NO994679L - Quinoline-2-carboxylic acid derivative and its use as excitatory amino acid antagonist - Google Patents
Quinoline-2-carboxylic acid derivative and its use as excitatory amino acid antagonistInfo
- Publication number
- NO994679L NO994679L NO994679A NO994679A NO994679L NO 994679 L NO994679 L NO 994679L NO 994679 A NO994679 A NO 994679A NO 994679 A NO994679 A NO 994679A NO 994679 L NO994679 L NO 994679L
- Authority
- NO
- Norway
- Prior art keywords
- quinoline
- excitatory amino
- carboxylic acid
- amino acid
- antagonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
(+) enantiomer av E 4-(4-acetylaminofenylkarbamoylmetylen)-5,7-diklor- 1,2,3,4-tetrahydroquinolin 2-karboksylsyre og salt derav som er antagonist av eksitatoriske aminosyrer, fremgangsmåter for fremstilling derav, farmasøytiske blandinger inneholdende disse og anvendelse i legemidler er beskrevet.(+) Enantiomers of E 4- (4-acetylaminophenylcarbamoylmethylene) -5,7-dichloro-1,2,3,4-tetrahydroquinoline 2-carboxylic acid and salt thereof which are antagonist of excitatory amino acids, processes for their preparation, pharmaceutical compositions containing these and use in drugs are described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9706294.7A GB9706294D0 (en) | 1997-03-26 | 1997-03-26 | Heterocyclic compound |
PCT/EP1998/001700 WO1998042673A1 (en) | 1997-03-26 | 1998-03-24 | Quinoline-2-carboxylic acid derivative and its use as excitatory amino acids antagonist |
Publications (2)
Publication Number | Publication Date |
---|---|
NO994679D0 NO994679D0 (en) | 1999-09-24 |
NO994679L true NO994679L (en) | 1999-11-24 |
Family
ID=10809909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO994679A NO994679L (en) | 1997-03-26 | 1999-09-24 | Quinoline-2-carboxylic acid derivative and its use as excitatory amino acid antagonist |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0971896A1 (en) |
JP (1) | JP2001518901A (en) |
KR (1) | KR20010005567A (en) |
CN (1) | CN1257482A (en) |
AP (1) | AP9901659A0 (en) |
AU (1) | AU731394B2 (en) |
BR (1) | BR9808424A (en) |
CA (1) | CA2284710A1 (en) |
EA (1) | EA199900755A1 (en) |
GB (1) | GB9706294D0 (en) |
HU (1) | HUP0001661A3 (en) |
ID (1) | ID24306A (en) |
IL (1) | IL131919A0 (en) |
IS (1) | IS5186A (en) |
NO (1) | NO994679L (en) |
NZ (1) | NZ337793A (en) |
PL (1) | PL335865A1 (en) |
TR (1) | TR199902315T2 (en) |
WO (1) | WO1998042673A1 (en) |
YU (1) | YU47699A (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9917822D0 (en) * | 1999-07-29 | 1999-09-29 | Imperial College | Nmda antagonist |
DE10132725A1 (en) | 2001-07-05 | 2006-08-03 | Grünenthal GmbH | Substituted γ-lactone compounds |
DE10137487A1 (en) * | 2001-08-03 | 2003-03-27 | Gruenenthal Gmbh | Substituted 5,6,6a, 11b-tetrahydro-7-oxa-6-aza-benzo [c] fluorene-6-carboxylic acid derivatives |
DE10306202A1 (en) * | 2003-02-13 | 2004-08-26 | Grünenthal GmbH | 2-(hetero)aryl-2-(N-((hetero)aryl)-amino)-acetic acid derivatives useful e.g. for treating anxiety, inflammation, allergy, depression, diarrhea or especially pain is NMDA antagonist |
JP4360891B2 (en) | 2003-12-09 | 2009-11-11 | アルパイン株式会社 | Electronic device having broadcast receiving function and display method of electronic program guide in the device |
RU2451014C2 (en) * | 2005-07-22 | 2012-05-20 | Мотида Фармасьютикал Ко., Лтд. | Novel heterocyclidene acetamide derivative |
BRPI0613771B1 (en) * | 2005-07-22 | 2021-11-23 | Mochida Pharmaceutical Co., Ltd | COMPOUND DERIVED FROM HETEROCYCLIDENE ACETAMIDE, PHARMACEUTICAL COMPOSITION AND TYPE I VANILOID RECEIVER ANTAGONIST WITH TRANSIENT RECEPTOR POTENTIAL (TRPV1) |
US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
RU2020100230A (en) | 2017-06-12 | 2021-07-13 | Глитек Ллс. | TREATMENT OF DEPRESSION WITH NMDA ANTAGONISTS AND D2 / 5-HT2A ANTAGONISTS OR SELECTIVE 5-HT2A ANTAGONISTS |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL93610A0 (en) * | 1989-03-08 | 1990-12-23 | Merck Sharp & Dohme | Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them |
WO1997012870A1 (en) * | 1995-09-29 | 1997-04-10 | Glaxo Wellcome S.P.A. | Tetrahydroquinolines as nmda antagonists |
GB9617305D0 (en) * | 1996-08-17 | 1996-09-25 | Glaxo Wellcome Spa | Heterocyclic compounds |
-
1997
- 1997-03-26 GB GBGB9706294.7A patent/GB9706294D0/en active Pending
-
1998
- 1998-03-24 YU YU47699A patent/YU47699A/en unknown
- 1998-03-24 PL PL98335865A patent/PL335865A1/en unknown
- 1998-03-24 KR KR1019997008630A patent/KR20010005567A/en not_active Application Discontinuation
- 1998-03-24 CA CA002284710A patent/CA2284710A1/en not_active Abandoned
- 1998-03-24 AU AU72094/98A patent/AU731394B2/en not_active Ceased
- 1998-03-24 BR BR9808424-0A patent/BR9808424A/en not_active IP Right Cessation
- 1998-03-24 JP JP54323498A patent/JP2001518901A/en active Pending
- 1998-03-24 NZ NZ337793A patent/NZ337793A/en unknown
- 1998-03-24 HU HU0001661A patent/HUP0001661A3/en unknown
- 1998-03-24 IL IL13191998A patent/IL131919A0/en unknown
- 1998-03-24 EP EP98919133A patent/EP0971896A1/en not_active Withdrawn
- 1998-03-24 WO PCT/EP1998/001700 patent/WO1998042673A1/en not_active Application Discontinuation
- 1998-03-24 CN CN98805302A patent/CN1257482A/en active Pending
- 1998-03-24 TR TR1999/02315T patent/TR199902315T2/en unknown
- 1998-03-24 AP APAP/P/1999/001659A patent/AP9901659A0/en unknown
- 1998-03-24 ID IDW991108A patent/ID24306A/en unknown
- 1998-03-24 EA EA199900755A patent/EA199900755A1/en unknown
-
1999
- 1999-09-17 IS IS5186A patent/IS5186A/en unknown
- 1999-09-24 NO NO994679A patent/NO994679L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TR199902315T2 (en) | 2000-05-22 |
CN1257482A (en) | 2000-06-21 |
ID24306A (en) | 2000-07-13 |
AU731394B2 (en) | 2001-03-29 |
HUP0001661A2 (en) | 2000-09-28 |
AP9901659A0 (en) | 1999-09-30 |
AU7209498A (en) | 1998-10-20 |
GB9706294D0 (en) | 1997-05-14 |
CA2284710A1 (en) | 1998-10-01 |
WO1998042673A1 (en) | 1998-10-01 |
JP2001518901A (en) | 2001-10-16 |
IL131919A0 (en) | 2001-03-19 |
NZ337793A (en) | 2001-02-23 |
BR9808424A (en) | 2000-05-23 |
YU47699A (en) | 2001-12-26 |
IS5186A (en) | 1999-09-17 |
HUP0001661A3 (en) | 2001-12-28 |
NO994679D0 (en) | 1999-09-24 |
EA199900755A1 (en) | 2000-08-28 |
EP0971896A1 (en) | 2000-01-19 |
KR20010005567A (en) | 2001-01-15 |
PL335865A1 (en) | 2000-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |