NO951507L - Enantiomeric cis-3- (4,6-dihydroxychromoman-3-yl-methyl) benzoic acids - Google Patents

Enantiomeric cis-3- (4,6-dihydroxychromoman-3-yl-methyl) benzoic acids

Info

Publication number
NO951507L
NO951507L NO951507A NO951507A NO951507L NO 951507 L NO951507 L NO 951507L NO 951507 A NO951507 A NO 951507A NO 951507 A NO951507 A NO 951507A NO 951507 L NO951507 L NO 951507L
Authority
NO
Norway
Prior art keywords
cis
ylmethyl
dihydroxychroman
preparation
benzoic acids
Prior art date
Application number
NO951507A
Other languages
Norwegian (no)
Other versions
NO951507D0 (en
Inventor
Iii Charles W Murtiashaw
Brian Clement Vanderplas
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO951507D0 publication Critical patent/NO951507D0/en
Publication of NO951507L publication Critical patent/NO951507L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Denne oppfinnelse vedrører enantiomerene cis-3-(4,6- dihydroksykroman-3-ylmetyl)benzosyrer og fremgangsmåter for fremstilling av slike forbindelser. Forbindelsene er anvendelige mellomprodukter ved fremstilling av optisk rene enantioroere av cis-3-(6-arylmetyloksy-4-hydroksy-kroman-3-ylmetyl)- anilinsulfonamider som er anvendelige ved behandling av astma, artritis, psoriasis, magesår, myokardialt infarkt og beslekte- de sykdommer. Nærmere bestemt vedrører den (3R-cis)-3-(4,6- dihydroksykroman-3-ylmetyl)benzosyre. Den vedrører også en forbedret fremgangsmåte for fremstilling av racemisk cis-3- (4,6-dihydroksykroman-3-ylmetyl)benzosyre.This invention relates to the enantiomers cis-3- (4,6-dihydroxychroman-3-ylmethyl) benzoic acids and processes for the preparation of such compounds. The compounds are useful intermediates in the preparation of optically pure enantiomers of cis-3- (6-arylmethyloxy-4-hydroxychroman-3-ylmethyl) aniline sulfonamides useful in the treatment of asthma, arthritis, psoriasis, gastric ulcer, myocardial infarction and related - the diseases. More specifically, it relates to (3R-cis) -3- (4,6-dihydroxychroman-3-ylmethyl) benzoic acid. It also relates to an improved process for the preparation of racemic cis-3- (4,6-dihydroxychroman-3-ylmethyl) benzoic acid.

NO951507A 1992-10-21 1995-04-20 Enantiomeric cis-3- (4,6-dihydroxychromoman-3-yl-methyl) benzoic acids NO951507L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96433692A 1992-10-21 1992-10-21
PCT/US1993/006061 WO1994008986A1 (en) 1992-10-21 1993-06-30 Enantiomeric cis-3-(4,6-dihydroxychroman-3-yl-methyl)benzoic acids

Publications (2)

Publication Number Publication Date
NO951507D0 NO951507D0 (en) 1995-04-20
NO951507L true NO951507L (en) 1995-04-20

Family

ID=25508434

Family Applications (1)

Application Number Title Priority Date Filing Date
NO951507A NO951507L (en) 1992-10-21 1995-04-20 Enantiomeric cis-3- (4,6-dihydroxychromoman-3-yl-methyl) benzoic acids

Country Status (16)

Country Link
EP (1) EP0665839A1 (en)
JP (1) JPH07507811A (en)
KR (1) KR950704291A (en)
CN (1) CN1090577A (en)
AU (1) AU4650493A (en)
CA (1) CA2146005A1 (en)
CZ (1) CZ100895A3 (en)
FI (1) FI934624A (en)
HU (1) HUT65128A (en)
IL (1) IL107293A0 (en)
MX (1) MX9306526A (en)
MY (1) MY131378A (en)
NO (1) NO951507L (en)
PL (1) PL308473A1 (en)
WO (1) WO1994008986A1 (en)
ZA (1) ZA937737B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU13299A (en) * 1996-09-16 2001-03-07 Pfizer Inc. Processes and intermediates for preparing substituted chromanol derivatives
HUP0203186A2 (en) 1999-10-27 2003-01-28 Nobex Corporation Resolution of intermediates in the synthesis of substantially pure bicalutamide
MY128449A (en) 2000-05-24 2007-02-28 Sugen Inc Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US6479692B1 (en) 2001-05-02 2002-11-12 Nobex Corporation Methods of synthesizing acylanilides including bicalutamide and derivatives thereof
CN101056868B (en) 2004-09-21 2012-05-02 马休爱德华兹股份有限公司 Substituted chroman derivatives, medicaments and use in therapy
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
CA2816319C (en) 2010-11-01 2020-06-30 Marshall Edwards, Inc. Isoflavonoid compounds and methods for the treatment of cancer
US10980774B2 (en) 2015-02-02 2021-04-20 Mei Pharma, Inc. Combination therapies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases

Also Published As

Publication number Publication date
IL107293A0 (en) 1994-01-25
FI934624A (en) 1994-04-22
NO951507D0 (en) 1995-04-20
ZA937737B (en) 1995-04-19
HUT65128A (en) 1994-04-28
MX9306526A (en) 1994-04-29
MY131378A (en) 2007-08-30
HU9302973D0 (en) 1993-12-28
AU4650493A (en) 1994-05-09
FI934624A0 (en) 1993-10-20
CN1090577A (en) 1994-08-10
JPH07507811A (en) 1995-08-31
KR950704291A (en) 1995-11-17
PL308473A1 (en) 1995-08-07
WO1994008986A1 (en) 1994-04-28
EP0665839A1 (en) 1995-08-09
CZ100895A3 (en) 1995-10-18
CA2146005A1 (en) 1994-04-28

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