NO944659L - Lactam dipeptides with HLE inhibitory activity - Google Patents
Lactam dipeptides with HLE inhibitory activityInfo
- Publication number
- NO944659L NO944659L NO944659A NO944659A NO944659L NO 944659 L NO944659 L NO 944659L NO 944659 A NO944659 A NO 944659A NO 944659 A NO944659 A NO 944659A NO 944659 L NO944659 L NO 944659L
- Authority
- NO
- Norway
- Prior art keywords
- amide derivatives
- hle
- dipeptides
- lactam
- inhibitory activity
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Foreliggende oppfinnelse vedrører besemte nye amid-deri- vater som er pyrido[3,4-b]indol-2-ylacetamider med formel (I) som er inhibitorer for human leukocytt elastase (HLE), også kjent som human neutrbfil elastase (HNE) som gjør dem anvende- lige når slik inhibering er ønsket, f.eks. forskningsverktøy i farmakologiske, diagnostiske og beslektede studier og ved behandling av sykdommer hos pattedyr hvor HLE inngår. Opp- finnnelsen omfatter også mellomprodukter som kan anvendes ved syntese av disse amid-derivater, fremgangsmåter for fremstil- ling av amid-derivatene, farmasøytiske preparater som innehol- der slike amid-derivater og fremgangsmåter for deres anvendelse.The present invention relates to novel novel amide derivatives which are pyrido [3,4-b] indol-2-ylacetamides of formula (I) which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE). which makes them useful when such inhibition is desired, e.g. research tools in pharmacological, diagnostic and related studies and in the treatment of mammalian diseases where HLE is included. The invention also includes intermediates which can be used in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide derivatives and methods for their use.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929211783A GB9211783D0 (en) | 1992-06-04 | 1992-06-04 | Amide derivatives |
| PCT/GB1993/001176 WO1993024519A1 (en) | 1992-06-04 | 1993-06-03 | Lactam dipeptides having hle inhibiting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO944659D0 NO944659D0 (en) | 1994-12-02 |
| NO944659L true NO944659L (en) | 1995-01-24 |
Family
ID=26300991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO944659A NO944659L (en) | 1992-06-04 | 1994-12-02 | Lactam dipeptides with HLE inhibitory activity |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO944659L (en) |
-
1994
- 1994-12-02 NO NO944659A patent/NO944659L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO944659D0 (en) | 1994-12-02 |
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