NO964472L - Halo methylamides as IL-1 prosthesis inhibitors - Google Patents
Halo methylamides as IL-1 prosthesis inhibitorsInfo
- Publication number
- NO964472L NO964472L NO964472A NO964472A NO964472L NO 964472 L NO964472 L NO 964472L NO 964472 A NO964472 A NO 964472A NO 964472 A NO964472 A NO 964472A NO 964472 L NO964472 L NO 964472L
- Authority
- NO
- Norway
- Prior art keywords
- methylamides
- prosthesis
- halo
- inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
- C07C255/25—Aminoacetonitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Forbindelser, preparater og metoder for inhibering av interleukin-lB-proteaseaktivitet, hvor forbindelsene har formel (A) som beskrevet heri.Compounds, preparations and methods for inhibiting interleukin-1B protease activity, wherein the compounds have formula (A) as described herein.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23642594A | 1994-04-29 | 1994-04-29 | |
PCT/US1995/005347 WO1995029672A1 (en) | 1994-04-29 | 1995-04-28 | HALOMETHYL AMIDES AS IL-1β PROTEASE INHIBITORS |
Publications (2)
Publication Number | Publication Date |
---|---|
NO964472L true NO964472L (en) | 1996-10-21 |
NO964472D0 NO964472D0 (en) | 1996-10-21 |
Family
ID=22889450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO964472A NO964472D0 (en) | 1994-04-29 | 1996-10-21 | Halo methylamides as IL-1 prosthesis inhibitors |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0758891A4 (en) |
JP (1) | JPH09512556A (en) |
CN (1) | CN1147201A (en) |
AU (1) | AU705321B2 (en) |
CA (1) | CA2189036A1 (en) |
FI (1) | FI964342A (en) |
MX (1) | MX9605196A (en) |
NO (1) | NO964472D0 (en) |
WO (1) | WO1995029672A1 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
AU5122196A (en) * | 1995-03-31 | 1996-10-16 | Takeda Chemical Industries Ltd. | Cysteine protease inhibitor |
US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
ATE296812T1 (en) | 1998-03-09 | 2005-06-15 | Vertex Pharma | 1,2-DIAZEPAN DERIVATIVES AS INHIBITORS OF THE INTERLEUKIN-1BETA CONVERTING ENZYME |
HU227920B1 (en) | 1998-03-19 | 2012-06-28 | Vertex Pharma | Inhibitors of caspases, pharmaceutical compositions comprising thereof and their use |
GB9922830D0 (en) | 1999-09-27 | 1999-11-24 | Novartis Ag | Processes |
JP2003525874A (en) * | 2000-01-06 | 2003-09-02 | メルク フロスト カナダ アンド カンパニー | Novel compounds and compositions as protease inhibitors |
PE20011350A1 (en) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROPHARMAC OF AN INHIBITOR OF INTERLEUKIN-1ß CONVERTER ENZYME (ICE) |
PT1533292E (en) | 2002-08-30 | 2007-05-31 | Japan Tobacco Inc | Dibenzylamine compound and medicinal use thereof |
CN100441186C (en) * | 2003-12-03 | 2008-12-10 | 和记黄埔医药企业有限公司 | Medical use of artificial lywrine |
EP1778221A2 (en) | 2004-05-27 | 2007-05-02 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1806291A1 (en) * | 1968-10-31 | 1970-05-14 | Badische Anilin Und & Soda Fab | fungicide |
US4195096A (en) * | 1977-01-12 | 1980-03-25 | Gaf Corporation | Carboxylic amides as fungicides to eumycotina in phanerogamia plant life |
DE2946910A1 (en) * | 1979-11-21 | 1981-07-02 | Hoechst Ag, 6230 Frankfurt | FUNGICIDAL SULFONYL, BZW. SULFINYL ACETANILIDE |
DE3122738A1 (en) * | 1980-06-12 | 1982-03-18 | CIBA-GEIGY AG, 4002 Basel | "USE OF IODOACETAMIDE FOR CONTROLLING PAD ORGANISMS AND AGENT FOR CONTROLLING" |
US4377587A (en) * | 1980-07-25 | 1983-03-22 | Ciba-Geigy Corporation | Arylamine derivatives and use thereof as microbicides |
JPS5798202A (en) * | 1980-12-09 | 1982-06-18 | Kumiai Chem Ind Co Ltd | Herbicide |
GB2094786B (en) * | 1981-03-04 | 1985-09-11 | Ici Plc | Herbicidal and fungicidal amide derivatives |
DE3339351A1 (en) * | 1983-10-29 | 1985-05-09 | Bayer Ag, 5090 Leverkusen | IODACETAMIDE |
US4800211A (en) * | 1986-08-18 | 1989-01-24 | Merck & Co., Inc. | 5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors |
US4874864A (en) * | 1988-05-24 | 1989-10-17 | Pfizer Inc. | Benzamide protease inhibitors |
US5258407A (en) * | 1991-12-31 | 1993-11-02 | Sterling Winthrop Inc. | 3,4-disubstituted phenols-immunomodulating agents |
-
1995
- 1995-04-28 CN CN95192847A patent/CN1147201A/en active Pending
- 1995-04-28 CA CA002189036A patent/CA2189036A1/en not_active Abandoned
- 1995-04-28 MX MX9605196A patent/MX9605196A/en unknown
- 1995-04-28 AU AU24634/95A patent/AU705321B2/en not_active Ceased
- 1995-04-28 JP JP7528446A patent/JPH09512556A/en active Pending
- 1995-04-28 EP EP95918877A patent/EP0758891A4/en not_active Withdrawn
- 1995-04-28 WO PCT/US1995/005347 patent/WO1995029672A1/en not_active Application Discontinuation
-
1996
- 1996-10-21 NO NO964472A patent/NO964472D0/en not_active Application Discontinuation
- 1996-10-28 FI FI964342A patent/FI964342A/en unknown
Also Published As
Publication number | Publication date |
---|---|
FI964342A0 (en) | 1996-10-28 |
EP0758891A1 (en) | 1997-02-26 |
FI964342A (en) | 1996-10-28 |
WO1995029672A1 (en) | 1995-11-09 |
EP0758891A4 (en) | 1997-12-03 |
JPH09512556A (en) | 1997-12-16 |
CN1147201A (en) | 1997-04-09 |
CA2189036A1 (en) | 1995-11-09 |
MX9605196A (en) | 1997-12-31 |
AU2463495A (en) | 1995-11-29 |
AU705321B2 (en) | 1999-05-20 |
NO964472D0 (en) | 1996-10-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |