NZ332809A - Immunogenic complex comprising a oligo- or polysaccharide epitope and a carrier protein with a portion of an OmpA-type outer membrane protein of a bacterial and vaccines of such complexes containing same - Google Patents

Immunogenic complex comprising a oligo- or polysaccharide epitope and a carrier protein with a portion of an OmpA-type outer membrane protein of a bacterial and vaccines of such complexes containing same

Info

Publication number
NZ332809A
NZ332809A NZ332809A NZ33280997A NZ332809A NZ 332809 A NZ332809 A NZ 332809A NZ 332809 A NZ332809 A NZ 332809A NZ 33280997 A NZ33280997 A NZ 33280997A NZ 332809 A NZ332809 A NZ 332809A
Authority
NZ
New Zealand
Prior art keywords
oligo
ompa
outer membrane
vaccines
bacterial
Prior art date
Application number
NZ332809A
Inventor
Hans Binz
Jean-Francois Haeuw
Stefan Svenson
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of NZ332809A publication Critical patent/NZ332809A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

The specification describes an immunogenic complex, characterised in that it contains at least one oligo- or polysaccharide epitope naturally present in bacteria, coupled with a carrier protein. The carrier protein comprises at least a fragment of an OmpA-type outer membrane protein of a gram-negative bacterium capable of enhancing the immunogenicity of the oligo-or polysaccharide epitope.
NZ332809A 1996-05-07 1997-05-06 Immunogenic complex comprising a oligo- or polysaccharide epitope and a carrier protein with a portion of an OmpA-type outer membrane protein of a bacterial and vaccines of such complexes containing same NZ332809A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9605692A FR2748476B1 (en) 1996-05-07 1996-05-07 IMMUNOGENIC COMPLEX, ITS USE, ITS PREPARATION METHOD AND VACCINE CONTAINING THE SAME
PCT/FR1997/000800 WO1997041888A1 (en) 1996-05-07 1997-05-06 Immunogenic complex, use, method of preparation thereof and vaccine containing same

Publications (1)

Publication Number Publication Date
NZ332809A true NZ332809A (en) 2000-05-26

Family

ID=9491907

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ332809A NZ332809A (en) 1996-05-07 1997-05-06 Immunogenic complex comprising a oligo- or polysaccharide epitope and a carrier protein with a portion of an OmpA-type outer membrane protein of a bacterial and vaccines of such complexes containing same

Country Status (9)

Country Link
EP (1) EP0914152A1 (en)
JP (1) JP2000509707A (en)
CN (1) CN1221348A (en)
AU (1) AU733845B2 (en)
BR (1) BR9708979A (en)
CA (1) CA2254084A1 (en)
FR (1) FR2748476B1 (en)
NZ (1) NZ332809A (en)
WO (1) WO1997041888A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2776521B1 (en) * 1998-03-27 2000-12-15 Pf Medicament USE OF P40 ACTIVE CONJUGATES BY NASAL
FR2785542B1 (en) * 1998-11-06 2001-02-09 Pf Medicament USE OF AN ENTEROMACTERY OmpA PROTEIN FOR THE SPECIFIC TARGETING OF A BIOLOGICALLY ACTIVE SUBSTANCE THAT IS ASSOCIATED WITH CELLS PRESENTING ANTIGENS SUCH AS HUMAN DENDRITIC CELLS
US6146902A (en) * 1998-12-29 2000-11-14 Aventis Pasteur, Inc. Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions
FR2789588B1 (en) * 1999-02-17 2001-05-04 Pf Medicament USE OF AN OMPA ENTEROBACTERIA PROTEIN ASSOCIATED WITH AN ANTIGEN IN A PHARMACEUTICAL COMPOSITION FOR GENERATING OR INCREASING ANTIVIRAL, PEST CONTROL OR ANTITUMOR CYTOTOXIC RESPONSE
FR2789902A1 (en) * 1999-02-24 2000-08-25 Pf Medicament Use of enterobacterial outer membrane protein as immunogenic carrier, particularly for contraceptive and anti-cancer vaccines, provides strong humoral response
FR2790959B1 (en) * 1999-03-15 2003-06-27 Pf Medicament USE OF BACTERIAL MEMBRANARY FRACTIONS WITH ADJUVANT EFFECT, THEIR PREPARATION METHODS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
FR2828106A1 (en) * 2001-08-02 2003-02-07 Pf Medicament Composition containing peptide from low molecular weight outer membrane protein, useful for preparing vaccines against infections or cancer
WO2007084856A2 (en) * 2006-01-13 2007-07-26 Baxter International Inc. Method for purifying polysaccharides
CN107184972B (en) * 2017-06-20 2020-12-01 康希诺生物股份公司 Mycobacterium tuberculosis OS-tb oligosaccharide conjugate and preparation method and application thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1331355C (en) * 1986-04-21 1994-08-09 Bioenterprises Pty. Ltd Immunopotentation
FR2682388B1 (en) * 1991-10-10 1995-06-09 Pasteur Merieux Serums Vacc PROCESS FOR THE PREPARATION OF AN OLIGOSIDE BY DEPOLYMERIZATION OF A POLYOSIDE DERIVED FROM A PATHOGENIC AGENT, OLIGOSIDE THUS OBTAINED AND ITS USE IN PARTICULAR AS A VACCINE AGENT.
US6153406A (en) * 1993-07-23 2000-11-28 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B
FR2718452B1 (en) * 1994-04-06 1996-06-28 Pf Medicament Element of immunogen, immunogenic agent, pharmaceutical composition and method of preparation.
FR2726471B1 (en) * 1994-11-07 1997-01-31 Pf Medicament PROCESS FOR IMPROVING THE IMMUNOGENICITY OF AN IMMUNOGENIC COMPOUND OR A HAPTENA AND APPLICATION TO THE PREPARATION OF VACCINES
FR2726472B1 (en) * 1994-11-07 1997-01-31 Pf Medicament CARRIER WITH ADJUVANT EFFECT, IMMUNOGENIC COMPLEX CONTAINING THE SAME, PREPARATION METHOD THEREOF, NUCLEOTIDE SEQUENCE AND VACCINE

Also Published As

Publication number Publication date
WO1997041888A1 (en) 1997-11-13
JP2000509707A (en) 2000-08-02
EP0914152A1 (en) 1999-05-12
BR9708979A (en) 1999-08-03
AU733845B2 (en) 2001-05-31
CA2254084A1 (en) 1997-11-13
CN1221348A (en) 1999-06-30
FR2748476A1 (en) 1997-11-14
FR2748476B1 (en) 1998-08-14
AU2901997A (en) 1997-11-26

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