NO945091L - Fluorine-containing dipeptides as inhibitors of human leukocyte elastase inhibitors - Google Patents

Fluorine-containing dipeptides as inhibitors of human leukocyte elastase inhibitors

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Publication number
NO945091L
NO945091L NO945091A NO945091A NO945091L NO 945091 L NO945091 L NO 945091L NO 945091 A NO945091 A NO 945091A NO 945091 A NO945091 A NO 945091A NO 945091 L NO945091 L NO 945091L
Authority
NO
Norway
Prior art keywords
inhibitors
amide derivatives
human leukocyte
fluorine
leukocyte elastase
Prior art date
Application number
NO945091A
Other languages
Norwegian (no)
Other versions
NO945091D0 (en
Inventor
Philip Duke Edwards
Peter Warner
Donald John Lanin
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929214053A external-priority patent/GB9214053D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of NO945091D0 publication Critical patent/NO945091D0/en
Publication of NO945091L publication Critical patent/NO945091L/en

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Abstract

Foreliggende oppfinnelse angår visse nye amid-derivater med formel (I) som er pyrido[3,4-d]pyrimidin-7-ylacetamider som er inhibitorer for human-leukocytt-elastase (HLE), også kjent som human-neutrofil-elastase (HNE), som gjør disse forbindelser brukbare når en slik hemming er ønskelig, for eksempel for forskning innenfor den farmakologiske industri, for diagnostiske formål eller tilsvarende undersøkelser, og ved behandling av sykdommer hos pattedyr hvor HLinngår.ppfinnelsen innbefatter også mellomprodukter som kan brukes for syntese av disse amid-derivater, fremgangsmåter for frem-stilling av amid-derivatene, foruten farmasøytiske preparater inneholdende slike amid-derivater og fremgangsmåter for deres anvendelse.The present invention relates to certain novel amide derivatives of formula (I) which are pyrido [3,4-d] pyrimidin-7-ylacetamides which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase ( HNE), which makes these compounds useful when such an inhibition is desired, for example for research in the pharmacological industry, for diagnostic purposes or similar studies, and in the treatment of diseases in mammals in which HL is incorporated. The invention also includes intermediates which can be used for synthesis. of these amide derivatives, processes for the preparation of the amide derivatives, in addition to pharmaceutical preparations containing such amide derivatives and processes for their use.

NO945091A 1992-07-02 1994-12-30 Fluorine-containing dipeptides as inhibitors of human leukocyte elastase inhibitors NO945091L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929214053A GB9214053D0 (en) 1992-07-02 1992-07-02 Heterocyclic amides
PCT/GB1993/001380 WO1994001455A1 (en) 1992-07-02 1993-07-01 Fluorine comprising dipeptides as inhibitors against human leucocyte elastase inhibitors

Publications (2)

Publication Number Publication Date
NO945091D0 NO945091D0 (en) 1994-12-30
NO945091L true NO945091L (en) 1995-02-16

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ID=26301172

Family Applications (1)

Application Number Title Priority Date Filing Date
NO945091A NO945091L (en) 1992-07-02 1994-12-30 Fluorine-containing dipeptides as inhibitors of human leukocyte elastase inhibitors

Country Status (1)

Country Link
NO (1) NO945091L (en)

Also Published As

Publication number Publication date
NO945091D0 (en) 1994-12-30

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