NO985810L - Enantiomer separation from chromanoic acid esters - Google Patents

Enantiomer separation from chromanoic acid esters

Info

Publication number
NO985810L
NO985810L NO985810A NO985810A NO985810L NO 985810 L NO985810 L NO 985810L NO 985810 A NO985810 A NO 985810A NO 985810 A NO985810 A NO 985810A NO 985810 L NO985810 L NO 985810L
Authority
NO
Norway
Prior art keywords
atoms
alcohols
substituted
eluents
alkanoyl
Prior art date
Application number
NO985810A
Other languages
Norwegian (no)
Other versions
NO985810D0 (en
Inventor
Ralf M Devant
Helmut Reubold
Michael Schulte
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO985810L publication Critical patent/NO985810L/en
Publication of NO985810D0 publication Critical patent/NO985810D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Pyrane Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

The invention relates to processes for the chromatographic separation of enantiomeric esters from 2-alkanoyl-chromane derivatives of the formula (I) in which Z is -(CH2)n1-(CHA)n2-(CH2)n3, where n1 = 0, 1, 2 or 3, n2 = 0 or 1, n3 = 0, 1, 2 or 3, with the proviso that n1 + n2 + n3 < 4, R<6>, R<7>, R<8> and R<9> are mutually independently H, A, OA, phenoxy, OH, F, Cl, Br, I, CN, CF3, NO2, NH2, NHA, NA2, Ac, Ph, cycloalkyl with 3 to 7 atoms, -CH2NH2, -CH2NHA, -CH2NA2, -CH2NHAc or -CH2NHSO2CH3, where two neighbouring radicals may also be an alkylene chain with 3 or 4 C atoms, A is alkyl with 1 to 6 C atoms, Ac is alkanoyl with 1 to 10 C atoms or aroyl with 7 to 11 C atoms, Ph is unsubstituted or R<5>, 2, 3 or 4-pyridyl or phenoxy-substituted phenyl, R<5> is unsubstituted or 1-5 F, CF3 or wholly or partially fluorine-substituted A, A and/or OA-substituted phenyl, by means of chromatography on sorbents containing aromatic carbamate-substituted polysaccharides, e.g. cellulose, especially cellulose-tris(3,5 dimethyl phenyl carbamate), using eluents containing C1 to C5 alcohols. Suitable eluents are C1 to C5 alcohols, especially methanol and ethanol or their mixtures. Preferred eluents are C1 to C5 alcohols and C1 to C10 hydrocarbons, especially mixtures of hexane or heptane with 2-propanol.
NO985810A 1996-06-14 1998-12-11 Enantiomer separation from chromanoic acid esters NO985810D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19623755 1996-06-14
PCT/EP1997/002314 WO1997047617A1 (en) 1996-06-14 1997-05-07 Enantiomer separation from chromane acid esters

Publications (2)

Publication Number Publication Date
NO985810L true NO985810L (en) 1998-12-11
NO985810D0 NO985810D0 (en) 1998-12-11

Family

ID=7796950

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985810A NO985810D0 (en) 1996-06-14 1998-12-11 Enantiomer separation from chromanoic acid esters

Country Status (17)

Country Link
EP (1) EP0906302B1 (en)
JP (1) JP2000512283A (en)
KR (1) KR20000016726A (en)
CN (1) CN1221413A (en)
AT (1) ATE203988T1 (en)
AU (1) AU2892497A (en)
BR (1) BR9709716A (en)
CA (1) CA2258032A1 (en)
DE (1) DE59704253D1 (en)
DK (1) DK0906302T3 (en)
ES (1) ES2162290T3 (en)
GR (1) GR3037032T3 (en)
NO (1) NO985810D0 (en)
PL (1) PL330422A1 (en)
PT (1) PT906302E (en)
SK (1) SK168298A3 (en)
WO (1) WO1997047617A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101328161B (en) * 2007-06-20 2011-09-14 北京德众万全药物技术开发有限公司 Method for separating and detecting nebivolol hydrochloride impurity by liquid phase chromatography
CN105218502B (en) * 2015-10-26 2017-12-15 浙江工业大学 A kind of method of asymmetric synthesis of chiral benzodihydropyran compound

Also Published As

Publication number Publication date
CA2258032A1 (en) 1997-12-18
DK0906302T3 (en) 2001-11-05
PL330422A1 (en) 1999-05-10
GR3037032T3 (en) 2002-01-31
BR9709716A (en) 1999-08-10
EP0906302B1 (en) 2001-08-08
KR20000016726A (en) 2000-03-25
NO985810D0 (en) 1998-12-11
PT906302E (en) 2002-01-30
JP2000512283A (en) 2000-09-19
CN1221413A (en) 1999-06-30
SK168298A3 (en) 1999-05-07
DE59704253D1 (en) 2001-09-13
ES2162290T3 (en) 2001-12-16
ATE203988T1 (en) 2001-08-15
WO1997047617A1 (en) 1997-12-18
AU2892497A (en) 1998-01-07
EP0906302A1 (en) 1999-04-07

Similar Documents

Publication Publication Date Title
DE60235900D1 (en) OSUPPRESSIVUM
ATE418534T1 (en) QUATERNARY AMMONIUM COMPOUNDS AND THEIR USE AS ANTIMUSCARINOMIC AGENTS
EA200100139A1 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING 2-CHINOLONES
SV2002000244A (en) METHODS AND COMPOUNDS TO INHIBIT MRP1 REF.X-13353
FR2379552A1 (en) ACTIVE MATRIX AND ACTIVATION METHOD FOR AFFINITY CHROMATOGRAPHY
NO985810L (en) Enantiomer separation from chromanoic acid esters
NO971384D0 (en) Pyrimidinylpyrazol derivative
EA199800792A1 (en) METHODS OF OBTAINING INTERMEDIATE CONNECTIONS FOR PESTICIDES
KR960703827A (en) SEPARATING AGENT FOR OPTICAL ISOMERS
FI963168A0 (en) New Indan-2-Mercaptoacetylamide Disulfide Derivatives Useful as Enkephalinase Inhibitors
CO4761036A1 (en) FUNGICIDE MIXTURES
DE69909091D1 (en) CHIRAL STATIONARY PHASES FOR THE SEPARATION OF ENANTIOMERS AND THEIR PRODUCTION
JP3121072B2 (en) Optical isomer separating agent bound to conalbumin
BR9809685B1 (en) fungicidal mixture, process for controlling harmful fungi, use of a compound, and composition.
BR9611789A (en) Process for the preparation of methoxy-phenylglyoxylic acid derivatives
AU662299B2 (en) Crystallization of optical isomers of leukotriene antagonists
PT909760E (en) NEW ESTROBILURINE ANALOGS WHICH HAVE FUNGICIDAL PROPERTIES AND THEIR APPLICATION FOR THE CONTROL OF PHYTOPATHOGENIC FUNGI
AR006861A1 (en) SYNERGIC FUNGICIDE MIXTURES, USEFUL TO COMBAT PHYTOPATHOGEN FUNGI, APPLICATION PROCEDURE FOR SUCH MIXTURES AND THE USE OF THE ACTIVE COMPONENTS TO OBTAIN THEM.
FR2399996A1 (en) 4-HYDROXY-4-METHYL-CYCLOHEXENE-2-ONE-1, USEFUL AS AN AROMATIC COMPONENT
CZ2017193A3 (en) Multimodal stationary phases for liquid chromatography, a method of their preparation and their use
Mitchard Steric course of a ketimine reduction
CA2392282A1 (en) Novel diazo derivatives and process for their preparation
JPH0478621B2 (en)
AR002305A1 (en) SUBSTITUTED QUINOLINE COMPOUNDS USEFUL AS INTERMEDIARIES FOR THE SYNTHESIS OF HERBICIDE ACID 2- (4-ISOPROPIL-4-METHYL-5-OXO-2-IMIDAZOLINYL) -5-METOXIMETILNICOTINIAS.