NZ331835A - Stabilising macrolides such as rapamycin and ascomycin against degradation by mixing the macrolides with an acid - Google Patents

Stabilising macrolides such as rapamycin and ascomycin against degradation by mixing the macrolides with an acid

Info

Publication number
NZ331835A
NZ331835A NZ331835A NZ33183595A NZ331835A NZ 331835 A NZ331835 A NZ 331835A NZ 331835 A NZ331835 A NZ 331835A NZ 33183595 A NZ33183595 A NZ 33183595A NZ 331835 A NZ331835 A NZ 331835A
Authority
NZ
New Zealand
Prior art keywords
macrolides
acid
macrolide
rapamycin
against degradation
Prior art date
Application number
NZ331835A
Inventor
Barbara Haeberlin
Sylvain Cottens
Richard Sedrani
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Priority claimed from NZ295655A external-priority patent/NZ295655A/en
Publication of NZ331835A publication Critical patent/NZ331835A/en

Links

Abstract

A pharmaceutical composition and use thereof, comprising a macrolide and an acid where the weight ratio of the macrolide to acid is from 1:5 to 5:1. The macrolide is selected from the group: 1) a compound of the rapamycin class 2) 33-epi-chloro-33-desoxyascomycin 3) {[1E-(1R,3R,4R)]1R,4S,5R,6S,9R,10E,13S,15S,16R,17S, 19S,20S}-9-ethyl-6,16,20-trihydroxy-4-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methylvinyl]-15,17-dimethoxy-5,11,13,19-tetramethyl-3-oxa-22-aza-tricyclo[18.6.1.0(1,22)]heptacos-10-ene-2,8,21,27-tetraone. The composition also comprises a mono-carboxylic acid with one or more hydrophillic groups to stabilise the lactam macrolide against degradation in said pharmaceutical composition.
NZ331835A 1994-10-26 1995-10-25 Stabilising macrolides such as rapamycin and ascomycin against degradation by mixing the macrolides with an acid NZ331835A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9421613A GB9421613D0 (en) 1994-10-26 1994-10-26 Organic compounds
NZ295655A NZ295655A (en) 1994-10-26 1995-10-25 Microemulsion preconcentrate containing sparingly soluble active agent and a carrier containing a hydrophillic phase, a lipophilic phase and a surfactant

Publications (1)

Publication Number Publication Date
NZ331835A true NZ331835A (en) 2000-04-28

Family

ID=10763458

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ331835A NZ331835A (en) 1994-10-26 1995-10-25 Stabilising macrolides such as rapamycin and ascomycin against degradation by mixing the macrolides with an acid

Country Status (6)

Country Link
CY (1) CY2213B1 (en)
GB (1) GB9421613D0 (en)
NZ (1) NZ331835A (en)
PL (1) PL184766B1 (en)
RU (1) RU2292887C2 (en)
ZA (1) ZA959081B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3107707A1 (en) 2018-07-27 2020-01-30 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
EP3829610A1 (en) 2018-07-27 2021-06-09 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US10966948B2 (en) 2019-07-23 2021-04-06 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US11166997B2 (en) 2018-07-27 2021-11-09 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
WO2020021481A1 (en) 2018-07-27 2020-01-30 Johnson & Johnson Vision Care, Inc. Compositions and methods for treating the eye

Also Published As

Publication number Publication date
ZA959081B (en) 1997-04-29
PL184766B1 (en) 2002-12-31
CY2213B1 (en) 2002-11-08
GB9421613D0 (en) 1994-12-14
RU2292887C2 (en) 2007-02-10

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Legal Events

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Free format text: THE OWNER HAS BEEN CORRECTED TO 890887, NOVARTIS AG, LICHTSTRASSE 35, CH-4056 BASEL, CH

Effective date: 20140409

EXPY Patent expired