MX9705466A - Cell cycle checkpoint pik-related kinase materials and methods. - Google Patents

Cell cycle checkpoint pik-related kinase materials and methods.

Info

Publication number
MX9705466A
MX9705466A MX9705466A MX9705466A MX9705466A MX 9705466 A MX9705466 A MX 9705466A MX 9705466 A MX9705466 A MX 9705466A MX 9705466 A MX9705466 A MX 9705466A MX 9705466 A MX9705466 A MX 9705466A
Authority
MX
Mexico
Prior art keywords
pik
cell cycle
cycle checkpoint
methods
kinase
Prior art date
Application number
MX9705466A
Other languages
Spanish (es)
Inventor
Merl F Hoekstra
Doug A Holtzman
Kathleen S Keegan
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Priority claimed from PCT/US1996/019337 external-priority patent/WO1997018323A2/en
Publication of MX9705466A publication Critical patent/MX9705466A/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Abstract

The present invention generally relates to genes encoding cell cycle checkpoint phosphatidylinositol kinase (PIK)-related proteins essential to DNA damage responses in cells. These PIK-related kinases are required in regulatory pathways that arrest the cell cycle following DNA damage to allow DNA repair prior to mitosis or initiation of DNA replication. More particularly, the invention provides a novel human cell cycle checkpoint PIK-related kinase, MCCS1, and polynucleotide sequences encoding the MCSS1. Assays for identifying modulators of MCCS1 useful as, for example, chemotherapy and radiation adjuvants, are also provided by the invention. Further, assays for identifying modulators of the cell cycle checkpoint phosphatidylinositol kinase (PIK)-related protein identified as ATM are provided.
MX9705466A 1995-11-16 1996-11-18 Cell cycle checkpoint pik-related kinase materials and methods. MX9705466A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55866695A 1995-11-16 1995-11-16
US731296P 1996-02-27 1996-02-27
US72530496A 1996-10-21 1996-10-21
PCT/US1996/019337 WO1997018323A2 (en) 1995-11-16 1996-11-18 Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity

Publications (1)

Publication Number Publication Date
MX9705466A true MX9705466A (en) 1997-10-31

Family

ID=27358333

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9705466A MX9705466A (en) 1995-11-16 1996-11-18 Cell cycle checkpoint pik-related kinase materials and methods.

Country Status (4)

Country Link
JP (1) JP2002515732A (en)
FI (1) FI973005A (en)
MX (1) MX9705466A (en)
SK (1) SK111597A3 (en)

Also Published As

Publication number Publication date
SK111597A3 (en) 1998-05-06
JP2002515732A (en) 2002-05-28
FI973005A (en) 1997-09-15
FI973005A0 (en) 1997-07-15

Similar Documents

Publication Publication Date Title
WO1997018323A3 (en) Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity
McVey et al. Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication
MX9902661A (en) High level expression of proteins
NO963371L (en) Hematopoietic protein as well as materials and methods for making it
Kaufmann et al. Enzymatic degradation of ribonucleoproteins of chromosomes, nucleoli and cytoplasm
DE69433552D1 (en) CYTOKIN BINDING TO THE HEK CELL SURFACE RECEPTOR
DE69841723D1 (en) EXPRESSION OF ENDOGENIC GENES THROUGH HOMOLOGOUS RECOMBINATION OF A VECTOR CONSTRUCTURE WITH CELLULAR DNA
ATE310015T1 (en) HIGH EXPRESSION RATE OF GREEN FLUORESCENT PROTEIN
DK265685D0 (en) THROMBIN INHIBITORS AND THEIR PREPARATION AND USE
EP0575546A4 (en) Prad1 cyclin and its cdna
WO2000075350A3 (en) Nucleic acid sequences encoding proteins involved in fatty acid beta-oxidation and methods of use
ATE469981T1 (en) TESTS FOR PROTEIN KINASES USING FLUORESCENT PROTEIN SUBSTRATES
DE69434614D1 (en) CDN APOPTOSIS MODULATING PROTEINS, THE ENCODING DNA, AND METHOD FOR THEIR USE
DE69229681D1 (en) A PROTEIN THAT RECOGNIZES SPECIFIC DNA STRUCTURES AND ITS USE
BR9912455A (en) nucleic acids encoding proteins involved in sensory transduction
EP1005539A4 (en) IKK-$g(a) PROTEINS, NUCLEIC ACIDS AND METHODS
NO962084L (en) DNA sequence encoding a BMP receptor
ATE294856T1 (en) LUNASIN PEPTIDES
DE60144021D1 (en) FOR CELL CYCLE PROTEINS CODING NUCLEIC ACID AND ITS USE
MX9705466A (en) Cell cycle checkpoint pik-related kinase materials and methods.
ATE205600T1 (en) LEUKOCYTE ADHESION TEST
Fellous et al. Association of p34cdc2 kinase and MAP kinase with microtubules during the meiotic maturation of Xenopus oocytes.
DE69837808D1 (en) pRb2 / p130 PEPTIDINHIBITORS OF cdk2 KINASEACTIVITY
WO1999020761A3 (en) Compositions and methods for identifying and testing therapeutics against hsv infection
WO1998031805A3 (en) Human zinc binding proteins