NZ263619A - Intradermal metered injection device, has a needle with a circumferential vacuum which secures the device to skin - Google Patents
Intradermal metered injection device, has a needle with a circumferential vacuum which secures the device to skinInfo
- Publication number
- NZ263619A NZ263619A NZ26361994A NZ26361994A NZ263619A NZ 263619 A NZ263619 A NZ 263619A NZ 26361994 A NZ26361994 A NZ 26361994A NZ 26361994 A NZ26361994 A NZ 26361994A NZ 263619 A NZ263619 A NZ 263619A
- Authority
- NZ
- New Zealand
- Prior art keywords
- piston
- skin
- vacuum
- medicament
- metered dose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3295—Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
- A61M5/3298—Needles arranged in parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Fuel-Injection Apparatus (AREA)
Description
New Zealand No. 263619 International No. PCT/IE94/00020
TO BE ENTERED AFTER ACCEPTANCE AND PUBLICATION
Priority dates: 08.04-. 1993;
International filing date: 07 APR 1994
Classification:(6) A61M5/42
Publication date:24 June 1997
Journal No.: 1417
NEW ZEALAND PATENTS ACT 1953
COMPLETE SPECIFICATION
Title of Invention:
Intradermal injection device
Name, address and nationality of applicant(s) as in international application form:
ELAN MEDICAL TECHNOLOGIES LIMITED, an Irish company of Monskland Industrial Estate, Athlone, County Westmeath, Ireland
New Zealand No. International No.
263619
NEW ZEALAND PATENTS ACT 1953 COMPLETE SPECIFICATION
Title of Invention: Intradermal injection device
Name, address and nationality of applicant(s) as in international application form:
ELAN MEDICAL TECHNOLOGIES LTD, an Irish company of Monskland Industrial Estate, Athlone, County Westmeath, Ireland
1
PCT /EE94/00020
263 6 19
Description INTRADERMAL INJECTION DEVICE
Technical Field
This invention relates to a device for administering intradermal^ a medicament in liquid form.
The use of the term "intradermal" herein is intended to embrace subcutaneous.
Background Art
Many drugs, active ingredients or medications, hereinafter 10 referred to collectively as medicaments, require administration by injection. This mode of administration tends to be inconvenient and also painful. Patients may be required to self-administer a medicament, such as insulin in the case of diabetics, and various attempts have been made to make this mode of administration more convenient, thereby, 15 increasing patient compliance. Thus, "pen" type injectors have been proposed.
There is a need for a device which can be used to automatically inject a metered dose of a medicament intradermally with the minimum of trauma. Such a device should ideally include a needle or needles 20 which enter the skin to a predetermined depth and allow precise penetration of the skin by the patient
Disclosure of the Invention
The invention provides a device for administering intradennally a metered dose of a medicament in liquid-form, said device comprising
1A
263
means which creates a vacuum so as to secure the device to the skin during medicament delivery, means which penetrates one or more skin layers and delivers said metered dose and means which releases said vacuum for removal of the device following delivery of the metered dose, the means which penetrates the or each skin layer comprising a plurality of hollow needles in communication with a reservoir for the medicament, and the vacuum being created circumferentially of each needle defining said penetrating means.
WO 94/23777 PCT/IE94/00020
263 6 1 9
The device according lo the invention can be used with a minimum of trauma by patients as well as by medical and nursing staff, 5 to administer a range of medicaments, including peptides and polypeptides, by the intradermal route as hereinbefore defined.
Preferably, the means which.creates the vacuum comprises a piston arrangement and an associated system of air channels.
The creation of the vacuum can cause the skin to be drawn towards, and penetrated by, said penetration means.
The piston arrangement, when such is present, is preferably actuated by a plunger mechanism integral with the piston. Further, preferably, the piston impinges on a displaceable membrane defining a boundary wall of the reservoir so as to expel the contents of the reservoir through the penetrating means when the piston is depressed. Further, preferably, the plunger has an internal air duct which is open to the atmosphere. ^
94/23777
PCT/E94/00020
3
When it is desired to release the vacuum and, thereby, the device from the skin of a patient following administration of the medicament, the piston is retracted.
The penetrating means can be movable within the device, such that when the vacuum is generated, said penetrating means is simultaneously or sequentially displaced towards the skin for penetration thereof.
According to a preferred embodiment, actuation of the device simultaneously creates the vacuum and causes movement of the skin penetrating means for penetration of the skin.
For example, following application of the device to the skin and actuation thereof, the vacuum generated can draw the skin against a plate structure in the device disposed on a skin-contacting surface thereof. The plate structure then maintains the skin in position while a set of needles is caused to descend and pass through a plurality of apertures in said plate structure and enter the skin to a predetermined depth.
Alternatively, a set of needles is fixed in position on such a plate structure and the act of drawing the skin against the plate causes the needles to penetrate the skin. The medicament is then delivered as a single dose through the set of needles.
The withdrawal of the needles from the skin can release the vacuum or vice versa.
The device according to the invention is preferably in the form of a disposable pre-filled product for once-off use, although the device can be readily adapted for continued use by the provision of filling means for replenishing the reservoir. In the case of a refillable device, the device is suitably provided with means for indicating when a quantity, corresponding to one or more metered doses, has been inserted therein.
4
2fi3 6 1 9
The medicament can have almost any viscosity, provided that it can be dispensed through the penetrating means at a rate which is pharmaceutical^ effective and acceptable.
The penetrating means will suitably be manufactured from medical-grade stainless steel. However, the penetrating means can also be composed of a suitable inert plastics material.
Other parts of the device may also be manufactured from suitable plastics materials.
The device according to the invention is suitable for the 10 administration, including self-administration, of a wide range of medicaments, including peptides and polypeptides. The device according to the invention is especially suitable for the administration of insulin.
The device according to the invention is also suitable for the 15 administration of vaccines in methods of vaccination.
The device according to the invention can be used to inject a medicament intradermally or subcutaneously automatically as desired by suitable adjustment of the length of the needles or the extent to which the needles are movable relative to
or within the device.
The device according to the invention allows for precise penetration of the skin which is an advantage over currently available automatic injection devices.
The device according to the invention can also be used to inject 25 controlled release formulations, suitably in a lipophilic base, allowing for convenient subcutaneous injection of depot formulations.
The device may be enclosed in a sterilised package until required for use. Furthermore, the needles will
O O " ' ' '■>
i - /
263 6 1 9
normally be either covered by a peel-off strip or stuck in an impermeable pad to prevent the medicament from leaking out of the device while in storage.
The invention will be further illustrated by the following description of an embodiment thereof given by way of example only with reference to tJhe accompanying Drawings.
Brief Description of the Drawings
In the accompanying Drawings:
Fig.l is a front elevation in section of an embodiment of the device according to the invention;?and
Fig. 2 is a plan view of the device of Fig. 1 taken on the line II-II.
Modes for Carrying Out the Invention
Referring to Figs. 1 and 2 of the Drawings, there is indicated generally at 10, a device for administering intradermally to a patient a metered dose of a medicament in liquid form. The device 10 comprises a housing 11 and a piston arrangement, indicated generally at 12, comprising a piston 13 movable in sealing engagement within a hollow chamber 14 disposed internally of the housing 11. The piston 13 is provided with an integral plunger mechanism 15 for actuation by the person administering the medicament. The plunger 15 has an internal airway 16 which is substantially L-shaped and which
WO 94/23777 PCT/HE94/00020
communicates with the atmosphere via an outlet 17. End 18 of the piston 13, which travels within the chamber 14, serves to close the end of the chamber 14 distal from the skin, in use, apart from a second outlet 19 of the airway 16. The end of the chamber 14 proximal to the 5 skin, in use, is defined by an elastomeric membrane 20 defining a boundary wall 21 of a reservoir 22 for the medicament 23.
The piston arrangement 12 is similar to that used in a conventional hypodermic syringe and thus end 18 of piston 13 which travels within chamber 14 has a circumferentially extending flexible 10 grooved sealing means.
The housing 11 has a cap 24 with an aperture 25 through which shaft 26 of the plunger mechanism 15 passes in sealing engagement therewith.
An air chamber 27 which communicates via extension 28 with 15 the space above end 18 of the piston 13 when the piston is depressed is disposed intermediate walls 29 of the housing 11 and the walls of the chamber 14 and is continuous within a skin-contacting part 30 of the housing 11 containing penetrating means 31 comprised of a plurality of needles 32. The air chaniber 27 is also in communication with an 20 aperture 33 surrounding each needle 32.
The air chamber 27 can be replaced by a plurality of narrow bore air chambers, typically four, spaced equidistantly about the circumference of the device 10 and being continuous with the space above end 18 of the piston 13 when the piston is depressed and with the 25 skin-contacting part 30.
The device 10 is provided with a circumferentially extending elastomeric sealing ring 34 for engagement with the skin in use.
In use, when it is desired to administer a liquid medicament such as insulin, the person administering the medicament, who may be the patient, selects the site on the skin at which the medicament is to be
7
26 3 6 1 9
administered. The device 10 is applied to the skin, the plunger mechanism 15 is depressed in the direction of the skin, causing the piston 13 to move towards the membrane 21.
The hollow chamber 14 is open to the atmosphere via outlet 17.
Depression of the piston 13 causes a reduction in pressure in space 28 and causes air to be sucked into said space via the air chamber 27, resulting in the creation of a vacuum at the site of application of the device 10. The creation of the vacuum causes the skin to be drawn towards and penetrated by the needles 32. As the plunger is fully 10 depressed, the medicament 23 is delivered through the needles 32 in response to the action of the piston 13 depressing the membrane 20 which forces the medicament 23 out of the reservoir 22 and into the needles 32 followed by intradermal delivery. To release the device 10 from the skin (not shown) following medicament delivery, the piston 15 13 is retracted releasing the vacuum and thereby releasing the device 10.
8
In the embodiment of Fig. 3, the needles 32 are not each provided with an aperture in contact with the air chamber 27'. Rather, when the flange 35 engages the skin, in use, and the piston 13 is depressed, air is sucked from the air chamber 27' into space 28 above 5 piston 13, so as to create a vacuum circumferentially and externally of the part of the device 10 housing the needles 32. The creation of the vacuum causes the device 10 to be held firmly in contact with the skin during delivery of the medicament. To release the device 10, the piston 13 is retracted in the same manner as for the embodiment 10 depicted in Fig. 1.
Claims (10)
1. A device for administering intradermally a metered dose of a medicament in liquid form, said device comprising means. Which creates a vacuum so as to secure the device to the skin during medicament delivery, means which penetrates one or more skin layers and delivers said metered dose and means which releases said vacuum for removal of the device following delivery of the metered dose, the means- which penetrates the or each skiri layer comprising a plurality hollow needles in communication with a reservoir for the medicament, and the vacuum being created circumferentially of each needle defining said penetrating means.
2. A device according to Claim 1, wherein the means which creates the vacuum comprises a piston arrangement and an associated system of air channels.
3. A device according to Claim 1 or 2, wherein the creation of the vacuum causes the skin to be drawn towards, and penetrated by, the needles.
4. A device according to claim 3 dependent on Claim 2, wherein the piston arrangement is actuated by a plunger mechanism integral with the piston.
5. A device according to Claim 4,wherein the piston impinges on a displaceable membrane defining a boundary wall of the reservoir so as to expel the contents of the reservoir through the penetrating means when the piston is depressed.
6. A device according to Claim 5 .wherein the piston and plunger arrangement has an internal air duct which is opeti/tc*tKer atmosphere. :;IPEA/EP;sheet;.
7* A device according to Claim retracted so as to release said vac ium. 263619 6 or 7 wherein the piston is
8. A device according ,o any preceding claim, wherein the means whi ch penetrates the or each skin layer is moveable within the device.
9. A device according to Claim 8 when dependent on Claim 2, wherein actuation of the piston causes movement of the means Which penetrates the skin.
10. A device for administering intradermally a metered dose of a medicament in liquid form, substantially as hereinbefore described vdth particular reference to and as illustrated in the accompanying drawings. END OF CLAIMS AMENDED SHEET/ IPEA/EP /
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IE930274A IE68890B1 (en) | 1993-04-08 | 1993-04-08 | Intradermal delivery device |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ263619A true NZ263619A (en) | 1997-06-24 |
Family
ID=11039936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ26361994A NZ263619A (en) | 1993-04-08 | 1994-04-07 | Intradermal metered injection device, has a needle with a circumferential vacuum which secures the device to skin |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0692989A1 (en) |
JP (1) | JPH08508901A (en) |
AU (1) | AU6436794A (en) |
CA (1) | CA2159588A1 (en) |
IE (1) | IE68890B1 (en) |
NZ (1) | NZ263619A (en) |
WO (1) | WO1994023777A1 (en) |
Families Citing this family (53)
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JP4054381B2 (en) * | 1996-09-17 | 2008-02-27 | デカ・プロダクツ・リミテッド・パートナーシップ | Drug delivery system by transfer |
US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6890553B1 (en) | 1999-07-08 | 2005-05-10 | Johnson & Johnson Consumer Companies, Inc. | Exothermic topical delivery device |
AU6076200A (en) | 1999-07-08 | 2001-01-30 | Johnson & Johnson Consumer Companies, Inc. | Exothermic bandage |
US7133717B2 (en) | 1999-08-25 | 2006-11-07 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery and diagnostic sampling |
US7113821B1 (en) | 1999-08-25 | 2006-09-26 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery |
US8465468B1 (en) | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
ES2239426T3 (en) * | 1999-12-03 | 2005-09-16 | Mattern, Udo | COMBINATION OF A DEVICE FOR THE INJECTION OF ANTIPARASITARIES IN DOMESTIC ANIMALS AND AN ANTIPARASITARY ACTIVE PRINCIPLE. |
US7404815B2 (en) | 2000-05-01 | 2008-07-29 | Lifescan, Inc. | Tissue ablation by shear force for sampling biological fluids and delivering active agents |
AU2001265056A1 (en) * | 2000-05-26 | 2001-12-11 | The Procter And Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
US6406456B1 (en) * | 2000-06-08 | 2002-06-18 | Avant Drug Delivery Systems, Inc. | Jet injector |
US7108681B2 (en) | 2000-10-16 | 2006-09-19 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
IT1320104B1 (en) * | 2000-11-27 | 2003-11-18 | Paolo Versini | INJECTOR DEVICE FOR MEDICAL AND COSMETIC TREATMENTS. |
US20040071734A1 (en) * | 2001-02-23 | 2004-04-15 | Nathalie Garcon | Novel vaccine |
US6663820B2 (en) | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
GB0108670D0 (en) * | 2001-04-06 | 2001-05-30 | Glaxosmithkline Biolog Sa | Novel device |
US6591124B2 (en) | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
EP1432466B1 (en) | 2001-09-12 | 2012-08-15 | Becton, Dickinson and Company | Microneedle-based pen device for drug delivery and method for using same |
US7429258B2 (en) * | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
JP4764626B2 (en) | 2002-05-06 | 2011-09-07 | ベクトン・ディキンソン・アンド・カンパニー | Method and device for controlling the pharmacokinetics of a drug |
WO2004024211A2 (en) * | 2002-09-12 | 2004-03-25 | Children's Hospital Medical Center | Method and device for painless injection of medication |
BRPI0414021B1 (en) | 2003-08-28 | 2023-09-26 | Becton, Dickinson And Company | INTRADERMAL INJECTION DEVICE |
JP2005087520A (en) * | 2003-09-18 | 2005-04-07 | Terumo Corp | Liquid medicine injector |
US8016811B2 (en) * | 2003-10-24 | 2011-09-13 | Altea Therapeutics Corporation | Method for transdermal delivery of permeant substances |
US7670314B2 (en) | 2004-02-17 | 2010-03-02 | Children's Hospital Medical Center | Injection device for administering a vaccine |
ES2820335T3 (en) | 2007-04-16 | 2021-04-20 | Corium Inc | Solvent Cast Microneedle Arrays Containing Active Agent |
WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
EP2566501B1 (en) | 2010-05-04 | 2019-03-13 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
JP5918752B2 (en) * | 2010-08-23 | 2016-05-18 | 南部化成株式会社 | Transdermal administration device and needle forming body used in the device |
DK2623146T3 (en) * | 2012-01-31 | 2017-01-23 | Trichoscience Innovations Inc | Injection devices |
US20130345638A1 (en) * | 2012-06-25 | 2013-12-26 | Flugen, Inc. | Multiple drug delivery device |
JP6037722B2 (en) * | 2012-08-27 | 2016-12-07 | 南部化成株式会社 | Needle |
MX2015008157A (en) | 2012-12-21 | 2016-02-22 | Corium Int Inc | Microarray for delivery of therapeutic agent and methods of use. |
CN105142711B (en) | 2013-03-12 | 2019-01-22 | 考里安国际公司 | Micro-protuberance applicator |
JP2016514133A (en) | 2013-03-15 | 2016-05-19 | コリウム インターナショナル, インコーポレイテッド | MICROARRAY CONTAINING FINE STRUCTURE CONTAINING NO POLYMER, MANUFACTURING METHOD AND USE METHOD |
EP4194028A1 (en) | 2013-03-15 | 2023-06-14 | Corium Pharma Solutions, Inc. | Multiple impact microprojection applicators |
CN105142695B (en) | 2013-03-15 | 2020-06-02 | 安进公司 | Body contour adaptable autoinjector device |
ES2908339T3 (en) | 2013-03-15 | 2022-04-28 | Corium Inc | Microarray for delivery of a therapeutic agent and methods of use |
ES2761580T3 (en) | 2013-03-15 | 2020-05-20 | Corium Inc | Microarrays for therapeutic agent delivery, methods of use and manufacturing methods |
WO2015138206A1 (en) * | 2014-03-10 | 2015-09-17 | 3M Innovative Properties Company | Micro-needle device |
TWI689326B (en) | 2014-08-06 | 2020-04-01 | 加拿大商複製細胞生命科學公司 | Injection devices |
EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
WO2016112361A1 (en) | 2015-01-08 | 2016-07-14 | University Of Washington | Systems and methods for inhibiting heterotopic ossification |
CN104524669A (en) * | 2015-01-14 | 2015-04-22 | 李洪湘 | Multi-syringe-needle adsorption injection needle |
EP3258988B1 (en) | 2015-02-17 | 2019-08-28 | Amgen Inc. | Drug delivery device with vacuum assisted securement and/or feedback |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
WO2017211628A1 (en) * | 2016-06-06 | 2017-12-14 | Sanofi-Aventis Deutschland Gmbh | Auto-injector device |
CN107213537A (en) * | 2017-08-01 | 2017-09-29 | 上海市第人民医院 | It is a kind of that servicing unit is precisely subcutaneously injected |
TWI674121B (en) * | 2018-08-30 | 2019-10-11 | 員全股份有限公司 | Mini micro needle syringe |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE596981C (en) * | 1931-10-30 | 1934-05-12 | Mario Demarchi Dr | Injection syringe |
US2743723A (en) * | 1954-06-03 | 1956-05-01 | George N Hein | Hypodermic injection apparatus |
NL276085A (en) * | 1961-03-20 | |||
GB1216813A (en) * | 1969-02-21 | 1970-12-23 | Shozo Narusawa | Transcutaneous injection device |
DE3019589A1 (en) * | 1974-11-19 | 1981-01-15 | Wolfgang Dr.Med. 1000 Berlin Wagner | Suction syringe has membrane pierced by hollow needle - after suction cut placed on skin and cover rotated |
-
1993
- 1993-04-08 IE IE930274A patent/IE68890B1/en not_active IP Right Cessation
-
1994
- 1994-04-07 JP JP6522956A patent/JPH08508901A/en active Pending
- 1994-04-07 AU AU64367/94A patent/AU6436794A/en not_active Abandoned
- 1994-04-07 CA CA 2159588 patent/CA2159588A1/en not_active Abandoned
- 1994-04-07 NZ NZ26361994A patent/NZ263619A/en unknown
- 1994-04-07 EP EP94912055A patent/EP0692989A1/en not_active Withdrawn
- 1994-04-07 WO PCT/IE1994/000020 patent/WO1994023777A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1994023777A1 (en) | 1994-10-27 |
JPH08508901A (en) | 1996-09-24 |
EP0692989A1 (en) | 1996-01-24 |
IE68890B1 (en) | 1996-07-24 |
CA2159588A1 (en) | 1994-10-27 |
AU6436794A (en) | 1994-11-08 |
IE930274A1 (en) | 1994-10-19 |
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