NO953865L - Bifunctional chelators and their use in radiopharmaceuticals - Google Patents

Bifunctional chelators and their use in radiopharmaceuticals

Info

Publication number
NO953865L
NO953865L NO953865A NO953865A NO953865L NO 953865 L NO953865 L NO 953865L NO 953865 A NO953865 A NO 953865A NO 953865 A NO953865 A NO 953865A NO 953865 L NO953865 L NO 953865L
Authority
NO
Norway
Prior art keywords
compounds
radiopharmaceuticals
preparation
bifunctional chelators
radiodiagnostic
Prior art date
Application number
NO953865A
Other languages
Norwegian (no)
Other versions
NO953865D0 (en
Inventor
Ludger Dinkelborg
Sebastian Erber
Gerhard Rohlfs
Paul-Eberhard Schulze
Bernhard Noll
Original Assignee
Diagnostikforschung Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagnostikforschung Inst filed Critical Diagnostikforschung Inst
Publication of NO953865D0 publication Critical patent/NO953865D0/en
Publication of NO953865L publication Critical patent/NO953865L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det beskrives nye technetium- og rheniumchelatfor- bindelser, fremgangsmåter ved deres fremstilling og radiofarmasøytiske midler som inneholder disse for- bindelser, samt konjugater av disse forbindelser med substanser som selektivt akkumuleres i av sykdom angrepet vev, spesielt peptider og proteiner. Dessuten beskrives fremstillingen av midler som inneholder slike forbindelser samt deres anvendelse ved radio- diagnostiske undersøkelser.New technetium and rhenium chelate compounds, methods of their preparation and radiopharmaceuticals containing these compounds are disclosed, as well as conjugates of these compounds with substances that are selectively accumulated in disease-infested tissues, especially peptides and proteins. In addition, the preparation of agents containing such compounds and their use in radiodiagnostic studies is described.

NO953865A 1993-03-31 1995-09-29 Bifunctional chelators and their use in radiopharmaceuticals NO953865L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4311021A DE4311021A1 (en) 1993-03-31 1993-03-31 Bifunctional chelating agents, their technetium and rhenium complexes, processes for their preparation and radiopharmaceutical compositions containing these compounds
PCT/DE1994/000369 WO1994022491A1 (en) 1993-03-31 1994-03-29 Bifunctional chelators and their use in radiopharmaceuticals

Publications (2)

Publication Number Publication Date
NO953865D0 NO953865D0 (en) 1995-09-29
NO953865L true NO953865L (en) 1995-11-23

Family

ID=6484685

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953865A NO953865L (en) 1993-03-31 1995-09-29 Bifunctional chelators and their use in radiopharmaceuticals

Country Status (10)

Country Link
EP (1) EP0692979A1 (en)
JP (1) JPH08508261A (en)
KR (1) KR960701667A (en)
AU (1) AU6501594A (en)
CA (1) CA2156618A1 (en)
DE (1) DE4311021A1 (en)
HU (1) HUT72733A (en)
NO (1) NO953865L (en)
NZ (1) NZ263792A (en)
WO (1) WO1994022491A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4310999C2 (en) * 1993-03-31 1996-07-18 Diagnostikforschung Inst Bifunctional chalkogen atom-interrupted chelating agents of the type XN¶1¶S¶1¶X 'for radioactive isotopes and their metal complexes, processes for their preparation and pharmaceutical compositions containing them
DE4311022C2 (en) * 1993-03-31 1996-07-11 Diagnostikforschung Inst Bifunctional chalcogen atom-interrupted chelating agents of the type S¶3¶N¶2¶ for radioactive isotopes and their metal complexes, processes for their preparation and pharmaceutical compositions containing them
DE4337600A1 (en) * 1993-11-01 1995-05-04 Diagnostikforschung Inst N-alkyl peptide chelating agents, their metal complexes with radionuclides, processes for their preparation and radiopharmaceutical compositions containing these compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
CA2217857A1 (en) * 1995-05-10 1996-11-14 Darwin Discovery Limited Peptide compounds which inhibit metalloproteinase and tnf liberation and their therapeutic uses
CA2229434A1 (en) * 1995-10-05 1997-04-10 Chiroscience Limited Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation
DE19652374A1 (en) * 1996-12-04 1998-06-10 Schering Ag Use of endothelin conjugates in therapy, new endothelin conjugates, agents containing them, and processes for their preparation
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
EA006860B1 (en) 2002-01-29 2006-04-28 Уайт Compositions and methods for modulating connexin hemichannels
EP2258401B1 (en) * 2002-05-06 2014-07-09 Endocyte, Inc. Folate-receptor targeted imaging agents
EP2869835A1 (en) * 2012-07-06 2015-05-13 Stichting Het Nederlands Kanker Instituut Cysteine protease capturing agents
RS63143B1 (en) 2016-06-01 2022-05-31 Athira Pharma Inc Compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE61746B1 (en) * 1987-07-16 1994-11-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
AU1995392A (en) * 1991-05-08 1992-12-21 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
JPH0570484A (en) * 1991-09-12 1993-03-23 Hitachi Chem Co Ltd Peptide and its salt
WO1993015771A1 (en) * 1992-02-06 1993-08-19 Mallinckrodt Medical, Inc. Ligands for improving metal chelate formation kinetics

Also Published As

Publication number Publication date
CA2156618A1 (en) 1994-10-13
WO1994022491A1 (en) 1994-10-13
HU9502858D0 (en) 1995-11-28
EP0692979A1 (en) 1996-01-24
AU6501594A (en) 1994-10-24
NZ263792A (en) 1997-02-24
KR960701667A (en) 1996-03-28
NO953865D0 (en) 1995-09-29
HUT72733A (en) 1996-05-28
DE4311021A1 (en) 1994-10-27
JPH08508261A (en) 1996-09-03

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