NO951163L - Method for antagonizing inositol 1,4,5-triphosphate - Google Patents

Method for antagonizing inositol 1,4,5-triphosphate

Info

Publication number
NO951163L
NO951163L NO951163A NO951163A NO951163L NO 951163 L NO951163 L NO 951163L NO 951163 A NO951163 A NO 951163A NO 951163 A NO951163 A NO 951163A NO 951163 L NO951163 L NO 951163L
Authority
NO
Norway
Prior art keywords
antagonizing
inositol
triphosphate
oligomers
oligomer
Prior art date
Application number
NO951163A
Other languages
Norwegian (no)
Other versions
NO951163D0 (en
Inventor
Kenneth A Stauderman
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO951163D0 publication Critical patent/NO951163D0/en
Publication of NO951163L publication Critical patent/NO951163L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Oligomerer av formel (I) S03-N.+ s\J -CH3 (D er blitt vist å være effektive antagon- ister av inositol-l,4,5-trifosfat (IP3) ved konkurrering med IP3 for bindings- seter. Ved konkurrerende inhibering av aktiviteten av IP3 kan oligomeren ifølge oppfinnelsen modulere frigiv- elsen av intracellulært kalsium og fremkalle de resulterende fysiologiske effekter.Oligomers of formula (I) SO3-N. + S \ J -CH by competitive inhibition of the activity of IP3, the oligomer of the invention can modulate the release of intracellular calcium and induce the resulting physiological effects.

NO951163A 1992-09-28 1995-03-27 Method for antagonizing inositol 1,4,5-triphosphate NO951163L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95239392A 1992-09-28 1992-09-28
PCT/US1993/008168 WO1994007507A1 (en) 1992-09-28 1993-08-30 Method for antagonizing inositol 1,4,5-triphosphate

Publications (2)

Publication Number Publication Date
NO951163D0 NO951163D0 (en) 1995-03-27
NO951163L true NO951163L (en) 1995-03-27

Family

ID=25492868

Family Applications (1)

Application Number Title Priority Date Filing Date
NO951163A NO951163L (en) 1992-09-28 1995-03-27 Method for antagonizing inositol 1,4,5-triphosphate

Country Status (13)

Country Link
EP (1) EP0661982A1 (en)
JP (1) JPH08502068A (en)
KR (1) KR950703347A (en)
AU (1) AU670962B2 (en)
CA (1) CA2145681A1 (en)
HU (1) HUT70192A (en)
IL (1) IL107066A (en)
MX (1) MX9305933A (en)
NO (1) NO951163L (en)
NZ (1) NZ256178A (en)
TW (1) TW260663B (en)
WO (1) WO1994007507A1 (en)
ZA (1) ZA936978B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2978995A (en) * 1994-06-30 1996-01-25 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Methods for treating cell proliferative disorders by modulating signal transduction
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
WO1996025157A1 (en) 1995-02-17 1996-08-22 Smithkline Beecham Corporation Il-8 receptor antagonists
US6083920A (en) * 1995-12-21 2000-07-04 Ayurcore, Inc. Compositions for modulating intracellular inositol trisphosphate concentration
US6005008A (en) * 1996-02-16 1999-12-21 Smithkline Beecham Corporation IL-8 receptor antagonists
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
AU3499497A (en) 1996-06-27 1998-01-14 Smithkline Beecham Corporation Il-8 receptor antagonists
TR199802694T2 (en) * 1996-06-27 1999-03-22 Smithkline Beecham Corporation IL-8 resept�r kar��tlar�
ATE358486T1 (en) * 2000-11-09 2007-04-15 Contrimmune Biotechnology Inc USE OF XESTOSPONGIN C TO TREAT OR PREVENT HIV INFECTION
CA2857374A1 (en) 2011-09-02 2013-03-07 The Trustees Of Columbia University In The City Of New York Camkii, ip3r, calcineurin, p38 and mk2/3 inhibitors to treat metabolic disturbances of obesity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB781479A (en) * 1953-08-27 1957-08-21 Ciba Ltd New polyureas and process for making them
US5276182A (en) * 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers

Also Published As

Publication number Publication date
TW260663B (en) 1995-10-21
AU4841793A (en) 1994-04-26
WO1994007507A1 (en) 1994-04-14
JPH08502068A (en) 1996-03-05
CA2145681A1 (en) 1994-04-14
KR950703347A (en) 1995-09-20
EP0661982A1 (en) 1995-07-12
NZ256178A (en) 1997-03-24
ZA936978B (en) 1994-04-18
NO951163D0 (en) 1995-03-27
MX9305933A (en) 1994-04-29
HUT70192A (en) 1995-09-28
AU670962B2 (en) 1996-08-08
IL107066A0 (en) 1993-12-28
HU9500891D0 (en) 1995-05-29
IL107066A (en) 1998-01-04

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