NO952748L - Polypeptid som spesifikt inhiberer Cathepsin L. - Google Patents
Polypeptid som spesifikt inhiberer Cathepsin L.Info
- Publication number
- NO952748L NO952748L NO952748A NO952748A NO952748L NO 952748 L NO952748 L NO 952748L NO 952748 A NO952748 A NO 952748A NO 952748 A NO952748 A NO 952748A NO 952748 L NO952748 L NO 952748L
- Authority
- NO
- Norway
- Prior art keywords
- polypeptide
- cathepsin
- osteoporosis
- specifically inhibits
- well
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102000004172 Cathepsin L Human genes 0.000 title abstract 3
- 108090000624 Cathepsin L Proteins 0.000 title abstract 3
- 208000001132 Osteoporosis Diseases 0.000 abstract 3
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 208000006386 Bone Resorption Diseases 0.000 abstract 1
- 206010039984 Senile osteoporosis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000024279 bone resorption Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer et polypeptid som har en aminosyresekvens representert ved Sekvens nr. l, og en katepsin L-spesifikk inhibitor, samt et terapeutisk middel mot osteoporose som inneholder polypeptidet som dets virkestoff. Siden polypeptidet ifølge foreliggende oppfinnelse har en sterk spesifikk inhiberende virkning på katepsin L, så vel som en sterkt benresorpsjonsinhiberende virkning, er polypeptidet anvendelig ved behandling av osteoporose, særlig senil osteo- porose.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28327093 | 1993-11-12 | ||
| JP31353393A JP3276753B2 (ja) | 1993-11-12 | 1993-12-14 | カテプシンｌ特異的阻害ポリペプチド |
| PCT/JP1994/001878 WO1995013302A1 (fr) | 1993-11-12 | 1994-11-08 | Polypeptide a inhibition specifique de la cathepsine l |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO952748D0 NO952748D0 (no) | 1995-07-11 |
| NO952748L true NO952748L (no) | 1995-07-11 |
Family
ID=26554960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO952748A NO952748L (no) | 1993-11-12 | 1995-07-11 | Polypeptid som spesifikt inhiberer Cathepsin L. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5698519A (no) |
| EP (1) | EP0679659B1 (no) |
| JP (1) | JP3276753B2 (no) |
| KR (1) | KR950704358A (no) |
| AT (1) | ATE178909T1 (no) |
| AU (1) | AU671783B2 (no) |
| CA (1) | CA2151059A1 (no) |
| DE (1) | DE69417872T2 (no) |
| HU (1) | HU214343B (no) |
| NO (1) | NO952748L (no) |
| WO (1) | WO1995013302A1 (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050148504A1 (en) * | 2002-11-29 | 2005-07-07 | Nobuhiko Katunuma | Cysteine protease inhibitor |
| WO2004084830A2 (en) * | 2003-03-21 | 2004-10-07 | Buck Institute | Method for treating alzheimer’s dementia |
| WO2008045017A2 (en) * | 2005-06-22 | 2008-04-17 | Diamond Scott L | Sars and ebola inhibitors and use thereof, and methods for their discovery |
| US20080227688A1 (en) * | 2007-03-13 | 2008-09-18 | Johnston Randal N | Inhibition of viral replication |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3938971A1 (de) * | 1989-11-24 | 1991-05-29 | Biotechnolog Forschung Gmbh | Leukozytenelastase und kathepsin g blockierendes peptid, dna, vektor, wirtsorganismus und verfahren zu seiner gewinnung sowie pharmazeutisches praeparat |
-
1993
- 1993-12-14 JP JP31353393A patent/JP3276753B2/ja not_active Expired - Fee Related
-
1994
- 1994-11-08 DE DE69417872T patent/DE69417872T2/de not_active Expired - Fee Related
- 1994-11-08 EP EP94931695A patent/EP0679659B1/en not_active Expired - Lifetime
- 1994-11-08 WO PCT/JP1994/001878 patent/WO1995013302A1/ja active IP Right Grant
- 1994-11-08 HU HU9501580A patent/HU214343B/hu not_active IP Right Cessation
- 1994-11-08 CA CA002151059A patent/CA2151059A1/en not_active Abandoned
- 1994-11-08 AU AU80674/94A patent/AU671783B2/en not_active Ceased
- 1994-11-08 AT AT94931695T patent/ATE178909T1/de not_active IP Right Cessation
- 1994-11-08 KR KR1019950702358A patent/KR950704358A/ko active IP Right Grant
-
1995
- 1995-06-07 US US08/478,520 patent/US5698519A/en not_active Expired - Fee Related
- 1995-07-11 NO NO952748A patent/NO952748L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT73415A (en) | 1996-07-29 |
| NO952748D0 (no) | 1995-07-11 |
| EP0679659A4 (en) | 1996-05-22 |
| DE69417872D1 (en) | 1999-05-20 |
| KR950704358A (ko) | 1995-11-20 |
| EP0679659B1 (en) | 1999-04-14 |
| DE69417872T2 (de) | 1999-08-12 |
| AU8067494A (en) | 1995-05-29 |
| JPH07179496A (ja) | 1995-07-18 |
| AU671783B2 (en) | 1996-09-05 |
| ATE178909T1 (de) | 1999-04-15 |
| WO1995013302A1 (fr) | 1995-05-18 |
| HU9501580D0 (en) | 1995-09-28 |
| CA2151059A1 (en) | 1995-05-18 |
| EP0679659A1 (en) | 1995-11-02 |
| US5698519A (en) | 1997-12-16 |
| HU214343B (hu) | 1998-03-02 |
| JP3276753B2 (ja) | 2002-04-22 |
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