NZ563913A - Markers for prostate cancer in LD Block A on chromosome 8q24.21 - Google Patents
Markers for prostate cancer in LD Block A on chromosome 8q24.21Info
- Publication number
- NZ563913A NZ563913A NZ563913A NZ56391306A NZ563913A NZ 563913 A NZ563913 A NZ 563913A NZ 563913 A NZ563913 A NZ 563913A NZ 56391306 A NZ56391306 A NZ 56391306A NZ 563913 A NZ563913 A NZ 563913A
- Authority
- NZ
- New Zealand
- Prior art keywords
- prostate cancer
- haplotype
- cancer
- marker
- allele
- Prior art date
Links
- 206010060862 Prostate cancer Diseases 0.000 title claims abstract description 384
- 208000000236 Prostatic Neoplasms Diseases 0.000 title claims abstract description 380
- 210000000349 chromosome Anatomy 0.000 title description 49
- 102000054766 genetic haplotypes Human genes 0.000 claims abstract description 425
- 108700028369 Alleles Proteins 0.000 claims abstract description 334
- 239000003550 marker Substances 0.000 claims abstract description 279
- 238000000034 method Methods 0.000 claims abstract description 167
- 238000012216 screening Methods 0.000 claims abstract description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 316
- 150000007523 nucleic acids Chemical class 0.000 claims description 129
- 102000039446 nucleic acids Human genes 0.000 claims description 115
- 108020004707 nucleic acids Proteins 0.000 claims description 115
- 230000003247 decreasing effect Effects 0.000 claims description 42
- 208000035392 hereditary 6 prostate cancer Diseases 0.000 claims description 34
- 208000032154 hereditary 8 prostate cancer Diseases 0.000 claims description 34
- 230000003321 amplification Effects 0.000 claims description 19
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 19
- 238000004393 prognosis Methods 0.000 claims description 17
- 238000012217 deletion Methods 0.000 claims description 14
- 230000037430 deletion Effects 0.000 claims description 14
- 230000008707 rearrangement Effects 0.000 claims description 13
- 230000000392 somatic effect Effects 0.000 claims description 13
- 238000003780 insertion Methods 0.000 claims description 10
- 230000037431 insertion Effects 0.000 claims description 10
- 230000005945 translocation Effects 0.000 claims description 8
- 238000000338 in vitro Methods 0.000 claims description 6
- 230000004044 response Effects 0.000 claims description 6
- 239000002243 precursor Substances 0.000 claims description 5
- 238000011277 treatment modality Methods 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 description 265
- 239000000523 sample Substances 0.000 description 116
- 208000026310 Breast neoplasm Diseases 0.000 description 112
- 206010006187 Breast cancer Diseases 0.000 description 111
- 201000001441 melanoma Diseases 0.000 description 110
- 208000020816 lung neoplasm Diseases 0.000 description 97
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 96
- 201000005202 lung cancer Diseases 0.000 description 96
- 108091092878 Microsatellite Proteins 0.000 description 79
- 108090000623 proteins and genes Proteins 0.000 description 78
- 230000002068 genetic effect Effects 0.000 description 69
- 108020004414 DNA Proteins 0.000 description 64
- 229920001184 polypeptide Polymers 0.000 description 61
- 238000004458 analytical method Methods 0.000 description 60
- 108090000765 processed proteins & peptides Proteins 0.000 description 60
- 102000004196 processed proteins & peptides Human genes 0.000 description 60
- 238000012360 testing method Methods 0.000 description 55
- 239000002773 nucleotide Substances 0.000 description 54
- 125000003729 nucleotide group Chemical group 0.000 description 54
- 201000010099 disease Diseases 0.000 description 42
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 42
- 210000002307 prostate Anatomy 0.000 description 42
- 238000009396 hybridization Methods 0.000 description 40
- 239000013615 primer Substances 0.000 description 33
- 210000004027 cell Anatomy 0.000 description 31
- 238000003745 diagnosis Methods 0.000 description 31
- 230000014509 gene expression Effects 0.000 description 31
- 102000007066 Prostate-Specific Antigen Human genes 0.000 description 29
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 29
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 26
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 26
- 230000035772 mutation Effects 0.000 description 26
- 239000002299 complementary DNA Substances 0.000 description 25
- 238000001514 detection method Methods 0.000 description 25
- 230000001681 protective effect Effects 0.000 description 24
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 23
- 230000000295 complement effect Effects 0.000 description 23
- 238000003556 assay Methods 0.000 description 22
- 238000003752 polymerase chain reaction Methods 0.000 description 21
- 230000004075 alteration Effects 0.000 description 20
- 239000000203 mixture Substances 0.000 description 20
- 108091028043 Nucleic acid sequence Proteins 0.000 description 18
- 238000011282 treatment Methods 0.000 description 18
- 239000003153 chemical reaction reagent Substances 0.000 description 15
- WGZDBVOTUVNQFP-UHFFFAOYSA-N N-(1-phthalazinylamino)carbamic acid ethyl ester Chemical compound C1=CC=C2C(NNC(=O)OCC)=NN=CC2=C1 WGZDBVOTUVNQFP-UHFFFAOYSA-N 0.000 description 14
- 150000001413 amino acids Chemical class 0.000 description 14
- 238000001574 biopsy Methods 0.000 description 13
- 238000004422 calculation algorithm Methods 0.000 description 13
- 239000000969 carrier Substances 0.000 description 13
- 230000000875 corresponding effect Effects 0.000 description 13
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 12
- 210000000481 breast Anatomy 0.000 description 12
- 239000013068 control sample Substances 0.000 description 12
- 239000002853 nucleic acid probe Substances 0.000 description 12
- 208000030381 cutaneous melanoma Diseases 0.000 description 11
- 238000009826 distribution Methods 0.000 description 11
- 239000012071 phase Substances 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 11
- 108700020796 Oncogene Proteins 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 230000008859 change Effects 0.000 description 10
- 230000002596 correlated effect Effects 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 239000012634 fragment Substances 0.000 description 10
- 230000006798 recombination Effects 0.000 description 10
- 238000005215 recombination Methods 0.000 description 10
- 230000010076 replication Effects 0.000 description 10
- 108091034117 Oligonucleotide Proteins 0.000 description 9
- 230000034994 death Effects 0.000 description 9
- 231100000517 death Toxicity 0.000 description 9
- 102000054765 polymorphisms of proteins Human genes 0.000 description 9
- 239000002987 primer (paints) Substances 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 230000007613 environmental effect Effects 0.000 description 8
- 108700020462 BRCA2 Proteins 0.000 description 7
- 102000052609 BRCA2 Human genes 0.000 description 7
- 101150008921 Brca2 gene Proteins 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 238000013459 approach Methods 0.000 description 7
- 238000012098 association analyses Methods 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 102100027962 2-5A-dependent ribonuclease Human genes 0.000 description 6
- 101001080057 Homo sapiens 2-5A-dependent ribonuclease Proteins 0.000 description 6
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 6
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 6
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 6
- 108091093037 Peptide nucleic acid Proteins 0.000 description 6
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 6
- 108010021428 Type 1 Melanocortin Receptor Proteins 0.000 description 6
- 238000003491 array Methods 0.000 description 6
- 230000002759 chromosomal effect Effects 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 238000003205 genotyping method Methods 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
- 230000003211 malignant effect Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 108020004999 messenger RNA Proteins 0.000 description 6
- 238000013188 needle biopsy Methods 0.000 description 6
- 239000002751 oligonucleotide probe Substances 0.000 description 6
- 230000037361 pathway Effects 0.000 description 6
- 238000010561 standard procedure Methods 0.000 description 6
- 238000001356 surgical procedure Methods 0.000 description 6
- 229920000936 Agarose Polymers 0.000 description 5
- 102100032187 Androgen receptor Human genes 0.000 description 5
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 5
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 5
- 241000701806 Human papillomavirus Species 0.000 description 5
- 238000003657 Likelihood-ratio test Methods 0.000 description 5
- 238000007476 Maximum Likelihood Methods 0.000 description 5
- 102100034216 Melanocyte-stimulating hormone receptor Human genes 0.000 description 5
- 206010027476 Metastases Diseases 0.000 description 5
- 238000000636 Northern blotting Methods 0.000 description 5
- 108700026244 Open Reading Frames Proteins 0.000 description 5
- 108091093018 PVT1 Proteins 0.000 description 5
- 238000012300 Sequence Analysis Methods 0.000 description 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 5
- 108010080146 androgen receptors Proteins 0.000 description 5
- 239000000090 biomarker Substances 0.000 description 5
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 5
- 230000029087 digestion Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 210000004602 germ cell Anatomy 0.000 description 5
- 238000002372 labelling Methods 0.000 description 5
- 238000013507 mapping Methods 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 230000000869 mutational effect Effects 0.000 description 5
- 108700024542 myc Genes Proteins 0.000 description 5
- 238000002966 oligonucleotide array Methods 0.000 description 5
- 238000001959 radiotherapy Methods 0.000 description 5
- 238000012163 sequencing technique Methods 0.000 description 5
- 238000007619 statistical method Methods 0.000 description 5
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 description 4
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 description 4
- 230000033616 DNA repair Effects 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 4
- 108700024394 Exon Proteins 0.000 description 4
- 101001134216 Homo sapiens Macrophage scavenger receptor types I and II Proteins 0.000 description 4
- 101100082065 Homo sapiens POU5F1B gene Proteins 0.000 description 4
- 102100034184 Macrophage scavenger receptor types I and II Human genes 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000002512 chemotherapy Methods 0.000 description 4
- 238000001962 electrophoresis Methods 0.000 description 4
- 230000037433 frameshift Effects 0.000 description 4
- 230000000670 limiting effect Effects 0.000 description 4
- 210000004379 membrane Anatomy 0.000 description 4
- 230000009401 metastasis Effects 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 4
- -1 tissue Substances 0.000 description 4
- 230000035897 transcription Effects 0.000 description 4
- 238000013518 transcription Methods 0.000 description 4
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 3
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 3
- 206010009944 Colon cancer Diseases 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 3
- 230000004544 DNA amplification Effects 0.000 description 3
- 238000000729 Fisher's exact test Methods 0.000 description 3
- 102100034145 Putative POU domain, class 5, transcription factor 1B Human genes 0.000 description 3
- 108020004511 Recombinant DNA Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000002105 Southern blotting Methods 0.000 description 3
- 238000011256 aggressive treatment Methods 0.000 description 3
- 230000003388 anti-hormonal effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 231100000504 carcinogenesis Toxicity 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 210000000038 chest Anatomy 0.000 description 3
- 208000029742 colonic neoplasm Diseases 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000000378 dietary effect Effects 0.000 description 3
- 238000013399 early diagnosis Methods 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000002962 histologic effect Effects 0.000 description 3
- 238000007901 in situ hybridization Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 210000002752 melanocyte Anatomy 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 238000007857 nested PCR Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 210000001672 ovary Anatomy 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 210000005259 peripheral blood Anatomy 0.000 description 3
- 239000011886 peripheral blood Substances 0.000 description 3
- 238000010837 poor prognosis Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 208000023958 prostate neoplasm Diseases 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 108091008146 restriction endonucleases Proteins 0.000 description 3
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 3
- 238000003757 reverse transcription PCR Methods 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- 102200112570 rs4792311 Human genes 0.000 description 3
- 230000000391 smoking effect Effects 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 238000001308 synthesis method Methods 0.000 description 3
- 210000001550 testis Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 229930024421 Adenine Natural products 0.000 description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 2
- 102000036365 BRCA1 Human genes 0.000 description 2
- 108700020463 BRCA1 Proteins 0.000 description 2
- 101150072950 BRCA1 gene Proteins 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 2
- 108020003215 DNA Probes Proteins 0.000 description 2
- 239000003155 DNA primer Substances 0.000 description 2
- 239000003298 DNA probe Substances 0.000 description 2
- 102100035184 General transcription and DNA repair factor IIH helicase subunit XPD Human genes 0.000 description 2
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 2
- 208000031448 Genomic Instability Diseases 0.000 description 2
- 101000876511 Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPD Proteins 0.000 description 2
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 2
- 101000669028 Homo sapiens Zinc phosphodiesterase ELAC protein 2 Proteins 0.000 description 2
- 108700019961 Neoplasm Genes Proteins 0.000 description 2
- 102000048850 Neoplasm Genes Human genes 0.000 description 2
- 208000007256 Nevus Diseases 0.000 description 2
- 108020004485 Nonsense Codon Proteins 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 description 2
- 108010087705 Proto-Oncogene Proteins c-myc Proteins 0.000 description 2
- 102000009092 Proto-Oncogene Proteins c-myc Human genes 0.000 description 2
- 108091034057 RNA (poly(A)) Proteins 0.000 description 2
- 101100017043 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HIR3 gene Proteins 0.000 description 2
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 description 2
- 102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 2
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 2
- 102100039877 Zinc phosphodiesterase ELAC protein 2 Human genes 0.000 description 2
- 229960000643 adenine Drugs 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 231100000357 carcinogen Toxicity 0.000 description 2
- 239000003183 carcinogenic agent Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 238000010195 expression analysis Methods 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 230000004077 genetic alteration Effects 0.000 description 2
- 230000005802 health problem Effects 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000010166 immunofluorescence Methods 0.000 description 2
- 238000001114 immunoprecipitation Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 201000005249 lung adenocarcinoma Diseases 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000021121 meiosis Effects 0.000 description 2
- 230000005184 men's health Effects 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 238000001558 permutation test Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 210000005267 prostate cell Anatomy 0.000 description 2
- 238000011471 prostatectomy Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 239000013074 reference sample Substances 0.000 description 2
- 230000022983 regulation of cell cycle Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000005382 thermal cycling Methods 0.000 description 2
- 229940113082 thymine Drugs 0.000 description 2
- 238000001890 transfection Methods 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- BAAVRTJSLCSMNM-CMOCDZPBSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-carboxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]pentanedioic acid Chemical compound C([C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(O)=O)C(O)=O)C1=CC=C(O)C=C1 BAAVRTJSLCSMNM-CMOCDZPBSA-N 0.000 description 1
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- PIINGYXNCHTJTF-UHFFFAOYSA-N 2-(2-azaniumylethylamino)acetate Chemical group NCCNCC(O)=O PIINGYXNCHTJTF-UHFFFAOYSA-N 0.000 description 1
- HUHGPYXAVBJSJV-UHFFFAOYSA-N 2-[3,5-bis(2-hydroxyethyl)-1,3,5-triazinan-1-yl]ethanol Chemical compound OCCN1CN(CCO)CN(CCO)C1 HUHGPYXAVBJSJV-UHFFFAOYSA-N 0.000 description 1
- FVFVNNKYKYZTJU-UHFFFAOYSA-N 6-chloro-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC(N)=NC(Cl)=N1 FVFVNNKYKYZTJU-UHFFFAOYSA-N 0.000 description 1
- 206010069754 Acquired gene mutation Diseases 0.000 description 1
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 1
- 102100022524 Alpha-1-antichymotrypsin Human genes 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 241000713836 Avian myelocytomatosis virus Species 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 208000011691 Burkitt lymphomas Diseases 0.000 description 1
- 229940126074 CDK kinase inhibitor Drugs 0.000 description 1
- 229940123587 Cell cycle inhibitor Drugs 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 241001432959 Chernes Species 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 108020004394 Complementary RNA Proteins 0.000 description 1
- 101100439668 Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) chrB1 gene Proteins 0.000 description 1
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 description 1
- 102100026804 Cyclin-dependent kinase 6 Human genes 0.000 description 1
- 102100034770 Cyclin-dependent kinase inhibitor 3 Human genes 0.000 description 1
- 102100026278 Cysteine sulfinic acid decarboxylase Human genes 0.000 description 1
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 description 1
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 102100027829 DNA repair protein XRCC3 Human genes 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 241001362574 Decodes Species 0.000 description 1
- 108700003861 Dominant Genes Proteins 0.000 description 1
- 101150116954 Elac2 gene Proteins 0.000 description 1
- 102000002494 Endoribonucleases Human genes 0.000 description 1
- 108010093099 Endoribonucleases Proteins 0.000 description 1
- 102000009024 Epidermal Growth Factor Human genes 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000002846 Familial prostate cancer Diseases 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 101710113436 GTPase KRas Proteins 0.000 description 1
- 102100036534 Glutathione S-transferase Mu 1 Human genes 0.000 description 1
- 108010070675 Glutathione transferase Proteins 0.000 description 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 1
- 108010010234 HDL Lipoproteins Proteins 0.000 description 1
- 102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 description 1
- 108091027305 Heteroduplex Proteins 0.000 description 1
- 101000678026 Homo sapiens Alpha-1-antichymotrypsin Proteins 0.000 description 1
- 101000945639 Homo sapiens Cyclin-dependent kinase inhibitor 3 Proteins 0.000 description 1
- 101001071694 Homo sapiens Glutathione S-transferase Mu 1 Proteins 0.000 description 1
- 101000957437 Homo sapiens Mitochondrial carnitine/acylcarnitine carrier protein Proteins 0.000 description 1
- 101001128138 Homo sapiens NACHT, LRR and PYD domains-containing protein 2 Proteins 0.000 description 1
- 101000981336 Homo sapiens Nibrin Proteins 0.000 description 1
- 101000738546 Homo sapiens Protein PTHB1 Proteins 0.000 description 1
- 101000628562 Homo sapiens Serine/threonine-protein kinase STK11 Proteins 0.000 description 1
- 101000610557 Homo sapiens U4/U6 small nuclear ribonucleoprotein Prp31 Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
- 108091092195 Intron Proteins 0.000 description 1
- 108010044467 Isoenzymes Proteins 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 208000007433 Lymphatic Metastasis Diseases 0.000 description 1
- 206010064912 Malignant transformation Diseases 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 108700011259 MicroRNAs Proteins 0.000 description 1
- 102100038738 Mitochondrial carnitine/acylcarnitine carrier protein Human genes 0.000 description 1
- 241000713862 Moloney murine sarcoma virus Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 102000010645 MutS Proteins Human genes 0.000 description 1
- 108010038272 MutS Proteins Proteins 0.000 description 1
- 108020000284 NAD(P)H dehydrogenase (quinone) Proteins 0.000 description 1
- 102100024403 Nibrin Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 description 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 description 1
- 101710098940 Pro-epidermal growth factor Proteins 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000025844 Prostatic disease Diseases 0.000 description 1
- 108020004518 RNA Probes Proteins 0.000 description 1
- 238000002123 RNA extraction Methods 0.000 description 1
- 238000010802 RNA extraction kit Methods 0.000 description 1
- 239000003391 RNA probe Substances 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 101001109965 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 60S ribosomal protein L7-A Proteins 0.000 description 1
- 101001109960 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 60S ribosomal protein L7-B Proteins 0.000 description 1
- 101710181599 Serine/threonine-protein kinase STK11 Proteins 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 239000007984 Tris EDTA buffer Substances 0.000 description 1
- 102100040118 U4/U6 small nuclear ribonucleoprotein Prp31 Human genes 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 206010046555 Urinary retention Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- 101710101493 Viral myc transforming protein Proteins 0.000 description 1
- 108010074310 X-ray repair cross complementing protein 3 Proteins 0.000 description 1
- DUDJTRNGXIUJEB-UHFFFAOYSA-N [N].NCC(O)=O Chemical group [N].NCC(O)=O DUDJTRNGXIUJEB-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000007844 allele-specific PCR Methods 0.000 description 1
- 125000006295 amino methylene group Chemical group [H]N(*)C([H])([H])* 0.000 description 1
- 238000002669 amniocentesis Methods 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 238000012197 amplification kit Methods 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000003172 anti-dna Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 239000013059 antihormonal agent Substances 0.000 description 1
- 238000007846 asymmetric PCR Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 238000010805 cDNA synthesis kit Methods 0.000 description 1
- 230000005773 cancer-related death Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000006369 cell cycle progression Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 108091092328 cellular RNA Proteins 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000012707 chemical precursor Substances 0.000 description 1
- 210000004252 chorionic villi Anatomy 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000003184 complementary RNA Substances 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 description 1
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 description 1
- 230000002559 cytogenic effect Effects 0.000 description 1
- 238000004163 cytometry Methods 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000003936 denaturing gel electrophoresis Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229940124466 diagnostic for cancer Drugs 0.000 description 1
- 230000005782 double-strand break Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000009585 enzyme analysis Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 208000020735 familial prostate carcinoma Diseases 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 238000002795 fluorescence method Methods 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Substances O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- 231100000221 frame shift mutation induction Toxicity 0.000 description 1
- 125000003843 furanosyl group Chemical group 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 231100000118 genetic alteration Toxicity 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 239000011544 gradient gel Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000007773 growth pattern Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 102000051324 human BBS9 Human genes 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 201000002313 intestinal cancer Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 208000030776 invasive breast carcinoma Diseases 0.000 description 1
- 238000001155 isoelectric focusing Methods 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 238000007834 ligase chain reaction Methods 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 108091005485 macrophage scavenger receptors Proteins 0.000 description 1
- 230000036212 malign transformation Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000010197 meta-analysis Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000002297 mitogenic effect Effects 0.000 description 1
- 238000001823 molecular biology technique Methods 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 230000003990 molecular pathway Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- JTSLALYXYSRPGW-UHFFFAOYSA-N n-[5-(4-cyanophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NC(C1=C2)=CNC1=NC=C2C1=CC=C(C#N)C=C1 JTSLALYXYSRPGW-UHFFFAOYSA-N 0.000 description 1
- 230000006780 non-homologous end joining Effects 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 238000003359 percent control normalization Methods 0.000 description 1
- 238000013081 phylogenetic analysis Methods 0.000 description 1
- 210000004694 pigment cell Anatomy 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920000155 polyglutamine Polymers 0.000 description 1
- 108010040003 polyglutamine Proteins 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
- 108010064775 protein C activator peptide Proteins 0.000 description 1
- 238000000734 protein sequencing Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000028617 response to DNA damage stimulus Effects 0.000 description 1
- 102200112573 rs119484086 Human genes 0.000 description 1
- 102200112567 rs5030739 Human genes 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 102000014452 scavenger receptors Human genes 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 201000003708 skin melanoma Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 230000037439 somatic mutation Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 201000010700 sporadic breast cancer Diseases 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003239 susceptibility assay Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
- 230000000381 tumorigenic effect Effects 0.000 description 1
- 108010032276 tyrosyl-glutamyl-tyrosyl-glutamic acid Proteins 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000004222 uncontrolled growth Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000010451 viral insertion Methods 0.000 description 1
- 102000009310 vitamin D receptors Human genes 0.000 description 1
- 108050000156 vitamin D receptors Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68214705P | 2005-05-18 | 2005-05-18 | |
| US79576806P | 2006-04-28 | 2006-04-28 | |
| PCT/IS2006/000012 WO2006123369A1 (en) | 2005-05-18 | 2006-05-18 | Variants at chr8q24.21 confer risk of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ563913A true NZ563913A (en) | 2010-03-26 |
Family
ID=36830953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ563913A NZ563913A (en) | 2005-05-18 | 2006-05-18 | Markers for prostate cancer in LD Block A on chromosome 8q24.21 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090317799A1 (enExample) |
| EP (1) | EP1888772A1 (enExample) |
| JP (1) | JP5227167B2 (enExample) |
| AU (1) | AU2006248591B2 (enExample) |
| BR (1) | BRPI0610794A2 (enExample) |
| CA (1) | CA2608567A1 (enExample) |
| IL (1) | IL187449A (enExample) |
| MX (1) | MX2007014447A (enExample) |
| NZ (1) | NZ563913A (enExample) |
| WO (1) | WO2006123369A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2677994A1 (en) * | 2007-02-07 | 2008-08-14 | Decode Genetics Ehf. | Genetic variants contributing to risk of prostate cancer |
| EP2164984A2 (en) * | 2007-05-25 | 2010-03-24 | Decode Genetics EHF. | Genetic variants on chr 5pl2 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment |
| US8697360B2 (en) * | 2007-11-30 | 2014-04-15 | Decode Genetics Ehf. | Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition |
| US20090226912A1 (en) * | 2007-12-21 | 2009-09-10 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with prostate cancer risk |
| US9732389B2 (en) | 2010-09-03 | 2017-08-15 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with prostate cancer risk |
| US9534256B2 (en) | 2011-01-06 | 2017-01-03 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with risk of aggressive prostate cancer |
| WO2013065072A1 (en) * | 2011-10-30 | 2013-05-10 | Decode Genetics Ehf | Risk variants of prostate cancer |
| KR101944927B1 (ko) | 2016-03-24 | 2019-02-07 | 서울대학교산학협력단 | 전립선암과 관련된 단일염기다형성 및 이를 이용한 유전 위험도 점수의 개발 |
| KR20250074712A (ko) | 2023-11-15 | 2025-05-28 | 주식회사 바스젠바이오 | 전립선암 발병의 위험도를 예측하기 위한 조성물 및 이를 이용한 방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| FI843529A0 (fi) | 1983-01-10 | 1984-09-10 | Gen Probe Inc | Foerfarande foer detektering, identifiering och kvantitering av organismer och virus. |
| US5288611A (en) | 1983-01-10 | 1994-02-22 | Gen-Probe Incorporated | Method for detecting, identifying, and quantitating organisms and viruses |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
| DE69132531T2 (de) | 1990-12-06 | 2001-09-13 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Verbindungen und ihre Verwendung in einer binären Synthesestrategie |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| EP0655090B1 (en) | 1992-04-27 | 2000-12-27 | The Trustees Of Dartmouth College | Detection of gene sequences in biological fluids |
| WO1999032644A2 (en) * | 1997-12-22 | 1999-07-01 | Genset | Prostate cancer gene |
-
2006
- 2006-05-18 BR BRPI0610794-0A patent/BRPI0610794A2/pt not_active IP Right Cessation
- 2006-05-18 JP JP2008511868A patent/JP5227167B2/ja not_active Expired - Fee Related
- 2006-05-18 EP EP06728429A patent/EP1888772A1/en not_active Withdrawn
- 2006-05-18 US US11/920,590 patent/US20090317799A1/en not_active Abandoned
- 2006-05-18 WO PCT/IS2006/000012 patent/WO2006123369A1/en not_active Ceased
- 2006-05-18 CA CA002608567A patent/CA2608567A1/en not_active Abandoned
- 2006-05-18 AU AU2006248591A patent/AU2006248591B2/en not_active Ceased
- 2006-05-18 NZ NZ563913A patent/NZ563913A/en not_active IP Right Cessation
- 2006-05-18 MX MX2007014447A patent/MX2007014447A/es active IP Right Grant
-
2007
- 2007-11-18 IL IL187449A patent/IL187449A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008539782A (ja) | 2008-11-20 |
| JP5227167B2 (ja) | 2013-07-03 |
| CA2608567A1 (en) | 2006-11-23 |
| AU2006248591A1 (en) | 2006-11-23 |
| BRPI0610794A2 (pt) | 2010-11-09 |
| AU2006248591A9 (en) | 2006-11-23 |
| AU2006248591B2 (en) | 2012-02-23 |
| IL187449A (en) | 2014-03-31 |
| AU2006248591A2 (en) | 2006-11-23 |
| MX2007014447A (es) | 2008-04-16 |
| WO2006123369A1 (en) | 2006-11-23 |
| WO2006123369A8 (en) | 2007-01-04 |
| EP1888772A1 (en) | 2008-02-20 |
| US20090317799A1 (en) | 2009-12-24 |
| IL187449A0 (en) | 2008-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2007310412B2 (en) | Cancer susceptibility variants on Chr8q24.21 | |
| US8865400B2 (en) | Genetic variants contributing to risk of prostate cancer | |
| AU2008256219B2 (en) | Genetic variants on Chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment | |
| US20110117545A1 (en) | Genetic variants on chr2 and chr16 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment | |
| EP2313523A2 (en) | Genetic variants predictive of cancer risk in humans | |
| EP2313525A2 (en) | Genetic variants for breast cancer risk assessment | |
| IL187449A (en) | And variants of chr8q24.21 as a cancer risk identification | |
| WO2010128530A1 (en) | Genetic variants contributing to risk of prostate cancer | |
| WO2009069152A2 (en) | Genetic variants on chr hq and 6q as markers for prostate and colorectal cancer predisposition | |
| WO2010131268A1 (en) | Genetic variants for basal cell carcinoma, squamous cell carcinoma and cutaneous melanoma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 18 MAY 2016 BY LEA SKYLLERSTEDT Effective date: 20130417 |
|
| LAPS | Patent lapsed |