NO983530L - Dihydrobenzofuran and related compounds useful as anti-inflammatory agents - Google Patents
Dihydrobenzofuran and related compounds useful as anti-inflammatory agentsInfo
- Publication number
- NO983530L NO983530L NO983530A NO983530A NO983530L NO 983530 L NO983530 L NO 983530L NO 983530 A NO983530 A NO 983530A NO 983530 A NO983530 A NO 983530A NO 983530 L NO983530 L NO 983530L
- Authority
- NO
- Norway
- Prior art keywords
- dihydrobenzofuran
- inflammatory agents
- compounds useful
- related compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
A compound having the structure: <IMAGE> pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/595,337 US5618835A (en) | 1996-02-01 | 1996-02-01 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
PCT/US1997/001314 WO1997028147A1 (en) | 1996-02-01 | 1997-01-30 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
Publications (2)
Publication Number | Publication Date |
---|---|
NO983530D0 NO983530D0 (en) | 1998-07-31 |
NO983530L true NO983530L (en) | 1998-09-30 |
Family
ID=24382842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO983530A NO983530L (en) | 1996-02-01 | 1998-07-31 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
Country Status (15)
Country | Link |
---|---|
US (1) | US5618835A (en) |
EP (1) | EP0888323B1 (en) |
JP (1) | JP3095424B2 (en) |
KR (1) | KR100322402B1 (en) |
CN (1) | CN1125062C (en) |
AT (1) | ATE267187T1 (en) |
AU (1) | AU730262B2 (en) |
BR (1) | BR9707247A (en) |
CA (1) | CA2244203A1 (en) |
DE (1) | DE69729183T2 (en) |
DK (1) | DK0888323T3 (en) |
ES (1) | ES2221950T3 (en) |
MX (1) | MX9806250A (en) |
NO (1) | NO983530L (en) |
WO (1) | WO1997028147A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69838789T2 (en) * | 1997-03-12 | 2008-10-30 | Suzanne Cambridge de la Monte | METHOD FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE |
AU7933298A (en) * | 1997-06-27 | 1999-01-19 | Kaneka Corporation | Heat shock factor activity inhibitors |
BR9812982A (en) | 1997-10-24 | 2000-08-08 | Shionogi & Co | Anti-rheumatic agent |
US20040058873A1 (en) * | 1998-03-12 | 2004-03-25 | Esmond Robert W. | Method for treating or preventing Alzheimer's disease |
US6191154B1 (en) | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
ES2315365T3 (en) | 2001-06-13 | 2009-04-01 | Magnachem International Laboratories, Inc. | FORMULATIONS OF LACTONE AND METHOD OF USE. |
WO2003009815A2 (en) | 2001-07-25 | 2003-02-06 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
EP1562930A4 (en) | 2002-11-05 | 2008-12-10 | Magnachem Int Lab Inc | Synthetic lactone formulations and method of use |
WO2004047760A2 (en) * | 2002-11-22 | 2004-06-10 | Smithkline Beecham Corporation | Novel chemical compounds |
WO2005102315A1 (en) | 2004-04-23 | 2005-11-03 | Magnachem International Laboratories, Inc. | Synthetic lactone formulations for pain control |
EP3827747A1 (en) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
PE20070083A1 (en) * | 2005-06-08 | 2007-01-27 | Smithkline Beecham Corp | (5Z) -5- (6-QUINOXALINYL METHYLIDENE) -2 - [(2,6-DICHLOROPHENYL) AMINO] -1,3-THIAZOL-4 (5H) -ONE |
KR20090071598A (en) | 2006-09-18 | 2009-07-01 | 랩터 파마슈티컬 인코포레이티드 | Treatment of liver disorders by administration of receptor-associated protein(rap)-conjugates |
US20100286041A1 (en) * | 2007-03-22 | 2010-11-11 | Smithkline Beecham Corporation | (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one |
WO2010048616A2 (en) | 2008-10-24 | 2010-04-29 | Magnachem International Laboratories, Inc. | Method for screening for compounds selectively interacting with rad9 |
CN102301215B (en) * | 2009-01-27 | 2014-03-26 | 国立大学法人名古屋大学 | Membrane tension measuring apparatus |
EP3395372B1 (en) | 2009-02-20 | 2022-04-06 | EnhanX Biopharm Inc. | Glutathione-based drug delivery system |
IL255113B (en) | 2009-05-06 | 2022-09-01 | Laboratory Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6019305B2 (en) * | 1976-07-02 | 1985-05-15 | ウェルファイド株式会社 | Dihydrobenzofuran derivative |
IT1093805B (en) * | 1978-01-31 | 1985-07-26 | Erba Carlo Spa | DERIVATIVES OF 2H-BENZOFURAN-3-ONE AND PROCEDURE FOR THEIR PREPARATION |
US4470440A (en) * | 1982-09-30 | 1984-09-11 | Thor Harry A | Impact producing tool |
EP0273647B1 (en) * | 1986-12-27 | 1992-03-11 | Takeda Chemical Industries, Ltd. | Coumaran derivatives, their production and use |
US4849428A (en) * | 1987-11-23 | 1989-07-18 | The Procter & Gamble Company | Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use |
JP2855341B2 (en) * | 1988-06-10 | 1999-02-10 | 武田薬品工業株式会社 | New 2-substituted coumaran derivatives |
US4966907A (en) * | 1988-08-12 | 1990-10-30 | Merck & Co., Inc. | 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis |
FR2645537B1 (en) * | 1989-04-05 | 1994-03-04 | Fabre Medicament Pierre | NOVEL SULFONAMIDES DERIVED FROM BENZOCYCLIC OR BENZOHETEROCYCLIC ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
US4975457A (en) * | 1989-09-25 | 1990-12-04 | Merck & Co., Inc. | Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis |
KR920701190A (en) * | 1989-11-17 | 1992-08-11 | 나까야마 히사시 | Benzofuran derivatives, preparation method thereof, and pharmaceuticals using the same |
US5091533A (en) * | 1990-03-12 | 1992-02-25 | Merck Frosst Canada, Inc. | 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors |
WO1991014674A2 (en) * | 1990-03-27 | 1991-10-03 | Smithkline Beecham Corporation | 5-lipoxygenase inhibitors |
ES2301161T3 (en) * | 1994-07-27 | 2008-06-16 | Vanderbilt University | DIHYDROBENZOFURAN COMPOUNDS AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS. |
US5684002A (en) * | 1994-09-07 | 1997-11-04 | The Procter & Gamble Company | Dihydorbenzofuran and related compounds useful as anti-inflammatory agents |
-
1996
- 1996-02-01 US US08/595,337 patent/US5618835A/en not_active Expired - Fee Related
-
1997
- 1997-01-30 DE DE69729183T patent/DE69729183T2/en not_active Expired - Fee Related
- 1997-01-30 JP JP09527762A patent/JP3095424B2/en not_active Expired - Fee Related
- 1997-01-30 DK DK97904019T patent/DK0888323T3/en active
- 1997-01-30 BR BR9707247A patent/BR9707247A/en not_active Application Discontinuation
- 1997-01-30 KR KR1019980705950A patent/KR100322402B1/en not_active IP Right Cessation
- 1997-01-30 CN CN97192018A patent/CN1125062C/en not_active Expired - Fee Related
- 1997-01-30 ES ES97904019T patent/ES2221950T3/en not_active Expired - Lifetime
- 1997-01-30 EP EP97904019A patent/EP0888323B1/en not_active Expired - Lifetime
- 1997-01-30 CA CA002244203A patent/CA2244203A1/en not_active Abandoned
- 1997-01-30 WO PCT/US1997/001314 patent/WO1997028147A1/en active IP Right Grant
- 1997-01-30 AT AT97904019T patent/ATE267187T1/en not_active IP Right Cessation
- 1997-01-30 AU AU18433/97A patent/AU730262B2/en not_active Ceased
-
1998
- 1998-07-31 NO NO983530A patent/NO983530L/en not_active Application Discontinuation
- 1998-08-03 MX MX9806250A patent/MX9806250A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1210530A (en) | 1999-03-10 |
KR100322402B1 (en) | 2002-05-09 |
DE69729183T2 (en) | 2004-10-07 |
DK0888323T3 (en) | 2004-08-09 |
US5618835A (en) | 1997-04-08 |
NO983530D0 (en) | 1998-07-31 |
WO1997028147A1 (en) | 1997-08-07 |
ES2221950T3 (en) | 2005-01-16 |
AU1843397A (en) | 1997-08-22 |
MX9806250A (en) | 1998-11-30 |
DE69729183D1 (en) | 2004-06-24 |
JP3095424B2 (en) | 2000-10-03 |
JPH11506121A (en) | 1999-06-02 |
BR9707247A (en) | 1999-07-20 |
KR19990082222A (en) | 1999-11-25 |
ATE267187T1 (en) | 2004-06-15 |
CA2244203A1 (en) | 1997-08-07 |
EP0888323A1 (en) | 1999-01-07 |
CN1125062C (en) | 2003-10-22 |
EP0888323B1 (en) | 2004-05-19 |
AU730262B2 (en) | 2001-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |