NZ333995A - Method and vaccine containing Helicobacter bacteria with antigenic properties - Google Patents

Method and vaccine containing Helicobacter bacteria with antigenic properties

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Publication number
NZ333995A
NZ333995A NZ333995A NZ33399595A NZ333995A NZ 333995 A NZ333995 A NZ 333995A NZ 333995 A NZ333995 A NZ 333995A NZ 33399595 A NZ33399595 A NZ 33399595A NZ 333995 A NZ333995 A NZ 333995A
Authority
NZ
New Zealand
Prior art keywords
culture
bacteria
phase
helicobacter bacteria
antigenic properties
Prior art date
Application number
NZ333995A
Inventor
John L Pace
Richard I Walker
Steven M Frey
Original Assignee
Antex Biolog Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/538,544 external-priority patent/US5897475A/en
Application filed by Antex Biolog Inc filed Critical Antex Biolog Inc
Priority claimed from NZ295877A external-priority patent/NZ295877A/en
Publication of NZ333995A publication Critical patent/NZ333995A/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A method for producing Helicobacter bacteria having enhanced antigenic properties which comprises growing a culture of the Helicobacter bacteria in vivo and a) a divalent cation chelator selected from 1.0-25ìM of BAPTA/AM, 0.5-10ìM EGTA and 1.0-100ìM EGTA/AM; b) at a temperature between 30-42oC; c) in air or an microaerophillic condition, wherein the microaerophillic condition comprises i) 5-20% CO2 with 80-95% air ii) 5-10% O2 with 10-20% CO2 with about 70-85% N2 for a sufficient time so that the culture is in a growth phase at about early log phase, between early log phase and stationary phase, or at about stationary phase, wherein the enhanced antigenic property is a higher level of immunogenic antigenicity when compared to the antigenic property of bacteria from a culture of Helicobacter species in brain heart infusion broth supplemented with bovine calf serum.
NZ333995A 1994-10-05 1995-10-04 Method and vaccine containing Helicobacter bacteria with antigenic properties NZ333995A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31840994A 1994-10-05 1994-10-05
US08/538,544 US5897475A (en) 1994-10-05 1995-10-03 Vaccines comprising enhanced antigenic helicobacter spp.
NZ295877A NZ295877A (en) 1994-10-05 1995-10-04 A vaccine comprising the helicobacter bacterium and its use

Publications (1)

Publication Number Publication Date
NZ333995A true NZ333995A (en) 2000-07-28

Family

ID=27353800

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ333995A NZ333995A (en) 1994-10-05 1995-10-04 Method and vaccine containing Helicobacter bacteria with antigenic properties

Country Status (1)

Country Link
NZ (1) NZ333995A (en)

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