NO950529L - Pharmaceutically active diketopiperazines - Google Patents
Pharmaceutically active diketopiperazinesInfo
- Publication number
- NO950529L NO950529L NO950529A NO950529A NO950529L NO 950529 L NO950529 L NO 950529L NO 950529 A NO950529 A NO 950529A NO 950529 A NO950529 A NO 950529A NO 950529 L NO950529 L NO 950529L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- nco2r11
- nhco
- optionally substituted
- diketopiperazines
- Prior art date
Links
Abstract
Diketopiperazin med formel (A): (A) hvor hver av R, til R10, som kan være like eller forskjellige, er uavhengig valgt fra hydrogen, C^-Cj-alkyl, usubstituert eller substituert med ett eller flere halogenatomer, C^-C^alkoksy, C^~C6- alkyltio, halogen, hydroksy, nitro, eventuelt sub- stituert fenyl, cyano, -CHZOH, -CH2COOH, -CO2R11, -NHCOR11, -NHS02R13, -SO2R13, -CON(R11R12) , -SOR13, -S02N(R11R12) , -N(R11R12), -0(CH2) nN (R11R12) , -0(CH2)nC02R11, -OCOR11, -CH2OCOR11,-CH2NHCOR11, -CH2NHCOOR13, -CH2SR11, -CH2SCOR11, -CH2S (O)mR13 hvor m er l eller 2, -CH2NHCO(CH2)nCO2R11, -N(R11)COR12, -NHCOCFj, -NHCOfCH^COjR11, -NHCO(CH2) nOCOR11 og -NHCO(CH2)nOR11, hvor n er O eller er et helt tall fra l til 6, hver av R11 og R12 er uavhengig H eller Cj-Cj-alkyl, og R13 er C^C^alkyl; eller enhver R, og R2, Rj og Rj, Rj og R4 og R4 og Rj, eller R6 og R7, R7 og Rg, Rj og R, og R, og R10 danner sammen med karbonatomene som de er knyttet til, en benzenring som eventuelt er substituert; eller et farmasaytisk akseptabelt salt eller en ester derav; er hemmere av plasminogen-aktivator-inhibitoren.Diketopiperazine of formula (A): (A) wherein each of R 1 to R 10, which may be the same or different, is independently selected from hydrogen, C 1 -C 2 alkyl, unsubstituted or substituted by one or more halogen atoms, C C1-4 alkoxy, C1-C6 alkylthio, halogen, hydroxy, nitro, optionally substituted phenyl, cyano, -CH2OH, -CH2COOH, -CO2R11, -NHCOR11, -NHSO2R13, -SO2R13, -CON (R11R12), - SOR13, -SO2N (R11R12), -N (R11R12), -0 (CH2) nN (R11R12), -0 (CH2) nCO2R11, -OCOR11, -CH2OCOR11, -CH2NHCOR11, -CH2NHCOOR13, -CH2SR11, -CH2SCOR11, - CH2S (O) mR13 where m is 1 or 2, -CH2NHCO (CH2) nCO2R11, -N (R11) COR12, -NHCOCFj, -NHCOfCH2COjR11, -NHCO (CH2) nOCOR11 and -NHCO (CH2) nOR11, where n is O or is an integer from 1 to 6, each of R 11 and R 12 is independently H or C 1 -C 3 alkyl, and R 13 is C 1 -C 4 alkyl; or any R, and R2, Rj and Rj, Rj and R4 and R4 and Rj, or R6 and R7, R7 and Rg, Rj and R, and R, and R10 together with the carbon atoms to which they are attached form a benzene ring which optionally substituted; or a pharmaceutically acceptable salt or ester thereof; are inhibitors of the plasminogen activator inhibitor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929217331A GB9217331D0 (en) | 1992-08-14 | 1992-08-14 | Pharmaceutical compounds |
PCT/GB1993/001734 WO1994004512A1 (en) | 1992-08-14 | 1993-08-16 | Pharmaceutically active diketopiperazines |
Publications (2)
Publication Number | Publication Date |
---|---|
NO950529D0 NO950529D0 (en) | 1995-02-13 |
NO950529L true NO950529L (en) | 1995-04-05 |
Family
ID=26301434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO950529A NO950529L (en) | 1992-08-14 | 1995-02-13 | Pharmaceutically active diketopiperazines |
Country Status (1)
Country | Link |
---|---|
NO (1) | NO950529L (en) |
-
1995
- 1995-02-13 NO NO950529A patent/NO950529L/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO950529D0 (en) | 1995-02-13 |
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