BR9708660A - Phosphorous organo compound - Google Patents

Phosphorous organo compound

Info

Publication number
BR9708660A
BR9708660A BR9708660-6A BR9708660A BR9708660A BR 9708660 A BR9708660 A BR 9708660A BR 9708660 A BR9708660 A BR 9708660A BR 9708660 A BR9708660 A BR 9708660A
Authority
BR
Brazil
Prior art keywords
amino
phosphonic acid
ethyl
acid
active
Prior art date
Application number
BR9708660-6A
Other languages
Portuguese (pt)
Inventor
David John Garnett
Original Assignee
Lovesgrove Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9607583.3A external-priority patent/GB9607583D0/en
Application filed by Lovesgrove Res Ltd filed Critical Lovesgrove Res Ltd
Publication of BR9708660A publication Critical patent/BR9708660A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Insects & Arthropods (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Birds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTO ORGANO FOSFOROSOS"<D>. São divulgados ácidos organo fosfónicos contendo a fórmula onde : n=0 ou 1 R~ 1~=H ou R~ 2~= R~ 3~= R~ 4~=H ou CH~ 3~ que forncecem biodisponibilidade aperfeiçoada de medicamentos e nutrientes por permeabilização de membranas celulares. Os produtos são preparados pelo processo de reação de um cloreto ácido de ácido alifático de cadeia longa contendo 10-20 átomos de carbono com um derivado de ácido alquil fosfónico contendo um grupo amino ativo ou grupo hidróxi ativo em clorofórmio a temperaturas abaixo de 5°C. Especialmente úteis são os produtos de reação de cloreto de palmitoíla ou de lauroíla com ácido etano-1-hidróxi-1, 1-difosfónico, ácido 2-amino-etil fosfónico ou ácido 1-amino-etil fosfónico.Invention Patent: <B> "PHOSPHORUS ORGAN COMPOUND" <D>. Organo phosphonic acids containing the formula are disclosed where: n = 0 or 1 R ~ 1 ~ = H or R ~ 2 ~ = R ~ 3 ~ = R ~ 4 ~ = H or CH ~ 3 ~ which provide improved drug bioavailability and nutrients by permeabilization of cell membranes. The products are prepared by reacting a long-chain aliphatic acid chloride containing 10-20 carbon atoms with an alkyl phosphonic acid derivative containing an active amino group or hydroxy group active in chloroform at temperatures below 5 ° C . Especially useful are the reaction products of palmitoyl or lauroyl chloride with ethane-1-hydroxy-1, 1-diphosphonic acid, 2-amino-ethyl-phosphonic acid or 1-amino-ethyl-phosphonic acid.

BR9708660-6A 1996-04-12 1997-04-14 Phosphorous organo compound BR9708660A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9607583.3A GB9607583D0 (en) 1996-04-12 1996-04-12 Organo phosphorous compounds
GB9617729A GB2311991B (en) 1996-04-12 1996-08-23 Organo phosphorus compounds
PCT/GB1997/001020 WO1997039004A1 (en) 1996-04-12 1997-04-14 Organo phosphorous compounds

Publications (1)

Publication Number Publication Date
BR9708660A true BR9708660A (en) 2000-01-04

Family

ID=26309109

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9708660-6A BR9708660A (en) 1996-04-12 1997-04-14 Phosphorous organo compound

Country Status (6)

Country Link
EP (1) EP0892806A1 (en)
CN (1) CN1218477A (en)
BR (1) BR9708660A (en)
GB (1) GB2323089B (en)
NO (1) NO984671L (en)
WO (1) WO1997039004A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0400988D0 (en) * 2004-01-16 2004-02-18 Oxoid Ltd Therapeutically useful antibacterial compounds
DE102004032781A1 (en) 2004-01-23 2005-08-11 Mcs Micro Carrier Systems Gmbh New lipid-modified bis-phosphonic acid derivatives, useful e.g. for transporting therapeutic or diagnostic agents, with affinity for bone, also as corrosion inhibitors
EP2344417B1 (en) * 2008-10-03 2017-01-04 Life Technologies Corporation Nanocrystals with functional ligands
CN107602610A (en) * 2017-09-09 2018-01-19 南通意特化工有限公司 It is a kind of can reuse sulfuric acid wastewater containing organic phospho acid production technology

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2304156A (en) * 1940-03-07 1942-12-08 Du Pont Organic compound and process of preparing the same
DE2530139C3 (en) * 1975-04-30 1979-06-21 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen N-acyl-1-aminoalkane-1,1-diphosphonic acids, their preparation and use
DE2651048A1 (en) * 1976-11-09 1978-05-18 Hoechst Ag PLASTIC DISPERSION WITH HIGH WET ADHESION AND METHOD FOR THEIR PRODUCTION
JP2612619B2 (en) * 1988-12-14 1997-05-21 財団法人相模中央化学研究所 Transdermal absorption enhancer consisting of phosphorus-containing compound
EP0550385A1 (en) * 1991-12-19 1993-07-07 Ciba-Geigy Ag Oral pharmaceutical compositions containing derivatives of methane-diphosphonic acid and 18-crown-6 ethers
GB2267033B (en) * 1992-03-07 1996-01-24 David Garnett Lysophospholipid Animal Feed Supplement
US5523430A (en) * 1994-04-14 1996-06-04 Bristol-Myers Squibb Company Protein farnesyl transferase inhibitors

Also Published As

Publication number Publication date
CN1218477A (en) 1999-06-02
GB2323089A8 (en) 1998-09-24
GB2323089A (en) 1998-09-16
EP0892806A1 (en) 1999-01-27
GB2323089B (en) 1999-02-10
NO984671D0 (en) 1998-10-06
NO984671L (en) 1998-12-04
WO1997039004A1 (en) 1997-10-23
GB9726184D0 (en) 1998-02-11

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]