NO960017L - New pseudopeptides with trifluoromethyl-substituted 2-azabicyclooctane - Google Patents

New pseudopeptides with trifluoromethyl-substituted 2-azabicyclooctane

Info

Publication number
NO960017L
NO960017L NO960017A NO960017A NO960017L NO 960017 L NO960017 L NO 960017L NO 960017 A NO960017 A NO 960017A NO 960017 A NO960017 A NO 960017A NO 960017 L NO960017 L NO 960017L
Authority
NO
Norway
Prior art keywords
azabicyclooctane
trifluoromethyl
substituted
residue
pseudopeptides
Prior art date
Application number
NO960017A
Other languages
Norwegian (no)
Other versions
NO960017D0 (en
Inventor
Siegfried Raddatz
Hanno Wild
Dieter Habich
Wolfgang Roben
Jutta Hansen
Arnold Paessens
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO960017D0 publication Critical patent/NO960017D0/en
Publication of NO960017L publication Critical patent/NO960017L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Det blir beskrevet nye pseudopeptider med trlfluor- metylsubstltuert 2-azabicyklooktan med den generelle formel (I) hvor A står for cyano eller for en rest med formelen -CO-\H2. R! står for en rest med formlene R7 N eller 12 hvor R2, R3. R4, R5. R6. R7, R8, R9. R10- R11 og R12 er Ilke eller forskjellige og står for fenyl, hyd- roksyl, hydrogen, halogen, rettkjedet eller forgre- net alkyl med opptil 4 karbonatomer, morfollnyl, fenyltlo eller cykloalkyl med 3 til 6 karbonatomer, a er et tall O eller l, og deres salter. Det blir dessuten beskrevet en fremgangsmåte for fremstilling av forbindelsene samt deres anvendelse som antiretrovirale midler.New pseudopeptides of trifluoromethyl-substituted 2-azabicyclooctane of general formula (I) wherein A stands for cyano or a residue of formula -CO- H 2 are described. R! represents a residue of the formulas R7 N or 12 wherein R2, R3. R4, R5. R6. R7, R8, R9. R10-R11 and R12 are the same or different and represent phenyl, hydroxyl, hydrogen, halogen, straight chain or branched alkyl of up to 4 carbon atoms, morpholyl, phenylthlo or cycloalkyl of 3 to 6 carbon atoms, a is a number O or l, and their salts. A process for the preparation of the compounds as well as their use as antiretroviral agents is also described.

NO960017A 1995-01-04 1996-01-03 New pseudopeptides with trifluoromethyl-substituted 2-azabicyclooctane NO960017L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19500122A DE19500122A1 (en) 1995-01-04 1995-01-04 New pseudopeptides with trifluoromethyl-substituted 2-azabicyclooctane

Publications (2)

Publication Number Publication Date
NO960017D0 NO960017D0 (en) 1996-01-03
NO960017L true NO960017L (en) 1996-07-05

Family

ID=7750988

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960017A NO960017L (en) 1995-01-04 1996-01-03 New pseudopeptides with trifluoromethyl-substituted 2-azabicyclooctane

Country Status (16)

Country Link
EP (1) EP0720988A1 (en)
JP (1) JPH08259534A (en)
KR (1) KR960029344A (en)
CN (1) CN1134941A (en)
AU (1) AU4068495A (en)
CA (1) CA2166372A1 (en)
CZ (1) CZ1196A3 (en)
DE (1) DE19500122A1 (en)
FI (1) FI960014A (en)
HU (1) HUT74806A (en)
IL (1) IL116621A0 (en)
NO (1) NO960017L (en)
NZ (1) NZ280730A (en)
PL (1) PL312147A1 (en)
SK (1) SK1396A3 (en)
ZA (1) ZA9626B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070001922A (en) 2003-12-12 2007-01-04 와이어쓰 Quinolines useful in treating cardiovascular disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1408675A (en) 1973-03-16 1975-10-01 Allen & Hanburys Ltd Amides derived from quinoxaline
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
DE4126485A1 (en) 1991-08-10 1993-02-11 Bayer Ag TRIFLUOROMETHYL-CONTAINING PSEUDOPEPTIDE
TW372972B (en) * 1992-10-23 1999-11-01 Novartis Ag Antiretroviral acyl compounds

Also Published As

Publication number Publication date
SK1396A3 (en) 1996-08-07
CN1134941A (en) 1996-11-06
JPH08259534A (en) 1996-10-08
NZ280730A (en) 1996-08-27
DE19500122A1 (en) 1996-07-11
CA2166372A1 (en) 1996-07-05
ZA9626B (en) 1996-07-10
PL312147A1 (en) 1996-07-08
KR960029344A (en) 1996-08-17
NO960017D0 (en) 1996-01-03
EP0720988A1 (en) 1996-07-10
HUT74806A (en) 1997-02-28
AU4068495A (en) 1996-07-11
FI960014A (en) 1996-07-05
FI960014A0 (en) 1996-01-02
HU9503928D0 (en) 1996-03-28
IL116621A0 (en) 1996-03-31
CZ1196A3 (en) 1997-05-14

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