NZ211897A - Foamable biocide composition - Google Patents
Foamable biocide compositionInfo
- Publication number
- NZ211897A NZ211897A NZ21189785A NZ21189785A NZ211897A NZ 211897 A NZ211897 A NZ 211897A NZ 21189785 A NZ21189785 A NZ 21189785A NZ 21189785 A NZ21189785 A NZ 21189785A NZ 211897 A NZ211897 A NZ 211897A
- Authority
- NZ
- New Zealand
- Prior art keywords
- composition
- alcohol
- chlorhexidine
- amounts
- group including
- Prior art date
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
New Zealand Paient Spedficaiion for Paient Number £11 897
211897
©
o
Priority Date(s}:
Complete Specification Filed:*?| CEass: ■?, 5/ff
Ay.K3J//.S3T.
Publication Date: .... ?.9.APRJ98a.... P.O. Journal, No: . /i£.9.7.
NO DRAWINGS
NEW ZEALAND The Patents Act, 1953 COMPLETE SPECIFICATION "Foamable biocide composition"
We, SOLTEC RESEARCH PTY. LTD., a Company incorporated under the laws of Victoria, of 7 Brand Road, Scoresby, Victoria, Australia do hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement:
t)
(followed by 1A)
-lfl-
211897
FOAKABLE BIOCIDE COMPOSITION
BACKGROUND OF THE INVENTION
The present invention relates to a foamable biocidal composition.
The chemical control of bacteria and viruses is assuming increasing importance in the hospital and medical environment. Outbreaks of infections such as Methicillin resistant Staph Aureus are causing illness, death and even temporary closure of wards in some hospitals.
This situation has been exacerbated by the failure of many bacteria to respond to conventional antibiotics. Accordingly, the need for effective control of bacterial and virus organisms is assuming greatly increased significance.
In the case of hand and skin disinfection a biocidal agent needs to kill the widest possible range of microorganisms in the least possible time without toxicity, irritation or other hazard and have a long shelf life.
Typical of these biocides are chlorine, iodophors and organic chemicals such as chlorhexidine which are commonly employed in hospitals and surgeries. The most widely accepted form of safe, effective biocide is chlorhexidine gluconate in aqueous ethanol. A full
%
discussion of this product appears in the paper entitled
"Detergents compared with each other and with antiseptics "
as skin 'degerminating agents'" by H.A. Lily et al in
.. Vol 82, 1979.
Journal of Hygiene (U.K.)y Further technical disclosure of the product appears in Australian Patents Nos. 157,758 and 222,033. Conventionally, chlorhexidine is commercially supplied in a pump pack or manufactured by the hospital pharmacist as required.
Unfortunately,, however, in use alcoholic chlorhexidine has inherent difficulties including the following:
(1) Openable bottles of alcoholic chlorhexidine are subject to contamination both at the time of fitting the pump head and when the pump is being operated.
•
X
i
*v ' . " 211597
' 0
(2) The 60-70% aqueous ethanol system is highly flammable. Spillage from the plastic bottle or dispenser at any time could result in a fire.
(3) The mist as applied from pump dispensers is 5 a highly flammable mist. This could be highly dangerous since it is being sprayed directly onto the skin.
(4) The spray mist does not confine itself to the target area, wastage occurs due to overspray.
(5) The alcoholic lotion as sprayed on the skin
^ 10
is difficult to control due to its low viscosity. It tends '•<** to run off the skin and evaporate rapidly before being evenly distributed.
(6) The shelf life of pump packs of a volatile fluid such as alcohol is restricted by the fact that they
do not seal the pack perfectly and evaporation can occur over a period of time.
(7) The spray or lotion product is messy to use f since once one hand has been sprayed it must become
| contaminated as the pack is held to spray the other hand.
;* 20 Accordingly, it is well known that chlorhexidine
I
■J must be formulated very carefully to optimise its biocidal
I
performance. v
DESCRIPTION OF THE JNVENTION With the above difficulties in mind, the present 25 invention provides an improved composition containing alcoholic chlorhexidine in aerosol form which is easy and safe to use. In this respect, extensive research over several years was necessary on a variety "of differing types of compositions before the viability of an aerosol type became 30 apparent. ,•
Accordingly, a biocidal composition is provided
■M
comprising:
(a) an alcoholic chlorhexidine solution
(b) from .1 to 20% w/w of a quick break foaming agent
(c) from 3-30% w/w of an aerosol propellairfc=ajgd
. \MftR»8al
211897
optionally
(d) a corrosion inhibitor
The inclusion of a corrosion inhibitor is necessary where the compositionn is stored in metal containers which are typical of tin plate or aluminium to counteract the corrosive nature of chlorohexidine formulations. However, if be the container is to7Tion metal e.g. glass the inclusion of a corrosion inhibitor is not necessary.
As stated -the composition of the invention is an aerosol form. This is most appropriate for a biocide as it avoids or minimizes the conventional defects of contamination and spillage. Pressurized aerosol containers are readily available, have been extensively tested and are well accepted.
PREFERRED FEATURES OF THE INVENTION
In an effort to minimize the aforementioned difficulty-of overspray and early evaporation, a foaming agent was included, more particularly of a quick break foam variety. This has the ability of providing a thick ball of foam which disintegrates easily when spread. Proper coverage can be effected to the surface to be cleansed without premature evaporation. A general discussion of quick break foams can be found in Australian Patent 463,216. In a preferred embodiment of the present invention, a particular quick breakfoaming agent has been developed which has not been previously disclosed in this context.
This composition comprises
(a) an aliphatic alcohol preferably in amounts from 40-90% w/w composition more preferably 55-70 % w/w and most preferably 60% w/w,
(b) water preferably in amounts from 10-40 % w/w
(c) a fatty alcohol preferably in amounts from 5-10%
% w/w and
(d) a surface active agent preferably an ethoxylated
'
o/
21189 'i sorbitan ester (as emulsifier); typically in amounts f rom .1-15% w/w.
From the viewpoint of performance it was known from the paper of H.A. Lilly et al that aqueous ethanol of approximately 70% w/w ethanol concentration is the best vehicle for chlorhexidine and this is the preferred form for use in the present composition.
It is also well known that a base formulation of chlorhexidine in aqueous ethanol tends to degrease and dry out the skin when used regularly (e.g. AO times per shift) in the hospital environment. Thus, an emollient is optionally incorporated which would help prevent dehydration of the skin without hindering the performance of chlorhexidine. Emollients which are particularly preferred are lanolin and polyols selected from glycerol, propylene glycerol and sorbitol.'
Other examples of emollients are vinyl alcohol and polyvinyl pyrollidone.
.When considering the preferred requirement for 70% w/w ethanol, it was found that the composition may have an effect on the solubility characteristics of other additive" e.g. fatty alcohols, lanolin and organic acid salts. It is believed the other additives react with the chlorhexidine causing it to be, to some extent, either precipitated or inactivated. Nevertheless, such compositions are still found to be useful.
The chlorhexidine component will normally b6 present in amounts of from .1-10% w/w though larger concentrations were found to be possible but with deleterious effects on the efficiency of entire system. Preferred.forms of chlorhexidine are as a gluconate, diacetate, hydrochloride or other salts thereof.
Care should be taken to select a propellent most compatible to the entire system and in this respect the • propellant is preferably selected from a group comprising propane, butane, dichloro difluoro methane, dichloro tetra fluoro ethane, octafluoro cyclo butane. As mentioned the
propellant should be presenting amounts from 3 - 30%*vi/'vf ^ though preferably from about 5 to 15/4 w/w and more preferably from 8 to 10% w/w.
Where the container is metal it is necessary to incorporate a corrosion inhibitor. This became apparent when researching the invention as several working formulations were achieved which however were found to corrode tin plate or aluminium containers at extraordinary rates resulting in short shelf lives. Typical corrosion inhibitors were organic acid salts more preferably the salts of a group including sorbic acid and benzoic acid, for example sodium benzoate and potassium sorbate.
These inhibitors ere preferably present in amounts of from .1 to 15%w/v and more preferably for .1 to 3% w/w.
Thus, a typical formulation of the present invention_
is as follows:
211897
Propellant (e.g. propane, butane, dichloro difluoro methane, dichloro tetra fluoro ethane, octafluoro cyclo butane and mixtures thereof) 5 Chlorhexidine (as gluconate, diacetate,
hydrochloride and mixtures thereof, & other solts)
Fatty alcohol (e.g. cetyl, stearyl, lauryl, myristyl, palmityl and mixtures thereof) 10 Aliphatic alcohol (e.g. methyl, ethyl, isopropy1, butyl and mixtures thereof)
VJater
Polyol (e.g. glycerol, propylene glycol, sorbitol & low molecular weight polymers
1 s " thereof) ... ..
the salts of
Organic acid salt (e.g./sorbic acid or benzoic acid)
Surface active agent (e.g.
ethyoxylated sorbitan stearate, palmitate, 20 oleate, nonyl phenol ethoxylates,
fatty alcohol ethoxylates)
% w/w 3-30
.1 - 10
-10
40 - 90
1
40 10
\ .1-15
.1 - 15
a
% w/w
Particularly Preferred formulations
Chlorhexidine gluconate 20% 5.0
Cetyl stearyl alcohol 2.5
Ethoxylated sorbitan monostearate 0.5
Propylene glycol 3.0
Ethyl alcohol (95%) 57-0
Sodium benzoate 0.2
Purified water 22.8 Dichloro difluoro methane )
Dichloro tetrafluoro ethane ) blend 9.0
100.0
Chlorhexidine diacetate 1.0
Myristyl alcohol 3.0
Ethoxylated cetylalcohol 0.8
Glycerol 2.5
Isopropyl alcohol 60.0
Potassium sorbate 0.3
Purified water . 25.4
Butane/propane 7.0
lOO.b
Chlorhexidine gluconate 20% Myristyl alcohol Glycerol
Ethoxylated myristyl alcohol Ethyl alcohol 95%
1 Potassium , sorbate Purified water
Dichloro difluoro methane ) Dichloro tetrafluoro ethane )
97
The following are details of tests which were carried out of such formulations in which the formulation is identified by the Trade mark HEXIFOAM.
TEST A
A series of In-vitro tests were performed on "Hexifoam" to determine the efficacy of the Chlorhexidine within this formulation.
The tests were designed to establish whether any loss of biocidal activity of the chlorhexidine was occurring. Comparative evaluations were also performed utilizing "Hexifoam" (without Chlorhexidine) and unformulated non-alcohol Chlorhexidine Gluconate Standard.
The product was evaluated in a suspension test based on the principles outlined in BS.3286 under the following test conditions.
1:2 v/v, 1:4 v/v 1 minute, 2 minutes, 3 minutes
minutes Pseudomonas aeruginosa NCTC
6749
% Sheep Serum 106 - 107 orgs/ml.
Distilled Water with 10% Sheep
Serum
Nutrient Broth N.2, Lecithin,
Tween 80
Ambient
Product Dilutions: Contact Time;
Organism:
Organic Challenge: Inoculum Density: Product Diluent:
Inactivator:
Temperature:
2 11897
Results
Test Organism: Pseudomonas aeruginosa Sample Dilution/ Initial Surviving Organisms
Concent- Count per per ml.
ration ml lmin 2min 3min 5min
0
Hexifoam 1:2 Hexifoam without 1:2 Chlorhexidine
8.OxlO
8 .0x10
10 10 10
10 10 10
1 min 2 mins 3 mins
Hexifoam 1:4 3.9x10
Hexifoam without 1:4 3.9x10*
Chlorhexidine Chlorhexidine 0.25% 5.0x10* Gluconate
10
1,500,000 800,000 500,000
10
o
Notes
1 At 1:4 dilution of Hexifoam the concentration of Chlorhexidine "is 0.25%.
2 ' / 1 indicates less than
Less than 10 is the detection 25 sensitivity of the test method i.e. no surviving organisms detected.
Conclusion«
The results have indicated that a dilution of the 30 product Hexifoam of 1:4 v/v continues to demonstrate excellent biocidal properties while the base material without chlorhexidine fails to show any significant
■«$s? v
" /
biocidal properties. This is indicative of little or no loss of activity of the chlorhexidine within the formulation.
The comparative tests with Chlorhexidine Gluconate standard at 0.25% confirmed that the biocidal activity under the above test conditions was found to be equivalent.
The product Hexifoam has shown very rapid biocidal action against the organisms Pseudomonas aeruginosa and Staphylococcus aureus (Our Ref N 17,614). Complete kill of the test organisms was achieved within 1 minute in the in-vitro tests performed to date.
TEST B
A sample of "Hexifoam" was received at the laboratory to be evaluated for its biocidal properties against the organism Staphylococcus aureus.
The product was evaluated in a suspension test in ccordance with the principles outlined in BS. 3286 under the following test conditions.
Product Dilution: Contact Time: Organism:
Organic Challenge: Inoculum Density: Product Diluent:
Inactivator:
Temperature:
Initial count 1 Min.
1:2 v/v
1 minute, 2 minutes, 5 minutes Staphylococcus aureus 4163 10% Sheep Serum 10^ orgs/ml.,
Standard Hard Water - 10% Sheep
Serum
Nutrient Broth No. 2 Lecithin
Tween 80
Ambient
Final Count per ml *
2 Mins. 5 Mins.
2.0 x lO
Less than 10
Less than 10 Less than 10
The Kill Factor achieved in all cases was greater than 2.0 x 105
* Results presented are Geometric Means of duplicate tests.
f .,
211897
TEST C
The product Heixifoam batch 4073 was evaluated for its biocidal activity using a suspension test based on the principles outlined in British Standard BS.3286. The 5 results obtained are as follows:-Product: Hexifoam
Test Organism: C.albicans ATCC 10231
Product Dilution: 1:2 w/v
Diluent: Distilled water with 10% sheep serum
Organic Challenge: 10% sheep serum Temperature: Ambient
Contact Time: One Minute
Inactivator: Nutrient Broth No. 2 (Oxoid) with lecithin and tween 80.
Initial Count Final Count Kill Factor % Kill
3.7 x 106 Less than 10 Greater Greater than than 99.99973
3.7 x 105
Notes
!• Results presented are geometric means of duplicate results.
2. Kill factor is defined as the ratio of initial, count versus final count.
3. A kill factor of 10^ is regarded as significant 25 biocidal activity.
TEST D
The product Hexifoam batch 4073 was evaluated for its biocidal activity using a suspension "test based on the principles outlined in British Standard BS.3286. The
results obtained are as follows: —
\
e
Product:
Test Organism: Product Dilution: Diluent:
Organic challenge: Temperature: Contact Time: Inactivator:
Initial Count orgs/ml.
Hexifoam
E.coli NCTC 8196 1:2 w/v
Distilled water with 10% Sheep serum 10% Sheep serum Ambient One minute
Nutrient broth No. 2 (Oxoid) with lecithin and tween 80.
Final Count Kill Factor % Kill orgs/ml.
6.7 x 10
Less than 10
Greater than 6.7x105
Greater than 99.99986
Notes:
Results presented are geometric means of duplicate results.
Kill factor is defined as the ratio of initial count versus final count.
A kill factor of 10 biocidal activity.
is regarded as significant
TEST E
The product Hexifoam batch 4073 was evaluated for its biocidal activity using a suspension test based on the principles outlined in British Standard BS.3286. The results obtained are as follows:- <■
Product:
Test Organism: Product Dilution: Diluent:
Organic Challenge: Temperature: Contact Time: Inactivator:
Hexifoam
S.typhirourium (clinical isolate) 1:2 w/v
Distilled water with 10% sheep serum 10% sheep serum
Ambient ,
One Minute
Nutrient broth No. 2 (Oxoid) with lecithin and tween 80.
s.K -
C
Initial Count Orgs/ml.
-3 3-
Final Count Kill Factor % Kill Orgs/ml.
211897
^40
than 99.99986
,5
6.7 x 10 Less than Greater Greater than
6.7 x 10*
Notes
1. Results presented are geometric means of duplicate results.
2. Kill factor as defined as the ratio of initial count versus final count.
3. A kill factor of 10^ is regarded as significant biocidal activity.
jl 5
TEST F
The product Hexifoam Batch 4073 was evaluated for its biocidal activity using a suspension test based on the principles outlined in British Standard BS.3286. The results obtained are as follows
Product:
Test Organism:
Product Dilution: Diluent:
Temperature: Contact Time: Inactivator:
Initial Count
4.6 x lO*
Hexifoam
S.aureus (Methicilli n Resistant, Clinical Isolate) 1:2 w/v
Sterile Distilled Water with 10% Sheep Serum.
Ambient One Minute *
Nutrient Broth No.2 (Oxoid) with
Lecithin and Tween 80.
Final Count Kill Factor % Kill (Orgs/ml.)
Less than 10
Greater than
4.6 x 10£
Greater than 99.995454
*•' ■
■ '•*' •v
Notes:
Results presented are geometric means of duplicate results.
Kill factor is defined as the ratio of initial count versus final count.
A Kill Factor of 10^ is regarded as significant biocidal activity.
0
TEST G
The product Hexifoam Batch 4073 was evaluated for its biocidal activity using a suspension test based on the principles outlined in British Standard BS.3286. The results obtained are as follows:-
Product:
Test Organism: Product" Dilution: Diluent:
Organic Challenge: Temperature: Contact Time: Inactivator:
Initial Count Orgs/ml.
Hexifoam
T.rubrum (clinical isolate)
1:2 w/v
Distilled Water with 10% Sheep Serum 10% Sheep Serum Ambient 5 minutes
Nutrient Broth No.2 (Oxoid) with lecithin and Tween 80 Final Count Kill Factor % Kill Orgs/ml.
1.0 x 10
Notes
2.
Less than 10
Greater than Greater
,6
1.0 x 10
than 99.9999
Results presented are geometric means of duplicate results.
Kill factor is defined as the ratio of initial count versus final count. *
2 II
-1 5-
TEST H
Hexifoam was evaluated in our laboratory in a short, preliminary in-vivo trial using various dosages and exposure times against Pseudomonas aeruginosa NCTC 6749. Experimental Design
Two volunteers from our laboratory were used. For the duration of the experiment the hands of the personnel were allowed to be washed only with traditional bar soap. No chlorhexidine based products such as our standard laboratory scrub were used to ensure there was no build up of chlorhexidine on the skin. The time interval between Hexifoam trials was at least three days.
Fresh 24 hour suspension cultures of P. aeruginosa NCTC 6749 were utilised for each trial. Cultures were grown in Wright and Mundy broth (Difco) for 24 hours at 37°C.
One ml. of P.aeruginosa representing at least g
1 x 10 cells was applied to the palm of one hand. This was then carefully rubbed over the surface of both hands. No culture was allowed to be dropped from the hands during this operation. If so the trial was declared void at that time, the person washed their hands and the inoculation was repeated after a break of at least two hours. The culture was allowed to dry completely on the hands before application of Hexifoam.
Hexifoam was weighed on to a plastic square and then applied to the hands. This procedure ensured accurate dosage by weight. The Hexifoam was rubbed over the entire surface of the hands. Exposure time was monitored with a stop watch. At the end of the allocated exposure time the hands were placed into 500 ml. of inactivator solution comprising 3% tween 80, 2% lecithin. For one minute the hands were scrubbed in the inactivator solution to release any surviving P.aeruginosa into the liquid.
Trial Weight of Exposure
Description Hexifoam Used Time
(g) (sec)
Recovery Control 0 0
Test 11 30
Test 2 2 30
Test 3 2 60
Results
Recovery Control
Culture Count onto Hands Total Cells
Control Recovery Total Cells
Volunteer 1 2
% Recovery
Volunteer 1 2
Geometric Mean % Recov-
2.8 x 10"
.5 x 106 21.0 x 106
0.196 0.750 0.384
0.384% is used to calculate the expected recovery in all Hexifoam trials. This adjusts for culture variation and is needed to calculate reductions achieved.
Hexifoam Trials
Trial
Description
1 g 30 Sec
2 g 30 Sec 2 g 60 Sec
Culture Count onto Hands Total Cells (y) 3.1 x 109 2.6 x 109 4.3 x 109
Recovery Total Cells
Volunteer 1 2
1.3 x 106 3.2 x 106 5.0 x 105 5.5 x 105 2.55 x 104 11.5 x 10"4
Trial
Description
Geometric mean
Recovery
Calculat ed
Recovery 0.384% X y
211897
Mean Log
Reduct
Kill ion
1
g
Sec
2
.03
X
106
11 .
9
X
!06
0
.768
82.95
2
g
Sec
.24
X
105
.
0
X
106
1
.281
94.76
2
g
60
Sec
. A
X
104
16.
X
106
2
.485
99.67
The foamable compositions within the present invention improve over prior chlorhexidine products commercially available as follows
(1) As a pressurised aerosol the pack cannot become internally contaminated.
(2) The aerosol cannot spill and therefore represents' no fire hazard.
(3) The foam, as dispensed, is very hard to ignite and will not readily burn as does a spray,
presenting a much reduced hazard.
(A) The foam is easily handled and does not .
allow any waste due to overspray.
(5) The foam as developed is of a fast breaking variety. When applied to the skin it is a stable lump, but body heat or friction cause it to melt and spread onto the skin in a unique, controllable, and fast dispersing manner.
(6) The shelf life of the aerosol is good and •with some formulation is probably in excess of five years almost irrespective of the storage environment.
(7) Since a ball of foam can be held in one hand the pack only needs to be touched once and the treated hands never need "to come into contact with it.
Quite unexpectedly, having regard to the prior research carried out the stated combination has in testing exceeded performance expectation. Further, as disclosed initial microbiological tests have shown' the compositions retain the full broad specrum of activity of chlorhexidine
/• <?.
_ wprw*
* *897
and to be surprisingly fast acting, killing 99% plus of M.R.S.A. in less than sixty seconds. This result is clearly superior to conventional chlorhexidine compositions.
O
0
'Si '
- - ' 211897
Claims (16)
1. A biocidal composition comprising: '(a) an alcoholic chlorhexidine solution (b) from .1 to 20% w/w of a quick breaking foaming agent (c) from 3 to 30% w/w of an aerosol propellant and optionally (d) a corrosion inhibitor
2. The composition of claim 1 wherein the chlorhexidine solution is present in amounts from .1 to 10% w/w.
3. The composition of claim 1 wherein the chlorhexidine in solution is in the form of a gluconate, diacetate, hydro chloride or mixtures thereof.
4. The composition of claim 1 wherein the foaming agent comprises an aliphatic alcohol, water, a fatty alcohol and a surface active agent.
5. The composition of claim 4 wherein the aliphatic alcohol is present in amounts of from 40 - 90% w/v water is present in-amounts from 10 - 40% w/w, the fatty alcohol is present in amounts of from 0.5 - 10% w/w and the surface active agenTJ ethoxylated sorbitan ester present in amounts of from 0.1 - 15% w/w.
6. The composition of claim 4 wherein the aliphatic alcohol is selected from the group including methanol, ethanol, isopropanol and butanol and mixtures thereof.
7. The composition of claim 4 wherein the fatty alcohol is selected from the group including cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol, palmityl alcohol and mixtures thereof. is_ . : . tttNRW88
V -20- 21189V 6. The composition of claim A wherein the surface active agent is selected from the group including ethoxylated sorbitan stearate, palmitate, oleate, nonyl phenol ethoxylates, fatty alcohol ethoxylates and mixtures thereof.
9. The composition of claim 1 wherein the propellant is selected from the group including propane, butane, dichlorodifluoro methane, dichloro tetra fluoro ethane, octafluoro cyclo butane and mixtures thereof.
10. The composition of claim 1 wherein the corrosion inhibitor is present in amounts of from .1 - 15% w/w. »
11. The composition of claim 1 wherein the corrosion inhibitor is an organic acid salt.
12. The composition of claim 11 wherein the organic acid SSlt^S of 3 salt is selected from th^/group including sorbic acid, benzoic acid, mixtures thereof and soluble forms thereof.
13. The composition of claim 12 wherein the organic acid salt is present in an amount of from 0.1 to 3% w/w.
14. The composition of claim 1 further including an emollient.
15. The composition of claim 13 wherein the embollient is ^ selected from the group including lanolin, polyols selec*^sd*T 0 t'/ Y : from the group including glycerol, propylene glycol, sorbitol, vinyl'alcohol and polyvinylpyrrolidone. Kj ^ \\ ^ W V- *n ^ V
16. A biocidal composition comprising: (a) 0.1 to 10% w/w of chlorhexidine (b) 0.1 to 20% w/w of a quick breaking foam -21- compr is ing (1) 40 to 90% w/w of an aliphatic alcohol (2) 0.5 to 10% w/w' of a fatty alcohol (3) 10 to 40% w/w water and (A) O.l to 15% w/vof an ethoxylated sorbitan ester (c) 3 to 30% w/w of an aerosol propellant and optionally <d) 0-1 — 15% w/w corrosion inhibitor. & S0LTEC RESEARCH PTY. LTD. By Thei^/AttoJrneys HENRY HUGHES LIMITED By: •WljW " " •
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ21189785A NZ211897A (en) | 1985-04-24 | 1985-04-24 | Foamable biocide composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ21189785A NZ211897A (en) | 1985-04-24 | 1985-04-24 | Foamable biocide composition |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ211897A true NZ211897A (en) | 1988-04-29 |
Family
ID=19921183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ21189785A NZ211897A (en) | 1985-04-24 | 1985-04-24 | Foamable biocide composition |
Country Status (1)
Country | Link |
---|---|
NZ (1) | NZ211897A (en) |
-
1985
- 1985-04-24 NZ NZ21189785A patent/NZ211897A/en unknown
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