NO994614L - Motilinhomologer - Google Patents

Motilinhomologer

Info

Publication number
NO994614L
NO994614L NO994614A NO994614A NO994614L NO 994614 L NO994614 L NO 994614L NO 994614 A NO994614 A NO 994614A NO 994614 A NO994614 A NO 994614A NO 994614 L NO994614 L NO 994614L
Authority
NO
Norway
Prior art keywords
motilin
present
novel
new
polynucleotides
Prior art date
Application number
NO994614A
Other languages
Norwegian (no)
Other versions
NO994614D0 (en
Inventor
Paul O Sheppard
Theresa A Deisher
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/822,897 external-priority patent/US6380158B1/en
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of NO994614D0 publication Critical patent/NO994614D0/en
Publication of NO994614L publication Critical patent/NO994614L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Foreliggende oppfinnelse er rettet mot polynukleotider, polypep- tider og peptidfragtnenter derav, og an- vendelser derav for en ny cDNA-sekvens som har homologi til motilin. Vevsfor- deling av mRNA-en for det nye polypep- tid er spesifikk for magen, tynntarmen og bukspyttkjertelen. Foreliggende opp- finnelse omfatter videre agonister, antagonister, antistoffer, vertsceller som uttrykker den cDNA som koder for de nye motilinhomologene, og fremgangs- måter for økning av magemotilitet under anvendelse av de nye molekylene.The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence having homology to motilin. Tissue distribution of the mRNA for the new polypeptide is specific to the stomach, small intestine and pancreas. The present invention further encompasses agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs, and methods for enhancing gastric motility using the new molecules.

NO994614A 1997-03-24 1999-09-23 Motilinhomologer NO994614L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4110297P 1997-03-24 1997-03-24
US08/822,897 US6380158B1 (en) 1997-03-24 1997-03-24 Motilin homologs
PCT/US1998/005620 WO1998042840A1 (en) 1997-03-24 1998-03-23 Motilin homologs

Publications (2)

Publication Number Publication Date
NO994614D0 NO994614D0 (en) 1999-09-23
NO994614L true NO994614L (en) 1999-11-23

Family

ID=26717805

Family Applications (1)

Application Number Title Priority Date Filing Date
NO994614A NO994614L (en) 1997-03-24 1999-09-23 Motilinhomologer

Country Status (9)

Country Link
JP (1) JP4335318B2 (en)
KR (1) KR20010005701A (en)
CN (1) CN1170933C (en)
AU (1) AU726423B2 (en)
BR (1) BR9808059A (en)
CA (1) CA2284733C (en)
NO (1) NO994614L (en)
NZ (1) NZ337958A (en)
WO (1) WO1998042840A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627729B1 (en) 1997-03-24 2003-09-30 Zymogenetics, Inc. TML peptides
US6420521B1 (en) 1999-06-30 2002-07-16 Zymogenetics, Inc. Short gastrointestinal peptides
CA2377721A1 (en) * 1999-06-30 2001-01-04 Zymogenetics, Inc. Sgip peptides
PT1197496E (en) * 1999-07-23 2007-08-29 Kenji Kangawa Novel peptides
ATE435871T1 (en) 1999-11-22 2009-07-15 Zymogenetics Inc METHOD FOR FORMING A PEPTIDE RECEPTOR COMPLEX WITH ZSIG33 POLYPEPTIDES.
WO2001087933A2 (en) * 2000-05-11 2001-11-22 Zymogenetics, Inc. Zsig33-like peptides
US6897286B2 (en) 2000-05-11 2005-05-24 Zymogenetics, Inc. Zsig33-like peptides
US6967237B2 (en) 2000-05-30 2005-11-22 Merck & Co., Inc. Ghrelin analogs
EP1633774B1 (en) 2003-06-18 2010-02-17 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
CN101528765B (en) 2006-09-11 2015-04-22 欧塞拉治疗有限公司 Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
CN102574904B (en) * 2009-07-29 2014-11-26 第一三共株式会社 Motilin-like peptide compound having transmucosal absorbability imparted thereto
JP7049775B2 (en) 2017-04-03 2022-04-07 リンナイ株式会社 Display device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US5006469A (en) * 1988-02-09 1991-04-09 Oregon Health Sciences University Vectors and host cells expressing prepromotilin and motilin-associated peptide (MAP)
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
JPH04299990A (en) * 1991-03-27 1992-10-23 Sanwa Kagaku Kenkyusho Co Ltd Conversion to activated human motilin analog and purification of human motilin analog

Also Published As

Publication number Publication date
WO1998042840A1 (en) 1998-10-01
JP4335318B2 (en) 2009-09-30
NO994614D0 (en) 1999-09-23
AU6576998A (en) 1998-10-20
CN1170933C (en) 2004-10-13
KR20010005701A (en) 2001-01-15
CA2284733C (en) 2010-10-26
AU726423B2 (en) 2000-11-09
CN1254375A (en) 2000-05-24
JP2001513651A (en) 2001-09-04
CA2284733A1 (en) 1998-10-01
NZ337958A (en) 2001-03-30
BR9808059A (en) 2000-03-08

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