NO971672D0 - Benzofuran and benzo-fused compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists - Google Patents

Benzofuran and benzo-fused compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists

Info

Publication number
NO971672D0
NO971672D0 NO971672A NO971672A NO971672D0 NO 971672 D0 NO971672 D0 NO 971672D0 NO 971672 A NO971672 A NO 971672A NO 971672 A NO971672 A NO 971672A NO 971672 D0 NO971672 D0 NO 971672D0
Authority
NO
Norway
Prior art keywords
ltb4
leukotriene
benzofuran
benzo
antagonists
Prior art date
Application number
NO971672A
Other languages
Norwegian (no)
Other versions
NO971672L (en
Inventor
Mark A Dombroski
Kevin Koch
Anthony D Piscopio
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO971672D0 publication Critical patent/NO971672D0/en
Publication of NO971672L publication Critical patent/NO971672L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
NO971672A 1994-10-13 1997-04-11 Benzofuran and benzo-fused compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists NO971672L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32287694A 1994-10-13 1994-10-13
PCT/IB1995/000401 WO1996011920A1 (en) 1994-10-13 1995-05-26 Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b4 (ltb4) antagonists

Publications (2)

Publication Number Publication Date
NO971672D0 true NO971672D0 (en) 1997-04-11
NO971672L NO971672L (en) 1997-06-11

Family

ID=23256829

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971672A NO971672L (en) 1994-10-13 1997-04-11 Benzofuran and benzo-fused compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists

Country Status (23)

Country Link
US (2) US6051601A (en)
EP (1) EP0785930A1 (en)
JP (1) JP2983295B2 (en)
KR (1) KR100232341B1 (en)
CN (1) CN1160399A (en)
AU (1) AU696890B2 (en)
BR (1) BR9504385A (en)
CA (1) CA2201742A1 (en)
CO (1) CO4480024A1 (en)
CZ (1) CZ111797A3 (en)
FI (1) FI971524A0 (en)
HU (1) HUT77515A (en)
IL (1) IL115529A0 (en)
MX (1) MX9702731A (en)
NO (1) NO971672L (en)
NZ (1) NZ285156A (en)
PE (1) PE10897A1 (en)
PL (1) PL319688A1 (en)
RU (1) RU2128655C1 (en)
TR (1) TR199501270A2 (en)
TW (1) TW304941B (en)
WO (1) WO1996011920A1 (en)
ZA (1) ZA958597B (en)

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AU713701B2 (en) * 1996-09-16 1999-12-09 Pfizer Inc. Processes and intermediates for preparing substituted chromanol derivatives
CA2274908A1 (en) * 1996-12-13 1998-06-18 Eli Lilly And Company Leukotriene antagonists for cerebral focal stroke
IL128731A0 (en) * 1998-03-12 2000-01-31 Pfizer Prod Inc Method of preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
SE0004245D0 (en) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
WO2002060888A1 (en) * 2001-01-30 2002-08-08 Pfizer Products Inc. Processes for preparing chromanylbenzoic acids
AU4239302A (en) * 2001-06-28 2003-01-02 Pfizer Products Inc. Benzoic acid substituted benzopyrans for the treatment of atherosclerosis
EA008148B1 (en) 2002-06-19 2007-04-27 Биовитрум Аб New compounds, their use and preparation
AU2005266088A1 (en) * 2004-07-22 2006-02-02 Pharmacia Corporation Compositions for treatment of inflammation and pain using a combination of a COX-2 selective inhibitor and a LTB4 receptor antagonist
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
CA2589363A1 (en) 2004-12-13 2006-06-22 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors
MX2007010328A (en) 2005-02-25 2008-03-13 Lilly Co Eli Spiro-heterocyclic chromans, thiochromans and dihydroquinolines.
US7842713B2 (en) * 2006-04-20 2010-11-30 Pfizer Inc Fused phenyl amido heterocyclic compounds
WO2008079427A1 (en) 2006-05-11 2008-07-03 Janssen Pharmaceutica N.V. 1,2,3,4-tetrahydro-quinoline derivatives as cetp inhibitors
WO2007134149A2 (en) * 2006-05-11 2007-11-22 Janssen Pharmaceutica N.V. 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as cetp inhibitors
NZ591366A (en) 2008-09-11 2012-05-25 Pfizer Heteroaryls amide derivatives and their use as glucokinase activators
EA018894B1 (en) * 2009-03-11 2013-11-29 Пфайзер Инк. N,n-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide used as glucokinase activator and pharmaceutical composition containing same
WO2013123081A2 (en) * 2012-02-14 2013-08-22 Children's Hospital Medical Center Use of small molecule inhibitors targeting the interaction between rac gtpase and p67 (phox)
CN102920692A (en) * 2012-10-25 2013-02-13 中国人民解放军第二军医大学 Application of (E)-2-(1-hydroyxl-4-cyclohexanone) aethyl-caffeic acid phenethyl ester in preparation of medicament for preventing and treating rheumatoid arthritis
US9745253B2 (en) 2015-03-13 2017-08-29 Forma Therapeutics, Inc. Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
TW201711999A (en) 2015-09-03 2017-04-01 佛瑪治療公司 [6,6] fused bicyclic HDAC8 inhibitors
US10336733B2 (en) 2015-11-30 2019-07-02 Merk Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
EP3383869B1 (en) 2015-11-30 2023-06-28 Merck Sharp & Dohme LLC Aryl sulfonamides as blt1 antagonists
US20190382363A1 (en) * 2015-11-30 2019-12-19 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
WO2017095723A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
US20190216790A1 (en) * 2016-10-13 2019-07-18 The Regents Of The University Of California Methods for Treating Pruritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
CA2019335C (en) * 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
US4996230A (en) * 1990-02-16 1991-02-26 Eli Lilly And Company Leukotriene antagonists
US5073562A (en) * 1990-05-10 1991-12-17 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5051438A (en) * 1990-05-16 1991-09-24 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use
US5124350A (en) * 1990-06-28 1992-06-23 G. D. Searle & Co. Leukotriene b4 antagonists
JP2813464B2 (en) * 1992-01-23 1998-10-22 フアイザー・インコーポレイテツド Benzopyran and related LTB 4 lower antagonists
MX9300312A (en) * 1992-01-23 1993-07-31 Pfizer BENZOPYRANIC AND RELATED ANTAGONISTS OF LTB.

Also Published As

Publication number Publication date
US6051601A (en) 2000-04-18
NZ285156A (en) 1999-01-28
KR100232341B1 (en) 2000-07-01
WO1996011920A1 (en) 1996-04-25
JP2983295B2 (en) 1999-11-29
KR970706270A (en) 1997-11-03
JPH09512035A (en) 1997-12-02
AU696890B2 (en) 1998-09-24
CA2201742A1 (en) 1996-04-25
NO971672L (en) 1997-06-11
BR9504385A (en) 1997-05-27
IL115529A0 (en) 1996-01-19
ZA958597B (en) 1997-04-14
CN1160399A (en) 1997-09-24
PL319688A1 (en) 1997-08-18
PE10897A1 (en) 1997-04-21
TW304941B (en) 1997-05-11
FI971524A (en) 1997-04-11
CO4480024A1 (en) 1997-07-09
EP0785930A1 (en) 1997-07-30
MX9702731A (en) 1997-06-28
TR199501270A2 (en) 1996-06-21
RU2128655C1 (en) 1999-04-10
AU2416795A (en) 1996-05-06
FI971524A0 (en) 1997-04-11
US6133286A (en) 2000-10-17
CZ111797A3 (en) 1998-07-15
HUT77515A (en) 1998-05-28

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