NZ217432A - 3-amino-dihydrobenzo(b)pyran derivatives; sulphur analogues and pharmaceutical compositions - Google Patents
3-amino-dihydrobenzo(b)pyran derivatives; sulphur analogues and pharmaceutical compositionsInfo
- Publication number
- NZ217432A NZ217432A NZ217432A NZ21743286A NZ217432A NZ 217432 A NZ217432 A NZ 217432A NZ 217432 A NZ217432 A NZ 217432A NZ 21743286 A NZ21743286 A NZ 21743286A NZ 217432 A NZ217432 A NZ 217432A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compounds
- lower alkyl
- denotes
- sulphur
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Dental Preparations (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of the formula: <IMAGE> in which Z denotes oxygen or sulphur, R denotes hydrogen or lower alkyl, R1 denotes hydrogen, lower alkyl or aryl(lower alkyl), R2 denotes hydrogen, lower alkyl or aryl(lower alkyl) or R1 and R2 together denote alkylene having 4-6 C atoms, R3 denotes hydrogen, hydroxyl, lower alkoxy, aryl(lower alkoxy), acyloxy or aryloxy in compounds having the meaning sulphur for Z, R3 denotes hydroxyl, lower alkoxy, aryl(lower alkoxy), acyloxy or aryloxy in compounds having the meaning oxygen for Z and R3 is bonded in position 5 or 8 in compounds having the meaning oxygen for Z, and R4 and R5 independently of one another denote hydrogen, lower alkyl or halogen, and pharmaceutically acceptable salts thereof, or mono- or di-S-oxides of compounds of the formula I in which Z denotes sulphur. The compounds can be used as modulators for the receptors of the central nervous system, for example as serotonin receptor antagonists in the treatment of disorders of the central nervous system.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77206885A | 1985-09-03 | 1985-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ217432A true NZ217432A (en) | 1990-03-27 |
Family
ID=25093804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ217432A NZ217432A (en) | 1985-09-03 | 1986-09-02 | 3-amino-dihydrobenzo(b)pyran derivatives; sulphur analogues and pharmaceutical compositions |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0222996B1 (en) |
| JP (1) | JPS6259273A (en) |
| KR (1) | KR900003883B1 (en) |
| AT (1) | ATE63744T1 (en) |
| AU (1) | AU596113B2 (en) |
| DD (1) | DD249480A5 (en) |
| DE (1) | DE3679378D1 (en) |
| DK (1) | DK418486A (en) |
| ES (1) | ES2001923A6 (en) |
| FI (1) | FI86720C (en) |
| GR (1) | GR862239B (en) |
| HU (1) | HU202853B (en) |
| IL (1) | IL79920A (en) |
| NO (1) | NO863507L (en) |
| NZ (1) | NZ217432A (en) |
| PH (1) | PH22522A (en) |
| PT (1) | PT83300B (en) |
| ZA (1) | ZA866685B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957928A (en) * | 1986-06-26 | 1990-09-18 | Ciba-Geigy Corporation | Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds |
| US4801605A (en) * | 1986-08-29 | 1989-01-31 | Ciba-Geigy Corporation | 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans |
| SE8605504D0 (en) * | 1986-12-19 | 1986-12-19 | Astra Laekemedel Ab | NOVEL CHROMAN DERIVATIVES |
| EP0322361A3 (en) * | 1987-12-23 | 1990-01-24 | Ciba-Geigy Ag | Hydrogenated 1-benzooxacycloalkyl pyridine-carboxylic-acid compounds |
| DE68921175T2 (en) * | 1988-12-23 | 1995-06-14 | Beecham Group Plc | Benzopyran type compounds. |
| AU627027B2 (en) * | 1989-04-27 | 1992-08-13 | Pharmacia & Upjohn Company | Substituted 3-amino chromans |
| SE8904127D0 (en) * | 1989-12-07 | 1989-12-07 | Astra Ab | NEW BIOCYCLIC AMINO-SUBSTITUTED COMPOUNDS |
| US5420151A (en) * | 1989-12-22 | 1995-05-30 | Aktiebolaget Astra | Chroman derivatives |
| SE8904361D0 (en) | 1989-12-22 | 1989-12-22 | Astra Ab | NEW CHROMAN AND THIOCHROMAN DERIVATIVES |
| US5616610A (en) * | 1989-12-22 | 1997-04-01 | Astra Aktiebolag | (R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans |
| FR2660657B1 (en) * | 1990-04-09 | 1993-05-07 | Adir | NOVEL 3-AMINOCHROMANE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| US5273994A (en) * | 1990-04-09 | 1993-12-28 | Adir Et Compagnie | 3-aminochroman compounds |
| FR2678617B1 (en) * | 1991-07-01 | 1995-01-20 | Adir | NEW PROCESS FOR THE SYNTHESIS OF ENANTIOMERS OF 3-AMINO CHROMAN DERIVATIVES. |
| FR2681325B1 (en) * | 1991-09-16 | 1993-12-17 | Fabre Medicament Pierre | DERIVATIVES OF AMINOMETHYL-4 PIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION. |
| HRP920935A2 (en) * | 1991-10-08 | 1995-08-31 | Astra Ab | New therapeutically active compound |
| FR2689509B1 (en) * | 1992-04-01 | 1994-06-03 | Adir | NEW SPIRANIC DERIVATIVES OF 3-AMINO CHROMANE, THEIR PREPARATION METHODS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| SK281507B6 (en) * | 1992-11-30 | 2001-04-09 | Smithkline Beecham Plc | Use of benzopyron analogues, benzopyron analogues, methods of their preparation, and pharmaceuticals with their content |
| US7125904B2 (en) * | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3629289A (en) * | 1969-04-24 | 1971-12-21 | Parke Davis & Co | Chromanamines |
| US3607886A (en) * | 1969-04-24 | 1971-09-21 | Parke Davis & Co | Chromanamines |
| US4203895A (en) * | 1978-04-14 | 1980-05-20 | Warner-Lambert Company | Process for the preparation of cis-(±)-3,4-dihydro-N,N,2-trimethyl-2H-1-benzopyran-3-amine and intermediates produced thereby |
-
1986
- 1986-09-01 EP EP86112104A patent/EP0222996B1/en not_active Expired - Lifetime
- 1986-09-01 GR GR862239A patent/GR862239B/en unknown
- 1986-09-01 AT AT86112104T patent/ATE63744T1/en not_active IP Right Cessation
- 1986-09-01 PH PH34204A patent/PH22522A/en unknown
- 1986-09-01 DE DE8686112104T patent/DE3679378D1/en not_active Expired - Lifetime
- 1986-09-02 HU HU863786A patent/HU202853B/en not_active IP Right Cessation
- 1986-09-02 IL IL79920A patent/IL79920A/en unknown
- 1986-09-02 ES ES8601568A patent/ES2001923A6/en not_active Expired
- 1986-09-02 NO NO863507A patent/NO863507L/en unknown
- 1986-09-02 NZ NZ217432A patent/NZ217432A/en unknown
- 1986-09-02 DD DD86294093A patent/DD249480A5/en not_active IP Right Cessation
- 1986-09-02 DK DK418486A patent/DK418486A/en unknown
- 1986-09-02 ZA ZA866685A patent/ZA866685B/en unknown
- 1986-09-03 AU AU62317/86A patent/AU596113B2/en not_active Ceased
- 1986-09-03 PT PT83300A patent/PT83300B/en not_active IP Right Cessation
- 1986-09-03 KR KR1019860007357A patent/KR900003883B1/en not_active IP Right Cessation
- 1986-09-03 FI FI863558A patent/FI86720C/en not_active IP Right Cessation
- 1986-09-03 JP JP61206047A patent/JPS6259273A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR900003883B1 (en) | 1990-06-04 |
| IL79920A0 (en) | 1986-12-31 |
| EP0222996B1 (en) | 1991-05-22 |
| ZA866685B (en) | 1987-04-29 |
| ES2001923A6 (en) | 1988-07-01 |
| KR870003088A (en) | 1987-04-15 |
| DE3679378D1 (en) | 1991-06-27 |
| DK418486D0 (en) | 1986-09-02 |
| PT83300B (en) | 1989-05-12 |
| EP0222996A3 (en) | 1987-12-02 |
| HU202853B (en) | 1991-04-29 |
| FI863558A0 (en) | 1986-09-03 |
| FI86720C (en) | 1992-10-12 |
| GR862239B (en) | 1986-12-31 |
| IL79920A (en) | 1991-07-18 |
| FI863558A (en) | 1987-03-04 |
| DD249480A5 (en) | 1987-09-09 |
| FI86720B (en) | 1992-06-30 |
| AU596113B2 (en) | 1990-04-26 |
| HUT44771A (en) | 1988-04-28 |
| NO863507L (en) | 1987-03-04 |
| EP0222996A2 (en) | 1987-05-27 |
| AU6231786A (en) | 1987-03-05 |
| DK418486A (en) | 1987-03-04 |
| PH22522A (en) | 1988-10-17 |
| PT83300A (en) | 1986-10-01 |
| NO863507D0 (en) | 1986-09-02 |
| JPS6259273A (en) | 1987-03-14 |
| ATE63744T1 (en) | 1991-06-15 |
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