KR950703347A - Method for Antagonizing Inositol 1,4,5-Triphosphate - Google Patents

Method for Antagonizing Inositol 1,4,5-Triphosphate Download PDF

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Publication number
KR950703347A
KR950703347A KR1019950701166A KR19950701166A KR950703347A KR 950703347 A KR950703347 A KR 950703347A KR 1019950701166 A KR1019950701166 A KR 1019950701166A KR 19950701166 A KR19950701166 A KR 19950701166A KR 950703347 A KR950703347 A KR 950703347A
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KR
South Korea
Prior art keywords
inositol
triphosphate
antagonizing
oligomers
activity
Prior art date
Application number
KR1019950701166A
Other languages
Korean (ko)
Inventor
케네쓰 에이. 스토더만
Original Assignee
스티븐 엘. 네스비트
메렐 다우 파마슈티칼스 인크.
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Application filed by 스티븐 엘. 네스비트, 메렐 다우 파마슈티칼스 인크. filed Critical 스티븐 엘. 네스비트
Publication of KR950703347A publication Critical patent/KR950703347A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

하기 일반식(Ⅰ)의 올리고머가 결합 부위를 놓고 이노시톨 1,4,5-트리포스페이트(IP2)와 경쟁적으로 다툼으로써 IP3의 효과적인 길항제인 것으로 밝혀졌다.The oligomers of formula (I) below have been found to be effective antagonists of IP 3 by competitively fighting inositol 1,4,5-triphosphate (IP 2 ) over the binding site.

IP3의 활성을 경쟁적으로 억제함으로써 본 발명의올리고머는 세포내 칼슘의 방출을 조정하고 그에 따른 생리적인 효과를 이끌어낼 수 있다.By competitively inhibiting the activity of IP 3 , the oligomers of the invention can modulate the release of intracellular calcium and elicit physiological effects accordingly.

Description

이노시톨 1,4,5-트리포스페이트의 길항 방법(Method for Antagonizing Inositol 1,4,5-Triphosphhate)Method for Antagonizing Inositol 1,4,5-Triphosphhate

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

이노시톨 1,4,5-트리포스페이트에 특이적인 수용체 부위를 하기 일반식 화합물 및 제약상 허용되는 그의 염이 차지하도록 함으로써 이노시톨 1,4,5-트리포스페이트의 활성을 억제하는 방법.A method of inhibiting the activity of inositol 1,4,5-triphosphate by having a receptor site specific for inositol 1,4,5-triphosphate occupied by the following general formula compound and a pharmaceutically acceptable salt thereof. 상기 식에서, n은 5 내지 20범위에서 선택된 정수이다.Wherein n is an integer selected from 5 to 20. n이 9인 제1항의 올리고머.The oligomer of claim 1, wherein n is 9. n이 15인 제1항의 올리고머.The oligomer of claim 1, wherein n is 15. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950701166A 1992-09-28 1993-08-30 Method for Antagonizing Inositol 1,4,5-Triphosphate KR950703347A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95239392A 1992-09-28 1992-09-28
US07/952393 1992-09-28
PCT/US1993/008168 WO1994007507A1 (en) 1992-09-28 1993-08-30 Method for antagonizing inositol 1,4,5-triphosphate

Publications (1)

Publication Number Publication Date
KR950703347A true KR950703347A (en) 1995-09-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950701166A KR950703347A (en) 1992-09-28 1993-08-30 Method for Antagonizing Inositol 1,4,5-Triphosphate

Country Status (13)

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EP (1) EP0661982A1 (en)
JP (1) JPH08502068A (en)
KR (1) KR950703347A (en)
AU (1) AU670962B2 (en)
CA (1) CA2145681A1 (en)
HU (1) HUT70192A (en)
IL (1) IL107066A (en)
MX (1) MX9305933A (en)
NO (1) NO951163D0 (en)
NZ (1) NZ256178A (en)
TW (1) TW260663B (en)
WO (1) WO1994007507A1 (en)
ZA (1) ZA936978B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2978995A (en) * 1994-06-30 1996-01-25 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Methods for treating cell proliferative disorders by modulating signal transduction
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
WO1996025157A1 (en) 1995-02-17 1996-08-22 Smithkline Beecham Corporation Il-8 receptor antagonists
US6083920A (en) * 1995-12-21 2000-07-04 Ayurcore, Inc. Compositions for modulating intracellular inositol trisphosphate concentration
US6005008A (en) * 1996-02-16 1999-12-21 Smithkline Beecham Corporation IL-8 receptor antagonists
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
AU3499497A (en) 1996-06-27 1998-01-14 Smithkline Beecham Corporation Il-8 receptor antagonists
JP2000514049A (en) * 1996-06-27 2000-10-24 スミスクライン・ビーチャム・コーポレイション IL-8 receptor antagonist
EP1331932B1 (en) * 2000-11-09 2007-04-04 Contrimmune Biotechnology Inc. Use of xestospongin c for treating or preventing hiv infection
AU2012301617A1 (en) 2011-09-02 2014-04-17 Salk Institute For Biological Studies CaMKII, IP3R, calcineurin, p38 and MK2/3 inhibitors to treat metabolic disturbances of obesity

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB781479A (en) * 1953-08-27 1957-08-21 Ciba Ltd New polyureas and process for making them
US5276182A (en) * 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers

Also Published As

Publication number Publication date
AU4841793A (en) 1994-04-26
NO951163L (en) 1995-03-27
NZ256178A (en) 1997-03-24
EP0661982A1 (en) 1995-07-12
NO951163D0 (en) 1995-03-27
HU9500891D0 (en) 1995-05-29
HUT70192A (en) 1995-09-28
JPH08502068A (en) 1996-03-05
CA2145681A1 (en) 1994-04-14
WO1994007507A1 (en) 1994-04-14
IL107066A (en) 1998-01-04
MX9305933A (en) 1994-04-29
ZA936978B (en) 1994-04-18
AU670962B2 (en) 1996-08-08
IL107066A0 (en) 1993-12-28
TW260663B (en) 1995-10-21

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