DK418486A - 3,4-DIHYDRO-2H- (1) - (BENZOPYRANE AND BENZOTHIOPYRANE) -3-AMINES AND SALTS THEREOF AND THEIR PREPARATION AND USE - Google Patents

3,4-DIHYDRO-2H- (1) - (BENZOPYRANE AND BENZOTHIOPYRANE) -3-AMINES AND SALTS THEREOF AND THEIR PREPARATION AND USE Download PDF

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Publication number
DK418486A
DK418486A DK418486A DK418486A DK418486A DK 418486 A DK418486 A DK 418486A DK 418486 A DK418486 A DK 418486A DK 418486 A DK418486 A DK 418486A DK 418486 A DK418486 A DK 418486A
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DK
Denmark
Prior art keywords
compounds
lower alkyl
denotes
aryl
sulphur
Prior art date
Application number
DK418486A
Other languages
Danish (da)
Other versions
DK418486D0 (en
Inventor
Alan J Hutchison
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK418486D0 publication Critical patent/DK418486D0/en
Publication of DK418486A publication Critical patent/DK418486A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Abstract

Compounds of the formula: <IMAGE> in which Z denotes oxygen or sulphur, R denotes hydrogen or lower alkyl, R1 denotes hydrogen, lower alkyl or aryl(lower alkyl), R2 denotes hydrogen, lower alkyl or aryl(lower alkyl) or R1 and R2 together denote alkylene having 4-6 C atoms, R3 denotes hydrogen, hydroxyl, lower alkoxy, aryl(lower alkoxy), acyloxy or aryloxy in compounds having the meaning sulphur for Z, R3 denotes hydroxyl, lower alkoxy, aryl(lower alkoxy), acyloxy or aryloxy in compounds having the meaning oxygen for Z and R3 is bonded in position 5 or 8 in compounds having the meaning oxygen for Z, and R4 and R5 independently of one another denote hydrogen, lower alkyl or halogen, and pharmaceutically acceptable salts thereof, or mono- or di-S-oxides of compounds of the formula I in which Z denotes sulphur. The compounds can be used as modulators for the receptors of the central nervous system, for example as serotonin receptor antagonists in the treatment of disorders of the central nervous system.
DK418486A 1985-09-03 1986-09-02 3,4-DIHYDRO-2H- (1) - (BENZOPYRANE AND BENZOTHIOPYRANE) -3-AMINES AND SALTS THEREOF AND THEIR PREPARATION AND USE DK418486A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77206885A 1985-09-03 1985-09-03

Publications (2)

Publication Number Publication Date
DK418486D0 DK418486D0 (en) 1986-09-02
DK418486A true DK418486A (en) 1987-03-04

Family

ID=25093804

Family Applications (1)

Application Number Title Priority Date Filing Date
DK418486A DK418486A (en) 1985-09-03 1986-09-02 3,4-DIHYDRO-2H- (1) - (BENZOPYRANE AND BENZOTHIOPYRANE) -3-AMINES AND SALTS THEREOF AND THEIR PREPARATION AND USE

Country Status (18)

Country Link
EP (1) EP0222996B1 (en)
JP (1) JPS6259273A (en)
KR (1) KR900003883B1 (en)
AT (1) ATE63744T1 (en)
AU (1) AU596113B2 (en)
DD (1) DD249480A5 (en)
DE (1) DE3679378D1 (en)
DK (1) DK418486A (en)
ES (1) ES2001923A6 (en)
FI (1) FI86720C (en)
GR (1) GR862239B (en)
HU (1) HU202853B (en)
IL (1) IL79920A (en)
NO (1) NO863507L (en)
NZ (1) NZ217432A (en)
PH (1) PH22522A (en)
PT (1) PT83300B (en)
ZA (1) ZA866685B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957928A (en) * 1986-06-26 1990-09-18 Ciba-Geigy Corporation Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (en) * 1986-12-19 1986-12-19 Astra Laekemedel Ab NOVEL CHROMAN DERIVATIVES
EP0322361A3 (en) * 1987-12-23 1990-01-24 Ciba-Geigy Ag Hydrogenated 1-benzooxacycloalkyl pyridine-carboxylic-acid compounds
ATE118492T1 (en) * 1988-12-23 1995-03-15 Beecham Group Plc BENZOPYRANT TYPE COMPOUNDS.
JPH04504721A (en) * 1989-04-27 1992-08-20 ジ・アップジョン・カンパニー Substituted 3-amino chromans
SE8904127D0 (en) 1989-12-07 1989-12-07 Astra Ab NEW BIOCYCLIC AMINO-SUBSTITUTED COMPOUNDS
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
SE8904361D0 (en) * 1989-12-22 1989-12-22 Astra Ab NEW CHROMAN AND THIOCHROMAN DERIVATIVES
US5616610A (en) * 1989-12-22 1997-04-01 Astra Aktiebolag (R)-5-carbamoyl-8-fluoro-3-N,N-disubstituted-amino-3,4-dihydro-2H-1-benzopyrans
FR2660657B1 (en) * 1990-04-09 1993-05-07 Adir NOVEL 3-AMINOCHROMANE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5273994A (en) * 1990-04-09 1993-12-28 Adir Et Compagnie 3-aminochroman compounds
FR2678617B1 (en) * 1991-07-01 1995-01-20 Adir NEW PROCESS FOR THE SYNTHESIS OF ENANTIOMERS OF 3-AMINO CHROMAN DERIVATIVES.
FR2681325B1 (en) * 1991-09-16 1993-12-17 Fabre Medicament Pierre DERIVATIVES OF AMINOMETHYL-4 PIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
HRP920935A2 (en) * 1991-10-08 1995-08-31 Astra Ab New therapeutically active compound
FR2689509B1 (en) * 1992-04-01 1994-06-03 Adir NEW SPIRANIC DERIVATIVES OF 3-AMINO CHROMANE, THEIR PREPARATION METHODS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
SK281507B6 (en) * 1992-11-30 2001-04-09 Smithkline Beecham Plc Use of benzopyron analogues, benzopyron analogues, methods of their preparation, and pharmaceuticals with their content
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607886A (en) * 1969-04-24 1971-09-21 Parke Davis & Co Chromanamines
US3629289A (en) * 1969-04-24 1971-12-21 Parke Davis & Co Chromanamines
US4203895A (en) * 1978-04-14 1980-05-20 Warner-Lambert Company Process for the preparation of cis-(±)-3,4-dihydro-N,N,2-trimethyl-2H-1-benzopyran-3-amine and intermediates produced thereby

Also Published As

Publication number Publication date
EP0222996B1 (en) 1991-05-22
ZA866685B (en) 1987-04-29
EP0222996A2 (en) 1987-05-27
ATE63744T1 (en) 1991-06-15
FI86720C (en) 1992-10-12
EP0222996A3 (en) 1987-12-02
KR870003088A (en) 1987-04-15
NZ217432A (en) 1990-03-27
DK418486D0 (en) 1986-09-02
AU6231786A (en) 1987-03-05
AU596113B2 (en) 1990-04-26
PT83300A (en) 1986-10-01
HU202853B (en) 1991-04-29
PT83300B (en) 1989-05-12
FI86720B (en) 1992-06-30
KR900003883B1 (en) 1990-06-04
ES2001923A6 (en) 1988-07-01
HUT44771A (en) 1988-04-28
NO863507D0 (en) 1986-09-02
FI863558A (en) 1987-03-04
FI863558A0 (en) 1986-09-03
IL79920A (en) 1991-07-18
NO863507L (en) 1987-03-04
IL79920A0 (en) 1986-12-31
PH22522A (en) 1988-10-17
GR862239B (en) 1986-12-31
DE3679378D1 (en) 1991-06-27
JPS6259273A (en) 1987-03-14
DD249480A5 (en) 1987-09-09

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