NO972868L - Oligonucleotide-dendrimer conjugates - Google Patents

Oligonucleotide-dendrimer conjugates

Info

Publication number
NO972868L
NO972868L NO972868A NO972868A NO972868L NO 972868 L NO972868 L NO 972868L NO 972868 A NO972868 A NO 972868A NO 972868 A NO972868 A NO 972868A NO 972868 L NO972868 L NO 972868L
Authority
NO
Norway
Prior art keywords
dendrimer
oligonucleotide
natural
modified
nucleic acid
Prior art date
Application number
NO972868A
Other languages
Norwegian (no)
Other versions
NO972868D0 (en
Inventor
Robert Haener
Konstantinos Skobridis
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO972868D0 publication Critical patent/NO972868D0/en
Publication of NO972868L publication Critical patent/NO972868L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Oligonukleotid-dendrimer konjugater, der dendrimeren er et enverdig residie av en dendrimer av første til tiende generasjon og oligonukleotidet er en naturlig, modifisert eller syntetisk sekvens som består av naturlige, modifiserte eller syntetiske deoksynukleosider eller peptidnukleinsyrebyggeblokker som er bundet via intemukleotidbroer og som omfatter en region som er komplementær, fortrinnsvis fullstendig komplementær, til en målnukleinsyre (mål-RNA eller mål-DNA), der dendrimeren er bundet til en intemukleotidbro, en nukleinsyrebase eller en sukker av nukleotidet, og saltene av disse.Oligonucleotide dendrimer conjugates, wherein the dendrimer is a monovalent residue of a first to tenth generation dendrimer and the oligonucleotide is a natural, modified or synthetic sequence consisting of natural, modified or synthetic deoxynucleosides or peptide nucleotide-linked building blocks such as which is complementary, preferably completely complementary, to a target nucleic acid (target RNA or target DNA), wherein the dendrimer is bound to an internucleotide bridge, a nucleic acid base or a sugar of the nucleotide, and its salts.

NO972868A 1994-12-21 1997-06-20 Oligonucleotide-dendrimer conjugates NO972868L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH385494 1994-12-21
CH4795 1995-01-09
PCT/EP1995/004933 WO1996019240A1 (en) 1994-12-21 1995-12-13 Oligonucleotide-dendrimer conjugates

Publications (2)

Publication Number Publication Date
NO972868D0 NO972868D0 (en) 1997-06-20
NO972868L true NO972868L (en) 1997-08-19

Family

ID=25683356

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972868A NO972868L (en) 1994-12-21 1997-06-20 Oligonucleotide-dendrimer conjugates

Country Status (9)

Country Link
EP (1) EP0790837A1 (en)
JP (1) JPH10510822A (en)
AU (1) AU4344696A (en)
CA (1) CA2206915A1 (en)
FI (1) FI972548A (en)
HU (1) HUT77521A (en)
IL (1) IL116456A0 (en)
NO (1) NO972868L (en)
WO (1) WO1996019240A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563255A (en) * 1994-05-31 1996-10-08 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
US5744460A (en) * 1996-03-07 1998-04-28 Novartis Corporation Combination for treatment of proliferative diseases
CA2291839A1 (en) * 1997-05-28 1998-12-03 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
GB9718129D0 (en) 1997-08-27 1997-10-29 Isis Innovation Branched structures
US6287765B1 (en) * 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
FR2906532B1 (en) 2006-09-28 2008-12-12 Biomerieux Sa NEW OLIGONUCLEOTIDE BRAND
FR2933410B1 (en) 2008-07-04 2010-08-20 Biomerieux Sa NEW DETECTION PROBE
JOP20210186A1 (en) 2019-01-10 2023-01-30 Janssen Biotech Inc Prostate neoantigens and their uses
US12018289B2 (en) 2019-11-18 2024-06-25 Janssen Biotech, Inc. Vaccines based on mutant CALR and JAK2 and their uses
CN112898580B (en) * 2019-12-03 2022-11-08 安序源生物科技(深圳)有限公司 Sequencing reagent
CN112898575B (en) * 2019-12-03 2022-10-21 深圳清华大学研究院 Preparation method of crotch-like macromolecule modified nucleotide
EP4175721A1 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
US20230029453A1 (en) 2020-07-06 2023-02-02 Janssen Biotech, Inc. Prostate Neoantigens And Their Uses
EP4176087A1 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. A method for determining responsiveness to prostate cancer treatment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE89743T1 (en) * 1986-08-18 1993-06-15 Dow Chemical Co CONJUGATE POETS STARS.
IL107715A0 (en) * 1992-11-25 1994-02-27 Baxter Int Water soluble non-immunogenic polyamide cross-linking agents
DE69433519T2 (en) * 1993-07-14 2004-11-11 The Regents Of The University Of California, Oakland SELF-ASSEMBLING POLYNUCLEOTID DELIVERY SYSTEM CONTAINING DENDRIMER POLYCATIONS
ZA951877B (en) * 1994-03-07 1996-09-09 Dow Chemical Co Bioactive and/or targeted dendrimer conjugates
IT1270994B (en) * 1994-03-18 1997-05-26 Bracco Spa POLYOXYKYLIC STRUCTURE MACROMOLECULES WITH THEIR USE

Also Published As

Publication number Publication date
FI972548A0 (en) 1997-06-16
IL116456A0 (en) 1996-03-31
FI972548A (en) 1997-06-23
WO1996019240A1 (en) 1996-06-27
HUT77521A (en) 1998-05-28
CA2206915A1 (en) 1996-06-27
EP0790837A1 (en) 1997-08-27
AU4344696A (en) 1996-07-10
JPH10510822A (en) 1998-10-20
NO972868D0 (en) 1997-06-20

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