NO973279L - PIK-related kinase materials and cell cycle checkpoint methods - Google Patents
PIK-related kinase materials and cell cycle checkpoint methodsInfo
- Publication number
- NO973279L NO973279L NO973279A NO973279A NO973279L NO 973279 L NO973279 L NO 973279L NO 973279 A NO973279 A NO 973279A NO 973279 A NO973279 A NO 973279A NO 973279 L NO973279 L NO 973279L
- Authority
- NO
- Norway
- Prior art keywords
- pik
- cell cycle
- cycle checkpoint
- mccs1
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Gener som koder for cellesyklus- kontrollpunkt-fosfatidyllnositolkinase (PIK)-beslektede proteiner som er vesentlige for DNA-skaderesponser i celler. Disse PIK-beslektede kinaser er nødvendige i regulatoriske reaksjons- veier som stanser cellesyklusen etter DNA-skade, for å tillate DNA-reparasjon før mitose eller initiering av DNA- replikasjon. En ny human cellesyklus- kontrollpunkt-PIK-beslektet kinase, MCCSl, og polynukleotidsekvenser som koder for MCCSl er nærmere beskrevet. Analyser for identifikasjon av modulatorer av MCCSl anvendelige som f.eks. kjemoterapi- og strålings- adjuvanser, er også beskrevet. Analyser for Identifikasjon av modulatorer av det cellesykluskontrollpunkt-fosfat- idylinositolkinase (PIK)-besLektede protein, identifisert som ATM, er også beskrevet.Genes encoding cell cycle checkpoint phosphatidyl nilositol kinase (PIK) -related proteins that are essential for DNA damage responses in cells. These PIK-related kinases are required in regulatory pathways that stop the cell cycle after DNA damage, to allow DNA repair before mitosis or initiation of DNA replication. A new human cell cycle checkpoint PIK-related kinase, MCCS1, and polynucleotide sequences encoding MCCS1 are described in more detail. Assays for identification of modulators of MCCS1 useful as e.g. chemotherapy and radiation adjuvants are also described. Assays for the identification of modulators of the cell cycle checkpoint phosphate-idylinositol kinase (PIK) -related protein, identified as ATM, are also described.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55866695A | 1995-11-16 | 1995-11-16 | |
US73129696A | 1996-02-27 | 1996-02-27 | |
US72530496A | 1996-10-21 | 1996-10-21 | |
PCT/US1996/019337 WO1997018323A2 (en) | 1995-11-16 | 1996-11-18 | Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
NO973279D0 NO973279D0 (en) | 1997-07-15 |
NO973279L true NO973279L (en) | 1997-09-16 |
Family
ID=27415779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO973279A NO973279L (en) | 1995-11-16 | 1997-07-15 | PIK-related kinase materials and cell cycle checkpoint methods |
Country Status (6)
Country | Link |
---|---|
CN (1) | CN1199420A (en) |
AU (1) | AU1461197A (en) |
IL (1) | IL121306A0 (en) |
NO (1) | NO973279L (en) |
PL (1) | PL322876A1 (en) |
WO (1) | WO1997018323A2 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5777093A (en) * | 1995-05-16 | 1998-07-07 | Ramot-University Authority For Applied Research & Industrial Development Ltd. | cDNAs associated with ataxia-telangiectasia |
US5858661A (en) * | 1995-05-16 | 1999-01-12 | Ramot-University Authority For Applied Research And Industrial Development | Ataxia-telangiectasia gene and its genomic organization |
GB9518220D0 (en) * | 1995-09-06 | 1995-11-08 | Medical Res Council | Checkpoint gene |
AU8400398A (en) * | 1997-07-11 | 1999-02-08 | Trustees Of The University Of Pennsylvania, The | Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use |
GB9714971D0 (en) * | 1997-07-16 | 1997-09-24 | Cancer Res Campaign Tech | Assays,therapeutic methods and means |
GB9718952D0 (en) * | 1997-09-05 | 1997-11-12 | Medical Res Council | Mammalian chk1 effector cell cycle checkpoint protein kinase materials and methods |
CA2216559A1 (en) * | 1997-09-25 | 1999-03-25 | Michel Roberge | G2 checkpoint inhibitors and assay |
GB9722320D0 (en) * | 1997-10-22 | 1997-12-17 | Janssen Pharmaceutica Nv | Human cell cycle checkpoint proteins |
US6071691A (en) * | 1998-04-27 | 2000-06-06 | Oregon Health Science University | Materials and methods for modulating differentiation |
US6348311B1 (en) | 1999-02-10 | 2002-02-19 | St. Jude Childre's Research Hospital | ATM kinase modulation for screening and therapies |
US6387640B1 (en) | 1999-02-10 | 2002-05-14 | St. Jude Children's Research Hospital | ATM kinase modulation for screening and therapies |
US6670167B1 (en) | 1999-11-01 | 2003-12-30 | Agouron Pharmaceuticals, Inc. | Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof |
GB0119863D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
WO2004038008A2 (en) * | 2002-10-25 | 2004-05-06 | University Of Massachusetts | Modulation of cellular proliferation |
US7429660B2 (en) | 2003-08-13 | 2008-09-30 | Kudos Pharmaceuticals Limited | ATM inhibitors |
US20070238731A1 (en) | 2004-09-20 | 2007-10-11 | Kudos Pharmaceuticals Limited | Dna-Pk Inhibitors |
TW200638938A (en) | 2005-02-09 | 2006-11-16 | Kudos Pharm Ltd | ATM inhibitors |
AR053358A1 (en) | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | DNA INHIBITORS - PK |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9518220D0 (en) * | 1995-09-06 | 1995-11-08 | Medical Res Council | Checkpoint gene |
-
1996
- 1996-11-18 AU AU14611/97A patent/AU1461197A/en not_active Abandoned
- 1996-11-18 IL IL12130696A patent/IL121306A0/en unknown
- 1996-11-18 PL PL96322876A patent/PL322876A1/en unknown
- 1996-11-18 WO PCT/US1996/019337 patent/WO1997018323A2/en not_active Application Discontinuation
- 1996-11-18 CN CN96192586.8A patent/CN1199420A/en active Pending
-
1997
- 1997-07-15 NO NO973279A patent/NO973279L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1997018323A3 (en) | 1997-10-09 |
NO973279D0 (en) | 1997-07-15 |
WO1997018323A2 (en) | 1997-05-22 |
CN1199420A (en) | 1998-11-18 |
AU1461197A (en) | 1997-06-05 |
PL322876A1 (en) | 1998-03-02 |
IL121306A0 (en) | 1998-01-04 |
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