another so as to prevent rotation of the cap closure device when in the second stable form.

By providing a limiting means, further rotation of the cap closure device, once in the collapsed state, may be prevented. As such, the cap closure device is prevented from rotating further into, or out of the cap. The cap closure device is thus secured in place. in some embodiments, the dispensercap may comprise one or more protrusions in the upper open end of the dispenser cap, the one or more protrusions being arranged to engage with a correspondingly shaped recess in the uppercap closure portion when the dispenser cap is closed by the dispenser closure device. Such an arrangement helps retain the dispenser cap closure device in place once inserted into the end of the ser cap.

The present invention also provides a dispenser cap closure device for closing an end of a dispenser cap of a medicament dispenser, the cap closure device sing: an upper cap closure portion for engaging with an upper open end of a dispenser cap to close an open end of a dispenser cap; a lower cap e portion for engaging with a an engageable portion of the upper open end of a dispenser cap to secure the closure device to a dispenser cap; and a bistable portion connecting the upper cap closure portion and the lower cap closure portion, the bistable portion being switchable between a first stable form in which the bistable portion is ed, and a second stable form in which the bistable portion is collapsed, wherein, when in the second stable form, the upper cap closure portion and lower cap closure portion are brought ‘15 closer together.

The dispenser cap closure device advantageously comprises the bistable n, which enables the cap closure device to be switched between two stable forms.

Furthermore, by using the above—mentioned cap closure device, a dispenser is able to be assembled where the medicament container of a dispenser can be fixed in the body in such a position that le and reproducible dosing can be achieved regardless of differences in the length of the spout and/or length of the container due to manufacturing tolerances. in embodiments of the dispenser cap closure device, the bistable n ses: a substantially rigid tor connected to the upper cap portion; and a resiliently able separator having first and second ends, the first end being connected to the substantially rigid separator via a resiliently deformabie joint, and the second end being connected to the lower cap closure portion via a resiliently deformable joint, wherein the resiliently deformable separator is configured to resiliently deform upon application of an opposing force n the upper cap closure portion and lower cap closure n so as to permit a change of form of the dispenser cap closure device between the first stable form and second stable form. Such a configuration advantageously provides the cap e device with the ability to be switched between the two stable forms.

Preferably, an angle d between an outer surface of the substantially rigid tor and the resiliently deformable separator is acute when in the second stable form, and obtuse when in the first stable form. in further embodiments of the dispenser cap e device, the lower cap closure portion comprises a plurality of protrusions extending radially outwards having an upper surface for engaging with an engageable portion of a dispenser cap, and wherein a lower surface of the lower cap closure portion is engageable with a surface of a medicament container in a dispenser. ably, the protrusions are substantially equally~spaced circumferentially around the lowercap closure portion. in some embodiments of the dispenser cap closure device, the dispenser cap closure device comprises a plurality of protrusions on a lower surface of the upper cap closure ‘15 portion for engaging with correspondingly—spaced teeth on a dispenser cap for preventing rotation of the dispenser cap closure device when in the collapsed state. in further embodiments, the upper cap e portion comprises a recess in the upper cap closure portion that is arranged to engage with a correspondingly shaped protrusion in an upper open end of a dispenser cap, Such an arrangementhelps retain the dispenser cap closure device in place once ed into the end of the dispenser cap.

The present invention also provides a dispenser cap for enclosing a portion of a. dispenser of a ment, the dispenser cap comprising: a hollow body having a lower open end for engaging with a body portion of a ser, and an upper open end for receiving a dispenser cap closure device for closing the upper open end, wherein the upper open end comprises an engageable portion for engaging with a dispenser cap e device for closing the upper open end of the hollow body. For example, the dispenser cap could be the dispenser cap as bed above.

By using the above—mentioned dispenser cap, a dispenser cap closure device may be used such that a ser is able to be assembled where the medicament container of a dispenser can be fixed in the body in such a position that reliable and reproducible dosing can be achieved regardless of differences in the length of the spout and/or length of the ner due to manufacturing tolerances. ln embodiments of the dispenser cap, the engageable portion comprises a ity of ramped portions around the circumference of the dispenser cap. Preferably, each of the ramped portions is separated by a gap. in some embodiments, the dispenser cap has an upper surface of the dispenser cap that comprises a limiting means for preventing rotation of a dispenser cap closure device when engaged with the ser cap. In such embodiments, the limiting means comprises a plurality of teeth located on the upper open end of the dispenser cap, the teeth for engaging with one or more sions on a dispenser cap closure device so as to t rotation of a dispenser cap closure device when engaged. in further embodiments, the dispenser cap may comprise one or more protrusions in the upper open end of the dispenser cap, the one or more protrusions being ed to engage with a correspondingly shaped recess in an uppercap closure portion of a dispenser cap e device for closing the dispenser cap. Such an arrangement helps retain the dispenser cap closure device in place once inserted into the end ofthe dispenser cap.

The present invention also es a dispenser for dispensing a dose of medicament from a substance , the dispenser comprising: a body for receiving a substance source, the body having a mouthpiece through which a medicament is dispensable; a substance source comprising a container containing a medicament to be dispensed; a dispenser cap arrangement as described above, wherein the dispenser cap arrangement is coupled to the body for enclosing the substance source. Such a dispenser may thus be closed using the cap closure device comprising the bistable portion, such that it may not be opened by a user or tampered with once closed.

By using the above—mentioned cap closure device, the dispenser can be assembled where the medicament container can be fixed in the body in such a position that reliable and reproducible dosing can be achieved less of differences in the length of the spout and/or length of the ner due to manufacturing tolerances.

In ments of the dispenser, the nce source is a pressurised metered—dose inhaler (pMDl). in further embodiments of the dispenser, the dispenser further comprises a dose counter for indicating a number of actuations of the dispenser corresponding to a number of doses sed from the substance or, or a number of doses remaining in the substance . Advantageously, the dose counter s the user to determine how many doses remain in the dispenser so that the user knows when to obtain a replacement dispenser.

The present invention further provides a method of closing a dispenserfor dispensing a dose of medicament from a substance source, the dispenser sing: a body for ing a substance source, the body having a mouthpiece through which a medicament is dispensable; a substance source comprising a nercontaining a medicament to be dispensed; and a dispenser cap arrangementfor coupling to the body for enclosing the nce source, the dispenser cap arrangement comprising a dispenser cap and dispenser cap closure device, the method comprising the steps of: inserting the substance source into the body of the dispenser and ng the dispenser cap to the body of the dispenser, or vice versa; inserting the dispenser cap closure 2O device into an upper open end of the dispenser cap; applying a force to the dispenser cap closure device to switch a bistable portion of the dispenser cap closure device from a first stable form in which the bistable portion is extended, and a second stable form in which the bistable portion is collapsed, wherein, when the bistable portion is in the second stable form, the upper cap closure portion engages with the upper open end of the dispenser cap to close the ser cap. The bistable portion of the cap closure device thus enables the dispenser to be closed.

By using the above-mentioned cap closure device, a dispenser is able to be assembled where the medicament container of a dispenser can be fixed in the body in such a 3O on that le and reproducible dosing can be achieved regardless ofdifferences in the length of the spout and/or length of the container due to manufacturing tolerances. in embodiments of the method, the method further comprises rotating the dispenser cap closure device prior to the step of applying a force, such that a plurality of sions extending radially outwardly from a lower cap closure portion of the dispenser cap closure device engage with a ramped portion on a lower lip of the upper open end of the dispenser cap. Thus the cap closure portion is secured to the cap so that it cannot be removed.

The t invention also provides a e arrangement for enclosing an e, the closure arrangement comprising: a hollow body for enclosing an article, having an upper open end for receiving a e device for closing the upper open end, the upper open end comprising an engageable portion; and a closure device, comprising: an upper closure portion for engaging with the upper open end of the hollow body to close the upper open end of the hollow body; a lower closure portion for engaging with the engageable portion to secure the closure device to the hollow body; and a le portion connecting the upper e portion and the lower e portion, the bistable portion being switchable between a first stable form in which the bistable portion is extended, and a second stable form in which the bistable portion is sed, wherein, when the bistable portion is in the second stable form, the upper closure portion s with the upper open end of the hollow body to close the upper open end of the hollow body such that an article in the hollow body is enclosed.

The hollow body, in combination with the closure device, provide a means of ing an article, Advantageously, the bistable portion of the closure device that is switchable between two stable forms (extended and collapsed) enables the closure device to be inserted and hollow body closed when the closure device is in the desired position relative to the hollow body. Furthermore, the closure device, once in a stable form, requires a force to be applied between the upper and lower closure portions to switch between the stable forms. As such, once in the collapsed form, the closure device is difficult to remove from the hollow body, thereby securing the closure device to the hollow body so that it cannot easily be d. Furthermore, by using the above— mentioned closure device, an article may be assembled where the a device of an 3O article can be fixed in the body in such a position that reliable and reproducible operation may be achieved regardless of differences in the length of the article due to manufacturing tolerances.

In embodiments of the e arrangement, the bistable portion of the closure device comprises: a substantially rigid separator connected to the upper closure portion; and a resiliently deformable separator having first and second ends, the first end being ted to the substantially rigid separator via a resiliently deformable joint, and the second end being connected to the lower cap closure portion via a resiliently deformable joint, wherein the resiliently deformable separator is configured to resiliently deform upon application of a force to the upper closure portion so as to permit a change of form of the closure device between the first stable form and second stable form. This configuration enables the bistable portion to be switchable between the two stable forms. ably, an angle defined between an outer e of the substantially rigid separator and the resiliently deformable separatoris acute when in the second stable form, and obtuse when in the first stable form.

In some embodiments of the closure arrangement, the lower closure portion comprises a plurality of protrusions ing radially outwards having an upper surface for engaging with the able portion of the hollow body, and wherein a lower surface of the lower lid closure portion is engageable with a e of an article to be enclosed. The plurality of protrusions extending from the lower closure n thus provide a means to secure the closure portion to the hollow body, Preferably, the engageable portion comprises a ramped portion, and wherein the ramped portion and protrusions on the lower e portion are configured such that rotation of the closure device causes the upper surface of the plurality of protrusions to ride along the ramped portion so as to draw the closure device further into the hollow body. Preferably, when the closure device is rotated, the riding of the upper surface of the protrusions along the ramped portion causes the lower surface of the lower closure portion to drive down onto an article to be enclosed.

By providing the ramped portions, the protrusions on the lower closure portion of the closure device may ride along the ramped portion and thus be drawn into the hollow body during rotation of the closure device. The position of the closure device relative to the hollow body may thus be adjusted prior to the bistable n being switched from the extended to the collapsed form. in embodiments of the closure arrangement, the ramped portion comprises a plurality of ramped portions around the circumference of a lip of the hollow body, the plurality of ramped portions equalling the number of plurality of protrusions on the lower lid portion of the lid closure device. Preferably, the ramped portions are separated from one another by a gap having a width that is greater than or equal to the width of a protrusion on the lower closure portion. in further embodiments of the closure ement, an upper surface of the hollow body ses a limiting means for preventing rotation of the e device when in the second stable form.

By providing a limiting means, further rotation of the closure device, once in the collapsed state, may be prevented. As such, the e device is prevented from rotating further into, or out of the hollow body. The closure device is thus secured in place.

Preferably, the limiting means comprises a plurality of teeth located on an upper surface of the hollow body, and wherein the closure device comprises a plurality of protrusions on a lower surface of the upper closure portion, the teeth and protrusions being ured to engage with one another so as to prevent rotation of the closure device when in the second stable form. in some embodiments, the hollow body may comprise one or more protrusions in the upper open end of the hollow body, the one or more sions being arranged to engage with a correspondingly shaped recess in the upperclosure portion when the hollow body is closed by the closure device. Such an arrangement helps retain the closure device in place once inserted into the end of the hollow body.

The present ion also provides a closure device for sealing an opening in a body comprising: a first portion for sealing an opening; a second n, and a connecting portion ting the first and second portions, the second portion being adapted to secure the device to a body, the connecting portion being adapted to switch from a first configuration to a second configuration upon application of a force to the , wherein in the first configuration the device can be applied to and secured to a body and in the second configuration the first n will seal an opening in the body. 1001527397 By using the above-mentioned closure device, a dispenser is able to be led where the ment container of a ser can be fixed in the body in such a position that reliable and reproducible dosing can be achieved regardless of differences in the length of the spout and/or length of the container due to manufacturing tolerances.

Preferably, in the second configuration the first portion and the second portion are closer to each other than in the first configuration.

The present invention further provides an enclosure arrangement for enciosing an article comprising: a hollow body for receiving an articie and having an upper open end, a closure device, as described above, for sealing said open end, wherein the hollow body and the closure device have respective IO engageable portions for securing the body and device together, and in the second configuration the second portion of the closure device is adapted to contact an article in the body and the first portion of the closure device is adapted to seal the opening in the upper end of the body.

Preferably, the engageable portions are d to secure the hollow body and closure device together upon relative rotation of the body and device.

The present ion further provides a dispenser cap for enclosing a portion of a dispenser of a medicament, the dispenser cap comprising: a hollow body having a lower open end for engaging with a body portion of a dispenser, and an upper open end for receiving a dispenser cap closure device for closing the upper open end, wherein the upper open end comprises an engageable portion for engaging with a dispenser 2O cap closure device for closing the upper open end of the hollow body and an upper surface of the dispenser cap ses a limiting means for ting rotation in either direction of said cap closure device when engaged with the dispenser cap.

LIST OF FIGURES The present invention will now be described, by way of example only, and with reference to the drawings, in which: FIG. I is a perspective view of a ser in a closed configuration; is a similar view of the dispenser in open uration; is an exploded view of a prior version of the dispenser; shows an upper portion of a preferred main body part of the ser; is an underside view of a preferred dispenser cap; is an upper—end view of the dispenser cap of FIG. Sb is a perspective view of the dispenser cap of is a cut-through view of the ser cap of h axis X-X of FIG. Sa; is a preferred dispenser cap ciosure device; is a cut-through view along the X-X line of the dispensercap closure device of ais the dispenser cap closure device of in an extended state; bis the dispenser cap closure device of in a collapsed state; FIGS. 11a to 11f show a sequence of steps of the dispenser cap assembly; and shows an alternative closure device.

ED DESCRIPTION OF THE PREFERRED EMBODIMENTS IO Referring first to FIGS. 1 to 4 of the drawings (of which figures 1 to 3 are taken from our corresponding granted patent US 7,721,731), the dispenser has a body 1 with a mouthpiece 2 and a pivoted mouthpiece cover 3. The mouthpiece is formed as an aperture 4 in a separate body part 5 clipped to a main body part 6 (although the skilled reader would appreciate that this formation could be made using a single—moulded piece). The main part 6 has upper and lower formations and the mouthpiece part has upper and lower complementary formations which engage when the mouthpiece part is slid from below to engage with the main part. The separate body part 5 has a cutaway with respect to the main body part 6, to define an air inlet 12 exposed by the cover 3 when this is . A medicament can C sits inside the body part 6. Immediately within the air inlet 12 is a guard 13 against fingers.

The cover 3 is pivoted about an axis A low in the body 6 at the joint between the two body parts. lntegrally d with the cover 3 is a C section shaft. The shaft carries a cam arrangement 23, comprising two cam lobes, togetherwith two fingers, a central one and an outer one. The latter is integral with one of a pair of discs, between which are the cam lobes, the shaft is bearingly supported by part circular ls in flanges integrally moulded within the main body part 6.

The body parts 5,6. and the coverB (with the shaft and cam ement) in the described embodiments are of moulded polypropylene al, y they can be fitted togetherwith a modicum of flexure.

The can Cis held in an opening 31 at the upper end ofthe main body part 6, where the body part extends completely around a valve crimp portion CP of the can C. A dispenser cap (not shown) s to the main body part6 to surround and encase the upper exposed end of the can C. The dispenser cap is coupled to the main body part 6 for example by means of protrusions 51. Other fixing means may be used so long as the main body part and dispenser cap are engaged together so that they do not come apart easily.

A junction member 41 is slidably accommodated in the body. The junction member also is of moulded polypropylene, lly, the junction member has a socket for an outlet stem 8 of the can C. The socket is continued by a passage, which has a thin wall, kinkable n and a nozzle end (moveable outlet member), which is coupled to a nozzle. When the kinkable portion is unkinked, a medicament dispensed from the can stem into the passage is released through the nozzle and into a mouthpiece of the dispenser. in operation, rotation of the mouthpiece cover 3 about the axis A causes the cam 23 to impart an upward force on the junction member 41. The resulting upward nt of the junction member 41 actuates the outlet stem 8 of the can, which dispenses a dose of medicament into the junction member and into the kink valve. The dispenser is now primed and ready with a dose of medicament.

Upon tion by a user through the mouthpiece 5, air drawn h the air inlet 12 impresses on the flap 61 causing the flap to move and release thejunction member41, which allows the kink valve to un-kink (due to the ence of the passageway making up the kink valve, and the pressure of the medicament in the valve) to release the dose of medicament into the mouthpiece. Continued inhalation by the user causes the dose of medicament to be drawn out of the mouthpiece and delivered to the user.

After inhalation, the user closes the mouthpiece cover, and the junction member 41 and flap 61 return to their initial, un—primed, positions. 3O As discussed above, tolerances in the length of the can and its spout and in other components with which the can is in contact mean that the can is not always seated in the same position relative to the body and a ser cap (not shown in figures 1 to 4, but the cap nds the upper portion of the can and is coupled to the main body part 6). Since the can C is preferably seated so that the movement of the junction member is able to effect dispensing of a e dose of medicament, there is need of a device to take up the variable height of the can 0 and/or its spout ve to the body.

We will now describe a dispenser cap arrangement, dispenser cap e device and dispenser cap that has been designed to take up these tolerances and to allow the dispenser to work as intended.

With reference to figures 5 to 7, a ser cap 71 has a plurality of openings 73 shaped and configured to engage with the protrusions 51 on the main body part 6 so that the dispenser cap and main body part remain affixed to one another. The lower open end 72 (the dispenser cap is shown upside down in figure 5) is shaped and dimensioned to receive the portion of the can that extends from the main body part when mounted in the main body part. The ser cap may also be shaped and dimensioned to receive a counter mechanism between the dispenser cap and the can.

Before assembly with the ser cap closure device, the dispenser cap has an open upper end 74.

A plurality of teeth 81 is provided along an upper part of the dispenser cap. These teeth are configured to engage with the dispenser cap closure device to prevent rotation once the latter is in the t position. Preferably. the teeth are provided at least partially around the circumference of the upper part of the dispenser cap. This will be described in more detail below. in preferred embodiments, there are three toothed sections around the circumference of the upper part of the dispenser cap, with gaps 75 between each section. Each toothed section has a lowerramped e 82. Again, this will be described in more detail with reference to the dispenser cap closure device.

One or more protrusions 91 may also be provided along an upper part of the dispenser cap 71, which are arranged to engage with a correspondingly shaped portion of the dispenser cap closure device 100 to help retain the dispensercap closure device in 3O place once inserted into the end of the dispenser cap. in preferred embodiments, there is one protrusion 91 for each gap 75.

We will now describe a cap closure device (or 'bung') that works with the above- described dispenser cap 71 to close the end of the dispenser, and take up any tolerances in the length of the container.

With reference to figures 8 to 10, the dispenser cap closure device 100 comprises an upper cap closure portion 101 and a lower cap closure n 102. The upper 101 and lower 102 cap closure portions are ted by a bistable portion 110, 111, 112, 113.

The upper cap closure portion 101 comprises a plurality of radial extending ribs or ridges 104 located on an underside or lower surface of the upper cap closure portion 101. The upper cap closure portion 101 is configured to engage with the upper open end 74 of the dispenser cap 71 and to close the upper open end 74 when the two are engaged. Protrusions in the form of radial ing ribs or ridges 104 are configured 1O to engage with the teeth 81 on the upper lip of the dispenser cap 71 to prevent rotation of the dispenser cap closure device 100 when engaged with the dispenser cap 71.

Furthermore, ridge 121 in the ferential edge of the upper cap closure portion 101 is configured to engage with the protrusions 91 in the dispensercap 71 to help retain the ser cap closure device in place once inserted into the end of the dispenser cap.

The lower cap closure portion 102 has a lower surface that is configured to contact the end of a canister C in the dispenserwhen the dispenser cap closure device is engaged with the dispenser cap. A plurality of protrusions 103 are also located ly around the lower cap closure portion. The protrusions 103 are configured to engage with the ramped portion 82 of the dispenser cap 71 as will be described below.

The bistable portion 110, 111, 112, 113 comprises a substantially rigid separator 110 and a ently deformable separator 111. The substantially rigid separator 110 is fixed to or integral with the upper cap closure portion 101. The ently deformable separator 111 is connected to the substantially rigid separator110 at one end by means of a resiliently deformable joint 112, and the resiliently deformable separator 111 is connected to the lower cap closure portion 102 at the other end by means of a resiliently deformable joint 1 13.

The structure of the resiliently deformable separator 111 and resiliently able joints 112, 113 are configured to enable the ser cap closure device to switch or invert between a first stable form in which the bistable portion is extended (shown in FlG. 10a) and a second stable form in which the bistable n is sed (shown in b). The upper 101 and lower 102 portions of the dispensercap closure device are brought closer together in the second stable form (Le. collapsed state). As can be seen in Fle. 10a and 10b, an angle between the outer surface of the ntially rigid separator 110 and the outer surface of the resiliently deformable separator111 is generally obtuse when the cap e device is in the first stable form, and generally acute when the cap closure device is in the second stableform. The purpose of these two stable forms will be explained below.

The structure of the resiliently deformable separator 111 and resiliently deformable joints 112, 113 are configured such that the bistable portion, once in one of the two 1O stable forms, remains in that stable form. A force applied to the upper 101 cap closure portion is required to switch the bistable portion from the first to the second stable form. Effectively, the force required to switch the bistable portion is proportional to the force required to deform the resiliently deformable separator 111 sufficiently such that the resiliently deformable separator 111 may pass through a substantially horizontal position (for example see figures 9 and 10), which coincides with the st distance between the ently deformable joints 112, 113.

The dispenser cap assembly sing the dispenser cap 71 and dispenser cap closure device 100 will now be described with reference to FIGS 11a to 111‘ In a, the ser cap 71 is affixed to the main body part 6 of the dispenser (not shown). The upper open end of the dispenser cap is ured to receive the canister or ner C, which is inserted through the upper opening and the spout S is seated in the on member 41 in the body (not shown). Alternatively, the container C may be located before the dispenser cap 71 is affixed to the main body part 6.

In Fle. 11b, 11c and 11d (once the canister Cis seated correctly), the dispenser cap closure device 100 (in its first stable form i.e. extended) is lowered into the upper open end of the dispenser cap 71 until the lower cap closure n 102 is seated on the end of the canister C. in order for this to happen, each of the protrusions 103 on the lower portion 102 is aligned with a corresponding gap 75 between the toothed sections or the upper open end of the cap, which allows the cap closure device 100 to drop through to the canister C. in FlG 11s, the cap closure device 100 is d. in doing so, protrusions 103 engage with the ramped surface 82 under each of the toothed sections 81. Each of the ramped portions 82 are configured such that rotation of the cap closure device 100 in one direction drives the protrusions (and therefore the cap closure device) downwards towards the canister C, which draws the cap closure device 100 further into the dispenser cap 71. Furthermore, this downward drive pushes the lower cap closure portion 102 against the end of the canister C. Continued rotation beyond an l contact between the protrusion 103, ramped portion 82 and the end of the canister will apply a positive force in a longitudinal axis of the dispenser against the er.

The amount of rotation of the dispenser cap e device 100 is dependent upon the length of the canister and/or its spout (i.e. the tolerances that are being negated), and whether or not a positive pressure on the canister is desirable. During assembly, the amount of rotation can be determined in advance of the dispensercap closure device 100 being inserted (lor example by ing the height of the end of the canister relative to the body), and the ly machinery could be ured to turn the cap closure device a specific number of degrees of rotation ing that the slope of the ramped portion 81 is known). Alternatively, a force measuring device could be used during assembly to measure a back force ering on the cap closure device 100 when it is being rotated (or an increase in torque ed to turn the cap closure device), with the machine being configured to stop rotation when a registered force reaches a threshold or d level.

In 1, and once the desired rotation of the cap closure device 100 has been reached, the upper portion 101 of the cap closure device is pushed down towards the canister such that is switches from the first stable form (ie. extended) to the second stable form (i.e. collapsed). In the second stable form (as shown), radially extending ribs or ridges 104 on the ide of the upper portion 101 engage with the teeth portions 81 on the upper end of the dispenser cap 71. Such engagement between the 3O ribs or ridges 104 and teeth portions 81 prevent further rotation (in eitherdirection) of the cap closure device 100. Furthermore, protrusions 91 in the dispenser cap 71 engage with the ridge 121 in the upper cap closure portion 101 to help retain the dispenser cap closure device in place once inserted into the end of the dispenser cap.

Since rised containers C generally have concave ends, the cap closure device 100 may extend below the original level of the lower portion 102 into the concave portion of such containers.

It will be noted that, since a force is required to deform the resiliently deformable separator 111 to overcome the horizontal position as described above (and therefore switch the bistable portion from the second to the first stable form), the sercap closure device 100 is prevented from opening of its own accord. As such, once the ser cap closure device is in the second stable form, it is very difficult to undo or remove the device, which increases safety and security of the dispenser, since it makes it difficult for the user to tamper or take the dispenser apart.

In preferred embodiments, the dispenser cap 71 is transparent so that a counter can be read from beneath the surface. Alternatively, a transparent portion ng a window may be provided on the dispenser cap. Preferably, the dispenser cap 71 is made from polypropylene (for example R7051 -1 ON).

In preferred embodiments, the dispenser cap e device 100 is made from polypropylene (for example ELTEX 200CA25).

In an ative ment of the closure device, the closure device works in the opposite way to the ways described above i.e. the closure device engages in the extended form rather than the contracted form.

Figure 12 illustrates the alternative closure . The lower cap closure n 102' engages with the dispenser cap 71' as described above ie with the protrusions 103' riding on the lower surface of a ramped portion, and the lower cap closure portion 102‘ contacting a container (not shown) in the dispenser. The cap closure device is rotated or screwed into the correct position (to allow for the variation in height of the container) as above.

A ntially rigid separator 110‘ separates the lower closure portion 102' from the upper closure portion 101, which comprises a resiliently deformable section 120. The figure shows the closure device in the first, collapsed, form. Once the closure device is in place, a force may be d to the resiliently deformable section 120, which causes the section to switch from the first, collapsed, stable form to a second, extended, stable form. in the extended form, the length of the upper closure portion is extended such that the upper closure portion engages with the ser cap 71' to close the upper open end of the dispenser cap.

As with the previous embodiments, protrusions may be d on a surface of the upper closure portion 101‘ to engage with correspondingly-shaped teeth located on the dispenser cap 71' to prevent further rotation of the cap e device when engaged with the dispenser cap.

Whilst we have described the invention in the context of a dispenser cap closure arrangement, or the ser cap closure device, we also envisage uses for the closure arrangement and closure device on articles other than with ment dispensers.

For example, the e arrangement could be adapted to enclose or store an e, for example to close a container into which articles may be placed. in such uses, the container could be adapted to receive the closure device by providing the teeth 81 and ramped portions 82 at an upper open end of the container to engage with the ponding features of the closure device (as described above with reference to the dispenser).

Since the closure device in such an alternative usage might not come into contact with a body such as a medicament container (to provide a suitable abutment surface to enable the bistable portion to be switched from the first stable form to the second stable form), an alternative could be to provide a surface (for example a protruding or raised surface on an inner circumferential surface of the container) to which the lower portion of the closure device could abut to enable the bistable portion to be switched.

Furthermore, the surface could be configured to provide a seal to close the container when the e device is in place and in the second (ie. collapsed) stable form (ie. when the lower closure portion of the closure device abuts the protruding e). in some embodiments, the seal between the ding surface and the lower portion of the closure device could be arranged to provide a fluid and/or air-tight seal between the inside and outside of the container. in such ments, the container could therefore be used to contain liquids and/or gasses at atmospheric pressure, at a higher pressure (lor example carbonated drinks, sparkling wines and the like) or at a reduced pressure (lor e, vacuum sealing).

Articles stored in such a container at atmospheric, or reduced atmospheric air pressures, would not influence the cap closure device, since the bistable portion retains the closure device in the second (collapsed) stable form where the teeth in the nerare engaged with the ridges or fingers 104 on the closure device.

If the al pressure of the container is greater than atmospheric pressure, then the closure device may need to be modified in order to remain in the collapsed configured when the closure ement is closed. In the above~described embodiments, the closure device has an open lower end exposing a portion of the le portion to the contents of the container being enclosed. If the internal pressure of the sealed container is sufficient enough to overcome the force required to switch the bistable ’15 portion from the collapsed to the extended positions, the closure device would not work.

However, a modification to overcome this problem could be to provide a sufficiently rigid surface below the bistable portion on the lower closure portion to take the force of the pressure of the container, and prevent that pressure from influencingthe bistable portion, Such a surface could be in line with the lower e portion, or could extend below the lower closure portion, The closure device may also be adapted to be openable by providing a handle ed to the upper closure portion in order to allow the user to pull the upper closure portion away from the ner (thus switching the bistable portion back to the first, extended form) and thus unscrew the e device from the lid of the container. In order to make this type of Closure tamper resistant, or child proof, the handle could be removable, for example using a screw fixing, or a slide mechanism to attach the handle to the closure device.

We therefore ge that the closure arrangement may be provided on items such as bottles for ning liquids, containers forcontaining articles and the like.

While the invention has been exemplified by the above description of specific embodiments, and uses thereof, the foregoing should not be considered by the reader as a limitation on the scope of the invention, which is defined in the appended claims.

In this specification, the term 'comprises' and its variants are not intended to e the presence of other integers, components or steps. in this specification, references to prior art are not intended to acknowledge or t that such prior art is widely known or forms part of the common generai knowledge in the fieid either in New d or elsewhere.

Claims (17)

CLAIMS :

1. A dispenser cap for enclosing a portion of a dispenser of a medicament, the dispenser cap comprising: a hollow body having a lower open end for engaging with a body portion of a dispenser, and an upper open end for receiving a dispenser cap closure device for closing the upper open end, wherein the upper open end comprises an engageable portion for engaging with a dispenser cap closure device for closing the upper open end of the hollow body and an 1O upper e of the dispenser cap comprises a limiting means for preventing rotation in either direction of said cap e device when d with the dispenser cap.

2. A dispenser cap according to claim 1, wherein the limiting means comprises a plurality of teeth located on an upper open end of the dispenser cap, the teeth for 15 engaging with one or more protrusions on a dispenser cap closure device so as to prevent rotation in either direction of a dispenser cap closure device when engaged.

3. A dispenser cap according to claim 1 or 2, wherein the engageable portion comprises a plurality of ramped portions around the circumference of the dispenser cap.

4. A dispenser cap according to claim 3, wherein each of the ramped portions is separated by a gap.

5‘ A dispenser cap according to any one of claims 1 to 4, wherein the dispenser cap 25 ses one or more protrusions in an upper open end of the dispenser cap, the one or more sions being arranged to engage with a correspondingly shaped recess in an upper cap closure portion for g the dispenser cap.

6. A dispenser cap according to any one of claims 1 to 5, wherein said cap has a 30 plurality of openings shaped and configured to engage with protrusions on said body portion of a ser so that said cap and said body portion are affixed.

7. A dispenser cap according to any one of claims 1 to 6, wherein said lower open end is shaped and ioned to receive a portion of a medicament canister that 35 extends from said body portion when d therein.

8. A dispenser cap according to claim 7, wherein said cap is shaped and dimensioned to receive a counter mechanism n said medicament canister and said cap.

9. A dispenser cap according to any one of claims 1 to 8, wherein said cap is arent.

10. A dispenser cap according to any one of claims 1 to 8, wherein said cap 1O comprises a transparent portion defining a window.

11. A dispenser cap according to any one of claims 1 to 10, wherein said cap is made from polypropylene 15

12. A dispenser cap according to any one of claims 1 to 11 in combination with a cap closure device.

13. A dispenser for dispensing a dose ofa medicament from a substance source, the dispenser comprising: 20 a body for receiving a substance source, the body having a mouthpiece through which a ment is dispensable; a substance source comprising a container containing a medicament to be dispensed; a cap e device; and 25 a ser cap according to any one of claims 1 to 12, the dispenser cap being coupled to the body for ing the substance source.

14. A dispenser according to claim 13, wherein the substance source is a pressurised metered—dose inhaler (pMDl).

15. A ser according to claim 13 or 14, further comprising a dose counter for indicating a number of ions of the dispenser corresponding to a number of doses dispensed from the substance or, or a number of doses remaining in the substance SOUI’CG.

16. A dispenser cap as claimed in any one of claims 1 to 12, substantially as herein described with reference to any one of the accompanying drawings.

17. A dispenser for dispensing a dose of medicament as d in any one of claims 13 to 15, substantially as herein described with reference to any one of the accompanying drawings.