NZ504104A - Novel tricyclic compounds and their use in medicine, a process for their preparation, pharmaceutical compositions containing them, and their use in the manufacture of a medicament for treating diseases in which insulin is the underlying pathophysiological mechanism - Google Patents

Novel tricyclic compounds and their use in medicine, a process for their preparation, pharmaceutical compositions containing them, and their use in the manufacture of a medicament for treating diseases in which insulin is the underlying pathophysiological mechanism

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Publication number
NZ504104A
NZ504104A NZ504104A NZ50410498A NZ504104A NZ 504104 A NZ504104 A NZ 504104A NZ 504104 A NZ504104 A NZ 504104A NZ 50410498 A NZ50410498 A NZ 50410498A NZ 504104 A NZ504104 A NZ 504104A
Authority
NZ
New Zealand
Prior art keywords
optionally substituted
group
represents hydrogen
hydrogen
aralkyl
Prior art date
Application number
NZ504104A
Inventor
Braj Bhushan Lohray
Vidya Bhushan Lohray
Ashok Channaveerappa Bajji
Shivaramayya Kalchar
Rajagopalan Ramanujam
Ranjan Chakrabarti
Original Assignee
Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr filed Critical Dr
Priority to NZ504104A priority Critical patent/NZ504104A/en
Priority claimed from PCT/US1998/001397 external-priority patent/WO1999019313A1/en
Publication of NZ504104A publication Critical patent/NZ504104A/en

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Abstract

Novel hypolipidemic, antihyperglycemic compounds of formula (I) and its compositions wherein: R1, R2, R3 and R4 are the same or different and represent hydrogen, halogen, hydroxy, nitro, cyano, formyl or optionally substituted groups as described in the complete specification; Ring A represents a 5-6 membered carbocyclic structure which may optionally be substituted and may be saturated or contain one or more double bonds or may be aromatic; X represents a heteroatom selected from oxygen, sulfur, or NR9 where R9 is hydrogen, alkyl, aryl, aralkyl, acyl, alkoxycarbonyl, aryloxycarbonyl or aralkoxycarbonyl; Ar represents an optionally substituted divalent single or fused aromatic or heterocyclic group; R5 represents hydrogen, hydroxy, alkoxy, halogen, lower alkyl, optionally substituted aralkyl group or forms a bond together with the adjacent R6; R6 represents hydrogen, hydroxy, alkoxy, halogen, lower alkyl group, acyl, optionally substituted aralkyl or forms a bond with R5; R7 represents hydrogen, or a optionally substituted group as described in the complete specification; R8 represents hydrogen or an optionally substituted group as described in the complete specification; Y represents oxygen or NR10 where R10 represents hydrogen, alkyl, aryl, hydroxyalkyl or aralkyl groups or R8 and R10 together form a 5 or 6 membered cyclic structure containing carbon atoms which may optionally contain one or more heteroatoms selected from oxygen, sulfur or nitrogen; n is an integer ranging from 1-4 and m is an integer 0 or 1.
NZ504104A 1998-01-23 1998-01-23 Novel tricyclic compounds and their use in medicine, a process for their preparation, pharmaceutical compositions containing them, and their use in the manufacture of a medicament for treating diseases in which insulin is the underlying pathophysiological mechanism NZ504104A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ504104A NZ504104A (en) 1998-01-23 1998-01-23 Novel tricyclic compounds and their use in medicine, a process for their preparation, pharmaceutical compositions containing them, and their use in the manufacture of a medicament for treating diseases in which insulin is the underlying pathophysiological mechanism

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1998/001397 WO1999019313A1 (en) 1997-10-27 1998-01-23 Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
NZ504104A NZ504104A (en) 1998-01-23 1998-01-23 Novel tricyclic compounds and their use in medicine, a process for their preparation, pharmaceutical compositions containing them, and their use in the manufacture of a medicament for treating diseases in which insulin is the underlying pathophysiological mechanism

Publications (1)

Publication Number Publication Date
NZ504104A true NZ504104A (en) 2003-03-28

Family

ID=19927850

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ504104A NZ504104A (en) 1998-01-23 1998-01-23 Novel tricyclic compounds and their use in medicine, a process for their preparation, pharmaceutical compositions containing them, and their use in the manufacture of a medicament for treating diseases in which insulin is the underlying pathophysiological mechanism

Country Status (1)

Country Link
NZ (1) NZ504104A (en)

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Owner name: DR. REDDY S LABORATORIES LIMITED, IN

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