NZ224756A - Heterocyclic compounds and pharmaceutical compositions - Google Patents

Heterocyclic compounds and pharmaceutical compositions

Info

Publication number
NZ224756A
NZ224756A NZ224756A NZ22475688A NZ224756A NZ 224756 A NZ224756 A NZ 224756A NZ 224756 A NZ224756 A NZ 224756A NZ 22475688 A NZ22475688 A NZ 22475688A NZ 224756 A NZ224756 A NZ 224756A
Authority
NZ
New Zealand
Prior art keywords
pharmaceutical compositions
heterocyclic compounds
diastereomers
enantiomers
oxides
Prior art date
Application number
NZ224756A
Inventor
Joachim Heider
Manfred Psiorz
Andreas Bomhard
Norbert Hauel
Berthold Narr
Klaus Noll
Jurgen Dammgen
Christian Lillie
Walter Kobinger
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NZ224756A publication Critical patent/NZ224756A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Gears, Cams (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cyclic amine derivatives of the formula <IMAGE> in which A, B, E, G, R, R1, R2, m and n are as defined in Claim 1, their enantiomers, their diastereomers, their N-oxides and their acid addition salts have useful pharmacological properties, in particular a bradycardic action. The novel compounds can be prepared by processes known per se.
NZ224756A 1987-05-25 1988-05-23 Heterocyclic compounds and pharmaceutical compositions NZ224756A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873717561 DE3717561A1 (en) 1987-05-25 1987-05-25 INDOL, ISOCHINOLINE AND BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF

Publications (1)

Publication Number Publication Date
NZ224756A true NZ224756A (en) 1991-02-26

Family

ID=6328351

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ224756A NZ224756A (en) 1987-05-25 1988-05-23 Heterocyclic compounds and pharmaceutical compositions

Country Status (21)

Country Link
EP (1) EP0292840B1 (en)
JP (1) JP2634190B2 (en)
KR (1) KR960009432B1 (en)
AT (1) ATE126225T1 (en)
AU (1) AU607765B2 (en)
CA (2) CA1330993C (en)
DD (1) DD284678A5 (en)
DE (2) DE3717561A1 (en)
DK (1) DK282188A (en)
ES (1) ES2076147T3 (en)
FI (1) FI94343C (en)
GR (1) GR3017550T3 (en)
HU (1) HU198201B (en)
IE (1) IE68842B1 (en)
IL (1) IL86477A (en)
IN (1) IN169514B (en)
NO (1) NO171017C (en)
NZ (1) NZ224756A (en)
PT (1) PT87567B (en)
SU (1) SU1561823A3 (en)
ZA (1) ZA883680B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3640641A1 (en) * 1986-11-28 1988-07-14 Thomae Gmbh Dr K NEW HETEROAROMATIC AMINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3835291A1 (en) * 1988-04-19 1989-11-02 Bayer Ag 1,3-DISUBSTITUTED PYRROLIDINES
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
IL89156A (en) * 1988-07-12 1993-05-13 Synthelabo Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics
EP0351283A1 (en) * 1988-07-12 1990-01-17 Synthelabo 2-[(4-Piperidinyl)methyl]-2,3-dihydro-1H-isoindole and 2,3,4,5-tetrahydro-1H-benzazepine derivatives, their preparation and therapeutical use
US4952692A (en) * 1989-04-04 1990-08-28 E. R. Squibb & Sons, Inc. Benzazepine derivatives
US4946840A (en) * 1989-04-06 1990-08-07 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US5356906A (en) * 1989-10-27 1994-10-18 The Du Pont Merck Pharmaceutical Company (N-phthalimidoalkyl) piperidines useful as treatments for psychosis
NZ235841A (en) * 1989-10-27 1993-03-26 Du Pont (n-phthalimidoalkyl) piperidine derivatives and pharmaceutical compositions
EP0497843A4 (en) * 1989-10-27 1992-09-23 The Du Pont Merck Pharmaceutical Company (n-phthalimidoalkyl) piperidines
EP0429341A3 (en) * 1989-11-20 1991-11-13 Rhone-Poulenc Sante Heterocyclic derivatives, their preparation and pharmaceuticals containing them
ATE441417T1 (en) 2002-12-20 2009-09-15 Glaxo Group Ltd BENZOADUAZEPINE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISEASES
FR2868776B1 (en) * 2004-04-13 2008-04-18 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE DERIVATIVES AND THE APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID
WO2007021308A1 (en) * 2005-08-12 2007-02-22 Astrazeneca Ab Metabotropic glutamate-receptor-potentiating isoindolones
AR059898A1 (en) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv DERIVATIVES OF 3-CIANO-PIRIDONA 1,4-DISUSTITUTED AND ITS USE AS ALLOSTERIC MODULATORS OF MGLUR2 RECEIVERS
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
MY152078A (en) 2007-09-14 2014-08-15 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
RU2512283C2 (en) 2008-11-28 2014-04-10 Янссен Фармасьютикалз, Инк. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EA020671B1 (en) 2009-05-12 2014-12-30 Янссен Фармасьютикалз, Инк. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF mGluR2 RECEPTORS
PT2430022E (en) 2009-05-12 2013-12-26 Janssen Pharmaceuticals Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
US9012448B2 (en) 2010-11-08 2015-04-21 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
RU2014109079A (en) 2011-08-12 2015-09-20 Бёрингер Ингельхайм Ветмедика Гмбх PHARMACEUTICAL COMPOSITION WITH MASKED TASTE
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
ME03518B (en) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
WO2015110435A1 (en) 2014-01-21 2015-07-30 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
JP6931456B2 (en) * 2017-04-03 2021-09-08 川崎化成工業株式会社 Photopolymerization sensitizer containing 2-haloalkoxy-6-substituted oxynaphthalene compound and 2-haloalkoxy-6-substituted oxynaphthalene compound

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2639718A1 (en) * 1976-09-03 1978-03-16 Thomae Gmbh Dr K NEW PHENYLAETHYLAMINE
DE3119874A1 (en) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS"
DE3418270A1 (en) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach NEW AMINOTETRAL DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3418271A1 (en) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3541811A1 (en) * 1985-11-27 1987-06-04 Thomae Gmbh Dr K NEW CYCLIC AMINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
EP0306375A1 (en) * 1987-08-07 1989-03-08 Synthelabo 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their use in therapy
IL89156A (en) * 1988-07-12 1993-05-13 Synthelabo Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics
FR2686339B1 (en) * 1992-01-22 1994-03-11 Adir Cie NOVEL NAPHTHALENIC AMIDES AND SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Also Published As

Publication number Publication date
EP0292840A2 (en) 1988-11-30
HUT46906A (en) 1988-12-28
NO171017C (en) 1993-01-13
NO882258D0 (en) 1988-05-24
HU198201B (en) 1989-08-28
IL86477A (en) 1992-07-15
DD284678A5 (en) 1990-11-21
NO171017B (en) 1992-10-05
DE3717561A1 (en) 1988-12-08
IL86477A0 (en) 1988-11-15
KR880013924A (en) 1988-12-22
JP2634190B2 (en) 1997-07-23
AU1656288A (en) 1988-12-01
CA1330993C (en) 1994-07-26
EP0292840A3 (en) 1990-04-11
EP0292840B1 (en) 1995-08-09
PT87567B (en) 1992-09-30
FI94343B (en) 1995-05-15
IE68842B1 (en) 1996-07-10
IE881559L (en) 1988-11-25
AU607765B2 (en) 1991-03-14
FI882418A0 (en) 1988-05-23
DK282188D0 (en) 1988-05-24
FI882418A (en) 1988-11-26
SU1561823A3 (en) 1990-04-30
KR960009432B1 (en) 1996-07-19
GR3017550T3 (en) 1995-12-31
DE3854280D1 (en) 1995-09-14
ZA883680B (en) 1990-01-31
PT87567A (en) 1989-05-31
IN169514B (en) 1991-11-02
DK282188A (en) 1988-11-26
ATE126225T1 (en) 1995-08-15
CA1287226C (en) 1991-08-06
JPS6445381A (en) 1989-02-17
NO882258L (en) 1988-11-28
ES2076147T3 (en) 1995-11-01
FI94343C (en) 1995-08-25

Similar Documents

Publication Publication Date Title
NZ224756A (en) Heterocyclic compounds and pharmaceutical compositions
MA21778A1 (en) PROCESS FOR OBTAINING N - (3-HYDROXY-4 PIPERIDINYL) DIHYDRO-BENZOFURANNE, DIHYDRO-2H-, BENZOPYRANNE OR DIHYDRO BENZODIOXIN) DERIVATIVES CARBOXAMIDE.
IL102093A0 (en) 1-methylcarbapenem derivatives,processes for the preparation thereof,and pharmaceutical compositions containing the same
DE3363545D1 (en) Substituted 1,4-dihydropyridines, method for their preparation and their use as pharmaceuticals
IL83850A (en) N-phenylalkyl-amino-alkyl-tetrahydronaphthalene or indane derivatives,their preparation and pharmaceutical compositions containing them
DE3864636D1 (en) AMID COMPOUNDS, METHOD FOR THEIR PRODUCTION AND COMPOSITION FOR THE ACTIVATION OF GASTROMOTORIC FUNCTIONS.
DE3264556D1 (en) Sulfimines, their salts and their preparation, and pharmaceutical compositions containing them
PL244610A1 (en) Process for preparing novel derivatives of benzazepine
HUT59399A (en) Process for producing substituted 3-aminosydnone imine derivatives and pharmaceutical compositions comprising same