NO960829L - Process for the preparation of 13-alkyl-11r - Google Patents

Process for the preparation of 13-alkyl-11r

Info

Publication number
NO960829L
NO960829L NO960829A NO960829A NO960829L NO 960829 L NO960829 L NO 960829L NO 960829 A NO960829 A NO 960829A NO 960829 A NO960829 A NO 960829A NO 960829 L NO960829 L NO 960829L
Authority
NO
Norway
Prior art keywords
alkyl
methyl
alkenyl
general formula
residue
Prior art date
Application number
NO960829A
Other languages
Norwegian (no)
Other versions
NO960829D0 (en
Inventor
Stefan Scholz
Eckhard Ottow
Gunter Neef
Walter Elger
Sybille Beier
Krzysztof Chwalisz
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3822770A external-priority patent/DE3822770A1/en
Publication of NO960829L publication Critical patent/NO960829L/en
Application filed by Schering Ag filed Critical Schering Ag
Priority to NO960829A priority Critical patent/NO960829D0/en
Publication of NO960829D0 publication Critical patent/NO960829D0/en

Links

Abstract

Fremgangsmåter for fremstilling av forbindelser med den generelle formel II hvor K betyr en i form av ketalet, tio- ketalet, oksimet eller metyloksimet blokkert ketogruppe; R1 er C2- til C6- alkenyl, tienyl, pyridyl, furyl, tiazolyl eller pyrimidyl; R2 er en a- eller p-metyl- eller en p-etylrest, idet når R2 er en a-metylrest, kan R1 i tillegg være en alkylrest med 1-6 kar- bonatomer, eller cyanfenyl; når R2 er en a-metylrest, er R4 hydroksy og R3 er Ci- til C6-alkyl, C2- til C6-alkenyl eller C2- til C6-alkynyl, alle eventuelt hydroksylert; når R2 er i p-stilling, er R3 hydroksy og R4 er Cj- til C6- alkyl, C2- til C6-alkenyl eller C2- til C6-alkynyl, alle eventuelt hydroksy- lert; og når R2 er i p-stilling, kan R1 ikke være isopropenyl; og R3' og R4' har de samme betydninger som R3 hhv. R4, idet eventuelt tilstedeværende hydrok- sygrupper i R3 og R4 er beskyttet; ved flertrinnssyntese fra enten en forbin- delse med den generelle formel III (l 111 hvor K og R2 har de ovenfor angitte betydninger, eller en forbindelse med den generelle formel VII (VII l hvor K og R2 har de allerede angitte betydninger.Processes for the preparation of compounds of general formula II wherein K means a keto group in the form of the ketal, thioketal, oxime or methyl oxime; R 1 is C 2 to C 6 alkenyl, thienyl, pyridyl, furyl, thiazolyl or pyrimidyl; R 2 is an α- or p-methyl or a p-ethyl residue, where R 2 is an α-methyl residue, R 1 may additionally be an alkyl residue of 1-6 carbon atoms, or cyanophenyl; when R 2 is an α-methyl radical, R 4 is hydroxy and R 3 is C 1 to C 6 alkyl, C 2 to C 6 alkenyl or C 2 to C 6 alkynyl, all optionally hydroxylated; when R 2 is in the β-position, R 3 is hydroxy and R 4 is C 1 to C 6 alkyl, C 2 to C 6 alkenyl or C 2 to C 6 alkynyl, all optionally hydroxylated; and when R2 is in the β-position, R1 cannot be isopropenyl; and R3 'and R4' have the same meanings as R3 and R3 respectively. R4, wherein any hydroxy groups present in R3 and R4 are protected; by multi-step synthesis from either a compound of the general formula III (111 where K and R2 have the meanings given above) or a compound of the general formula VII (VII 1 where K and R2 have the meanings already given).

NO960829A 1988-07-01 1996-02-29 Process for the preparation of 13-alkyl-11r NO960829D0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO960829A NO960829D0 (en) 1988-07-01 1996-02-29 Process for the preparation of 13-alkyl-11r

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3822770A DE3822770A1 (en) 1988-07-01 1988-07-01 13-ALKYL-11SS-PHENYLGONANE
PCT/DE1989/000443 WO1990000174A1 (en) 1988-07-01 1989-07-03 13-ALKYL-11β-PHENYLGONANES
NO905609A NO180451C (en) 1988-07-01 1990-12-27 Analogous Process for the Preparation of Therapeutically Active 13-Alkyl-11
NO960829A NO960829D0 (en) 1988-07-01 1996-02-29 Process for the preparation of 13-alkyl-11r

Publications (2)

Publication Number Publication Date
NO960829L true NO960829L (en) 1991-02-28
NO960829D0 NO960829D0 (en) 1996-02-29

Family

ID=27197882

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960829A NO960829D0 (en) 1988-07-01 1996-02-29 Process for the preparation of 13-alkyl-11r

Country Status (1)

Country Link
NO (1) NO960829D0 (en)

Also Published As

Publication number Publication date
NO960829D0 (en) 1996-02-29

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