NO960829L - Process for the preparation of 13-alkyl-11r - Google Patents
Process for the preparation of 13-alkyl-11rInfo
- Publication number
- NO960829L NO960829L NO960829A NO960829A NO960829L NO 960829 L NO960829 L NO 960829L NO 960829 A NO960829 A NO 960829A NO 960829 A NO960829 A NO 960829A NO 960829 L NO960829 L NO 960829L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- methyl
- alkenyl
- general formula
- residue
- Prior art date
Links
Abstract
Fremgangsmåter for fremstilling av forbindelser med den generelle formel II hvor K betyr en i form av ketalet, tio- ketalet, oksimet eller metyloksimet blokkert ketogruppe; R1 er C2- til C6- alkenyl, tienyl, pyridyl, furyl, tiazolyl eller pyrimidyl; R2 er en a- eller p-metyl- eller en p-etylrest, idet når R2 er en a-metylrest, kan R1 i tillegg være en alkylrest med 1-6 kar- bonatomer, eller cyanfenyl; når R2 er en a-metylrest, er R4 hydroksy og R3 er Ci- til C6-alkyl, C2- til C6-alkenyl eller C2- til C6-alkynyl, alle eventuelt hydroksylert; når R2 er i p-stilling, er R3 hydroksy og R4 er Cj- til C6- alkyl, C2- til C6-alkenyl eller C2- til C6-alkynyl, alle eventuelt hydroksy- lert; og når R2 er i p-stilling, kan R1 ikke være isopropenyl; og R3' og R4' har de samme betydninger som R3 hhv. R4, idet eventuelt tilstedeværende hydrok- sygrupper i R3 og R4 er beskyttet; ved flertrinnssyntese fra enten en forbin- delse med den generelle formel III (l 111 hvor K og R2 har de ovenfor angitte betydninger, eller en forbindelse med den generelle formel VII (VII l hvor K og R2 har de allerede angitte betydninger.Processes for the preparation of compounds of general formula II wherein K means a keto group in the form of the ketal, thioketal, oxime or methyl oxime; R 1 is C 2 to C 6 alkenyl, thienyl, pyridyl, furyl, thiazolyl or pyrimidyl; R 2 is an α- or p-methyl or a p-ethyl residue, where R 2 is an α-methyl residue, R 1 may additionally be an alkyl residue of 1-6 carbon atoms, or cyanophenyl; when R 2 is an α-methyl radical, R 4 is hydroxy and R 3 is C 1 to C 6 alkyl, C 2 to C 6 alkenyl or C 2 to C 6 alkynyl, all optionally hydroxylated; when R 2 is in the β-position, R 3 is hydroxy and R 4 is C 1 to C 6 alkyl, C 2 to C 6 alkenyl or C 2 to C 6 alkynyl, all optionally hydroxylated; and when R2 is in the β-position, R1 cannot be isopropenyl; and R3 'and R4' have the same meanings as R3 and R3 respectively. R4, wherein any hydroxy groups present in R3 and R4 are protected; by multi-step synthesis from either a compound of the general formula III (111 where K and R2 have the meanings given above) or a compound of the general formula VII (VII 1 where K and R2 have the meanings already given).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO960829A NO960829D0 (en) | 1988-07-01 | 1996-02-29 | Process for the preparation of 13-alkyl-11r |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3822770A DE3822770A1 (en) | 1988-07-01 | 1988-07-01 | 13-ALKYL-11SS-PHENYLGONANE |
PCT/DE1989/000443 WO1990000174A1 (en) | 1988-07-01 | 1989-07-03 | 13-ALKYL-11β-PHENYLGONANES |
NO905609A NO180451C (en) | 1988-07-01 | 1990-12-27 | Analogous Process for the Preparation of Therapeutically Active 13-Alkyl-11 |
NO960829A NO960829D0 (en) | 1988-07-01 | 1996-02-29 | Process for the preparation of 13-alkyl-11r |
Publications (2)
Publication Number | Publication Date |
---|---|
NO960829L true NO960829L (en) | 1991-02-28 |
NO960829D0 NO960829D0 (en) | 1996-02-29 |
Family
ID=27197882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO960829A NO960829D0 (en) | 1988-07-01 | 1996-02-29 | Process for the preparation of 13-alkyl-11r |
Country Status (1)
Country | Link |
---|---|
NO (1) | NO960829D0 (en) |
-
1996
- 1996-02-29 NO NO960829A patent/NO960829D0/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO960829D0 (en) | 1996-02-29 |
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