NO983860L - Novel triazolopurins, their method of preparation and their use as drugs - Google Patents

Novel triazolopurins, their method of preparation and their use as drugs

Info

Publication number
NO983860L
NO983860L NO983860A NO983860A NO983860L NO 983860 L NO983860 L NO 983860L NO 983860 A NO983860 A NO 983860A NO 983860 A NO983860 A NO 983860A NO 983860 L NO983860 L NO 983860L
Authority
NO
Norway
Prior art keywords
triazolopurins
drugs
novel
preparation
receptors
Prior art date
Application number
NO983860A
Other languages
Norwegian (no)
Other versions
NO983860D0 (en
Inventor
Fner-M Hl Ulrike K
Werner Kummer
Gerald Pohl
Wolfram Gaida
Erich Lehr
Joachim Mierau
Thomas Weiser
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002242097A external-priority patent/CA2242097C/en
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO983860D0 publication Critical patent/NO983860D0/en
Publication of NO983860L publication Critical patent/NO983860L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oppfinnelsen vedrører triazolopurin-derivater med formel (I). Forbindelsene ifølge oppfinnelsen viser en affinitet til adenosin-reseptorene og utgjør således en ny klasse adensin-reseptorer. Generelt kan adenosin-antagonister ha en terapeutisk anvendelig virkning i tilfeller hvor sykdommer eller patologiske situasjoner medfører aktivering av adenosin-reseptorer.The invention relates to triazolopurine derivatives of formula (I). The compounds of the invention show an affinity for the adenosine receptors and thus constitute a new class of adensin receptors. In general, adenosine antagonists may have a therapeutically useful effect in cases where diseases or pathological situations result in activation of adenosine receptors.

NO983860A 1996-07-20 1998-08-21 Novel triazolopurins, their method of preparation and their use as drugs NO983860L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19629378A DE19629378A1 (en) 1996-07-20 1996-07-20 New triazolopurines, process for their preparation and their use as medicaments
PCT/EP1997/003841 WO1998003511A1 (en) 1996-07-20 1997-07-17 New triazolopurines, method of preparing them and their use as drugs
CA002242097A CA2242097C (en) 1996-07-20 1998-06-26 Imidazotriazolopyrimidines, process for preparing them and their use as pharmaceutical compositions

Publications (2)

Publication Number Publication Date
NO983860D0 NO983860D0 (en) 1998-08-21
NO983860L true NO983860L (en) 1998-10-21

Family

ID=32963000

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983860A NO983860L (en) 1996-07-20 1998-08-21 Novel triazolopurins, their method of preparation and their use as drugs

Country Status (25)

Country Link
EP (2) EP0880524B1 (en)
JP (1) JP3020281B2 (en)
CN (1) CN1219936A (en)
AT (1) ATE191913T1 (en)
AU (1) AU3695597A (en)
BG (1) BG102707A (en)
BR (1) BR9710747A (en)
CA (1) CA2256736A1 (en)
CZ (1) CZ265498A3 (en)
DE (2) DE19629378A1 (en)
DK (1) DK0880524T3 (en)
EE (1) EE9800451A (en)
ES (1) ES2147453T3 (en)
GR (1) GR3033842T3 (en)
HR (1) HRP970395A2 (en)
HU (1) HUP9902311A3 (en)
ID (1) ID19106A (en)
IL (1) IL126453A0 (en)
NO (1) NO983860L (en)
PL (1) PL328824A1 (en)
PT (1) PT880524E (en)
SK (1) SK114498A3 (en)
TR (1) TR199801659T2 (en)
WO (1) WO1998003511A1 (en)
ZA (1) ZA976331B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826843A1 (en) * 1998-06-16 1999-12-23 Boehringer Ingelheim Pharma Novel imidazotriazolopyrimidines, process for their preparation and their use as medicaments
US6492377B1 (en) 1998-06-25 2002-12-10 Boehringer Ingelheim Pharma Kg Imidazotriazolopyrimidines with adenosine-antagonistic activity
WO2000012511A1 (en) * 1998-08-27 2000-03-09 Boehringer Ingelheim Pharma Kg Imidazotriazolopyrimidines
WO2004075846A2 (en) 2003-02-25 2004-09-10 Bristol-Myers Squibb Company Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
US7071333B2 (en) 2003-07-30 2006-07-04 Bristol-Myers Squibb Company Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
EP2044074A2 (en) * 2006-06-23 2009-04-08 Incyte Corporation Purinone derivatives as hm74a agonists
IL303087B1 (en) 2018-02-27 2024-08-01 Incyte Corp Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors
US11168089B2 (en) 2018-05-18 2021-11-09 Incyte Corporation Fused pyrimidine derivatives as A2A / A2B inhibitors
CN113166153A (en) 2018-07-05 2021-07-23 因赛特公司 Fused pyrazine derivatives as A2A/A2B inhibitors
JP7241871B2 (en) 2018-11-30 2023-03-17 メルク・シャープ・アンド・ドーム・エルエルシー 9-substituted aminotriazoloquinazoline derivatives, pharmaceutical compositions and their use as adenosine receptor antagonists
TWI829857B (en) 2019-01-29 2024-01-21 美商英塞特公司 Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors
CN112778311B (en) * 2019-11-01 2024-06-04 上海翰森生物医药科技有限公司 Nitrogen-containing fused ring derivative inhibitor, preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA902282B (en) * 1989-03-29 1990-12-28 Merrell Dow Pharma Selective adenosine receptor compounds
IT1264901B1 (en) * 1993-06-29 1996-10-17 Schering Plough S P A HETEROCYCLIC ANALOGUES OF 1,2,4-TRIAZOLE(15-C)PYRIMIDINES WITH ANTAGONIST ACTIVITY FOR THE ADENOSINE A2 RECEPTOR
JPH083169A (en) * 1994-06-15 1996-01-09 Yamasa Shoyu Co Ltd 4-methyl-1h-(1,2,4)triazolo(1,5-a)purin-9(4h)-ones

Also Published As

Publication number Publication date
DE59701467D1 (en) 2000-05-25
NO983860D0 (en) 1998-08-21
BG102707A (en) 1999-09-30
ES2147453T3 (en) 2000-09-01
ID19106A (en) 1998-06-18
PT880524E (en) 2000-07-31
JP2000501420A (en) 2000-02-08
EP0978517A3 (en) 2003-11-12
PL328824A1 (en) 1999-02-15
ATE191913T1 (en) 2000-05-15
HUP9902311A2 (en) 1999-10-28
BR9710747A (en) 1999-08-17
AU3695597A (en) 1998-02-10
EP0880524A1 (en) 1998-12-02
CZ265498A3 (en) 1998-12-16
JP3020281B2 (en) 2000-03-15
CA2256736A1 (en) 1998-01-29
TR199801659T2 (en) 1998-12-21
IL126453A0 (en) 1999-08-17
HUP9902311A3 (en) 2000-06-28
GR3033842T3 (en) 2000-10-31
WO1998003511A1 (en) 1998-01-29
DK0880524T3 (en) 2000-07-17
EE9800451A (en) 1999-06-15
HRP970395A2 (en) 1998-08-31
ZA976331B (en) 1999-01-25
EP0978517A2 (en) 2000-02-09
EP0880524B1 (en) 2000-04-19
CN1219936A (en) 1999-06-16
DE19629378A1 (en) 1998-01-29
SK114498A3 (en) 1999-02-11

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FC2A Withdrawal, rejection or dismissal of laid open patent application