AU607765B2 - Cyclic amine derivatives - Google Patents
Cyclic amine derivativesInfo
- Publication number
- AU607765B2 AU607765B2 AU16562/88A AU1656288A AU607765B2 AU 607765 B2 AU607765 B2 AU 607765B2 AU 16562/88 A AU16562/88 A AU 16562/88A AU 1656288 A AU1656288 A AU 1656288A AU 607765 B2 AU607765 B2 AU 607765B2
- Authority
- AU
- Australia
- Prior art keywords
- cyclic amine
- amine derivatives
- diastereomers
- enantiomers
- oxides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Gears, Cams (AREA)
- Valve-Gear Or Valve Arrangements (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Cyclic amine derivatives of the formula <IMAGE> in which A, B, E, G, R, R1, R2, m and n are as defined in Claim 1, their enantiomers, their diastereomers, their N-oxides and their acid addition salts have useful pharmacological properties, in particular a bradycardic action. The novel compounds can be prepared by processes known per se.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3717561 | 1987-05-25 | ||
DE19873717561 DE3717561A1 (en) | 1987-05-25 | 1987-05-25 | INDOL, ISOCHINOLINE AND BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
AU1656288A AU1656288A (en) | 1988-12-01 |
AU607765B2 true AU607765B2 (en) | 1991-03-14 |
Family
ID=6328351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU16562/88A Ceased AU607765B2 (en) | 1987-05-25 | 1988-05-24 | Cyclic amine derivatives |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0292840B1 (en) |
JP (1) | JP2634190B2 (en) |
KR (1) | KR960009432B1 (en) |
AT (1) | ATE126225T1 (en) |
AU (1) | AU607765B2 (en) |
CA (2) | CA1330993C (en) |
DD (1) | DD284678A5 (en) |
DE (2) | DE3717561A1 (en) |
DK (1) | DK282188A (en) |
ES (1) | ES2076147T3 (en) |
FI (1) | FI94343C (en) |
GR (1) | GR3017550T3 (en) |
HU (1) | HU198201B (en) |
IE (1) | IE68842B1 (en) |
IL (1) | IL86477A (en) |
IN (1) | IN169514B (en) |
NO (1) | NO171017C (en) |
NZ (1) | NZ224756A (en) |
PT (1) | PT87567B (en) |
SU (1) | SU1561823A3 (en) |
ZA (1) | ZA883680B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU624280B2 (en) * | 1989-11-20 | 1992-06-04 | Rhone-Poulenc Sante | Heterocyclic derivatives, their preparation and medicinal products containing them |
AU625817B2 (en) * | 1988-04-19 | 1992-07-16 | Bayer Aktiengesellschaft | 1,3-disubstituted pyrrolidines |
AU655406B2 (en) * | 1989-10-27 | 1994-12-22 | Du Pont Merck Pharmaceutical Company, The | (N-phthalimidoalkyl) piperidines |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3640641A1 (en) * | 1986-11-28 | 1988-07-14 | Thomae Gmbh Dr K | NEW HETEROAROMATIC AMINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
US4902684A (en) * | 1988-06-20 | 1990-02-20 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
EP0351283A1 (en) * | 1988-07-12 | 1990-01-17 | Synthelabo | 2-[(4-Piperidinyl)methyl]-2,3-dihydro-1H-isoindole and 2,3,4,5-tetrahydro-1H-benzazepine derivatives, their preparation and therapeutical use |
IL89156A (en) * | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
US4952692A (en) * | 1989-04-04 | 1990-08-28 | E. R. Squibb & Sons, Inc. | Benzazepine derivatives |
US4946840A (en) * | 1989-04-06 | 1990-08-07 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
US5356906A (en) * | 1989-10-27 | 1994-10-18 | The Du Pont Merck Pharmaceutical Company | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis |
WO1991006297A1 (en) * | 1989-10-27 | 1991-05-16 | The Du Pont Merck Pharmaceutical Company | (n-phthalimidoalkyl) piperidines |
BR0317483A (en) | 2002-12-20 | 2005-11-16 | Glaxo Group Ltd | Benzodiazepine derivatives for the treatment of neurological disorders |
FR2868776B1 (en) * | 2004-04-13 | 2008-04-18 | Servier Lab | NOVEL PROCESS FOR THE SYNTHESIS OF 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE DERIVATIVES AND THE APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID |
JP2009509921A (en) * | 2005-08-12 | 2009-03-12 | アストラゼネカ アクチボラグ | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators |
TWI417095B (en) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mglur2-receptors |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
CN101801951B (en) | 2007-09-14 | 2013-11-13 | 杨森制药有限公司 | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones |
ES2439291T3 (en) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | 3-Azabicyclo [3.1.0] hexyl derivatives as modulators of metabotropic glutamate receptors |
US8691813B2 (en) | 2008-11-28 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MX2011011962A (en) | 2009-05-12 | 2012-02-28 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors. |
ME01573B (en) | 2009-05-12 | 2014-09-20 | Addex Pharma Sa | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
AU2011328195B2 (en) | 2010-11-08 | 2015-04-02 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
JP5852666B2 (en) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor |
MX2014001556A (en) | 2011-08-12 | 2014-03-31 | Boehringer Ingelheim Vetmed | Taste masked pharmaceutical composition. |
JO3368B1 (en) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
JO3367B1 (en) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
PL3096790T3 (en) | 2014-01-21 | 2020-01-31 | Janssen Pharmaceutica, N.V. | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
KR20200036063A (en) | 2014-01-21 | 2020-04-06 | 얀센 파마슈티카 엔.브이. | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
JP6931456B2 (en) * | 2017-04-03 | 2021-09-08 | 川崎化成工業株式会社 | Photopolymerization sensitizer containing 2-haloalkoxy-6-substituted oxynaphthalene compound and 2-haloalkoxy-6-substituted oxynaphthalene compound |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6576486A (en) * | 1985-11-27 | 1987-06-04 | Dr. Karl Thomae Gmbh | Cyclic amine derivatives |
AU2047588A (en) * | 1987-08-07 | 1989-02-09 | Synthelabo | 2-((4-piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy |
AU2961789A (en) * | 1988-07-12 | 1990-01-18 | Synthelabo | Derivatives of 2-{(4-piperidinyl)methyl}-1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2639718A1 (en) * | 1976-09-03 | 1978-03-16 | Thomae Gmbh Dr K | NEW PHENYLAETHYLAMINE |
DE3119874A1 (en) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS" |
DE3418271A1 (en) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
DE3418270A1 (en) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW AMINOTETRAL DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
FR2686339B1 (en) * | 1992-01-22 | 1994-03-11 | Adir Cie | NOVEL NAPHTHALENIC AMIDES AND SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
-
1987
- 1987-05-25 DE DE19873717561 patent/DE3717561A1/en not_active Ceased
-
1988
- 1988-05-17 EP EP88107867A patent/EP0292840B1/en not_active Expired - Lifetime
- 1988-05-19 IN IN400/CAL/88A patent/IN169514B/en unknown
- 1988-05-20 CA CA000567464A patent/CA1330993C/en not_active Expired - Fee Related
- 1988-05-20 DD DD88315962A patent/DD284678A5/en not_active IP Right Cessation
- 1988-05-20 CA CA000567453A patent/CA1287226C/en not_active Expired - Lifetime
- 1988-05-23 FI FI882418A patent/FI94343C/en not_active IP Right Cessation
- 1988-05-23 NZ NZ224756A patent/NZ224756A/en unknown
- 1988-05-24 AT AT88107867T patent/ATE126225T1/en not_active IP Right Cessation
- 1988-05-24 DK DK282188A patent/DK282188A/en not_active Application Discontinuation
- 1988-05-24 ZA ZA883680A patent/ZA883680B/en unknown
- 1988-05-24 IL IL86477A patent/IL86477A/en unknown
- 1988-05-24 DE DE3854280T patent/DE3854280D1/en not_active Expired - Fee Related
- 1988-05-24 HU HU882647A patent/HU198201B/en not_active IP Right Cessation
- 1988-05-24 KR KR88006072A patent/KR960009432B1/en not_active IP Right Cessation
- 1988-05-24 SU SU884355736A patent/SU1561823A3/en active
- 1988-05-24 AU AU16562/88A patent/AU607765B2/en not_active Ceased
- 1988-05-24 ES ES88107867T patent/ES2076147T3/en not_active Expired - Lifetime
- 1988-05-24 NO NO882258A patent/NO171017C/en unknown
- 1988-05-24 IE IE155988A patent/IE68842B1/en not_active IP Right Cessation
- 1988-05-24 JP JP63126910A patent/JP2634190B2/en not_active Expired - Lifetime
- 1988-05-24 PT PT87567A patent/PT87567B/en not_active IP Right Cessation
-
1995
- 1995-09-28 GR GR950402663T patent/GR3017550T3/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6576486A (en) * | 1985-11-27 | 1987-06-04 | Dr. Karl Thomae Gmbh | Cyclic amine derivatives |
AU2047588A (en) * | 1987-08-07 | 1989-02-09 | Synthelabo | 2-((4-piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy |
AU2961789A (en) * | 1988-07-12 | 1990-01-18 | Synthelabo | Derivatives of 2-{(4-piperidinyl)methyl}-1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU625817B2 (en) * | 1988-04-19 | 1992-07-16 | Bayer Aktiengesellschaft | 1,3-disubstituted pyrrolidines |
AU655406B2 (en) * | 1989-10-27 | 1994-12-22 | Du Pont Merck Pharmaceutical Company, The | (N-phthalimidoalkyl) piperidines |
AU624280B2 (en) * | 1989-11-20 | 1992-06-04 | Rhone-Poulenc Sante | Heterocyclic derivatives, their preparation and medicinal products containing them |
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