NO972150L - Metode og apparatur for måling av elektrokjemoluminescens-emisjon - Google Patents
Metode og apparatur for måling av elektrokjemoluminescens-emisjonInfo
- Publication number
- NO972150L NO972150L NO972150A NO972150A NO972150L NO 972150 L NO972150 L NO 972150L NO 972150 A NO972150 A NO 972150A NO 972150 A NO972150 A NO 972150A NO 972150 L NO972150 L NO 972150L
- Authority
- NO
- Norway
- Prior art keywords
- electrochemiluminescent
- electrode
- cell
- light
- ecl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 67
- 239000007788 liquid Substances 0.000 claims description 55
- 238000006243 chemical reaction Methods 0.000 claims description 31
- 230000001105 regulatory effect Effects 0.000 claims description 31
- 239000003792 electrolyte Substances 0.000 claims description 20
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 16
- 150000002500 ions Chemical class 0.000 claims description 10
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical group CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 claims description 7
- 230000008030 elimination Effects 0.000 claims description 6
- 238000003379 elimination reaction Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000003623 enhancer Substances 0.000 claims description 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 4
- BZSVVCFHMVMYCR-UHFFFAOYSA-N 2-pyridin-2-ylpyridine;ruthenium Chemical group [Ru].N1=CC=CC=C1C1=CC=CC=N1.N1=CC=CC=C1C1=CC=CC=N1.N1=CC=CC=C1C1=CC=CC=N1 BZSVVCFHMVMYCR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052702 rhenium Inorganic materials 0.000 claims description 3
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 44
- 239000006249 magnetic particle Substances 0.000 description 25
- 238000005259 measurement Methods 0.000 description 22
- 238000001514 detection method Methods 0.000 description 18
- 238000003411 electrode reaction Methods 0.000 description 17
- 101710145634 Antigen 1 Proteins 0.000 description 15
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical compound N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 13
- 238000004140 cleaning Methods 0.000 description 13
- 239000000427 antigen Substances 0.000 description 12
- 102000036639 antigens Human genes 0.000 description 12
- 108091007433 antigens Proteins 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- 229910021607 Silver chloride Inorganic materials 0.000 description 11
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 10
- 239000002245 particle Substances 0.000 description 9
- 238000010586 diagram Methods 0.000 description 7
- 125000006850 spacer group Chemical group 0.000 description 7
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000005868 electrolysis reaction Methods 0.000 description 4
- 239000008151 electrolyte solution Substances 0.000 description 4
- 239000004925 Acrylic resin Substances 0.000 description 3
- 229920000178 Acrylic resin Polymers 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 239000004809 Teflon Substances 0.000 description 3
- 229920006362 Teflon® Polymers 0.000 description 3
- 239000013522 chelant Substances 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- 150000003304 ruthenium compounds Chemical class 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- 230000001052 transient effect Effects 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical class [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920004890 Triton X-100 Polymers 0.000 description 2
- 239000013504 Triton X-100 Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000000840 electrochemical analysis Methods 0.000 description 2
- 238000001378 electrochemiluminescence detection Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 230000005283 ground state Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 229910052707 ruthenium Inorganic materials 0.000 description 2
- 239000012780 transparent material Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012496 blank sample Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229940125758 compound 15 Drugs 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 230000005518 electrochemistry Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 239000010956 nickel silver Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- FHHJDRFHHWUPDG-UHFFFAOYSA-L peroxysulfate(2-) Chemical compound [O-]OS([O-])(=O)=O FHHJDRFHHWUPDG-UHFFFAOYSA-L 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- -1 ruthenium-tris-bipyridyl compound Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229910000859 α-Fe Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
- G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26077595 | 1995-09-12 | ||
| PCT/JP1996/002612 WO1997010498A1 (fr) | 1995-09-12 | 1996-09-12 | Procede et appareil de detection d'electrochemiluminescence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO972150D0 NO972150D0 (no) | 1997-05-09 |
| NO972150L true NO972150L (no) | 1997-07-09 |
Family
ID=17352563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO972150A NO972150L (no) | 1995-09-12 | 1997-05-09 | Metode og apparatur for måling av elektrokjemoluminescens-emisjon |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0791821A4 (de) |
| JP (1) | JP3574457B2 (de) |
| CA (1) | CA2205050A1 (de) |
| NO (1) | NO972150L (de) |
| WO (1) | WO1997010498A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3366842B2 (ja) * | 1997-08-29 | 2003-01-14 | エーザイ株式会社 | 電気化学発光測定用セル |
| AU2006201608B2 (en) * | 1998-05-11 | 2007-06-07 | Bioveris Corporation | Improved Apparatus and Methods for Carrying Out Electrochemiluminescence Test Measurements |
| US6200531B1 (en) * | 1998-05-11 | 2001-03-13 | Igen International, Inc. | Apparatus for carrying out electrochemiluminescence test measurements |
| AU2003200956B2 (en) * | 1998-05-11 | 2006-01-19 | Bioveris Corporation | Improved Apparatus and Methods for Carrying Out Electrochemiluminescence Test Measurements |
| WO2004001380A2 (en) | 2002-06-20 | 2003-12-31 | Igen International, Inc | Electrochemiluminescence flow cell and flow cell components |
| US7815854B2 (en) * | 2004-04-30 | 2010-10-19 | Kimberly-Clark Worldwide, Inc. | Electroluminescent illumination source for optical detection systems |
| US7796266B2 (en) | 2004-04-30 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Optical detection system using electromagnetic radiation to detect presence or quantity of analyte |
| CN103913447B (zh) * | 2014-03-31 | 2016-08-31 | 南京医科大学 | 一种电致化学发光成像装置及其应用 |
| CN105842233A (zh) * | 2016-05-10 | 2016-08-10 | 山东大学 | 一种采集双波长电致化学发光光强信息的检测系统 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071429A (en) * | 1976-12-29 | 1978-01-31 | Monsanto Company | Electrolytic flow-cell apparatus and process for effecting sequential electrochemical reaction |
| GB2079474B (en) * | 1980-07-10 | 1984-05-10 | Nat Res Dev | Electrocatalytic activation of electrodes |
| US4500840A (en) * | 1982-10-28 | 1985-02-19 | International Business Machines Corporation | High speed, power potentiostat/galvanostat with IR compensation for use with an electrochemical cell |
| US4591550A (en) * | 1984-03-01 | 1986-05-27 | Molecular Devices Corporation | Device having photoresponsive electrode for determining analytes including ligands and antibodies |
| US5238808A (en) * | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| EP0265519B1 (de) * | 1986-04-30 | 1995-09-13 | IGEN, INC. (a California corporation) | Elektrochemilumineszenz-testverfahren |
| AU2827389A (en) * | 1987-11-04 | 1989-06-01 | Igen, Inc. | Electrochemiluminescent rhenium moieties and methods |
| IL90105A (en) * | 1988-04-29 | 1993-05-13 | Igen Inc | Method and apparatus for conducting electro- chemiluminescence measurements |
| WO1990005296A1 (en) * | 1988-11-03 | 1990-05-17 | Igen, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US5632957A (en) * | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
| JPH0634548A (ja) * | 1992-07-16 | 1994-02-08 | Omron Corp | 電気化学発光測定装置 |
| JP3157053B2 (ja) * | 1992-09-16 | 2001-04-16 | ティーディーケイ株式会社 | Ｄｎａ作用物質の結合様式特定方法 |
-
1996
- 1996-09-12 EP EP96930380A patent/EP0791821A4/de not_active Withdrawn
- 1996-09-12 WO PCT/JP1996/002612 patent/WO1997010498A1/ja not_active Application Discontinuation
- 1996-09-12 JP JP51183997A patent/JP3574457B2/ja not_active Expired - Lifetime
- 1996-09-12 CA CA 2205050 patent/CA2205050A1/en not_active Abandoned
-
1997
- 1997-05-09 NO NO972150A patent/NO972150L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3574457B2 (ja) | 2004-10-06 |
| NO972150D0 (no) | 1997-05-09 |
| WO1997010498A1 (fr) | 1997-03-20 |
| EP0791821A1 (de) | 1997-08-27 |
| EP0791821A4 (de) | 1999-10-27 |
| CA2205050A1 (en) | 1997-03-20 |
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