NZ337394A - Formulations for hydrophobic pharmaceutical agents which are indolinone, quinazoline or nitrothiazole - Google Patents

Formulations for hydrophobic pharmaceutical agents which are indolinone, quinazoline or nitrothiazole

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Publication number
NZ337394A
NZ337394A NZ337394A NZ33739498A NZ337394A NZ 337394 A NZ337394 A NZ 337394A NZ 337394 A NZ337394 A NZ 337394A NZ 33739498 A NZ33739498 A NZ 33739498A NZ 337394 A NZ337394 A NZ 337394A
Authority
NZ
New Zealand
Prior art keywords
optionally substituted
alkoxy
indolinone
trihalomethyl
ester
Prior art date
Application number
NZ337394A
Inventor
Narmada Shenoy
Gregory Wagner
Original Assignee
Sugen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc filed Critical Sugen Inc
Priority claimed from PCT/US1998/004134 external-priority patent/WO1998038984A2/en
Publication of NZ337394A publication Critical patent/NZ337394A/en

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Abstract

A formulation comprises: (a) one or more hydrophobic pharmaceutical agents being either quinazoline, nitrothiazole or indolinone based compounds; (b) one or more polyoxyhydrocarbyl compounds and (c) one or more pharmaceutically acceptable surfactants. The indolinone base compound, which is present in the composition in a concentration of 0.1 to 100 mg/ml, has the formula (VI) wherein: R1, R2, R3, and R4 are independently hydrogen, trihalomethyl, hydroxyl, amine, thioether, cyano, alkoxy, alkyl, amino, bromo, fluoro, chloro, iodo, mercapto, thio, cyanoamido, alkylthio, aryl, heteroaryl, carboxyl, ester, oxo, alkoxycarbonyl, alkenyl, alkoxy, nitro, alkoxyl, or amido moieties and R5 is an optionally substituted aryl or heteroaryl cyclic moiety. At least one of the surfactants for the indolinone based compound is PEG-400 present in a concentration of 0.01 to 10 g/ml and at least one of the polyoxyhydrocarbyl compounds for the indolinone based compound is ethoxylated castor oil present in a concentration of 0.01 to 10 g/ml. The quinazoline based compound has the formula (I) wherein: R1, R2, R3, R4, R5 and R6 are independently hydrogen or an optionally saturated alkyl, optionally substituted aryl, optionally substituted amine, halogen, trihalomethyl, ketone, carboxylic acid or ester, alcohol, alkoxy, amide, -SO2NX11X12, wherein X11 and X12 are as defined in the specification, optionally substituted homocyclic or heterocyclic ring moiety, aldehyde, sulphone or nitro. The nitrothiazole based compound has the formula IV wherein: R1, R2, and R3 are independently hydrogen or an optionally saturated alkyl, optionally substituted aryl, optionally substituted amine, halogen, trihalomethyl, ketone, carboxylic acid or ester, alcohol, alkoxy, halogen, trihalomethyl, ketone, carboxylic acid or ester, alcohol, alkoxy, amide, -SO2NX11X12, wherein X11 and X12 are as defined in the specification, optionally substituted homocyclic or heterocyclic ring moiety, aldehyde, sulphone or nitro.
NZ337394A 1997-03-05 1998-03-04 Formulations for hydrophobic pharmaceutical agents which are indolinone, quinazoline or nitrothiazole NZ337394A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3987097P 1997-03-05 1997-03-05
US4135197A 1997-03-18 1997-03-18
PCT/US1998/004134 WO1998038984A2 (en) 1997-03-05 1998-03-04 Formulations for hydrophobic pharmaceutical agents

Publications (1)

Publication Number Publication Date
NZ337394A true NZ337394A (en) 2001-05-25

Family

ID=26716540

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ337394A NZ337394A (en) 1997-03-05 1998-03-04 Formulations for hydrophobic pharmaceutical agents which are indolinone, quinazoline or nitrothiazole

Country Status (1)

Country Link
NZ (1) NZ337394A (en)

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