NO980700D0 - Peripherally active anti-hyperalgesia opiates - Google Patents
Peripherally active anti-hyperalgesia opiatesInfo
- Publication number
- NO980700D0 NO980700D0 NO980700A NO980700A NO980700D0 NO 980700 D0 NO980700 D0 NO 980700D0 NO 980700 A NO980700 A NO 980700A NO 980700 A NO980700 A NO 980700A NO 980700 D0 NO980700 D0 NO 980700D0
- Authority
- NO
- Norway
- Prior art keywords
- hyperalgesia
- opiates
- active anti
- alpha
- methods
- Prior art date
Links
- 230000003070 anti-hyperalgesia Effects 0.000 title abstract 2
- 229940127240 opiate Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002093 peripheral effect Effects 0.000 abstract 2
- 208000004454 Hyperalgesia Diseases 0.000 abstract 1
- 208000035154 Hyperesthesia Diseases 0.000 abstract 1
- 102000003840 Opioid Receptors Human genes 0.000 abstract 1
- 108090000137 Opioid Receptors Proteins 0.000 abstract 1
- 230000001142 anti-diarrhea Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Methods for treatment of peripheral hyperalgesia are provided, comprising administering compositions containing an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors, but that do not, upon topical or local administration, elicit central nervous system side effects. The anti-diarrheal compound 4-( rho -chlorophenyl)-4-hydroxy-N-N-dimethyl- alpha , alpha -diphenyl-1-piperidinebutyramide hydrochloride is preferred for use in the methods.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/528,510 US5849761A (en) | 1995-09-12 | 1995-09-12 | Peripherally active anti-hyperalgesic opiates |
PCT/US1996/014727 WO1997009973A2 (en) | 1995-09-12 | 1996-09-12 | Peripherally active anti-hyperalgesic opiates |
Publications (2)
Publication Number | Publication Date |
---|---|
NO980700D0 true NO980700D0 (en) | 1998-02-19 |
NO980700L NO980700L (en) | 1998-05-12 |
Family
ID=24105973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO980700A NO980700L (en) | 1995-09-12 | 1998-02-19 | Peripherally active anti-hyperalgesia opiates |
Country Status (9)
Country | Link |
---|---|
US (4) | US5849761A (en) |
EP (1) | EP0852494A2 (en) |
JP (2) | JP3553083B2 (en) |
KR (1) | KR19990044182A (en) |
AU (1) | AU727982C (en) |
BR (1) | BR9610345A (en) |
CA (2) | CA2356097A1 (en) |
NO (1) | NO980700L (en) |
WO (1) | WO1997009973A2 (en) |
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-
1995
- 1995-09-12 US US08/528,510 patent/US5849761A/en not_active Expired - Lifetime
-
1996
- 1996-09-12 BR BR9610345A patent/BR9610345A/en not_active Application Discontinuation
- 1996-09-12 AU AU70710/96A patent/AU727982C/en not_active Ceased
- 1996-09-12 KR KR1019980701417A patent/KR19990044182A/en not_active Application Discontinuation
- 1996-09-12 US US08/712,881 patent/US5994372A/en not_active Expired - Lifetime
- 1996-09-12 JP JP51213697A patent/JP3553083B2/en not_active Expired - Fee Related
- 1996-09-12 WO PCT/US1996/014727 patent/WO1997009973A2/en not_active Application Discontinuation
- 1996-09-12 CA CA002356097A patent/CA2356097A1/en not_active Abandoned
- 1996-09-12 EP EP96931567A patent/EP0852494A2/en not_active Withdrawn
- 1996-09-12 CA CA002229814A patent/CA2229814C/en not_active Expired - Fee Related
-
1998
- 1998-02-19 NO NO980700A patent/NO980700L/en not_active Application Discontinuation
- 1998-11-24 US US09/199,873 patent/US6166039A/en not_active Expired - Lifetime
-
2000
- 2000-10-23 US US09/695,745 patent/US6576650B1/en not_active Expired - Fee Related
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2001
- 2001-07-25 JP JP2001224729A patent/JP2002069004A/en active Pending
Also Published As
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WO1997009973A2 (en) | 1997-03-20 |
AU727982C (en) | 2001-10-18 |
WO1997009973A3 (en) | 1997-06-05 |
BR9610345A (en) | 1999-06-01 |
US6166039A (en) | 2000-12-26 |
US5994372A (en) | 1999-11-30 |
MX9801514A (en) | 1998-10-31 |
JP3553083B2 (en) | 2004-08-11 |
AU7071096A (en) | 1997-04-01 |
JPH11512438A (en) | 1999-10-26 |
KR19990044182A (en) | 1999-06-25 |
CA2229814C (en) | 2001-12-04 |
NO980700L (en) | 1998-05-12 |
CA2229814A1 (en) | 1997-03-20 |
CA2356097A1 (en) | 1997-03-20 |
US5849761A (en) | 1998-12-15 |
AU727982B2 (en) | 2001-01-04 |
EP0852494A2 (en) | 1998-07-15 |
JP2002069004A (en) | 2002-03-08 |
US6576650B1 (en) | 2003-06-10 |
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