NO970263L - Process for preparing a halogen-substituted aromatic acid - Google Patents
Process for preparing a halogen-substituted aromatic acidInfo
- Publication number
- NO970263L NO970263L NO970263A NO970263A NO970263L NO 970263 L NO970263 L NO 970263L NO 970263 A NO970263 A NO 970263A NO 970263 A NO970263 A NO 970263A NO 970263 L NO970263 L NO 970263L
- Authority
- NO
- Norway
- Prior art keywords
- benzenedicarboxylic acid
- amino
- sodium salt
- halogen
- preparing
- Prior art date
Links
- 159000000032 aromatic acids Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- IUEVXLACZFKZSP-UHFFFAOYSA-L disodium;5-aminobenzene-1,3-dicarboxylate Chemical compound [Na+].[Na+].NC1=CC(C([O-])=O)=CC(C([O-])=O)=C1 IUEVXLACZFKZSP-UHFFFAOYSA-L 0.000 abstract 3
- 239000012266 salt solution Substances 0.000 abstract 2
- JEZJSNULLBSYHV-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid Chemical compound NC1=C(I)C(C(O)=O)=C(I)C(C(O)=O)=C1I JEZJSNULLBSYHV-UHFFFAOYSA-N 0.000 abstract 1
- NBDAHKQJXVLAID-UHFFFAOYSA-N 5-nitroisophthalic acid Chemical compound OC(=O)C1=CC(C(O)=O)=CC([N+]([O-])=O)=C1 NBDAHKQJXVLAID-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 230000026045 iodination Effects 0.000 abstract 1
- 238000006192 iodination reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
The present invention refers to a process for the preparation of 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid, comprising the following steps: a) catalytic hydrogenation of 5-nitro-1,3-benzenedicarboxylic acid in neutral or basic environment, which gives an aqueous solution of 5-amino-1,3-benzenedicarboxylic acid sodium salt; b) direct iodination of the 5-amino-1,3-benzenedicarboxylic acid sodium salt solution deriving from step a), without further purification, with a solution of ICl in HCl, being the 5-amino-1,3-benzenedicarboxylic acid sodium salt solution previously added with HCl and H2SO4.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI951045A IT1274547B (en) | 1995-05-23 | 1995-05-23 | Process for the preparation of 5-amino-2,4,6- triiodoisophthalic acid |
| ITRM950549 IT1277899B1 (en) | 1995-08-04 | 1995-08-04 | Prepn. of 5-amino- 2,4,6-tri:iodo-1,3-benzene di:carboxylic acid - by catalytic hydrogenation of 5-nitro-1,3-benzene di:carboxylic acid and iodination of the product |
| PCT/EP1996/002105 WO1996037458A1 (en) | 1995-05-23 | 1996-05-17 | Process for the preparation of a halosubstituted aromatic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO970263D0 NO970263D0 (en) | 1997-01-21 |
| NO970263L true NO970263L (en) | 1997-03-24 |
| NO314257B1 NO314257B1 (en) | 2003-02-24 |
Family
ID=26331278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19970263A NO314257B1 (en) | 1995-05-23 | 1997-01-21 | Process for the preparation of a halogen-substituted aromatic acid |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5763650A (en) |
| EP (1) | EP0773923B1 (en) |
| JP (1) | JP4012568B2 (en) |
| KR (1) | KR100269079B1 (en) |
| CN (1) | CN1109670C (en) |
| AT (1) | ATE192138T1 (en) |
| AU (1) | AU707177B2 (en) |
| BR (1) | BR9606487A (en) |
| CA (1) | CA2195635C (en) |
| CZ (1) | CZ289771B6 (en) |
| DE (2) | DE773923T1 (en) |
| DK (1) | DK0773923T3 (en) |
| ES (1) | ES2103254T3 (en) |
| GR (2) | GR970300029T1 (en) |
| HU (1) | HU217686B (en) |
| IL (1) | IL118360A (en) |
| MX (1) | MX9700549A (en) |
| NO (1) | NO314257B1 (en) |
| PL (1) | PL318285A1 (en) |
| PT (1) | PT773923E (en) |
| SI (1) | SI9620011A (en) |
| SK (1) | SK8997A3 (en) |
| WO (1) | WO1996037458A1 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2413761T3 (en) | 2005-12-19 | 2013-07-17 | Ge Healthcare As | Iodixanol purification procedure |
| WO2009091758A1 (en) * | 2008-01-14 | 2009-07-23 | Mallinckrodt Inc. | Process for the preparation of iosimenol |
| EP2093206A1 (en) * | 2008-02-20 | 2009-08-26 | BRACCO IMAGING S.p.A. | Process for the iodination of aromatic compounds |
| EP2230227A1 (en) | 2009-03-20 | 2010-09-22 | Bracco Imaging S.p.A | Process for the preparation of triiodinated carboxylic aromatic derivatives |
| EP2243767A1 (en) | 2009-04-21 | 2010-10-27 | Bracco Imaging S.p.A | Process for the iodination of aromatic compounds |
| PT2451994E (en) * | 2009-07-07 | 2014-01-07 | Bracco Imaging Spa | Process for the preparation of a iodinating agent |
| US7999134B2 (en) | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using milling |
| US7999135B2 (en) | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using ultrasound |
| WO2011063551A1 (en) | 2009-11-26 | 2011-06-03 | Hovione China Holding Limited | Preparation and purification of iodixanol |
| EP2394984A1 (en) | 2010-06-10 | 2011-12-14 | Bracco Imaging S.p.A | Process for the iodination of phenolic derivatives |
| CN104955798A (en) | 2012-12-11 | 2015-09-30 | 伯拉考成像股份公司 | Continuous process for the preparation of (S)-2-acetoxypropionyl chloride |
| PT3369724T (en) | 2013-11-05 | 2021-02-10 | Bracco Imaging Spa | Process for the preparation of iopamidol |
| HUE049284T2 (en) | 2014-06-10 | 2020-09-28 | Bracco Imaging Spa | Process for the preparation of (S) -2-acetyloxypropionic acid and its derivatives |
| US11691875B2 (en) | 2017-06-07 | 2023-07-04 | Bracco Imaging Spa | Process for the recovery of iodine from aqueous solutions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2820814A (en) * | 1955-03-21 | 1958-01-21 | Schering Corp | Polyiodinated 5-aminoisophthalic acids, salts, and esters |
| SU502875A1 (en) * | 1973-03-26 | 1976-02-15 | Войсковая Часть 41598 | Method for preparing 4-dimethylaminosalicylic acid methyl ester |
| SU502874A1 (en) * | 1973-12-07 | 1976-02-15 | Институт Органического Катализа И Электрохимии | The method of obtaining m-aminoisophthalic acid |
| US4102917A (en) * | 1977-06-01 | 1978-07-25 | American Cyanamid Company | Substituted phenyl naphthalenesulfonic acids |
| JP2765696B2 (en) * | 1989-12-27 | 1998-06-18 | 三井化学株式会社 | Method for producing 5-amino-2,4,6-triiodoisophthalic acid |
-
1996
- 1996-05-13 US US08/645,448 patent/US5763650A/en not_active Expired - Lifetime
- 1996-05-17 SK SK89-97A patent/SK8997A3/en unknown
- 1996-05-17 DE DE0773923T patent/DE773923T1/en active Pending
- 1996-05-17 ES ES96919779T patent/ES2103254T3/en not_active Expired - Lifetime
- 1996-05-17 EP EP96919779A patent/EP0773923B1/en not_active Expired - Lifetime
- 1996-05-17 MX MX9700549A patent/MX9700549A/en unknown
- 1996-05-17 DK DK96919779T patent/DK0773923T3/en active
- 1996-05-17 WO PCT/EP1996/002105 patent/WO1996037458A1/en not_active Ceased
- 1996-05-17 BR BR9606487A patent/BR9606487A/en not_active Application Discontinuation
- 1996-05-17 CA CA002195635A patent/CA2195635C/en not_active Expired - Lifetime
- 1996-05-17 DE DE69607921T patent/DE69607921T2/en not_active Expired - Lifetime
- 1996-05-17 JP JP53534796A patent/JP4012568B2/en not_active Expired - Lifetime
- 1996-05-17 CN CN96190526A patent/CN1109670C/en not_active Expired - Lifetime
- 1996-05-17 AT AT96919779T patent/ATE192138T1/en active
- 1996-05-17 KR KR1019970700404A patent/KR100269079B1/en not_active Expired - Lifetime
- 1996-05-17 SI SI9620011A patent/SI9620011A/en unknown
- 1996-05-17 CZ CZ1997185A patent/CZ289771B6/en not_active IP Right Cessation
- 1996-05-17 HU HU9700189A patent/HU217686B/en unknown
- 1996-05-17 AU AU58189/96A patent/AU707177B2/en not_active Ceased
- 1996-05-17 PT PT96919779T patent/PT773923E/en unknown
- 1996-05-17 PL PL96318285A patent/PL318285A1/en unknown
- 1996-05-22 IL IL11836096A patent/IL118360A/en not_active IP Right Cessation
-
1997
- 1997-01-21 NO NO19970263A patent/NO314257B1/en not_active IP Right Cessation
- 1997-09-30 GR GR970300029T patent/GR970300029T1/en unknown
-
2000
- 2000-07-14 GR GR20000401642T patent/GR3033957T3/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |