NO950529L - Pharmaceutically active diketopiperazines - Google Patents

Pharmaceutically active diketopiperazines

Info

Publication number
NO950529L
NO950529L NO950529A NO950529A NO950529L NO 950529 L NO950529 L NO 950529L NO 950529 A NO950529 A NO 950529A NO 950529 A NO950529 A NO 950529A NO 950529 L NO950529 L NO 950529L
Authority
NO
Norway
Prior art keywords
alkyl
nco2r11
nhco
optionally substituted
diketopiperazines
Prior art date
Application number
NO950529A
Other languages
Norwegian (no)
Other versions
NO950529D0 (en
Inventor
Mark Anthony David Collins
Maria Ines Chicarelli-Robinson
John Richardson Shaw
Justin Stephen Bryans
Christopher John Latham
Stephen James Brocchini
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929217331A external-priority patent/GB9217331D0/en
Application filed by Xenova Ltd filed Critical Xenova Ltd
Publication of NO950529D0 publication Critical patent/NO950529D0/en
Publication of NO950529L publication Critical patent/NO950529L/en

Links

Abstract

Diketopiperazin med formel (A): (A) hvor hver av R, til R10, som kan være like eller forskjellige, er uavhengig valgt fra hydrogen, C^-Cj-alkyl, usubstituert eller substituert med ett eller flere halogenatomer, C^-C^alkoksy, C^~C6- alkyltio, halogen, hydroksy, nitro, eventuelt sub- stituert fenyl, cyano, -CHZOH, -CH2COOH, -CO2R11, -NHCOR11, -NHS02R13, -SO2R13, -CON(R11R12) , -SOR13, -S02N(R11R12) , -N(R11R12), -0(CH2) nN (R11R12) , -0(CH2)nC02R11, -OCOR11, -CH2OCOR11,-CH2NHCOR11, -CH2NHCOOR13, -CH2SR11, -CH2SCOR11, -CH2S (O)mR13 hvor m er l eller 2, -CH2NHCO(CH2)nCO2R11, -N(R11)COR12, -NHCOCFj, -NHCOfCH^COjR11, -NHCO(CH2) nOCOR11 og -NHCO(CH2)nOR11, hvor n er O eller er et helt tall fra l til 6, hver av R11 og R12 er uavhengig H eller Cj-Cj-alkyl, og R13 er C^C^alkyl; eller enhver R, og R2, Rj og Rj, Rj og R4 og R4 og Rj, eller R6 og R7, R7 og Rg, Rj og R, og R, og R10 danner sammen med karbonatomene som de er knyttet til, en benzenring som eventuelt er substituert; eller et farmasaytisk akseptabelt salt eller en ester derav; er hemmere av plasminogen-aktivator-inhibitoren.Diketopiperazine of formula (A): (A) wherein each of R 1 to R 10, which may be the same or different, is independently selected from hydrogen, C 1 -C 2 alkyl, unsubstituted or substituted by one or more halogen atoms, C C1-4 alkoxy, C1-C6 alkylthio, halogen, hydroxy, nitro, optionally substituted phenyl, cyano, -CH2OH, -CH2COOH, -CO2R11, -NHCOR11, -NHSO2R13, -SO2R13, -CON (R11R12), - SOR13, -SO2N (R11R12), -N (R11R12), -0 (CH2) nN (R11R12), -0 (CH2) nCO2R11, -OCOR11, -CH2OCOR11, -CH2NHCOR11, -CH2NHCOOR13, -CH2SR11, -CH2SCOR11, - CH2S (O) mR13 where m is 1 or 2, -CH2NHCO (CH2) nCO2R11, -N (R11) COR12, -NHCOCFj, -NHCOfCH2COjR11, -NHCO (CH2) nOCOR11 and -NHCO (CH2) nOR11, where n is O or is an integer from 1 to 6, each of R 11 and R 12 is independently H or C 1 -C 3 alkyl, and R 13 is C 1 -C 4 alkyl; or any R, and R2, Rj and Rj, Rj and R4 and R4 and Rj, or R6 and R7, R7 and Rg, Rj and R, and R, and R10 together with the carbon atoms to which they are attached form a benzene ring which optionally substituted; or a pharmaceutically acceptable salt or ester thereof; are inhibitors of the plasminogen activator inhibitor.

NO950529A 1992-08-14 1995-02-13 Pharmaceutically active diketopiperazines NO950529L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929217331A GB9217331D0 (en) 1992-08-14 1992-08-14 Pharmaceutical compounds
PCT/GB1993/001734 WO1994004512A1 (en) 1992-08-14 1993-08-16 Pharmaceutically active diketopiperazines

Publications (2)

Publication Number Publication Date
NO950529D0 NO950529D0 (en) 1995-02-13
NO950529L true NO950529L (en) 1995-04-05

Family

ID=26301434

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950529A NO950529L (en) 1992-08-14 1995-02-13 Pharmaceutically active diketopiperazines

Country Status (1)

Country Link
NO (1) NO950529L (en)

Also Published As

Publication number Publication date
NO950529D0 (en) 1995-02-13

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