NO962906L - Process for the preparation of naphthyridinecarboxylic acids and their salts - Google Patents

Process for the preparation of naphthyridinecarboxylic acids and their salts

Info

Publication number
NO962906L
NO962906L NO962906A NO962906A NO962906L NO 962906 L NO962906 L NO 962906L NO 962906 A NO962906 A NO 962906A NO 962906 A NO962906 A NO 962906A NO 962906 L NO962906 L NO 962906L
Authority
NO
Norway
Prior art keywords
amino
salts
naphthyridinecarboxylic
acids
preparation
Prior art date
Application number
NO962906A
Other languages
Norwegian (no)
Other versions
NO962906D0 (en
Inventor
Carlos Picornell Darder
Pedro Hernandez
Antonio Cosme Gomez
Maria Luisa Salas Gonzalez
Original Assignee
Sint Quimica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sint Quimica Sa filed Critical Sint Quimica Sa
Publication of NO962906D0 publication Critical patent/NO962906D0/en
Publication of NO962906L publication Critical patent/NO962906L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Den foreliggende oppfinnelse angår en fremgangs- måte til å oppnå naftyridiner med generell formel l, i hvilken R betegner 3-amino-l-pyrrolidinyl (tosufloksacin eller (RS)-7-(3-amino-l-pyrrolidi- ny l)-6-fluor-1 -(2,4-difluorfeny 1)-1,4-dihydro-4- okso-l,8-naftyridin-3-karboksylsyre (la)) eller (la,5a,6a)-6-amino-3-azabicyklo[3.1.0]heks-yl) (trovafloksacin eller 7-{(la,5a,6a)-6-amino-3- azabicyklo[3. l .0]heks-3-yl}6-fluor- l-(2,4-difluor- fenyl)-1,4-dihydro-4-okso-l ,8-naftyridin-3-karbok- sylsyre (lb)), og deres respektive hydrater og salter, som er syntetiske forbindelser med fordelaktige terapeutiske egenskaper, som hører til fluorokino- lonfamilien, som har antibakteriell virkning.The present invention relates to a process for obtaining naphthyridines of general formula I in which R represents 3-amino-1-pyrrolidinyl (tosufloxacin or (RS) -7- (3-amino-1-pyrrolidinyl) - 6-Fluoro-1- (2,4-difluorophenyl) -1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (1a) or (1a, 5a, 6a) -6-amino -3-azabicyclo [3.1.0] hex-yl) (trovafloxacin or 7 - {(1a, 5a, 6a) -6-amino-3-azabicyclo [3.1.0] hex-3-yl} 6-fluoro 1- (2,4-difluorophenyl) -1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (1b)) and their respective hydrates and salts which are synthetic compounds with beneficial therapeutic properties, belonging to the fluoroquinolone family, which have antibacterial activity.

NO962906A 1995-07-27 1996-07-10 Process for the preparation of naphthyridinecarboxylic acids and their salts NO962906L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09501512A ES2095809B1 (en) 1995-07-27 1995-07-27 PROCEDURE FOR THE PREPARATION OF NAFTIRIDIN CARBOXYLIC ACIDS AND THEIR SALTS.

Publications (2)

Publication Number Publication Date
NO962906D0 NO962906D0 (en) 1996-07-10
NO962906L true NO962906L (en) 1997-01-28

Family

ID=8291178

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962906A NO962906L (en) 1995-07-27 1996-07-10 Process for the preparation of naphthyridinecarboxylic acids and their salts

Country Status (13)

Country Link
KR (1) KR970006303A (en)
AR (1) AR002848A1 (en)
CO (1) CO4700471A1 (en)
CZ (1) CZ204796A3 (en)
ES (1) ES2095809B1 (en)
FI (1) FI962852A (en)
GR (1) GR960100244A (en)
HU (1) HUP9602071A3 (en)
MX (1) MX9602953A (en)
NO (1) NO962906L (en)
PL (1) PL315423A1 (en)
PT (1) PT101897B (en)
SK (1) SK92396A3 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU198709B (en) * 1987-04-08 1989-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing quinoline-carboxylic acid derivatives
NZ224150A (en) * 1987-04-08 1990-11-27 Chinoin Gyogyszer Es Vegyeszet Preparation of piperazinyl-substituted quinoline derivatives
KR970005911B1 (en) * 1987-06-24 1997-04-22 치노인 교기스져 에스 베게스제티 테르메케크 기야라 알티 Process for preparing quinoline carboxylic acid derivatives
IE62600B1 (en) * 1987-08-04 1995-02-22 Abbott Lab Naphtyridine antianaerobic compounds
US5164402A (en) * 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
ES2020786A6 (en) * 1990-07-19 1991-09-16 Inke Sa Procedure for obtaining (+)-7-(3-amino-1-pyrrolidinyl)-1- (2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8- naphthyridine-3-carboxylic acid and salts thereof
CA2181351C (en) * 1994-01-18 1999-09-28 Tamim F. Braish Process and intermediates for preparing naphthyridonecarboxylic acid salts

Also Published As

Publication number Publication date
ES2095809B1 (en) 1997-12-16
ES2095809A1 (en) 1997-02-16
AR002848A1 (en) 1998-04-29
MX9602953A (en) 1997-06-28
GR960100244A (en) 1997-03-31
KR970006303A (en) 1997-02-19
SK92396A3 (en) 1997-06-04
CO4700471A1 (en) 1998-12-29
PT101897B (en) 1999-07-30
PT101897A (en) 1997-06-30
CZ204796A3 (en) 1997-02-12
HU9602071D0 (en) 1996-09-30
PL315423A1 (en) 1997-02-03
NO962906D0 (en) 1996-07-10
FI962852A (en) 1997-01-28
HUP9602071A2 (en) 1997-03-28
FI962852A0 (en) 1996-07-15
HUP9602071A3 (en) 2000-03-28

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application