NZ312876A - Intranasal, muscosal and systemic vaccination against C. difficile inducing a mucosal immune response in the gastrointestinal and/or genitourinary tracts - Google Patents
Intranasal, muscosal and systemic vaccination against C. difficile inducing a mucosal immune response in the gastrointestinal and/or genitourinary tractsInfo
- Publication number
- NZ312876A NZ312876A NZ312876A NZ31287696A NZ312876A NZ 312876 A NZ312876 A NZ 312876A NZ 312876 A NZ312876 A NZ 312876A NZ 31287696 A NZ31287696 A NZ 31287696A NZ 312876 A NZ312876 A NZ 312876A
- Authority
- NZ
- New Zealand
- Prior art keywords
- toxin
- difficile
- composition
- toxoid
- immune response
- Prior art date
Links
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- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- 231100000033 toxigenic Toxicity 0.000 description 1
- 230000001551 toxigenic effect Effects 0.000 description 1
- 238000003151 transfection method Methods 0.000 description 1
- 238000011426 transformation method Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 229940125575 vaccine candidate Drugs 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49922995A | 1995-07-07 | 1995-07-07 | |
| PCT/US1996/010987 WO1997002835A1 (en) | 1995-07-07 | 1996-06-26 | Intranasal vaccination against gastrointestinal disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ312876A true NZ312876A (en) | 2000-06-23 |
Family
ID=23984386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ312876A NZ312876A (en) | 1995-07-07 | 1996-06-26 | Intranasal, muscosal and systemic vaccination against C. difficile inducing a mucosal immune response in the gastrointestinal and/or genitourinary tracts |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0877623A1 (enExample) |
| JP (1) | JPH11510793A (enExample) |
| CN (1) | CN1195993A (enExample) |
| AU (1) | AU722653B2 (enExample) |
| CA (1) | CA2226392A1 (enExample) |
| NZ (1) | NZ312876A (enExample) |
| WO (1) | WO1997002835A1 (enExample) |
| ZA (1) | ZA965737B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6153201A (en) * | 1993-03-09 | 2000-11-28 | University Of Rochester | Oral immunization with papillomavirus virus-like particles |
| US6969520B2 (en) | 1997-10-20 | 2005-11-29 | Acambis Inc. | Active immunization against clostridium difficile disease |
| US6585975B1 (en) * | 1998-04-30 | 2003-07-01 | Acambis, Inc. | Use of Salmonella vectors for vaccination against helicobacter infection |
| US7074454B1 (en) | 1999-11-01 | 2006-07-11 | Mucovax Holding B.V. | Production of mammary secretion antibodies in farm animals |
| EP1226176B1 (en) * | 1999-11-01 | 2006-02-08 | MucoVax Holding B.V | Production of mammary secretion antibodies in farm animals |
| US6974573B2 (en) | 1999-11-01 | 2005-12-13 | Mucovax Holdings, B.V. | Antibody production in farm animals |
| GB0029919D0 (en) * | 2000-12-07 | 2001-01-24 | Chiron Spa | Helicobacter pylori prime & boost vaccination |
| WO2008146830A1 (ja) * | 2007-05-28 | 2008-12-04 | The Kitasato Institute | パラ百日咳菌全菌体ワクチン組成物 |
| CN106039299A (zh) * | 2007-09-14 | 2016-10-26 | 赛诺菲巴斯德生物制剂有限责任公司 | 含艰难梭菌类毒素a和b的药物组合物 |
| KR20110100189A (ko) * | 2008-12-03 | 2011-09-09 | 베링거잉겔하임베트메디카게엠베하 | 백신 생산 방법 |
| WO2011068953A2 (en) * | 2009-12-02 | 2011-06-09 | Tufts University | Atoxic recombinant holotoxins of clostridium difficile as immunogens |
| DK3549949T5 (da) | 2011-04-22 | 2024-09-02 | Wyeth Llc | Sammensætninger vedrørende et mutant Clostridium-difficile-toksin og fremgangsmåder dertil |
| EP2780351B1 (en) | 2011-11-18 | 2019-12-18 | National Research Council of Canada (NRC) | Clostridium difficile lipoteichoic acid and uses thereof |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141970A (en) * | 1975-05-07 | 1979-02-27 | Internationale Octrooimaatschappij "Octropa" B.V. | Method for enhancing the resistance of new born mammalian young to gastro-intestinal infections |
| US4713240A (en) * | 1985-04-04 | 1987-12-15 | Research Corporation | Vaccines based on insoluble supports |
| US4944942A (en) * | 1987-08-27 | 1990-07-31 | Mobay Corporation | Intranasal vaccination of horses with inactivated microorganisms or antigenic material |
| JP2849632B2 (ja) * | 1988-04-08 | 1999-01-20 | 社団法人北里研究所 | ワクチン製剤 |
| US5601823A (en) * | 1989-10-31 | 1997-02-11 | Ophidian Pharmaceuticals, Inc. | Avian antitoxins to clostridium difficle toxin A |
| GB9209118D0 (en) * | 1992-04-28 | 1992-06-10 | Sb 120 Amsterdam Bv | Vaccine compositions |
| IL106362A (en) * | 1992-07-16 | 1998-12-06 | Oxford University | A system for launching multiple particle antigens |
-
1996
- 1996-06-26 AU AU64799/96A patent/AU722653B2/en not_active Ceased
- 1996-06-26 JP JP9505849A patent/JPH11510793A/ja active Pending
- 1996-06-26 NZ NZ312876A patent/NZ312876A/en unknown
- 1996-06-26 EP EP96924312A patent/EP0877623A1/en not_active Withdrawn
- 1996-06-26 CA CA002226392A patent/CA2226392A1/en not_active Abandoned
- 1996-06-26 WO PCT/US1996/010987 patent/WO1997002835A1/en not_active Ceased
- 1996-06-26 CN CN96196763A patent/CN1195993A/zh active Pending
- 1996-07-05 ZA ZA965737A patent/ZA965737B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11510793A (ja) | 1999-09-21 |
| AU6479996A (en) | 1997-02-10 |
| CN1195993A (zh) | 1998-10-14 |
| ZA965737B (en) | 1997-05-13 |
| WO1997002835A1 (en) | 1997-01-30 |
| CA2226392A1 (en) | 1997-01-30 |
| EP0877623A4 (enExample) | 1998-11-18 |
| EP0877623A1 (en) | 1998-11-18 |
| AU722653B2 (en) | 2000-08-10 |
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