NO984671L - Organofosforsammensetninger - Google Patents

Organofosforsammensetninger

Info

Publication number
NO984671L
NO984671L NO984671A NO984671A NO984671L NO 984671 L NO984671 L NO 984671L NO 984671 A NO984671 A NO 984671A NO 984671 A NO984671 A NO 984671A NO 984671 L NO984671 L NO 984671L
Authority
NO
Norway
Prior art keywords
acid
chloride
products
aminoethylphosphonic
lauroyloyl
Prior art date
Application number
NO984671A
Other languages
Norwegian (no)
Other versions
NO984671D0 (en
Inventor
David John Garnett
Original Assignee
Lovesgrove Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9607583.3A external-priority patent/GB9607583D0/en
Application filed by Lovesgrove Research Ltd filed Critical Lovesgrove Research Ltd
Publication of NO984671D0 publication Critical patent/NO984671D0/en
Publication of NO984671L publication Critical patent/NO984671L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl

Abstract

Organofosfonsyrer med formel (I):der n = 0 eller 1; Ri = H eller (a); R= (b) eller (c);. R= en alkylgruppe inneholdende > 10 karbonatomer; og K, = H eller CH, som gir forbedret biotilgjengelighet for medikamenter og næringsmidler ved permabilisering av cellemembraner.Produktene fremstilles ved omsetning av et syreklorid av en langkjedet C--aIifatisk syre med et alkylfosfonsyrederivat inneholdende en aktiv amino- eller hydroksygruppe i kloroform ved temperaturer under 5°C.Særlig brukbare er omsetningsproduktene av palmitoyl- eller lauryoylklorid med etan-l-hydroksy-l.l-difosfonsyre, 2-aminoetylfosfonsyre eller 1-aminoetylfosfonsyre.Organophosphonic acids of formula (I): where n = 0 or 1; R 1 = H or (a); R = (b) or (c); R = an alkyl group containing> 10 carbon atoms; and K, = H or CH, which provides improved bioavailability of drugs and nutrients by permabilization of cell membranes. The products are prepared by reacting an acid chloride of a long chain C below 5 DEG C. Particularly useful are the reaction products of palmitoyl or lauroyloyl chloride with ethane-1-hydroxy-11-diphosphonic acid, 2-aminoethylphosphonic acid or 1-aminoethylphosphonic acid.

NO984671A 1996-04-12 1998-10-06 Organofosforsammensetninger NO984671L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9607583.3A GB9607583D0 (en) 1996-04-12 1996-04-12 Organo phosphorous compounds
GB9617729A GB2311991B (en) 1996-04-12 1996-08-23 Organo phosphorus compounds
PCT/GB1997/001020 WO1997039004A1 (en) 1996-04-12 1997-04-14 Organo phosphorous compounds

Publications (2)

Publication Number Publication Date
NO984671D0 NO984671D0 (en) 1998-10-06
NO984671L true NO984671L (en) 1998-12-04

Family

ID=26309109

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984671A NO984671L (en) 1996-04-12 1998-10-06 Organofosforsammensetninger

Country Status (6)

Country Link
EP (1) EP0892806A1 (en)
CN (1) CN1218477A (en)
BR (1) BR9708660A (en)
GB (1) GB2323089B (en)
NO (1) NO984671L (en)
WO (1) WO1997039004A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0400988D0 (en) * 2004-01-16 2004-02-18 Oxoid Ltd Therapeutically useful antibacterial compounds
DE102004032781A1 (en) 2004-01-23 2005-08-11 Mcs Micro Carrier Systems Gmbh New lipid-modified bis-phosphonic acid derivatives, useful e.g. for transporting therapeutic or diagnostic agents, with affinity for bone, also as corrosion inhibitors
EP2344417B1 (en) * 2008-10-03 2017-01-04 Life Technologies Corporation Nanocrystals with functional ligands
CN107602610A (en) * 2017-09-09 2018-01-19 南通意特化工有限公司 It is a kind of can reuse sulfuric acid wastewater containing organic phospho acid production technology

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2304156A (en) * 1940-03-07 1942-12-08 Du Pont Organic compound and process of preparing the same
DE2530139C3 (en) * 1975-04-30 1979-06-21 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen N-acyl-1-aminoalkane-1,1-diphosphonic acids, their preparation and use
DE2651048A1 (en) * 1976-11-09 1978-05-18 Hoechst Ag PLASTIC DISPERSION WITH HIGH WET ADHESION AND METHOD FOR THEIR PRODUCTION
JP2612619B2 (en) * 1988-12-14 1997-05-21 財団法人相模中央化学研究所 Transdermal absorption enhancer consisting of phosphorus-containing compound
EP0550385A1 (en) * 1991-12-19 1993-07-07 Ciba-Geigy Ag Oral pharmaceutical compositions containing derivatives of methane-diphosphonic acid and 18-crown-6 ethers
GB2267033B (en) * 1992-03-07 1996-01-24 David Garnett Lysophospholipid Animal Feed Supplement
US5523430A (en) * 1994-04-14 1996-06-04 Bristol-Myers Squibb Company Protein farnesyl transferase inhibitors

Also Published As

Publication number Publication date
CN1218477A (en) 1999-06-02
NO984671D0 (en) 1998-10-06
GB9726184D0 (en) 1998-02-11
GB2323089B (en) 1999-02-10
BR9708660A (en) 2000-01-04
EP0892806A1 (en) 1999-01-27
GB2323089A (en) 1998-09-16
WO1997039004A1 (en) 1997-10-23
GB2323089A8 (en) 1998-09-24

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application