NZ239909A - Anti hiv agents containing glycoprotein cd-4 and dextrin sulphate - Google Patents

Anti hiv agents containing glycoprotein cd-4 and dextrin sulphate

Info

Publication number
NZ239909A
NZ239909A NZ239909A NZ23990991A NZ239909A NZ 239909 A NZ239909 A NZ 239909A NZ 239909 A NZ239909 A NZ 239909A NZ 23990991 A NZ23990991 A NZ 23990991A NZ 239909 A NZ239909 A NZ 239909A
Authority
NZ
New Zealand
Prior art keywords
agent
agents containing
hiv agents
anti hiv
containing glycoprotein
Prior art date
Application number
NZ239909A
Inventor
Donald Selwyn Davies
Jonathan Norden Weber
Original Assignee
Ml Lab Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ml Lab Plc filed Critical Ml Lab Plc
Publication of NZ239909A publication Critical patent/NZ239909A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The invention provides an agent against HIV and related viruses, in dosage unit form, comprising CD4 or a CD4-like material and a polyanionic anti-HIV agent, the content of CD4 or CD4-like material in the agent being less than the anti-virally effective dose of the CD4 or CD4-like material alone. It has been found that when the CD4 or CD4-like material is used together with a polyanionic anti-HIV agent, the combination is more effective against HIV infection than would be the case if the anti-viral effect was simply additive.
NZ239909A 1990-09-25 1991-09-23 Anti hiv agents containing glycoprotein cd-4 and dextrin sulphate NZ239909A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909020872A GB9020872D0 (en) 1990-09-25 1990-09-25 Pharmaceutical compositions and use thereof

Publications (1)

Publication Number Publication Date
NZ239909A true NZ239909A (en) 1993-02-25

Family

ID=10682731

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ239909A NZ239909A (en) 1990-09-25 1991-09-23 Anti hiv agents containing glycoprotein cd-4 and dextrin sulphate

Country Status (10)

Country Link
EP (1) EP0550529A1 (en)
JP (1) JPH06502846A (en)
AU (1) AU653962B2 (en)
CA (1) CA2092093A1 (en)
GB (1) GB9020872D0 (en)
IE (1) IE913341A1 (en)
NZ (1) NZ239909A (en)
PT (1) PT99058B (en)
WO (1) WO1992004909A1 (en)
ZA (1) ZA917596B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272261A (en) * 1989-01-11 1993-12-21 Merrell Dow Pharmaceuticals Inc. Preparation of sulfated polysaccharide fractions
GB9209874D0 (en) * 1992-05-07 1992-06-24 Ml Lab Plc Pharmaceutical compositions
FR2838649B1 (en) * 2002-04-19 2006-01-13 Commissariat Energie Atomique ANTI-HIV COMPOSITION, METHOD OF MANUFACTURE AND MEDICINAL PRODUCT

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293826A3 (en) * 1987-06-02 1989-05-10 Stichting REGA V.Z.W. Therapeutic and prophylactic application of sulfated polysaccharides against aids
DE3808353A1 (en) * 1988-03-12 1989-09-21 Basf Ag COMBINATIONS OF POLYSULFATED HEPARINES IN THE FIGHT AGAINST RETROVIRUS INFECTIONS
WO1989011860A1 (en) * 1988-06-10 1989-12-14 Biogen, Inc. Combinations of soluble t4 proteins and anti-retroviral agents and methods for treating or preventing aids, arc and hiv infection
WO1990000596A1 (en) * 1988-07-07 1990-01-25 The Trustees Of The University Of Pennsylvania Method of modulating virus-host cell interactions using carbohydrates and carbohydrate derivatives

Also Published As

Publication number Publication date
PT99058B (en) 1999-02-26
EP0550529A1 (en) 1993-07-14
JPH06502846A (en) 1994-03-31
PT99058A (en) 1992-08-31
IE913341A1 (en) 1992-02-25
CA2092093A1 (en) 1992-03-26
WO1992004909A1 (en) 1992-04-02
ZA917596B (en) 1992-05-27
AU653962B2 (en) 1994-10-20
AU8612791A (en) 1992-04-15
GB9020872D0 (en) 1990-11-07

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