NO982185L - Novel macrocyclic compounds as metalloproteinase inhibitors - Google Patents
Novel macrocyclic compounds as metalloproteinase inhibitorsInfo
- Publication number
- NO982185L NO982185L NO982185A NO982185A NO982185L NO 982185 L NO982185 L NO 982185L NO 982185 A NO982185 A NO 982185A NO 982185 A NO982185 A NO 982185A NO 982185 L NO982185 L NO 982185L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- metalloproteinase inhibitors
- macrocyclic compounds
- inhibitors
- novel macrocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Denne oppfinnelsen vedrører makro- sykliske molekyler som inhiberer metalloproteinaser, inkludert aggrekanase, og produksjonen av tumornekrosefaktor (TNF). Særlig er forbindelsene inhibitorer for metalloproteinaser som er involvert i vevs- nedbrytning, og inhibitorer for frigjørelsen av tumornekrosefaktor. Fore- liggende oppfinnelse vedrører også farmasøytiske preparater som omfatter slike forbindelser, og fremgangsmåter for anvendelse av disse forbindelsene til behandling av inflammatoriske syk- dommer.This invention relates to macrocyclic molecules that inhibit metalloproteinases, including aggregate kinase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of tumor necrosis factor release. The present invention also relates to pharmaceutical compositions comprising such compounds, and methods of using these compounds for the treatment of inflammatory diseases.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US668495P | 1995-11-14 | 1995-11-14 | |
US64690296A | 1996-05-08 | 1996-05-08 | |
US74343996A | 1996-11-01 | 1996-11-01 | |
PCT/US1996/018382 WO1997018207A2 (en) | 1995-11-14 | 1996-11-13 | Novel macrocyclic compounds as metalloprotease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO982185D0 NO982185D0 (en) | 1998-05-13 |
NO982185L true NO982185L (en) | 1998-07-13 |
Family
ID=27358171
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO982185A NO982185L (en) | 1995-11-14 | 1998-05-13 | Novel macrocyclic compounds as metalloproteinase inhibitors |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0863885A2 (en) |
JP (1) | JP2000502050A (en) |
CN (1) | CN1202161A (en) |
BR (1) | BR9611563A (en) |
CA (1) | CA2237524A1 (en) |
CZ (1) | CZ144798A3 (en) |
EE (1) | EE9800115A (en) |
HR (1) | HRP960533A2 (en) |
HU (1) | HUP0201479A2 (en) |
IL (1) | IL124366A0 (en) |
LV (1) | LV12167B (en) |
MX (1) | MX9803851A (en) |
NO (1) | NO982185L (en) |
PL (1) | PL326714A1 (en) |
SI (1) | SI9620120A (en) |
SK (1) | SK63498A3 (en) |
WO (1) | WO1997018207A2 (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6281352B1 (en) | 1995-11-14 | 2001-08-28 | Dupont Pharmaceuticals Company | Macrocyclic compounds as metalloprotease inhibitors |
US5952320A (en) * | 1997-01-07 | 1999-09-14 | Abbott Laboratories | Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion |
ZA9820B (en) * | 1997-01-07 | 1998-07-02 | Abbott Lab | Macrocyclic inhibitors of matrix metalloproteinases and tnf x secretion |
US5985911A (en) * | 1997-01-07 | 1999-11-16 | Abbott Laboratories | C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion |
US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
EA200001007A1 (en) | 1998-03-31 | 2001-04-23 | Дюпон Фармасьютикалз Компани | PHARMACEUTICAL PREPARATIONS FOR THE VISUALIZATION OF ANGIOGENIC DISORDERS |
US6524553B2 (en) | 1998-03-31 | 2003-02-25 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
US6548663B1 (en) | 1998-03-31 | 2003-04-15 | Bristol-Myers Squibb Pharma Company | Benzodiazepine vitronectin receptor antagonist pharmaceuticals |
EP1084113A1 (en) | 1998-06-11 | 2001-03-21 | Du Pont Pharmaceuticals Company | A process for the preparation of macrocyclic metalloprotease inhibitors |
NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
AU2371400A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | Vitronectin receptor antagonist pharmaceuticals |
US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
CN1356913A (en) | 1998-12-18 | 2002-07-03 | 杜邦药品公司 | Vitronectic receptor antagonist pharmaceuticals |
US6511649B1 (en) | 1998-12-18 | 2003-01-28 | Thomas D. Harris | Vitronectin receptor antagonist pharmaceuticals |
US6794518B1 (en) | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
US6649377B1 (en) | 1999-05-10 | 2003-11-18 | Syntex (U.S.A.) Llc | Human aggrecanase and nucleic acid compositions encoding the same |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
US6989139B2 (en) | 2000-02-15 | 2006-01-24 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
IL147629A0 (en) | 2000-06-01 | 2002-08-14 | Bristol Myers Squibb Pharma Co | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
CA2451955C (en) | 2001-06-26 | 2015-09-29 | Abgenix, Inc. | Antibodies to opgl |
PE20030701A1 (en) | 2001-12-20 | 2003-08-21 | Schering Corp | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS |
US7491794B2 (en) | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
WO2005044780A1 (en) * | 2003-11-10 | 2005-05-19 | Kyorin Pharmaceutical Co., Ltd. | Aminocarboxylic acid derivative, addition salt thereof, and s1p receptor control agent |
EP2234608A2 (en) | 2007-12-11 | 2010-10-06 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
EP2429290B1 (en) | 2009-05-11 | 2014-01-01 | Purdue Research Foundation | Compounds and methods for treating aids and hiv infections |
RU2598840C2 (en) | 2011-05-19 | 2016-09-27 | Фундасион Сентро Насиональ Де Инвестигасионес Онколохикас Карлос Iii | Novel compounds |
CN102276546B (en) * | 2011-05-31 | 2014-06-25 | 中国科学院广州生物医药与健康研究院 | Compound used as aggrecanase modifier and application thereof |
CN108623530B (en) * | 2016-09-18 | 2021-05-11 | 广西师范大学 | 1,2, 8-oxo-diazacyclononane-9-thioketone derivative and synthetic method and application thereof |
BR112021006407A8 (en) | 2018-10-04 | 2022-12-06 | Inst Nat Sante Rech Med | use of egfr inhibitors for keratoderms |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9102635D0 (en) * | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
US5427954A (en) * | 1992-04-29 | 1995-06-27 | Shriner's Hospitals For Crippled Children | Compositions and methods for detection and treatment of human osteoarthritis |
-
1996
- 1996-11-13 EP EP96943497A patent/EP0863885A2/en not_active Withdrawn
- 1996-11-13 BR BR9611563A patent/BR9611563A/en not_active IP Right Cessation
- 1996-11-13 PL PL96326714A patent/PL326714A1/en unknown
- 1996-11-13 IL IL12436696A patent/IL124366A0/en unknown
- 1996-11-13 CA CA002237524A patent/CA2237524A1/en not_active Abandoned
- 1996-11-13 HU HU0201479A patent/HUP0201479A2/en unknown
- 1996-11-13 EE EE9800115A patent/EE9800115A/en unknown
- 1996-11-13 HR HR08/743,439A patent/HRP960533A2/en not_active Application Discontinuation
- 1996-11-13 CN CN96198327A patent/CN1202161A/en active Pending
- 1996-11-13 WO PCT/US1996/018382 patent/WO1997018207A2/en not_active Application Discontinuation
- 1996-11-13 CZ CZ981447A patent/CZ144798A3/en unknown
- 1996-11-13 SK SK634-98A patent/SK63498A3/en unknown
- 1996-11-13 JP JP9519119A patent/JP2000502050A/en active Pending
- 1996-11-13 SI SI9620120A patent/SI9620120A/en unknown
-
1998
- 1998-05-13 NO NO982185A patent/NO982185L/en unknown
- 1998-05-14 MX MX9803851A patent/MX9803851A/en unknown
- 1998-07-07 LV LVP-98-104A patent/LV12167B/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL326714A1 (en) | 1998-10-26 |
SK63498A3 (en) | 1999-01-11 |
SI9620120A (en) | 1999-06-30 |
MX9803851A (en) | 1998-09-30 |
BR9611563A (en) | 1999-03-02 |
IL124366A0 (en) | 1998-12-06 |
WO1997018207A3 (en) | 1997-07-24 |
LV12167B (en) | 1999-03-20 |
CN1202161A (en) | 1998-12-16 |
JP2000502050A (en) | 2000-02-22 |
CZ144798A3 (en) | 1998-10-14 |
CA2237524A1 (en) | 1997-05-22 |
HRP960533A2 (en) | 1998-04-30 |
NO982185D0 (en) | 1998-05-13 |
EE9800115A (en) | 1998-10-15 |
LV12167A (en) | 1998-11-20 |
WO1997018207A2 (en) | 1997-05-22 |
EP0863885A2 (en) | 1998-09-16 |
HUP0201479A2 (en) | 2002-08-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO982185L (en) | Novel macrocyclic compounds as metalloproteinase inhibitors | |
NO20000784L (en) | Novel aggrecanase inhibitors and matrix metalloproteinases for the treatment of arthritis | |
FI961976A0 (en) | Peptidyl compounds and their therapeutic use as metalloproteinase inhibitors | |
NO20055863L (en) | W-carboxyaryl-substituted diphenylurea compounds as raf kinase inhibitors | |
EA200200768A1 (en) | INDAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR MODULATION OR INHIBITION OF CELLULAR PROLIFERATION | |
UA48939C2 (en) | Disubstituted furanons, methods for synthesis, pharmaceutical composition, method for treating inflammatory disease, intermediate substances | |
BR9916930A (en) | Aromatic heterocyclic compounds as anti-inflammatory agents | |
MXPA04002070A (en) | Substituted indazole compounds for the treatment of inflammation. | |
NO20052595L (en) | Compositions useful as inhibitors of ROCK and other protein kinases. | |
NO20054769L (en) | Substituted phenylalkanoic acids | |
NO326660B1 (en) | Imidazolyl-cyclic acetal compounds, pharmaceutical compositions containing these compounds and use of the compounds | |
AU2003209118A1 (en) | Aryl ureas as kinase inhibitors | |
NO20064120L (en) | 3,4-heterocyclyl-1,2,3-triazol-1-yl-N-aryl-benzamide are inhibitors of cytokine production for the treatment of chronic inflammatory diseases | |
EA200501676A1 (en) | PHOSPHONATE-CONTAINING KINASE INHIBITORS (OPTIONS), METHOD FOR THEIR RECEIVING, PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL FORM ON THEIR BASIS AND METHOD FOR INHIBING KINASE IN MOLOPYTIC TREATMENT THEM | |
DE602004003806D1 (en) | 1- (2H-PYRAZOL-3-YL) -3-ä4-Ä1- (BENZOYL) -PIPERIDIN-4-YLMETHYLÜ-PHENYLU-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE P38 KINASE AND / OR TNF FOR THE TREATMENT OF INFLAMMATION | |
ATE329909T1 (en) | 1,2,3-TRIAZOLAMIDE DERIVATIVES AS CYTOKIN INHIBITORS | |
AU7385398A (en) | Novel macrocyclic compounds as metalloprotease inhibitors | |
NO975503L (en) | 4,4- (Disubstituted) Cyclohexan-1-oler Monomers and Related Compounds | |
EA199800372A1 (en) | NEW MICROCYCLIC COMPOUNDS INHIBITORS | |
ATE482217T1 (en) | DITHIOLOPYRROLONE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | |
NO972906D0 (en) | 4,4- (Disubstituted) Cyclohexan-1-ol Monomers and Related Compounds | |
NO972907L (en) | 3,3- (Disubstituted) Cyclohexan-1-ol Monomers and Related Compounds | |
WO2024006956A3 (en) | Deubiquitinase inhibitors and methods of use thereof | |
BG105763A (en) | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |