NO973279L - PIK-related kinase materials and cell cycle checkpoint methods - Google Patents

PIK-related kinase materials and cell cycle checkpoint methods

Info

Publication number
NO973279L
NO973279L NO973279A NO973279A NO973279L NO 973279 L NO973279 L NO 973279L NO 973279 A NO973279 A NO 973279A NO 973279 A NO973279 A NO 973279A NO 973279 L NO973279 L NO 973279L
Authority
NO
Norway
Prior art keywords
pik
cell cycle
cycle checkpoint
mccs1
kinase
Prior art date
Application number
NO973279A
Other languages
Norwegian (no)
Other versions
NO973279D0 (en
Inventor
Merl F Hoekstra
Doug A Holtzman
Kathleen S Keegan
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of NO973279D0 publication Critical patent/NO973279D0/en
Publication of NO973279L publication Critical patent/NO973279L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Abstract

Gener som koder for cellesyklus- kontrollpunkt-fosfatidyllnositolkinase (PIK)-beslektede proteiner som er vesentlige for DNA-skaderesponser i celler. Disse PIK-beslektede kinaser er nødvendige i regulatoriske reaksjons- veier som stanser cellesyklusen etter DNA-skade, for å tillate DNA-reparasjon før mitose eller initiering av DNA- replikasjon. En ny human cellesyklus- kontrollpunkt-PIK-beslektet kinase, MCCSl, og polynukleotidsekvenser som koder for MCCSl er nærmere beskrevet. Analyser for identifikasjon av modulatorer av MCCSl anvendelige som f.eks. kjemoterapi- og strålings- adjuvanser, er også beskrevet. Analyser for Identifikasjon av modulatorer av det cellesykluskontrollpunkt-fosfat- idylinositolkinase (PIK)-besLektede protein, identifisert som ATM, er også beskrevet.Genes encoding cell cycle checkpoint phosphatidyl nilositol kinase (PIK) -related proteins that are essential for DNA damage responses in cells. These PIK-related kinases are required in regulatory pathways that stop the cell cycle after DNA damage, to allow DNA repair before mitosis or initiation of DNA replication. A new human cell cycle checkpoint PIK-related kinase, MCCS1, and polynucleotide sequences encoding MCCS1 are described in more detail. Assays for identification of modulators of MCCS1 useful as e.g. chemotherapy and radiation adjuvants are also described. Assays for the identification of modulators of the cell cycle checkpoint phosphate-idylinositol kinase (PIK) -related protein, identified as ATM, are also described.

NO973279A 1995-11-16 1997-07-15 PIK-related kinase materials and cell cycle checkpoint methods NO973279L (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55866695A 1995-11-16 1995-11-16
US73129696A 1996-02-27 1996-02-27
US72530496A 1996-10-21 1996-10-21
PCT/US1996/019337 WO1997018323A2 (en) 1995-11-16 1996-11-18 Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity

Publications (2)

Publication Number Publication Date
NO973279D0 NO973279D0 (en) 1997-07-15
NO973279L true NO973279L (en) 1997-09-16

Family

ID=27415779

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973279A NO973279L (en) 1995-11-16 1997-07-15 PIK-related kinase materials and cell cycle checkpoint methods

Country Status (6)

Country Link
CN (1) CN1199420A (en)
AU (1) AU1461197A (en)
IL (1) IL121306A0 (en)
NO (1) NO973279L (en)
PL (1) PL322876A1 (en)
WO (1) WO1997018323A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5777093A (en) * 1995-05-16 1998-07-07 Ramot-University Authority For Applied Research & Industrial Development Ltd. cDNAs associated with ataxia-telangiectasia
US5858661A (en) * 1995-05-16 1999-01-12 Ramot-University Authority For Applied Research And Industrial Development Ataxia-telangiectasia gene and its genomic organization
GB9518220D0 (en) * 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
AU8400398A (en) * 1997-07-11 1999-02-08 Trustees Of The University Of Pennsylvania, The Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use
GB9714971D0 (en) 1997-07-16 1997-09-24 Cancer Res Campaign Tech Assays,therapeutic methods and means
GB9718952D0 (en) * 1997-09-05 1997-11-12 Medical Res Council Mammalian chk1 effector cell cycle checkpoint protein kinase materials and methods
CA2216559A1 (en) * 1997-09-25 1999-03-25 Michel Roberge G2 checkpoint inhibitors and assay
GB9722320D0 (en) * 1997-10-22 1997-12-17 Janssen Pharmaceutica Nv Human cell cycle checkpoint proteins
US6071691A (en) * 1998-04-27 2000-06-06 Oregon Health Science University Materials and methods for modulating differentiation
US6348311B1 (en) 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
US6387640B1 (en) 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
US6670167B1 (en) 1999-11-01 2003-12-30 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
AU2003286729A1 (en) * 2002-10-25 2004-05-13 University Of Massachusetts Modulation of cellular proliferation
CN1867566B (en) 2003-08-13 2010-06-16 库多斯药物有限公司 Aminopyrones and their use as ATM inhibitors
US7402607B2 (en) 2004-09-20 2008-07-22 Kudos Pharmaceuticals Limited DNA-PK inhibitors
TW200638938A (en) 2005-02-09 2006-11-16 Kudos Pharm Ltd ATM inhibitors
AR053358A1 (en) 2005-04-15 2007-05-02 Cancer Rec Tech Ltd DNA INHIBITORS - PK

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9518220D0 (en) * 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene

Also Published As

Publication number Publication date
CN1199420A (en) 1998-11-18
WO1997018323A2 (en) 1997-05-22
NO973279D0 (en) 1997-07-15
IL121306A0 (en) 1998-01-04
AU1461197A (en) 1997-06-05
PL322876A1 (en) 1998-03-02
WO1997018323A3 (en) 1997-10-09

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